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| 1 | Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro显示文摘Gastrin and cyclooxygenase-2(COX-2) playimportant roles in the carcinogenesis and progression ofgastric cancer.However,it remains unknown whether the combination of cholecystokinin-2(CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric cancer.Here,we demonstrated that the combination of AG-041R(a CCK-2 receptor antagonist) plus NS-398(a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition,apoptosis induction,down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 cells.These results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone.(C)2008 Elsevier Ireland Ltd.All rights reserved. | Sun, W. H. | 2008 | 南京医科大学学报(自然科学版)2008，28，9： | 30 |
| 2 | RESEARCH ON THE EVALUATION METHOD OF FRICTION AND LUBRICATION IN DEEP DRAWING显示文摘The deformation characteristic of bland in deep drawing is discussed. It is pointed out that the friction and lubrication conditions in for drawing are different from that in mechanical motion or machine work or other plastic process. The common test methods in laboratories are analyzed. It shows that though all those test methods can test the friction coefficient, the probe test method is most suitable for the research of friction and lubrication and the process in deep drawing, for this method is identical with the actual work condition either from the test principle or deformation status of the blank. Last the successful application in the deep drawing simulator newly developed the the probe method are intro- duced in detail. | D. N. He, X. F. Yin, H. Z. Thao, D. L*, X. Y. Ruan, J. L. Cheng and J. Y. Jiang 1) Shanghai Jiao Tong University, National Die & Mold CAD E. R. C, Shanghai 200030, China 2) Shanghai Vopkswagen Automotive Company Ltd., Shanghai 201805, China Manuscript re | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 13 |
| 3 | A Single Transcript CRISPR-Cas9 System for Efficient Genome Editing in Plants显示文摘 | Tang, Xu Zheng, Xuelian Qi, Yiping Zhang, Dengwei Cheng, Yan Tang, Aiting Voytas, Daniel F. Zhang, Yong | 2016 | Molecular Plant2016，9，7： | 8 |
| 4 | Genome-wide Analysis of Transcriptional Variability in a Large Maize-Teosinte Population显示文摘基因表示规定在控制植物显型和改编起一个重要作用。这里,我们报导对通过 transcriptome 的基因表示变化的一个全面评价大 maize-teosinte 分析试验性的人口。染色体宽的印射识别了 25 ? 660 表示为 17 的量的特点 loci (eQTL )? 311 基因,捕获表示变化的一个崭新的范围。我们发现本地 eQTL 更经常被印射到邻近的基因,显示表示 piggybacking 的一个模式,它因而创造了共同调整的基因簇。在共同调整的基因簇以内的基因趋于有相关功能和分享的染色质修正。远 eQTL 与他们显著地在特定的功能的范畴充实的目标形成了 125 个重要远 eQTL 热点。由集成信息的不同来源,我们为许多新陈代谢的小径识别了通常认为的 trans- 管理者。我们证明 bHLH 抄写因素 R1 和 hexokinase HEX9 可能分别地为 flavonoid 生合成和 glycolysis 充当关键管理者。而且,我们证明驯服或改进显著地影响了全球基因表示,与选择指向的许多基因。特别兴趣,为生合成可能经历了的 benzoxazinoid 的 Bx 基因协调了在玉米和 teosinte 之间的 cis 规章的分叉,并且当玉米与一个不同草食动物社区传播了进适度的环境,使 Bx12 失去活性的 transposon 插入在强壮的选择下面。 | Xufeng Wang Qiuyue Chen Yaoyao Wu Zachary H. Lemmon Guanghui Xu Cheng Huang Yameng Liang Dingyi Xu Dan Li John F. Doebley Feng Tian | 2018 | Molecular Plant2018，11，3： | 7 |
| 5 | Comprehensive characterization of indoor airborne bacterial profile显示文摘This is the first detailed characterization of the airborne bacterial profiles in indoor environments. Two restaurants were selected for this study. Fifteen genera of bacteria were isolated from each restaurant and identified by three different bacterial identification systems including MIDI, Biolog and Riboprinter . The dominant bacteria of both restaurants were Gram-positive bacteria in which Micrococcus and Bacillus species were the most abundant. Most bacteria identified were representative species of skin and respiratory tract of human, and soil. Although the bacterial levels in these two restaurants were below the limit of the Hong Kong Indoor Air Quality Objective (HKIAQO) Level 1 standard (i.e., < 500 cfu/m3), the majority of these bacteria were opportunistic pathogens. These results suggested that the identity of airborne bacteria should also be included in the IAQ to ensure there is a safety guideline for the public. | P. L. Chan P. H. F. Yu Y. W. Cheng C. Y. Chan P. K. Wong | 2009 | Journal of Environmental Sciences2009，21，8： | 5 |
