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| 1 | Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma: Prognosis and outcomes显示文摘AIM: To analyze the combined treatment of resection and intraoperative radiofrequency ablation (RFA) for multifocal hepatocellular carcinoma in terms of prognosis and surgical outcomes.METHODS: This study was a retrospective case comparison study using prospectively collected data. The study covered the period from April 2001 to December 2006. The data of 200 patients with histologically confirmed hepatocellular carcinoma were reviewed. Nineteen patients (17 men and 2 women) having received resection in combination with RFA were chosen as subjects of the study (the combination group). Fiftyfour patients (43 men and 11 women) having received resection alone were selected for comparison (the resection group). The two groups matched tumor number and tumor size, and all the patients in the two groups displayed no tumor rupture, major vascular involvement and distant metastasis. Their demographics, preoperative assessment, disease recurrence patterns, overall survival and diseasefree survival were compared.RESULTS: In the combination group, the medianage was 65 years (range, 3477 years), the median tumor number was 3 (range, 29), and the median tumor size was 6 cm (range, 1.214 cm). In the resection group, the median age was 51.5 years (range, 2780 years, P = 0.003), the median tumor number was 3 (range, 29, P = 0.574), and the median tumor size was 6 cm (range, 114 cm, P = 0.782). The two groups were similar in characteristics of tumors and comorbidities, and had comparable results in preoperative liver function tests. All patients had ChildPugh class A status. Bilobar involvement occurred in 14 patients (73.6%) in the combination group and 3 patients (5.5%) in the resection group (P = 0.04). Six patients (32%) in the combination group and 35 patients (65%) in the resection group underwent major hepatectomy. Thirteen patients (68%) in the combination group and 19 patients (35%) in the resection group underwent minor hepatectomy (P = 0.012). The combination group had fewer major resections (32% vs 65%, P = 0.012), less blood loss (400 vs 657 mL, P = 0.007), shorter operation time (270 vs 400 min, P = 0.001), and shorter hospital stay (7 vs 8.5 d, P = 0.042). The two groups displayed no major differences in surgical complications (15.8% vs 31.5%, P = 0.24), disease recurrence (63.2% vs 50%, P = 0.673), hospital mortality (5.3% vs 5.6%, P = 1), and overall survival (53 vs 44.5 mo, P = 0.496).CONCLUSION: Safe and effective for selected patients with multifocal hepatocellular carcinoma, the combination of resection and intraoperative RFA widens the applicability of surgical intervention for the disease. | Tan To Cheung Kelvin K Ng Kenneth S Chok See Ching Chan Ronnie T Poon Chung Mau Lo Sheung Tat Fan | 2010 | World Journal of Gastroenterology2010，16，24： | 14 |
| 2 | 澳大利亚临床共识指南:儿童卒中的诊断和急性期处理显示文摘卒中是导致儿童死亡的十大原因之一,幸存的致残患儿将面临几十年的残疾生活,给患儿及其家庭带来了巨大负担。由于安全性和有效性的证据有限,以及诊断的延误,目前卒中患儿无法接受再灌注治疗。儿童卒中诊断和急性期处理的澳大利亚临床共识指南,旨在最大限度地减少临床诊疗中的不确定性,并记录与成人卒中不同的危险因素、病因和假性卒中情况的最佳证据。临床问题的阐述来自于对2007年至2017年数据库的系统检索,但仅限于英语和儿科研究。该指南应用SIGN方法和国家健康与医学研究委员会系统对证据进行筛选和分类,通过推荐、评估、发展和评价系统(GRADE系统)对推荐进行强弱分级。该指南提供了60多项基于证据的推荐,以帮助参与院前和急症处理的临床医师快速识别儿童卒中,选择最合适的初步检查方案来确定诊断、明确病因,并选择最恰当的干预措施以挽救脑组织、预防复发。同时,指南也提供了颅内压和先天性心脏病管理方面的推荐。该指南的实施需要将院前和急诊系统重组,包括建立区域性卒中网络,建立儿科卒中疾病编码,快速MRI,以及对能够提供再灌注治疗的初级儿科卒中中心进行认证。该指南能够审核治疗的基准时间线,获得急性期的干预措施及预后判断。它还将促进澳大利亚儿童卒中登记的发展,并与国际登记处建立数据联系,以便准确收集卒中发病率、治疗和结果相关的数据。 | Medley TL Miteff C Andrews I Ware T Cheung M Monagle P Mandelstam S Wray A Pridmore C Troedson C Dale RC Fahey M Sinclair A Walsh P Stojanovski S Macka MT 徐佳丽(译) 吴川杰(译) 肖潇(译) 吕俊萱(译) 张博维(译) 吉训明(译) | 2019 | 中国脑血管病杂志2019，16，4： | 9 |
| 3 | 儿童期肥胖、成年期肥胖和心血管风险因子显示文摘过去30年,儿童超重或肥胖的发生率明显增加[1]。儿童期肥胖是死亡率增加的预测因子,这主要是由于儿童期肥胖可导致心血管疾病发生率增加。相关的预测研究提示"肥胖流行症"可能改变目前心血管疾病死亡率下降的趋势,使现今儿童的寿命缩短。 | Juonala M Magnussen CG Berenson GS Venn A Burns TL Sabin MA Srinivasan SR Daniels SR Davis PH Chen W Sun C Cheung M Viikari JS Dwyer T Raitakari OT 叶鹏 | 2012 | 中华高血压杂志2012，20，1： | 6 |
