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| 1 | Manganese salts function as potent adjuvants显示文摘Aluminum-containing adjuvants have been used for nearly 100 years to enhance immune responses in billions of doses of vaccines.To date,only a few adjuvants have been approved for use in humans,among which aluminum-containing adjuvants are the only ones widely used.However,the medical need for potent and safe adjuvants is currently continuously increasing,especially those triggering cellular immune responses for cytotoxic T lymphocyte activation,which are urgently needed for the development of efficient virus and cancer vaccines.Manganese is an essential micronutrient required for diverse biological activities,but its functions in immunity remain undefined.We previously reported that Mn^(2+) is important in the host defense against cytosolic dsDNA by facilitating cGAS-STING activation and that Mn^(2+)alone directly activates cGAS independent of dsDNA,leading to an unconventional catalytic synthesis of 2′3′-cGAMP.Herein,we found that Mn^(2+) strongly promoted immune responses by facilitating antigen uptake,presentation,and germinal center formation via both cGAS-STING and NLRP3 activation.Accordingly,a colloidal manganese salt(Mn jelly,MnJ)was formulated to act not only as an immune potentiator but also as a delivery system to stimulate humoral and cellular immune responses,inducing antibody production and CD4^(+)/CD8^(+)T-cell proliferation and activation by either intramuscular or intranasal immunization.When administered intranasally,MnJ also worked as a mucosal adjuvant,inducing high levels of secretory IgA.MnJ showed good adjuvant effects for all tested antigens,including T cell-dependent and T cell-independent antigens,such as bacterial capsular polysaccharides,thus indicating that it is a promising adjuvant candidate. | Rui Zhang Chenguang Wang Yukun Guan Xiaoming Wei Mengyin Sha Mengran Yi Miao Jing Mengze Lv Wen Guo Jing Xu Yi Wan Xin-Ming Jia Zhengfan Jiang | 2021 | Cellular & Molecular Immunology2021，18，5： | 7 |
| 2 | A new distance correction method for sulfur analysis in coal using online XRF measurement system显示文摘When X-ray fluorescence(XRF)technology is used to measure the sulfur concentration in coal online,the measurement accuracy is affected by the coal’s uneven surface and the particle size.In order to improve the accuracy of sulfur concentration measurement,an online measurement system,consisting of a portable X-ray fluorescence instrument and an auxiliary distance correction module,was developed in this paper.By measuring the standard coal samples of known sulfur concentration,we obtained a calibration curve that can be used to analyze the sulfur concentration.We studied the relationship between the X-ray fluorescence intensity(I)and the distance(D)from surfaces to instrument.The results showed that there was a good linear relationship between I and D when the sulfur content was certain.Based on these knowledge,the distance correction formula of X-ray fluorescence intensity was proposed.By applying the distance correction formula to experimental sulfur concentration measurement,we demonstrated that the measurement accuracy can be significantly increased. | JIA WenBao ZHANG Yan GU ChenGuang HEI DaQian LING YongShen SHAN Qing | 2014 | Science China(Technological Sciences)2014，57，1： | 4 |
| 3 | Change in relative density of WC-Co cemented carbides in spark plasma sintering process显示文摘The relative density of WC-Co cemented carbides during spark plasma sintering(SPS) was analyzed.Based on the change in displacement of the ram in the SPS system,the relative densities in the sintering process can be achieved at different temperatures.The results indicated that densification of the samples started at near 900°C,the density rapidly reached its maximum at the increasing temperature stage,in which the temperature was lower than the sintering temperature of 1200°C,and most of the densification took place in the stage.Besides,the theoretical values were consistent with the experimental results. | SUN Lan LIN Chenguang JIA Chengchang JIA Xian XIAN Mina | 2008 | Rare Metals2008，27，1： | 4 |
