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| 1 | Porous Graphene Microflowers for High-Performance Microwave Absorption显示文摘Graphene has shown great potential in microwave absorption(MA) owing to its high surface area, low density,tunable electrical conductivity and good chemical stability.To fully realize graphenes& MA ability, the microstructure of graphene should be carefully addressed. Here we prepared graphene microflowers(Gmfs) with highly porous structure for high-performance MA filler material. The efficient absorption bandwidth(reflection loss B-10 dB) reaches 5.59 GHz and the minimum reflection loss is up to -42.9 dB, showing significant increment compared with stacked graphene. Such performance is higher than most graphene-based materials in the literature. Besides, the low filling content(10 wt%) and low density(40–50 mg cm^(-3))are beneficial for the practical applications. Without compounding with magnetic materials or conductive polymers,Gmfs show outstanding MA performance with the aid of rational microstructure design. Furthermore, Gmfs exhibit advantages in facile processibility and large-scale production compared with other porous graphene materials including aerogels and foams. | Chen Chen Jiabin Xi Erzhen Zhou Li Peng Zichen Chen Chao Gao | 2018 | Nano-Micro Letters2018，10，2： | 20 |
| 2 | MOTION VELOCITY SMOOTH LINK IN HIGH SPEED MACHINING显示文摘To deal with over-shooting and gouging in high speed machining,a novel approach for velocity smooth link is proposed. Considering discrete tool path,cubic spline curve fitting is used to find dangerous points,and according to spatial geometric properties of tool path and the kinematics theory,maximum optimal velocities at dangerous points are obtained. Based on method of velocity control characteristics stored in control system,a fast algorithm for velocity smooth link is analyzed and formulated. On-line implementation results show that the proposed approach makes velocity changing more smoothly compared with traditional velocity control methods and improves producti-vity greatly. | REN Kun FU Jianzhong CHEN Zichen | 2007 | Chinese Journal of Mechanical Engineering2007，20，2： | 9 |
| 3 | First-generation EGFR tyrosine kinase inhibitor therapy in 106 patients with compound EGFR-mutated lung cancer: a single institution’s clinical practice experience显示文摘Background:The antitumour efficacy of tyrosine kinase inhibitors(TKIs)in lung cancer patients with compound epidermal growth factor receptor(EGFR)mutations has not been resolved.Our study summarizes a single institutional experience of first-generation TKI therapy for lung cancers with compound EGFR mutations.Methods:A total of 106 consecutive patients with tumours bearing compound EGFR mutations were identified between January 2012 and May 2016;all patients received first-generation TKI therapy.Deletions in exon 19 and the L858R point mutation in exon 21 were considered common mutations;T790M was considered separately because of its association with TKIs resistances.Any other mutation was defined as a rare mutation.Patients were divided as follows:double common mutations(group A);common plus T790M mutations(group B);common plus rare muta-tions(group C);double rare mutations(group D);and rare plus T790M mutations(group E).A separate group of 115 consecutive patients with a single common mutation was created for comparative analysis(group F).Results:The frequency of patients with compound EGFR was 2.9%(114/3925)and their response rate to first-genera-tion TKIs was 50.9%,which was not significantly different from group F(67.0%,P=0.088).The progression-free survival(PFS)of the 106 patients receiving TKI therapy was worse than that of group F(median,9.1 vs.13.0 months,respec-tively;P<0.001).The PFS of the compound mutation group was shorter than that of the single common mutation group(median,10.1 months in group A,P=0.240;9.1 months in group B,P<0.001;9.6 months in group C,P=0.010;6.5 months in group D,P=0.048;5.4 months in group E,P=0.017).Patients with a co-occurring mutation in exon 20(excluding T790M)exhibited significantly worse PFS than the patients with other compound mutations or with a single common mutation(median,6.5 vs.9.1 vs.13.0 months,respectively,P=0.002).Conclusions:There was significant heterogeneity among the compound EGFR mutations and their response to first-generation TKIs.Individualized treatment in clinical practice should be considered for each case. | Xiangyang Yu Xuewen Zhang Zichen Zhang Yongbin Lin Yingsheng Wen Yongqiang Chen Weidong Wang Lanjun Zhang | 2018 | Cancer Communications2018，38，1： | 5 |