| 4 | Cyclin A2:At the crossroads of cell cycle and cell invasion显示文摘Cyclin A2 is an essential regulator of the cell division cycle through the activation of kinases that participate to the regulation of S phase as well as the mitotic entry. However,whereas its degradation by the proteasome in mid mitosis was thought to be essential for mitosis to proceed,recent observations show that a small fraction of cyclin A2 persists beyond metaphase and is degraded by autophagy. Its implication in the control of cytoskeletal dynamics and cell movement has unveiled its role in the modulation of Rho A activity. Since this GTPase is involved in both cell rounding early in mitosis and later,in the formation of the cleavage furrow,this suggests that cyclin A2 is a novel actor in cytokinesis. Taken together,these data point to this cyclin as a potential mediator of cell-niche interactions whose dysregulation could be taken as a hallmark of metastasis. | Abdelhalim Loukil Caroline T Cheung Nawal Bendris Bénédicte Lemmers Marion Peter Jean Marie Blanchard | 2015 | World Journal of Biological Chemistry2015，6，4： | 6 |
| 5 | Ozone and related gaseous pollutants in the boundary layer of eastern China:Overview of the recent measurements at a rural site显示文摘 | Wang T Cheung V T F Anson M | 2001 | Geophysical Research Letters2001，28，12： | 2 |
| 6 | Emission characteristics of CO,NOx,SO2 and indications of biomass burning observed at a rural site in eastern China显示文摘 | Wang T Cheung V T F Li Y S | | J Geophys Res0，107，12： | 2 |
| 7 | Visualization of ischaemic penumbra using a computed tomography pefusion method 显示文摘 | Cheung R T Cheng P W Lui W M | 2003 | Cerebrovasc Dis2003，15，： | 1 |
| 8 | CD59 expressed on a tumor cell surface modulates decay2acceleratingfactor expression and enhances tumor growth in a rat model of human neuroblastoma 显示文摘 | Chen S Caragine T Cheung NK | 2000 | Cancer Res2000，60，11： | 1 |
| 9 | Seasonal variations in clinical and laboratory variables among chronic hemodialysis patients显示文摘 | Cheung AK Yan G Greene T | 2002 | J Am Soc Nephrol2002，13，： | 1 |
| 10 | Remodeling of networks of interstitial cells of Cajal in a murine model of diabetic gastmparesis显示文摘 | Ordog T Takayama I Cheung WK | | 0，，10： | 1 |
| 11 | Splicing factors PTBP1 and PTBP2 promote proliferation and migration of glioma cell lines 显示文摘 | Cheung HC Hal T Zhu W | 2009 | Bra/n2009，132，8： | 1 |
| 12 | Remodeling of networks of interstitial cells of Cajal in a murine model of diabetic gastroparesis显示文摘 | Ordog T Takayama I Cheung WK | 2000 | Diabetes2000，49，10： | 1 |
| 13 | Model-based probabilistic frequent itemset mining显示文摘 | BERNECKER T CHENG R CHEUNG D W | 2013 | Knowledge and Informa- tion System2013，37，1： | 1 |
| 14 | Effects of high- flux hemodialysis on clinical outcomes: results of the HEMO study显示文摘 | Cheung A K Levin N W Greene T | 2003 | J Am Soc Nephrol2003，14，12： | 1 |
| 15 | The motivations and environmental attitudes of nature-based visitors to protected areas in Hong Kong显示文摘 | CHEUNG L T O FOK L | 2014 | International Journal of Sustainable Development&World Ecology2014，21，1： | 1 |
| 16 | Improving phosphate removal ol sand infiltration system using alkaline fly ash 显示文摘 | Cheung K C Venkitachalam T H | 2000 | Chemosphere2000，41，12： | 1 |
| 17 | Overexpression of NDRG1 is an indicator of poor prognosis in hepatocellular carcinorna显示文摘 | Chua M S Sun H Cheung S T | 2007 | Modern Pathology2007，20，： | 1 |
| 18 | pH-sensitive polymers that enhance intracellular drug delivery in vivo显示文摘 | Kyriakides T R Cheung C Y Murthy N | 2002 | J Control Release2002，78，13： | 1 |
| 19 | CD59 expressed on a tumor cell surface modulates decay-accelerating factor expression and enhances tumor growth in a rat model of human neuroblastoma显示文摘 | Chen S Caragine T Cheung N K | 2000 | Cancer Res2000，60，11： | 1 |
| 20 | Can positron emission tomography with the dual tracers acetate and fludeoxyglucose predict microvascular invasion in hepatocellular carcinoma? 显示文摘 | CHEUNG T T CHAN S C HO C L | 2011 | Liver Transpl2011，17，10： | 1 |
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