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| 1 | Research on optimal immunization strategies for hepatitis B in different endemic areas in China显示文摘INTRODUCTION At present hepatitis B vaccine immunization is an unique effective measure for controlling hepatitis B.It is important o determine optimal immunization | Li H Wang L Wang SS Gong J Zeng XJ Li RC Nong Y Huang YK Chen XR Huang ZN | 2000 | World Journal of Gastroenterology2000，6，3： | 9 |
| 2 | Pulmonary infection control window in treatment of severe respiratory failure of chronic obstructive pulmonary diseases: a prospective, randomized controlled, multi-centred study显示文摘Background Early withdraw from invasive mechanical ventilation (MV) followed by noninvasive MV is a new strategy for changing modes of treatment. This study was conducted to estimate the feasibility and the efficacy of early extubation and sequential noninvasive MV commenced at beginning of pulmonary infection control window in patients with exacerbated hypercapnic respiratory failure caused by chronic obstructive pulmonary diseases (COPD). Methods A prospective, randomized controlled study was conducted in eleven teaching hospitals' respiratory or medical intensive care units in China. Ninety intubated COPD patients with severe hypercapnic respiratory failure triggered by pulmonary infection (pneumonia or purulent bronchitis) were involved in the study. When the pulmonary infection had been controlled by antibiotics and comprehensive therapy, the 'pulmonary infection control window (PIC window)' has been reached. Each case was randomly assigned to study group (extubation and noninvasive MV via facial mask immediately) or control group (invasive MV was received continuously after PIC window by using conventional weaning technique).Results Study group (n=47) and control group (n=43) had similar clinical characteristics initially and at the time of PIC window. Compared with control group, study group had shorter duration of invasive MV [(6.4±4.4) days vs (11.3±6.2) days, P=0.000], lower rate of ventilator associated pneumonia (VAP) (3/47 vs 12/43, P=0.014), fewer days in ICU [(12±8) days vs (16±11) days, P=0.047] and lower hospital mortality (1/47 vs 7/43, P=0.025).Conclusions In COPD patients requiring intubation and invasive MV for hypercapnic respiratory failure, which is exacerbated by pulmonary infection, early extubation followed by noninvasive MV initiated at the start of PIC window may decrease significantly the duration of invasive MV, the risk of VAP and hospital mortality. | Wang, C Zhan, QY Cao, ZX Wei, LQ Cheng, ZZ Liu, S Zhang, JL Chen, RC Luo, Q Niu, SF Zhu, L Wu, DW Fang, BM Wu, TH Wang, CZ Liu, YN | 2005 | Chinese Medical Journal2005，，19： | 6 |
| 3 | 糖尿病、糖尿病前期与亚临床心肌损害发生率显示文摘众所周知,处于糖尿病前期者和糖尿病患者存在较高的心血管事件发生风险。然而,糖尿病前期和糖尿病与亚临床心肌损害发生间的关系尚不明确。方法与结果:应用高敏心肌肌钙蛋白T (highly sensitive cardiac troponin T hs-cTnT)分析,测定社区动脉粥样硬化风险研究中9331例受试者两个时间点(间隔6年)的心肌肌钙蛋白T(cardiac troponin T,cTnT)水平,所有受试者为无糖尿病或处于糖尿病前期,或糖尿病不伴心血管疾病(包括心电图检测出来的无临床症状的心肌梗死)。 | Selvin E Lazo M Chen Y Shen L Rubin J McEvoy JW Hoogeveen RC Sharrett AR Ballantyne CM Coresh J 刘莉 | 2014 | 中华高血压杂志2014，22，9： | 2 |
| 4 | MAPKAPK2 and HSP27 are downstream effectors of p38 MAP kinase-mediated matrix metalloproteinase type 2 activation and cell invasion in human prostate cancer 显示文摘 | Xu L Chen S Bergan RC | 2006 | Oncogene2006，25，21： | 1 |
| 5 | Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease显示文摘 | Lai RC Chen TS Lira SK | 2011 | Regen Med2011，6，4： | 1 |
| 6 | Heparin-binding EGF-like growth factor mediates the biological effects of P450 arachidonate epoxygenase metabolites in epithelial cells显示文摘 | Chen JK Capdevila J Harris RC | 2002 | Proc Natl Acad Sci USA2002，99，9： | 1 |
| 7 | Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses显示文摘 | Chen WY Wang DH Yen RC | 2005 | Cell2005，123，3： | 1 |
| 8 | Functional connectivity and laterality of the motor and sensory components in the volitional swallo- wing network 显示文摘 | Lowell SY Reynolds RC Chen G | 2012 | Exp Brain Res2012，219，1： | 1 |
| 9 | Impaired function of CDI9(+) CD24(hi) CD38(hi) regulatory B cells in patients with pemphigus显示文摘 | Zhu HOa Xu RC Chen YY | 2015 | BrJ Dermatol2015，172，1： | 1 |
| 10 | Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pe- diatric acute lymphoblastic leukemia: a Children' s Ontology Group study显示文摘 | Chen IM Harvey RC Mullighan CG | 2012 | Blood2012，119，15： | 1 |
| 11 | Papillomavirus capsid mutation to escape dendritic cell-dependent innate immunity in cervical cancer显示文摘 | Wheeler CM Chen XJ | 2005 | Journal of Virology2005，79，11： | 1 |
| 12 | Assessment of vascularity in hepatic tumors: comparison of power Dopller sonography and intraarterial CO2 - enhanced sonography显示文摘 | Chen RC Chen WT Tu HY | 2002 | A JR Am J Roentgenol2002，178，1： | 1 |
| 13 | Is ulnar nerve transposition beneficial during open reduction internal fixation of distal humerus fractures 显示文摘 | Chen RC Harris DJ Ledus S | 2010 | J Orthop Trauma2010，24，7： | 1 |
| 14 | Urgent reduction, fixa- tion ,and arthrotomy for unstable slipped capital femoral epiphysis显示文摘 | Chen RC Schoenecker PL Dobbs MB | 2009 | J Pediatr Orthop2009，29，7： | 1 |
| 15 | MR cholangiopancreatography:prospective comparison of 3-dimensional turbo spin echo and single -shot turbo spin echo with ERCP显示文摘 | Chen RC Lin KY Lii JM | 2003 | J Formos Med Assoc2003，102，3： | 1 |
| 16 | Is asymptomatic bronchial hyperrespon siveness an indication of potential asthma? A two-year follow-up of young students with bronchial hyperres ponsiveness显示文摘 | ZHONG NS CHEN RC YANG MO | 1992 | Chest1992，102，： | 1 |
| 17 | The clinical investigation of disparity of nonalcoholic fatty liver disease in a chinese occupational population in Taipei, Taiwan: experience at a teaching hospital显示文摘 | WANG J CHIU WH CHEN RC | 2013 | Asia Pac J Public Health2013，，： | 1 |
| 18 | Health related quality of life in adult patients with epilepsy compared with a general reference population in Taiwan显示文摘 | Liou HH Chen RC Chen CC | 2005 | Epilepsy Res2005，64，3： | 1 |
| 19 | Comparison of one-tube multiplex PCR, automated ribotyping and intergenic spacer (ITS) sequencing for rapid identification of Acinetobacter bau- mannii显示文摘 | Chen TL Siu LK Wu RC | 2007 | Clin Microbiol Infect2007，13，8： | 1 |
| 20 | MR cholangiopancreatography:prospective comparison of 3-dimensional turbo spin echo and single-shot turbo spin echo with ERCP显示文摘 | Chen RC Lin KY Li JM | 2003 | J Formos Med Assoc2003，102，3： | 1 |
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