| 4 | NON-CONTACT MEASUREMENT SYSTEM OF FREEFORM SURFACE AND NURBS RECONSTRUCTION OF MEASUREMENT POINTS显示文摘Based on the development of the non-contact measurement system of free-form surface, NURBS reconstruc-tion of measurement points of freeform surface is effectively realized by modifying the objective function and recursiveprocedure and calculating the optimum number of control points. The reconstruction precision is evaluated through Ja-cobi's transformation method. The feasibility of the measurement system and effectiveness of the reconstruction algo-rithm above are proved by experiment. | Li Jian Wang Wen Chen Zichen Institute of Advanced Manufacturing Engineering, Zhejiang University, Hangzhou 310027, China | 2002 | Chinese Journal of Mechanical Engineering2002，15，4： | 4 |
| 5 | Molecular mechanism mediating enteric bacterial translocation after severe burn:the role of cystic fibrosis transmembrane conductance regulator显示文摘Background:Gut ischemia and hypoxia post severe burn leads to breakdown of intestinal epithelial barrier and enteric bacterial translocation(EBT),resulting in serious complications,such as systemic inflammatory response syndrome,sepsis and multiple organ failure.Cystic fibrosis transmembrane conductance regulator(CFTR)is known to be downregulated by hypoxia and modulate junctional complexes,which are crucial structures maintaining the intestinal barrier.This study aimed to investigate whether CFTR plays a role in both regulating the intestinal barrier and mediating EBT post severe burn,as well as the signaling pathways involved in these processes.Methods:An in vitro Caco-2 cell model subjected to hypoxic injury and an in vivo mouse model with a 30%total body surface area full-thickness dermal burn were established.DF 508 mice(mice with F508del CFTR gene mutation)were used as an in vivo model to further demonstrate the role of CFTR in maintaining normal intestinal barrier function.QRT-PCR,western blot,ELISA,TER assay and immunofluorescence staining were used to detect the expression and localization of CFTR and tight junction proteins,as well as the function of tight junctions.Results:Our data indicated that,in Caco-2 cells,the hypoxia condition significantly reduced CFTR expression;activated extracellular signal-regulated kinase and nuclear factor-κB signaling;elevated secretion of inflammatory factors(tumor necrosis factor-α,interleukin-1βand interleukin-8);downregulated zonula occludens-1,occludin and E-cadherin expression;decreased transepithelial electrical resistance values;and led to a cellular mislocation of ZO-1.More importantly,knockdown of CFTR caused similar alterations.The upregulation of inflammatory factors and downregulation of tight junction proteins(ZO-1 and occludin)induced by knockdown of CFTR could be reversed by specific extracellular signal-regulated kinase or nuclear factor-κB inhibition.In support of the in vitro data,exuberant secretion of pro-inflammatory mediators and EBT was observed in the intestine of severely burnt mice in vivo.EBT occurred in DF508 mice(mice with the F508del CFTR gene mutation),accompanied by augmented tumor necrosis factor-α,interleukin-1βand interleukin-8 levels in the ileum compared to wildtype mice.In addition,vitamin D3 was shown to protect the intestinal epithelial barrier from hypoxic injury.Conclusions:Collectively,the present study illustrated that CFTR and downstream signaling were critical in modulating the intestinal epithelial junction and EBT post severe burn. | Xinzhu Liu Yu Chen Bo You Yuan Peng Yajie Chen Zichen Yang Yixin Zhang Jing Chen | 2021 | Burns & Trauma2021，9，1： | 4 |
| 6 | Bioprinting of novel 3D tumor array chip for drug screening显示文摘Biomedical field has been seeking a feasible standard drug screening system consisting of 3D tumor model array for drug researching due to providing sufficient samples and simulating actual in vivo tumor growth situation,which is still a challenge to rapidly and uniformly establish though.Here,we propose a novel drug screening system,namely 3D tumor array chip with“layer cake”structure,for drug screening.Accurate gelatin methacryloyl hydrogel droplets(~0.1μL)containing tumor cells can be automatically deposited on demand with electrohydrodynamic 3D printing.Transparent conductive membrane is introduced as a chip basement for preventing charges accumulation during fabricating and convenient observing during screening.Culturing chambers formed by stainless steel and silicon interlayer is convenient to be assembled and recycled.As this chip is compatible with the existing 96-well culturing plate,the drug screening protocols could keep the same as convention.Important properties of this chip,namely printing stability,customizability,accuracy,microenvironment,tumor functionalization,are detailly examined.As a demonstration,it is applied for screening of epirubicin and paclitaxel with breast tumor cells to confirm the compatibility of the proposed screening system with the traditional screening methods.We believe this chip will potentially play a significant role in drug evaluation in the future. | Mingjun Xie Qing Gao Jianzhong Fu Zichen Chen Yong He | 2020 | Bio-Design and Manufacturing2020，3，3： | 3 |