| 4 | Pediatric cancer surveillance in China:A hospital-based introduction显示文摘Background In recent years,increasing numbers of families have been affected by childhood cancer.According to data from the International Agency for Research on Cancer(IARC)of the World Health Organization,approximately 279000 new cases of cancer were predicted in children and adolescents aged 0–19 years worldwide in 2020.The global incidence of childhood cancer is 10.9 per 100000(global standard rate)and the mortality rate is 4.2 per 100000.1 According to data from the China National Cancer Center,the incidences of cancer in 2017 were 9.9 per 100000 in children aged 0–14 years and 11.5 per 100000 in adolescents aged 15–19 years.2 There are estimated to be approximately 22000 new cases of childhood cancer in China each year,and the incidence of malignant tumors in children aged 0–14 years has increased by 2.5%annually in the past decade. | Zhe Li Rongshou Zheng Xin Xu Yuanhu Liu Chenguang Jia Guoshuang Feng Xiao Zhang Xinping Li Guoliang Bai Xin Ni | 2021 | Pediatric Investigation2021，5，2： | 3 |
| 5 | Recombinant adenovirus-mediated overexpression of 3β-hydroxysteroid-Δ24 reductase显示文摘3β-Hydroxysteroid-Δ24 reductase(DHCR24) is a multifunctional enzyme that localizes to the endoplasmic reticulum and has neuroprotective and cholesterol-synthesizing activities. DHCR24 overexpression confers neuroprotection against apoptosis caused by amyloid β deposition. The present study aimed to construct two recombinant adenoviruses driving DHCR24 expression specifically in neurons. Two SYN1 promoter DNA fragments were obtained from human(h) and rat(r). Recombinant Ad-r(h)SYN1-DHCR24 was transfected into AD-293, N2A(mouse neuroblastoma), and MIN6(mouse pancreatic carcinoma) cells. Western blot analysis showed DHCR24 was specially expressed in 293 and N2A cells, but no specific band was found in MIN6 cells. This demonstrates that the recombinant adenoviruses successfully express DHCR24, and no expression is observed in non-neuronal cells. TUNEL assay results showed apoptosis was inhibited in adenovirus-transfected neurons. Detecting reactive oxygen species by immunofluorescence, we found that adenovirus transfection inhibits apoptosis through scavenging excess reactive oxygen species. Our findings show that the recombinant DHCR24 adenoviruses induce neuron-specific DHCR24 expression, and thereby lay the foundation for further studies on DHCR24 gene therapy for Alzheimer's disease. | Xiuli Lu Dan Jia Chenguang Zhao Weiqi Wang Ting Liu Shuchao Chen Xiaoping Quan Deliang Sun Bing Gao | 2014 | Neural Regeneration Research2014，9，5： | 1 |
| 6 | Self-Assembly 3D Porous Crumpled MXene Spheres as Efficient Gas and Pressure Sensing Material for Transient All-MXene Sensors显示文摘Environmentally friendly degradable sensors with both hazardous gases and pressure efficient sensing capabilities are highly desired for various promising applications,including environmental pollution monitoring/prevention,wisdom medical,wearable smart devices,and artificial intelligence.However,the transient gas and pressure sensors based on only identical sensing material that concurrently meets the above detection needs have not been reported.Here,we present transient all-MXene NO_(2) and pressure sensors employing three-dimensional porous crumpled MXene spheres prepared by ultrasonic spray pyrolysis technology as the sensing layer,accompanied with water-soluble polyvinyl alcohol substrates embedded with patterned MXene electrodes.The gas sensor achieves a ppb-level of highly selective NO_(2) sensing,with a response of up to 12.11%at 5 ppm NO_(2) and a detection range of 50 ppb-5 ppm,while the pressure sensor has an extremely wide linear pressure detection range of 0.14-22.22 kPa and fast response time of 34 ms.In parallel,all-MXene NO_(2) and pressure sensors can be rapidly degraded in medical H_(2)O_(2) within 6 h.This work provides a new avenue toward environmental monitoring,human physiological signal monitoring,and recyclable transient electronics. | Zijie Yang Siyuan Lv Yueying Zhang Jing Wang Li Jiang Xiaoteng Jia Chenguang Wang Xu Yan Peng Sun Yu Duan Fangmeng Liu Geyu Lu | 2022 | Nano-Micro Letters2022，14，4： | 1 |
| 7 | Immunoregulatory effects of indoleamine 2, 3-dioxygenase in transplantation显示文摘 | Lining Jia Puxun Tian Chenguang Ding | 2009 | Transplant Immunology2009，，： | 1 |