| 6 | Generation of X-ray Emission in Repetitive Nanosecond-pulse Discharge at Atmospheric Pressure显示文摘Pulsed discharges can generate high power densities and high equivalent electric fields in plasma to emit X-rays,which is closely related to discharge mechanism.In this paper,discharge characteristics and X-ray emission of typical nanosecond-pulse discharges(corona,diffuse,spark or arc)are reviewed.Especially,the diffuse discharges are observed at pulse repetition frequencies up to 1 kHz.Factors influencing the discharge characteristics and X-ray emission are analyzed,such as the gap spacing,parameters of the applied pulse(amplitude,pulse repetition frequency),anode and cathode materials,and curvature radius of cathode.It is concluded that the maximum X-ray intensity is obtained in a diffuse discharge,and the X-ray intensity is affected by the pulse repetition frequency,applied voltage,anode material,and curvature radius of cathode.For example,X-ray intensity increases with the pulse repetition frequency and the atomic numbers of the anode material,but it decrease with the increase of curvature radius.It is also shown that the cathode material has no obvious influence on the X-ray intensity. | ZHANG Cheng SHAO Tao YAN Ping Victor F. Tarasenko | 2013 | 高电压技术2013，39，9： | 5 |
| 7 | Emission inventory of anthropogenic air pollutants and VOC species in the Yangtze River Delta region, China显示文摘 | Huang C. Chen C. H. Li L. Cheng Z. Wang H. L. Huang H. Y. Streets D. G. Wang Y. J. Zhang G. F. Chen Y. R | 2011 | Atmospheric Chemistry and Physics2011，，230： | 4 |
| 8 | The level of oncogene H-Ras correlates with tumorigenicity and malignancy显示文摘Normal bovine adrenocortical cells and some human fibroblasts can be transformed by SV40T and H-Ras in a Ras-dependent manner. We recently reported that high levels of Ras derived from 5' LTR of retrovirrus can induce highly malignant and fast growing tumors, while lower levels of Ras derived from internal ribosome entry site(IRES) promotes slower tumor growth and loss of malignancy. Ras derived from CMV promoters resulted in much lower Ras levels and loss of tumor malignancy and growth. Further studies showed that the tumors formed in the presence of lower levels of Ras and dominant negative P53(P53DD) had fewer apoptotic cells and grew faster than the tumors formed from cells with same level Ras and SV40T. Our studies suggest that low levels of Ras are insufficient to inhibit apoptosis induced by pRb inactivation. In contrast, high levels of Ras not only allow normal cells to exit senescence and form tumors, but also protect against pRb inhibition-induced cell apoptosis. | Sun, B. C. Gao, Y. Deng, L. Li, G. Q. Cheng, F. Wang, X. H. Nanjing Med Univ, Liver Transplantat Ctr, Affiliated Hosp 1, Jiangsu 210029, Peoples R China. Nanjing Med Univ, Liver Transplantat Ctr, Ctr Canc, Jiangsu 210029, Peoples R China. | 2008 | 南京医科大学学报(自然科学版)2008，28，6： | 3 |
| 9 | Emission inventory of anthropogenic air pollutants and VOC species in the Yangtze River Delta region, China显示文摘 | Huang C. Chen C. H. Li L. Cheng Z. Wang H. L. Huang H. Y. Streets D. G. Wang Y. J. Zhang G. F. Chen Y. R | 2011 | Atmospheric Chemistry and Physics2011，，230： | 2 |
| 10 | Analysis of the impacts of combining carbon taxation and emission trading on different industry sectors显示文摘 | Cheng F. Lee Sue J. Lin Charles Lewis | 2007 | Energy Policy2007，，2： | 2 |
| 11 | Composite anode material of silicon/graphite/carbon nanotubes for Li-ion batteries显示文摘 | Y. Zhang X.G. Zhang H.L. Zhang Z.G. Zhao F. Li C. Liu H.M. Cheng | 2006 | Electrochimica Acta2006，，23： | 2 |
| 12 | Low-frequency ultrasound increases non-viral gene transfer to the mouse lung显示文摘如果在 3035 kHz 的范围,低频率的超声(美国) 增加非病毒的基因转移到老鼠肺,学习的目的是估计。美国极大地在空气 / 织物接口由于大精力损失在肺被稀释。低频率的美国的优点,与高周波的美国相比:(i) 增加了成穴(为在房间膜的短暂毛孔的形成负责) 并且(ii ) 在肺穿入期间减少了精力损失。Cationic 类脂化合物 GL67/plasmid DNA (pDNA ) , polyethylenimine (PEI )/pDNA 和裸体 pDNA 经由 intranasal 灌输被交付,动物然后为 10 min 在 0.07 或 0.1 MPa 暴露于美国(sonoporation ) 。在这些条件下面,美国没提高 GL67 或调停 PEI 的 transfection。然而,它确实由约 4 褶层增加了裸体 pDNA 基因转移。重要地,这当 microbubbles 不在时被完成,它是关键的为通常使用高周波(1 MHz ) sonoporation 但是不能在临床上相关的安装承受 nebulization。肺出血也被估计并且出现以一种剂量依赖者方式与美国压力增加。这样,我们证实了低频率的美国能与裸体 pDNA 提高肺基因转移,这改进比更有效以前报导了 1 个 MHz 美国。 | Stefania Xenariou Hai-Dong Liang Uta Griesenbach Jie Zhu Raymond Farley Lucinda Somerton Charanjit Singh Peter K. Jeffery Ronald K. Scheule Seng H. Cheng Duncan M. Geddes Martin Blomley Eric W. F. W. Alton | 2010 | Acta Biochimica et Biophysica Sinica2010，42，1： | 2 |