| 7 | GENERATE TRIANGUUTED SURFACES FROM MASSIVE UNORGANIZED POINTS显示文摘triangulated 从巨大的未组织起来的点出现的为重建的一个成长区域的方法被介绍。节省记忆空间,戒指数据结构被采用造在点和 triangulated 表面之间的连接。数据结构允许所有附近的顶点的有效检索和给定的绿色冰的三角形。为了缩小搜索,邻近的点变化并且避免 trinangle 交叉,一个影响区域为 eachactive 边被定义。在 triangulated 表面的成长区域的过程, minimum-edge-angle-productalgorithm 被提出选择一个适当的点为一个活跃的边形成一个新三角形。结果显示介绍方法有高效率并且需要更少的存储器空格,有可靠拓扑的质量的优化 triangulated 表面能在三角测量以后被获得。 | WU Shixiong WANG Chengyong CHEN Zichen | 2006 | Chinese Journal of Mechanical Engineering2006，19，1： | 3 |
| 8 | NeuroBiometric:An Eye Blink Based Biometric Authentication System Using an Event-Based Neuromorphic Vision Sensor显示文摘The rise of the Internet and identity authentication systems has brought convenience to people's lives but has also introduced the potential risk of privacy leaks.Existing biometric authentication systems based on explicit and static features bear the risk of being attacked by mimicked data.This work proposes a highly efficient biometric authentication system based on transient eye blink signals that are precisely captured by a neuromorphic vision sensor with microsecond-level temporal resolution.The neuromorphic vision sensor only transmits the local pixel-level changes induced by the eye blinks when they occur,which leads to advantageous characteristics such as an ultra-low latency response.We first propose a set of effective biometric features describing the motion,speed,energy and frequency signal of eye blinks based on the microsecond temporal resolution of event densities.We then train the ensemble model and non-ensemble model with our Neuro Biometric dataset for biometrics authentication.The experiments show that our system is able to identify and verify the subjects with the ensemble model at an accuracy of 0.948 and with the non-ensemble model at an accuracy of 0.925.The low false positive rates(about 0.002)and the highly dynamic features are not only hard to reproduce but also avoid recording visible characteristics of a user's appearance.The proposed system sheds light on a new path towards safer authentication using neuromorphic vision sensors. | Guang Chen Fa Wang Xiaoding Yuan Zhijun Li Zichen Liang Alois Knoll | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，1： | 3 |
| 9 | CNC NON-CONTACT MEASURING SYSTEM FOR FREEFORM SURFACE显示文摘Developing CNC measuring method on the base of coordinate machine can make the best of the hardware resource of CNC system and realize the integration of CAD/CAM/CAT. Based on the evenly spaced parallel planes scanning, a new adaptive digitizing approach for freeform surface namely arc length extrapolation is put forward. By this way, the digitizing approach can be added to the CNC system, while the system's hardware and software are not changed. | JuHua Wang Wen Chen Zichen Li Jian Wang Hengkui Institute of Production Engineering, Zhejiang University, Hangzhou 310027, China | 2002 | Chinese Journal of Mechanical Engineering2002，15，2： | 3 |
| 10 | Identification of Kinematic Errors of Five-axis Machine Tool Trunnion Axis from Finished Test Piece显示文摘Compared with the traditional non-cutting measurement,machining tests can more accurately reflect the kinematic errors of five-axis machine tools in the actual machining process for the users.However,measurement and calculation of the machining tests in the literature are quite difficult and time-consuming.A new method of the machining tests for the trunnion axis of five-axis machine tool is proposed.Firstly,a simple mathematical model of the cradle-type five-axis machine tool was established by optimizing the coordinate system settings based on robot kinematics.Then,the machining tests based on error-sensitive directions were proposed to identify the kinematic errors of the trunnion axis of cradle-type five-axis machine tool.By adopting the error-sensitive vectors in the matrix calculation,the functional relationship equations between the machining errors of the test piece in the error-sensitive directions and the kinematic errors of C-axis and A-axis of five-axis machine tool rotary table was established based on the model of the kinematic errors.According to our previous work,the kinematic errors of C-axis can be treated as the known quantities,and the kinematic errors of A-axis can be obtained from the equations.This method was tested in Mikron UCP600 vertical machining center.The machining errors in the error-sensitive directions can be obtained by CMM inspection from the finished test piece to identify the kinematic errors of five-axis machine tool trunnion axis.Experimental results demonstrated that the proposed method can reduce the complexity,cost,and the time consumed substantially,and has a wider applicability.This paper proposes a new method of the machining tests for the trunnion axis of five-axis machine tool. | ZHANG Ya FU Jianzhong CHEN Zichen | 2014 | Chinese Journal of Mechanical Engineering2014，27，5： | 3 |
