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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Elevated adipogenesis of marrow mesenchymal stem cells during early steroid-associated osteonecrosis development显示文摘 | Sheng HH Zhang GG Cheung WH | 2007 | J Orthop Surg2007，2，： | 1 |
| 3 | Delayed stimulatory effect of low - intensity shock waves on human periostealcells 显示文摘 | Tam KF Cheung WH Lee KM | 2005 | Clin Orthop Relat Res2005，438，： | 1 |
| 4 | Primary non-Hodgkin's lymphoma of the nose and nasopharynx:clinical features,tumor immunophenotype,and treatment outcome in 113 patients显示文摘 | Cheung MM Chan JK Lau WH | 1998 | J Clin Oncol1998，16，1： | 1 |
| 5 | Cdk5is involved in BDNF-stimulated dendritic growth in hippocampal neurons显示文摘 | Cheung ZH Chin WH Chen Y | 2007 | PloS Biol2007，5，4： | 1 |
| 6 | Early stage nasal NK/T-cell lymphoma: clinical outcome, prognostic factors, and the effect of treatment modality显示文摘 | Cheung MM Chan JK Lau WH | 2002 | Int J Radiat Oncol Biol Phys2002，54，1： | 1 |
| 7 | Long-term improvement in homocystein levels and arterial endothelial function after 1-year folic acid supplementation显示文摘 | Woo KS Chook P Chan LL Cheung AS Fung WH Oiao M | 2002 | Am J Med2002，112，7： | 1 |
| 8 | Low intensity pulsed ultrasound stimulates osteogenic activity of human periosteal cells显示文摘 | Leung KS Cheung WH Zhang C | 2004 | Clin Orthop Relat Res2004，418，： | 1 |
| 9 | Low intensity pulsed ultrasound stimulates osteogenic activity of human periosteal cells显示文摘 | Leung KS Cheung WH Zhang C | | 0，，418： | 1 |
| 10 | Early stage nasal NK/T-cell lymphoma: clinical outcome, prognostic factors, and the effect of treatment modality显示文摘 | Cheung MM Chan JK Lau WH | 2002 | Int J Radiat Oncol Biol Phys2002，54，1： | 1 |
| 11 | Early stage nasal NK/T- cell lymphoma:clinical outcome, prognostic factors, and the effect of treatment modality 显示文摘 | Cheung MM Chan JK Lau WH | 2002 | Int J Radiat Oncol Biol Phys2002，54，： | 1 |
| 12 | Primary non Hodgkin' lymphoma of the nose and nasopharynx:clinical features,tumor immunophenotype and treament outcome in 113 patients 显示文摘 | Cheung MM Chan JC Lau WH | 1998 | Journal of Clinical Oncology1998，16，1： | 1 |
| 13 | Early stage nasal NK/Tcell lymphoma:clinical outcome,prognostic factors,and the effect of treatment modality显示文摘 | Chan JK Lau WH | 2002 | Int J Radiat Oncol Biol Phys2002，54，1： | 1 |
| 14 | Delayed stimulatory effect of low-intensity shock wave on human periosteal ceils 显示文摘 | Tam KF Cheung WH Lee KM | 2005 | Clin Orthop Relat Res2005，438，： | 1 |
| 15 | Impaired neutrophil activity and increased susceptibility tobacterial infection in mice lacking glucose-6-phosphatase-beta显示文摘 | Cheung YY Kim SY Yiu WH Pan CJ Jun HS Ruef RA etal | 2007 | J Clin Invest2007，117，3： | 1 |
| 16 | Hyperbilirubinemia and cholelithiasis in Chinese patients with hemoglobin H disease显示文摘 | Au WY Cheung WC Hu WH | | 0，，10： | 1 |
| 17 | Delayed stimulatory effcet of low-intensity shockwave on human periosteal cell显示文摘 | Tam KF Cheung WH Lee KM | 2005 | Clin Orthop Relat Res2005，438，： | 1 |
| 18 | Early stage nasal NK/T-cell lymphoma: clinical outcome, prognostic factors, and the effect of treatment modality显示文摘 | Cheung MM Chan JX Lau WH | 2002 | Int J Radiat 0ncol Biol Phys2002，54，1： | 1 |
| 19 | Earlystage nasalNK/T cell lymphoma clinical outcome,prognostic factors,and the effect of treatment modality显示文摘 | Cheung MM Chan JK Lau WH | 2002 | Int J Radiat Oneol Biolphys2002，54，2： | 1 |
| 20 | Early stage nasal NIL/T-cell lymphoma: clinical outcome, prognostic factors, and the effect of treatment modality 显示文摘 | Cheung MM Chan JK Lau WH | 2002 | Int J Radiat Oncol Biol Phys2002，54，1： | 1 |
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