| 8 | Registration of intervention trials of Traditional Chinese Medicine for four neurological diseases on Chinese Clinical Trial Registry and Clinical Trials.gov:a narrative review显示文摘OBJECTIVE:To analyze the current status of clinical trial registration of Traditional Chinese Medicine(TCM)for the treatment of neurological diseases.METHODS:Interventional clinical trials of TCM treatment for ischemic stroke,hemorrhagic stroke,vascular cognitive impairment,tension-type headache before September 22,2020 on the platform of Chinese Clinical Trial Registry(Chi CTR),and Clinical Trials.gov were searched.Two researchers independently selected the literature and extracted data.RESULTS:A total of 180 interventional clinical trials were included for analysis.Out of 180 trials,127 were from Chi CTR and 53 from Clinical Trials.gov.The countries primary sponsoring the included trials were China(176,97.8%),and the common categories of primary sponsors were hospital(131,72.8%).Among the study design,the largest proportion of allocation was randomized(172,95.6%),interventional model assignment was parallel(163,90.6%),masking was double blind 49(27.2%),and the sample size was≤400(144,80.0%).The trials were most carried out at a single center(102,56.7%).Among the included studies,112(62.2%)registered on Chi CTR attached the ethical approval documents.In terms of trial stages,50(27.7%)studies were in phaseⅣ.The mostly used intervention was Chinese herbal medicines(99,55%),acupuncture(68,37.8%)was the second.By searching the registration number on China National Knowledge Infrastructure Database and Pub Med,38(21.1%)registered trials were published,including 25 protocol studies and 14 research results with one(NCT02275949)published both the protocol and the results.CONCLUSIONS:Irregular and inadequate reporting,untimely update and publication,insufficient information on traditional medicine unique characteristics,and lack of international collaborations are the problems existing in the interventional clinical registration trials of traditional medicine treatment on neurological diseases.More efforts need to be made from the above aspects to standardize and improve the registration of traditional medicine trials. | WEI Jingjing GUO Rongjuan FU Guojing LIANG Xiao XU Zhenmin JIA Min ZENG Zixiu DU Wanqing JIAO Weiwei SUN Linjuan LIU Hongmei GUO Chunli TONG Chenguang ZHANG Yunling LIAO Xing | 2022 | Journal of Traditional Chinese Medicine2022，42，1： | 1 |
| 9 | Effect of Poria Cocos in Preventing Acute Rejection of Renal Allograft显示文摘 | Chenguang Ding Puxun Tian Wujun Xue Zhihui Guan Guanqun Ge Zhankui Jin Zhaolun Li Lining Jia Xiaoming Ding Xiaoyan Pan Hang Yan | 2010 | 器官移植内科学杂志2010，5，2： | 0 |
| 10 | β-decay Study of Tz=-3/2Proton-rich Nucleus 29S显示文摘The exotic decay of nuclei far from the stability has recently become a hot topic of nuclear structure research.The nuclide 29S is not well investigated in the A=4n+1,Tz=-3/2series of strong+β-delayed proton precursors.The decay schemes of these nuclei are characterized | ZHONG Fupeng XU Xinxing LIN Chengjian WANG Jiansong LI Zhihuan YANG Lei MA Nanru WANG Dongxi WEN Peiwei SUN Lijie WU Hongyi LUO Diwen WU Chenguang JIANG Ying LIU Yang ZANG Hongliang LIANG Pengfei LI Pengjie LI Xiaojing ZHAO Qingqing SHI Guozhu MA Junbing MA Peng YU Gongming Dipikap Patel BAI Zhen YANG Feng JIA Huiming ZHANG Huanqiao WANG Jianguo YANG Yanyun MA Weihu HU Qiang JIN Shuya ZHOU Xiaohong LI Ren HOU Dongsheng LIU Minliang HU Zhengguo MA Xinwen YANG Weiqing GAO Zhihao DUAN Fangfang YU Yuechao WANG Yufeng WANG Peng ZHOU Qingwu CUI Danteng WANG Xiang HU Liyuan PAN Min ZHANG Gaolong WANG Xiaoyu | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 11 | Allogeneic hematopoietic stem cell transplantation with the modified myeloablative conditioning regimen for children with chronic active Epstein–Barr virus infection显示文摘Importance:Allogeneic hematopoietic stem cell transplantation(alloHSCT)is considered the only effective treatment for chronic active Epstein–Barr virus infection(CAEBV).The clinical efficacy and safety of allo-HSCT with different conditioning regimens in children with CAEBV remain unclear.Objective:To evaluate the effectiveness and safety of allo-HSCT with the modified myeloablative conditioning(MAC)regimen for children with CAEBV and also the factors affecting the outcomes.Methods:We retrospectively analyzed children with CAEBV who underwent allo-HSCT with the modified MAC regimen at