| 11 | High-Performance Photo-Modulated Thin-Film Transistor Based on Quantum dots/Reduced Graphene Oxide Fragment-Decorated ZnO Nanowires显示文摘In this paper, a photo-modulated transistor based on the thin-film transistor structure was fabricated on the flexible substrate by spin-coating and magnetron sputtering. A novel hybrid material that composed of Cd Se quantum dots and reduced graphene oxide(RGO) fragment-decorated ZnO nanowires was synthesized to overcome the narrow optical sensitive waveband and enhance the photo-responsivity. Due to the enrichment of the interface and heterostructure by RGO fragments being utilized, the photo-responsivity of the transistor was improved to 2000 AW^(-1) and the photo-sensitive wavelength was extended from ultraviolet to visible. In addition, a positive back-gate voltage was employed to reduce the Schottky barrier width of RGO fragments and ZnO nanowires. As a result, the amount of carriers was increased by 10 folds via the modulation of back-gate voltage. With these inherent properties, such as integrated circuit capability and wide optical sensitive waveband, the transistor will manifest great potential in the future applications in photodetectors. | Zhi Tao Yi-an Huang Xiang Liu Jing Chen Wei Lei Xiaofeng Wang Lingfeng Pan Jiangyong Pan Qianqian Huang Zichen Zhang | 2016 | Nano-Micro Letters2016，8，3： | 2 |
| 12 | AED-Net:An Abnormal Event Detection Network显示文摘It has long been a challenging task to detect an anomaly in a crowded scene.In this paper,a selfsupervised framework called the abnormal event detection network(AED-Net),which is composed of a principal component analysis network(PCAnet)and kernel principal component analysis(kPCA),is proposed to address this problem.Using surveillance video sequences of different scenes as raw data,the PCAnet is trained to extract high-level semantics of the crowd’s situation.Next,kPCA,a one-class classifier,is trained to identify anomalies within the scene.In contrast to some prevailing deep learning methods,this framework is completely self-supervised because it utilizes only video sequences of a normal situation.Experiments in global and local abnormal event detection are carried out on Monitoring Human Activity dataset from University of Minnesota(UMN dataset)and Anomaly Detection dataset from University of California,San Diego(UCSD dataset),and competitive results that yield a better equal error rate(EER)and area under curve(AUC)than other state-of-the-art methods are observed.Furthermore,by adding a local response normalization(LRN)layer,we propose an improvement to the original AED-Net.The results demonstrate that this proposed version performs better by promoting the framework’s generalization capacity. | Tian Wang Zichen Miao Yuxin Chen Yi Zhou Guangcun Shan Hichem Snoussi | 2019 | Engineering2019，5，5： | 2 |
| 13 | EXPERIMENTAL STUDY ON THE HOT EMBOSSING POLYMER MICROFLUIDIC CHIP显示文摘Experiments are used to study the fabrication of polymer microfluidic chip with hot embossing method.The pattern fidelity with respect to the process parameters is analyzed. Experiment results show that the relationship between the imprint temperature and the microchannel width is approximately exponential.However,the depth of micro channel isn't sensitive to the imprint temperature.When the imprint pressure is larger than 1 MPa and the imprint time is longer than 2 rain,the increasing of imprint pressure and holding time has little impact on the microchannel width. So over long holding time is not needed in hot embossing.Based on the experiment analysis,a series of optimization process parameters is obtained and a fine microfluidic chip is fabricated.The electrophoresis separation experiment are used to verify the microfluidic chip performance after bonding.The results show that 100bp-ladder DNA sample can be separated in less than 5 min successfully. | HE Yong FU Jianzhong CHEN Zichen | 2008 | Chinese Journal of Mechanical Engineering2008，21，3： | 2 |