| 13 | The safety profile of ustekinumab in the treatment of patients with psoriasis and concurrent hepatitis B or C显示文摘 | H.‐Y. Chiu C.‐H. Chen M.‐S. Wu Y.‐P. Cheng T.‐F. Tsai | 2013 | Br J Dermatol2013，，6： | 2 |
| 14 | THEORETICAL STUDY OF HEAT TRANSFER ENHANCEMENT IN PIPE WITH POROUS BODY显示文摘WT5”BZ]A theoretical investigation of the fluid flow and heat transfer in a pipe with porous body of high porosity twisted by metal wire was carried out. A theoretical model of a circular pipe with porous matrix attached at the channel wall and extended inward the centerline was set up. Through analyzing the flow in the porous matrix by the Brinkman-extended-Darcy equation and through including the effect of dispersion by adding the dispersion coefficient into the energy equation, the theoretical solutions of velocity distribution and temperature fields were obtained. Finally the effect of the properties of the porous matrix on the flow and heat transfer in the porous body was studied, which indicates that dispersion can really enhance the heat transfer in pipe. [WT5”HZ] | Gong, W.P. Han, J.T. Cheng, F. | 2001 | Journal of Hydrodynamics2001，13，1： | 2 |
| 15 | Effect of microstructure and inclusions on hydrogen induced cracking susceptibility and hydrogen trapping efficiency of X120 pipeline steel显示文摘 | F. Huang J. Liu Z.J. Deng J.H. Cheng Z.H. Lu X.G. Li | 2010 | Materials Science & Engineering A2010，，26： | 2 |
| 16 | Generation of Runaway Electrons in Atmospheric Pressure Air Under 30-200 kV Voltage Pulses of Rise Time 1.5 ns显示文摘A pulse generator with a voltage rise time of~1.5 ns and voltage amplitude variable from 30 kV to 200 kV was designed for generating runaway electron beams in atmospheric pressure air with different interelectrode gaps.The influence of the voltage amplitude and gap length on the generation was studied.In the gas diode geometry under study,the gap voltage at which the generation of a runaway electron beam begins was determined.Decreasing the voltage pulse amplitude does not increase the beam current pulse width measured with a time resolution of~0.1 ns.It is shown that the escape of beam electrons to the downstream of the foil is sync in time with the voltage drop across the gap,and that the delay of beam current generation increases gradually from 1.1 ns to 2.6 ns as the voltage pulse amplitude across the gap decreases from~100 kV to 40 kV. | Sergey B. Alekseev Mikhail I. Lomaev Dmitry V. Rybka V. F. Tarasenko SHAO Tao ZHANG Cheng YAN Ping | 2013 | 高电压技术2013，39，9： | 2 |
| 17 | In-Hospital Mortality in Patients With Acute Decompensated Heart Failure Requiring Intravenous Vasoactive Medications显示文摘 | William T. Abraham Kirkwood F. Adams Gregg C. Fonarow Maria Rosa Costanzo Robert L. Berkowitz Thierry H. LeJemtel Mei L. Cheng Janet Wynne | 2005 | Journal of the American College of Cardiology2005，，： | 2 |
| 18 | Characterization and Temporal Variation of Asian Dust Aerosol from a Site in the Northern Chinese Deserts显示文摘 | X. Y. Zhang S. L. Gong R. Arimoto Z. X. Shen F. M. Mei D. Wang Y. Cheng | 2003 | Journal of Atmospheric Chemistry2003，，3： | 1 |
| 19 | Effect of cyclosporine a on circulating immune complexes in IgA nephropathy显示文摘 | K. N. Lai C. W. K. Lam I. K. P. Cheng J. S. L. Tam F. M. Lai | 1991 | International Urology and Nephrology1991，，3： | 1 |
| 20 | N-Phosphoryl Amino Acids and Biomolecular Origins. Review Paper in Honor of the 50th Anniversary of the Publication of ``A Production of Amino Acids under Possible Primitive Earth Conditions’’ (Miller, 1953)显示文摘 | C. M. Cheng X. H. Liu Y. M. Li Y. Ma B. Tan R. Wan Y. F. Zhao | 2004 | Origins of Life and Evolution of the Biosphere2004，，5： | 1 |
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