Beijing Children’s Hospital,Capital Medical University from October 2016 to June 2021.Data related to the clinical manifestations,engraftment,and outcome were extracted from the medical records.Results:The cohort comprised 41 patients(24 males,17 females)with a median transplantation age of 92.6(60.4,120.7)months and a median follow-up time of 28.2(15.3,40.2)months.Four patients(9.8%)died,among which three died from primary disease relapse,and one died from grade IV acute graft-versus-host diseases(aGVHD)after stopping treatment.The 3-year overall survival(OS)and 3-year event-free survival(EFS)rates were 88.8%±5.4%and 85.0%±5.7%,respectively.The 3-year OS and EFS did not significantly differ between the patients with hemophagocytic lymphohistiocytosis(HLH)and the patient without HLH(87.7%±6.8%vs.91.7%±8.0%,P=0.790;85.0%±6.9%vs.84.6%±10.0%,P=0.921),or among the patients with complete remission,partial remission,and activity disease before HSCT(all P>0.05).Multivariate analysis showed that grade III–IV aGVHD was a risk factor for mortality(Hazards ratio:11.65,95%confidence interval:1.00,136.06;P=0.050).Interpretation:Allo-HSCT with the modified MAC regimen is safe and effective for pediatric CAEBV.This treatment benefits patients with HLH or active disease.Patients with Grade III–IV aGVHD may be associated with worse outcomes. | Yanhui Luo Ang Wei Bin Wang Guanghua Zhu Rui Zhang Chenguang Jia Yan Yan Xuan Zhou Jun Yang Maoquan Qin Tianyou Wang | 2022 | Pediatric Investigation2022，6，4： | 0 |
| 12 | Microstructural evolution and mechanical properties of in situ nano Ta_(4)HfC_(5) reinforced SiBCN composite ceramics显示文摘The in situ nano Ta_(4)HfC_(5) reinforced SiBCN-Ta_(4)HfC_(5) composite ceramics were prepared by a combination of two-step mechanical alloying and reactive hot-pressing sintering.The microstructural evolution and mechanical properties of the resulting SiBCN-Ta_(4)HfC_(5) were studied.After the first-step milling of 30 h,the raw materials of TaC and HfC underwent crushing,cold sintering,and short-range interdiffusion to finally obtain the high pure nano Ta_(4)HfC_(5).A hybrid structure of amorphous SiBCN and nano Ta_(4)HfC_(5) was obtained by adopting a second-step ball-milling.After reactive hot-pressing sintering,amorphous SiBCN has crystallized to 3C-SiC,6H-SiC,and turbostratic BN(C)phases and Ta_(4)HfC_(5) retained the form of the nanostructure.With the in situ generations of 2.5 wt% Ta_(4)HfC_(5),Ta_(4)HfC_(5) is preferentially distributed within the turbostratic BN(C);however,as Ta_(4)HfC_(5) content further raised to 10 wt%,it mainly distributed in the grain-boundary of BN(C) and SiC.The introduction of Ta_(4)HfC_(5) nanocrystals can effectively improve the flexural strength and fracture toughness of SiBCN ceramics,reaching to 344.1 MPa and 4.52 MPa·m^(1/2),respectively.This work has solved the problems of uneven distribution of ultra-high temperature phases in the ceramic matrix,which is beneficial to the real applications of SiBCN ceramics. | Bingzhu WANG Daxin LI Zhihua YANG Dechang JIA Jingyi GUAN Hao PENG Delong CAI Peigang HE Xiaoming DUAN Yu ZHOU Tao ZHANG Chenguang GAO | 2020 | Journal of Advanced Ceramics2020，9，6： | 0 |
| 13 | Enhanced monopole transition strength from the cluster decay of ^(13)C显示文摘The inelastic excitations and cluster decay of ^(13)C have been measured using the reaction,9Be(^(13)C, ^(13)C* →~9Be + α)~9Be. We observe strong excitation to the 14.3-MeV(1/2-) resonant state from the cluster-decay channel, leading to an enhanced monopole matrix element of(6.3 ± 0.6) fm^2. This large cluster-related monopole strength is a clear indication of the cluster-structure domination of this state and is consistent with the recent prediction of the orthogonality condition model(OCM). It would be interesting to further explore the three-center molecular rotational band that is initiated from the observed band-head. | Jun Feng YanLin Ye Biao Yang ChengJian Lin HuiMin Jia DanYang Pang ZhiHuan Li JianLing Lou QiTe Li XiaoFei Yang Jing Li HongLiang Zang Qiang Liu Wei Jiang ChenGuang Li Yang Liu ZhiQiang Chen HongYi Wu ChunGuang Wang Wei Liu Xiang Wang JingJing Li DiWen Luo Ying Jiang ShiWei Bai JinYan Xu NanRu Ma LiJie Sun DongXi Wang | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，1： | 0 |
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