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| 1 | Linagliptin alleviates fatty liver disease in diabetic db/db mice显示文摘AIM To study the effects of linagliptin on the structural signs of non-alcoholic fatty liver disease(NAFLD) in db/db mice. METHODS Male diabetic db /db mice(BKS.Cg-Dock7m+/+Leprdb/J) aged 10 wk received the dipeptidyl peptidase 4(DPP4) inhibitor linagliptin(10 mg/kg) or saline as a placebo once per day by gavage for 8 wk. Intact db/db mice served as controls. Structural changes in the liver were analyzed from light and electron microscopic images of sections from intact, placebo-treated and linagliptin-treated animals. We estimated the changes in hepatocytes, sinusoidal cells, liver microvasculature and lymphatic roots. Hepatic staining for lymphatic vessel endothelial hyaluronan receptor-1(LYVE-1) was assessed by immunohistochemistry. RESULTS In 18-wk-old diabetic mice, liver steatosis(predominantly microvesicular and mediovesicular steatosis) was accompanied by dilation of the roots of the lymphatic system, interlobular blood vessels and bile canaliculi. Compared to saline-treated mice, linagliptin-treated mice exhibited a reduction in the mean numeral densities of hepatocytes with lipid droplets(92.4% ± 1.7% vs 64.9% ± 5.8% per field of view, P = 0.0002) and a lower proportion of hepatocytes with a high density of lipid droplets(20.7% ± 3.6% vs 50.4% ± 3.1%, P = 0.0007). We observed heterogeneous hepatocytes and relatively preserved cell structures in the linagliptin group. Dilation of blood and lymphatic vessels, as well as ultrastructural changes in the hepatocyte endoplasmic reticulum and mitochondria, were alleviated by linagliptin treatment. In intact and placebo-treated mice, immunohistochemical staining for LYVE-1 was observed in the endothelial cells of interlobular lymphatic vessels and on the membranes of some endothelial sinusoidal cells. We observed an enlarged LYVE-1 reaction area in linagliptin-treated mice compared to intact and placebo-treated mice. The improvement in the structural parameters of the liver in linagliptin-treated mice was independent to changes in the plasma glucose levels. CONCLUSION The DPP4 inhibitor linagliptin alleviates liver steatosis and structural changes in the hepatic microvasculature and lymphatic roots in a model of NAFLD in diabetic db/db mice. | Svetlana V Michurina Irina Ju Ishenko Vadim V Klimontov Sergey A Archipov Natalia E Myakina Marina A Cherepanova Eugenii L Zavjalov Galina V Koncevaya Vladimir I Konenkov | 2016 | World Journal of Diabetes2016，7，19： | 2 |
| 2 | Determination of Wood Moisture Properties Using a CT-Scanner in a Controlled High-Temperature Environment显示文摘 | Lars Hansson Ekaterina Cherepanova | 2012 | Journal of Civil Engineering and Architecture2012，6，3： | 2 |
| 3 | KLF4 dependent phenotypic modulation of smooth muscle ceils has a key role in atherosclerotie plaque pathogenesis 显示文摘 | SHANKMAN L S GOMEZ D CHEREPANOVA O A | 2015 | Nat Med2015，21，6： | 1 |
| 4 | Female reproductive health in the urban areas of varying anthropogenic load 显示文摘 | Dautov FF Tukhvatullina LM Cherepanova EN | 2009 | Gig Sa- nit2009，，1： | 1 |
| 5 | Molecular Peculiarities of the ChitinBinding Peroxida- ses of Plants显示文摘 | Maksimov I V Cherepanova E A Kuzmina O I | 2010 | Russian Journal of Bioorganic Chemis- try2010，36，： | 1 |
| 6 | Ku protein as the main cellular target of cell-surface-bound circulating DNA显示文摘 | Cherepanova A V Bushuev A V Duzhak T G et aI | 2012 | Expert Opin Biol Ther2012，12，1： | 1 |
| 7 | Oxidized phospholipids induce phenotypic switching of vascular smooth muscle cells in vivo and in vitro显示文摘 | Pidkovka NA Cherepanova OA Yoshida T | 2007 | Circ Res2007，101，8： | 1 |
| 8 | Hemostatic changes during the treatment of acute promyelocytic leukemia with a11-transretinoic acid显示文摘 | Medvodeva N A Cherepanova V V Tarasova L N | 2000 | Ter Arkh2000，72，7： | 1 |
| 9 | Hemostatic changes during the treatment of acute promyelocytic leukemia with all-transretinoic acid 显示文摘 | Cherepanova VV Tarasova LN | 2000 | Ter Arkh2000，72，7： | 1 |
| 10 | High-resolution cryo-EM structure of the F- actin-fimbrin/plastin ABD2 complex 显示文摘 | Galkin V E Orlova A Cherepanova O | 2008 | Proe Natl Acad Sci USA2008，105，5： | 1 |
| 11 | Influence of the Mg and Al Ratio on the Restructuring of Hydrotalcite显示文摘 | Leont'eva N N Cherepanova S V Drozdov V A | 2012 | Theoretical and Experimental Chemistry2012，48，4： | 1 |
| 12 | Formation of Micro, Nano and Atomic-Level Structure of CoAIOICo-AI Cermets Prepared by Mechanical Alloying显示文摘 | Andrey Andreev Aleksey Salanov Serguei Tikhov Svetlana Cherepanova Vladimir Zaikovskii Vladimir Usoltsev Vladislav Sadykov Olga Lapina | 2012 | 材料科学与工程(中英文A版)2012，2，2： | 1 |
| 13 | 显示文摘 | Ermakova M A Ermakov D Y Cherepanova S V | 2002 | Phys Chem B 20022002，，11： | 1 |
| 14 | Oxidized phospholipids induce phenotypic switching of vascular smooth muscle cells in vivo and in vitro 显示文摘 | Pidkovka N A Cherepanova O A Yoshida T | 2007 | Circ Res2007，101，8： | 1 |
| 15 | Metasomatism in lithospheric mantle roots: Constraints from whole-rock and mineral chemical composition of deformed peridotite xenoliths from kimberlite pipe Udachnaya显示文摘 | A.M. Agashev D.A. Ionov N.P. Pokhilenko A.V. Golovin Yu. Cherepanova I.S. Sharygin | 2012 | LITHOS2012，，： | 1 |
| 16 | Deoxyribonuclease activity and circulating DNA concentration in blood plasma of patients with prostate tumors显示文摘 | CHEREPANOVA A V TAMKOVICH S N BRYZGUNO- VA 0 E | 2008 | Ann N Y Acad Sci2008，11，37： | 1 |
| 17 | Circulating DNA and DNase activity in human blood显示文摘 | TAMKOVICH S N CHEREPANOVA A V KOLESNIKO- VA EV | 2006 | Ann N Y Acad Sci2006，9，1075： | 1 |
| 18 | Paleoenvironmental changes in the south Japan Sea and surround area during the end Pleistocene-Holocene显示文摘 | Verkhovskaya N V Gorbarenko S A and Cherepanova M V | 1992 | Pacific Ocean Geology1992，2，： | 1 |
| 19 | X-ray, Raman and FTIRS Studies of the Microstructural Evolution Zirconia Particles Caused by the Themlal Treatment 显示文摘 | Dmitry Zyuzin A Sveflana Cherepanova V Ella Moroz M | 2006 | Journal of Solid State Chemistry2006，179，： | 1 |
| 20 | Circulating DNA and DNase activity in human blood显示文摘 | Tamkovich S N Cherepanova A V Kolesnikova E V | 2006 | Ann N Y Acad Sci2006，1075，： | 1 |
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