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| 1 | Osteoarthritis:toward a comprehensive understanding of pathological mechanism显示文摘Osteoarthritis(OA) is the most common degenerative joint disease and a major cause of pain and disability in adult individuals. The etiology of OA includes joint injury, obesity, aging, and heredity. However, the detailed molecular mechanisms of OA initiation and progression remain poorly understood and, currently,there are no interventions available to restore degraded cartilage or decelerate disease progression. The diathrodial joint is a complicated organ and its function is to bear weight, perform physical activity and exhibit a joint-specific range of motion during movement. During OA development, the entire joint organ is affected, including articular cartilage, subchondral bone, synovial tissue and meniscus. A full understanding of the pathological mechanism of OA development relies on the discovery of the interplaying mechanisms among different OA symptoms, including articular cartilage degradation, osteophyte formation, subchondral sclerosis and synovial hyperplasia, and the signaling pathway(s) controlling these pathological processes. | Di Chen Jie Shen Weiwei Zhao Tingyu Wang Lin Han John L Hamilton Hee-Jeong Im | 2017 | Bone Research2017，5，1： | 121 |
| 2 | Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7显示文摘The voltage-gated Na^+ channel subtype Nav1.7 is important for pain and itch in rodents and humans. We previously showed that a Nav1.7-targeting monoclonal antibody(SVmab) reduces Na+ currents and pain and itch responses in mice. Here, we investigated whether recombinant SVmab(rSVmab) binds to and blocks Nav1.7 similar to SVmab. ELISA tests revealed that SVmab was capable of binding to Nav1.7-expressing HEK293 cells,mouse DRG neurons, human nerve tissue, and the voltagesensor domain Ⅱ of Nav1.7. In contrast, rSVmab showed no or weak binding to Nav1.7 in these tests. Patch-clamp recordings showed that SVmab, but not rSVmab, markedly inhibited Na+ currents in Nav1.7-expressing HEK293 cells. Notably, electrical field stimulation increased the blocking activity of SVmab and rSVmab in Nav1.7-expressing HEK293 cells. SVmab was more effective than rSVmab in inhibiting paclitaxel-induced mechanical allodynia. SVmab also bound to human DRG neurons and inhibited their Na^+ currents. Finally, potential reasons for the differential efficacy of SVmab and rSVmab and future directions are discussed. | Sangsu Bang Jiho Yoo Xingrui Gong Di Liu Qingjian Han Xin Luo Wonseok Chang Gang Chen Sang-Taek Im Yong Ho Kim Judith A.Strong Ma-Zhong Zhang Jun-Ming Zhang Seok-Yong Lee Ru-Rong Ji | 2018 | Neuroscience Bulletin2018，34，1： | 2 |
| 3 | Frequency and clinical significance of the expression of the multidrug resistance proteins MDR1/P-glycoprotein,MRP1,and LRP in acute myeloid leukemia:a Southwest Oncology Group Study显示文摘 | Leith CP Kopecky KJ Chen IM | 1999 | Blood1999，94，3： | 1 |
| 4 | Proliferation inhibition, DNA damage, and cell-cycle arrest of human astrocytoma tells after aeryl- amide exposure显示文摘 | Chen JH Tsou TC Chiu IM | 2010 | Chem Res Toxicol2010，23，9： | 1 |
| 5 | Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pe- diatric acute lymphoblastic leukemia: a Children' s Ontology Group study显示文摘 | Chen IM Harvey RC Mullighan CG | 2012 | Blood2012，119，15： | 1 |
| 6 | False-positive flow cytometric platelet glycoprotein Ⅱb/Ⅲa expression in myeloid leukemias secondary to platelet adherence to blasts显示文摘 | Betz SA Foucar K Chen IM | 1992 | Blood1992，79，9： | 1 |
| 7 | A negative feedback mechanism involving nitric oxide and nuclear factor kappa-B modulates endothelial nitric oxide synthase transcription 显示文摘 | Grumbach IM Chen W Aguilar Mertens S | 2005 | J Mol Cell Cardiol2005，39，4： | 1 |
| 8 | FK506-binding protein 52 is essential to uterine reproductive physiology controlled by the progesterone receptor A isoform显示文摘 | wolf IM Chen H | 2006 | Mol Endocrinol2006，20，11： | 1 |
| 9 | MDR1expression is highly predictive for achivement of complete remission(CR)in acute myeloid leukemia(AML)in the elderly:a southwest oncology group study显示文摘 | Leith CP Kopecky KJ Chen IM | 1995 | blood1995，86，6： | 1 |
| 10 | Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress显示文摘 | Ward IM Chen J | 2001 | J Biol Chem2001，276，47： | 1 |
| 11 | Effect of composition on the stability of liposomal irinotecan prepared by a pH gradient method 显示文摘 | Chou TH Chen SC Chu IM | 2003 | J Biosci Bioeng2003，95，4： | 1 |
| 12 | Mediation of β-endorphin by ginsenoside Rh2 to lower plasma glucose in streptozotocin-induced diabetic rats显示文摘 | Tu YK Liu IM Chen PF Cheng JT | 2006 | Planta Med2006，72，： | 1 |
| 13 | Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis显示文摘 | Hinchey J Lee S Jeon BY Basaraba RJ Venkataswamy MM Chen B Chan J Braunstein M Orme IM Derrick SC Morris SL Jacobs WR Jr Porcelli SA | 2007 | J Clin Invest2007，117，8： | 1 |
| 14 | A genotype-based system for identification and classification of mycoplasmalike organisms(MLOs)in the aster yellows MLO strain cluster显示文摘 | Lee IM Davis RE Chen TA | 1992 | Phytopathology1992，82，： | 1 |
| 15 | Modulation of cell proliferation by heterotrimeric G protein in Arabidopsis显示文摘 | ULLAH H CHEN J G YOUNG J C IM K H SUSSMAN M R JONES A M | 2001 | Science2001，292，： | 1 |
| 16 | Hand, foot, and mouth disease in China : patterns of spread and transmissibility 显示文摘 | Wang Y Feng Z Yang Y Self S Gao Y Longini IM Wakefield J Zhang J Wang L Chen X Yao L Stanaway JD Wang Z Yang W | 2011 | Epidemi- ology2011，22，6： | 1 |
| 17 | A negative feedback mechanism involving nitric oxide and nuclear factor kappa-B modulates endothelial nitric oxide synthase transcription 显示文摘 | Grumbach IM Chen W Mertens SA | 2005 | J Mol Cell Cardiol2005，39，4： | 1 |
| 18 | Effects of desflurane on spinal somatosensory-evoked potentials and conductive spinal cord evoked potential显示文摘 | Jou IM Chern TC Chen TY | 2003 | Spine2003，28，16： | 1 |
| 19 | Correlation between visual a-cuity changes and optical coherence tomography morpho-logical findings in idiopathic epiretinal membranes 显示文摘 | FANG IM HSU CC CHEN LL | 2016 | Graefes Arch Clin Eocp Ophthalmol2016，254，43： | 1 |
| 20 | High resolution physical mapping of 8 polymorphic markers in the pericentromeric region of chromosome 2 显示文摘 | Korenberg JR Rasmussen IM Chen X-N | 1993 | Cytogenet Cell Genet1993，64，： | 1 |
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