| 14 | LOOK-AHEAD ALGORITHM FOR VELOCITY CONTROL BASED ON PARAMETERIZED CURVE INTERPOLATOR显示文摘To avoid suffering gouge and transient overshooting in high speed cutting machining,a novel parameterized curve interpolator model with velocity look-ahead algorithm is proposed.Based on a prearrangement step interpolation algorithm for parameterized curves and considering high curvature points,parameterized curve tool path is divided into acceleration segments and deceleration segments by look-ahead algorithm.Under condition of characteristics of acceleration and deceleration stored in control system,deceleration before high curvature points and acceleration after high curvature points are realized in real-time in high speed cutting machining.Based on new parameterized curve interpolator model with velocity look-ahead algorithm,a real cubic spline is machined simulativly.The simulation results show that velocity look-ahead algorithm improves velocity changing more smoothly. | REN Kun FU Jianzhong CHEN Zichen | 2008 | Chinese Journal of Mechanical Engineering2008，21，2： | 2 |
| 15 | Bioresponsive nanotherapy for preventing dental caries by inhibiting multispecies cariogenic biofilms显示文摘Early childhood caries(ECC)is a public healthcare concern that greatly reduces the quality of life of young children.As a leading factor of ECC,cariogenic biofilms are composed of acidogenic/aciduric pathogens and extracellular polysaccharides(EPSs),creating an acidic and protected microenvironment.Antimicrobial photodynamic therapy(aPDT)is a noninvasive,painless,and efficient therapeutic approach that is suitable for treating ECC.However,due to the hyperfine structure of cariogenic biofilms,most photosensitizers(PSs)could not access and penetrate deeply in biofilms,which dramatically hamper their efficiency in the clinic.Herein,bioresponsive nanoparticle loaded with chlorin e6(MPP-Ce6)is developed,which largely increases the penetration depth(by over 75%)and retention(by over 100%)of PS in the biofilm compared with free Ce6.Furthermore,MPP-Ce6-mediated aPDT not only kills the bacteria in preformed biofilms but also inhibits multispecies biofilm formation.A rampant caries model is established to mimic ECC in vivo,where the population of cariogenic bacteria is decreased to 10%after MPP-Ce6-mediated aPDT.Importantly,the number and severity of carious lesions are efficiently reduced via Keyes’scoring and micro-CT analysis.This simple but effective strategy can serve as a promising approach for daily oral hygiene in preventing ECC. | Danfeng Liu Xianbin Ma Yaoting Ji Rourong Chen Shuhui Zhou Hantao Yao Zichen Zhang Mengjie Ye Zhigang Xu Minquan Du | 2022 | Bioactive Materials2022，7，8： | 2 |
| 16 | RESEARCH ON ADAPTIVE DATA COMPRESSION METHOD FOR TRIANGULATED SURFACES显示文摘NC code or STL file can be generated directly from measuring data in a fast reverse-engineering mode.Compressing the massive data from laser scanner is the key of the new mode.An adaptive compression method based on triangulated-surfaces model is put forward.Normal-vector angles between triangles are computed to find prime vertices for removal.Ring data structure is adopted to save massive data effectively.It allows the efficient retrieval of all neighboring vertices and triangles of a given vertices.To avoid long and thin triangles,a new re-triangulation approach based on normalized minimum-vertex-distance is proposed,in which the vertex distance and interior angle of triangle are considered.Results indicate that the compression method has high efficiency and can get reliable precision.The method can be applied in fast reverse engineering to acquire an optimal subset of the original massive data. | Wang Wen Wu Shixiong Chen Zichen Department of Mechanical Engineering,Zhejiang University,Hangzhou 310027, China | 2004 | Chinese Journal of Mechanical Engineering2004，17，2： | 2 |
| 17 | On-line chatter detection and identification based on wavelet and support vector machine显示文摘 | Yao Zhehe Mei Deqing Chen Zichen | | 0，，05： | 1 |
| 18 | Application studies of activated carbon derived from rice husks produced by chemical-thermal process—A review显示文摘 | Yue Chen Yanchao Zhu Zichen Wang Ying Li Lili Wang Lili Ding Xiaoyan Gao Yuejia Ma Yupeng Guo | 2010 | Advances in Colloid and Interface Science2010，，1： | 1 |
| 19 | Chinese automobile manufacturing mass customization production pattern research 显示文摘 | GU Xinjian CHEN Zichen XIONG Li | 2002 | China Industrial Economy2002，，6： | 1 |
| 20 | Machining tests to identify kinematic errors of machine tool table rotation axis based on sensitive directions显示文摘 | ZHANG Ya FU Jianzhong CHEN Zichen | 2013 | The International Journal of Advanced Manufacturing Technology2013，67，14： | 1 |
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