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| 1 | Adjunctive aripiprazole for antipsychotic-related hyperprolactinaemia in patients with first-episode schizophrenia:a metaanalysis显示文摘Background Hyperprolactinaemia is a common antipsychotic(AP)-induced adverse effect,particularly in female patients.Aims This meta-analysis examined the efficacy and safety of adjunctive aripiprazole in preventing AP-related hyperprolactinaemia in patients with first-episode schizophrenia.Methods PubMed,PsycINFO,EMBASE,Cochrane Library,WanFang and China Journal Net databases were searched to identify eligible randomised controlled trials(RCTs).Primary outcomes were the reductions of serum prolactin level and prolactin-related symptoms.Data were independently extracted by two reviewers and analysed using RevMan(V.5.3).Weighted/standardised mean differences(WMDs/SMDs)±95%Cis were reported.Results In the five RCTs(n=400),the adjunctive aripiprazole(n=197)and the control groups(n=203)with a mean of 11.2 weeks of treatment duration were compared.The aripiprazole group had a significantly lower endpoint serum prolactin level in all patients(five RCTs,n=385;WMD:-50.43 ng/mL(95%Cl:-75.05 to-25.81),p<0.00001;l2=99%),female patients(two RCTs,n=186;WMD:-22.58 ng/mL(95%Cl:-25.67 to-19.49),p<0.00001;l2=0%)and male patients(two RCTs,n=127;WMD:-68.80 ng/mL(95%Cl:-100.11 to-37.49),p<0.0001).In the sensitivity analysis for the endpoint serum prolactin level in all patients,the findings remained significant(p<0.00001;l2=96%).The aripiprazole group was s叩erior to the control group in improving negative symptoms as assessed by the Positive and Negative Syndrome Scale(three RCTs,n=213;SMD:-0.51(95%Cl:-0.79 to-0.24),p=0.0002;l2=0%).Adverse effects and discontinuation rates were similar between the two groups.Conclusions Adjunctive aripiprazole appears to be associated with reduced AP-induced hyperprolactinaemia and improved prolactin-related symptoms in first-episode schizophrenia.Further studies with large sample sizes are needed to confirm these findings. | Wei Zheng Dong-Bin Cai Xin-Hu Yang Wei Zheng Gabor S Ungvari Chee H Ng Zhan-Ming Shi Mei-Ling Hu Yu-Ping Ning Yu-Tao Xiang | 2019 | General Psychiatry2019，32，5： | 4 |
| 2 | Adjunctive Peony-Glycyrrhiza decoction for antipsychotic-induced hyperprolactinaemia:a meta-analysis of randomised controlled trials显示文摘Background Hyperprolactinaemia is a common adverse effect of antipsychotics(APs). The results of PeonyGlycyrrhiza decoction(PGD) as a potentially useful adjunctive treatment for hyperprolactinaemia are inconsistent.Aim This meta-analysis of randomised controlled trials(RCTs) examined the efficacy and safety of adjunctive PGD therapy for AP-induced hyperprolactinaemia.Methods English(PubMed, Embase, Cochrane Library,PsycINFO) and Chinese(Chinese National Knowledge Infrastructure, Wanfang Data) databases were systematically searched up to 10 June 2018. The inclusion criteria were based on PIC0 S一/^rticipants: adult patients with schizophrenia; Aitervention: PGD plus APs; Cbmparison: APs plus placebo or AP monotherapy;(Xjtcomes: efficacy and safety; Study design: RCTs. The weighted mean difference(WMD) and risk ratio(RR) along with their 95% CIs were calculated using Review Manager(RevMan) V.5.3 software.Results Five RCTs(n=450) were included and analysed.Two RCTs(n=140) were double-blind and four RCTs(n=409) reported ‘random' assignment with specific description. The PGD group showed a significantly lower serum prolactin level at endpoint than the control group(n=380, WMD:-32.69 ng/mL(95% Cl-41.66 to 23.72),/X0.00001, ^=97%). Similarly, the superiority of PGD over the control groups was also found in the improvement of hyperprolactinaemia-related symptoms. No difference was found in the improvement of psychiatric symptoms assessed by the Positive and Negative Syndrome Scale(n=403,WMD:-0.62(95% Cl-2.38 to 1.15), p=0.49, ^=0%). There were similar rates of all-cause discontinuation(n=330, RR0.93(95% Ci 0.63 to 1.37),/t=0.71, ^=0%) and adverse drug reactions between the two groups. According to the Grading of Recommendations Assessment, Development and Evaluation approach, the level of evidence of primary and secondary outcomes ranged from ‘very low'(14.3%),‘low'(42.8%),‘moderate'(14.3%),to ‘high,(28.6%>.Conclusions Current evidence supports the adjunctive use of PGD to suppress elevated prolactin and improve prolactininduced symptoms without significant adverse events in adult patients with AP-induced hyperprolactinaemia. Highquality RCTs with longer duration are needed to confirm these findings.Trial registration number 42016037017. | Wei Zheng Dong-Bin Cai Hai-Yan Li Yu-Jie Wu Chee H Ng Gabor S Ungvari Shan-Shan Xie Zhan-Ming Shi Xiao-Min Zhu Yu-Ping Ning Yu-Tao Xiang | 2018 | General Psychiatry2018，31，4： | 3 |
| 3 | Epidemiology of constipation (EPOC) study in the United States: relation of clinical subtypes to sociodemographic features显示文摘 | Walter F Stewart Joshua N Liberman Robert S Sandler Michael S Woods Annette Stemhagen Elsbeth Chee Richard B Lipton Christina E Farup | 1999 | The American Journal of Gastroenterology1999，，12： | 2 |
| 4 | Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two-color fluorescence analysis显示文摘 | Hacia J G Brody L C Chee M S | | 0，，： | 2 |
| 5 | Antipsychotic Medications in Major Depression and the Association with Treatment Satisfaction and Quality of Life: Findings of Three National Surveys on Use of Psychotropics in China Between 2002 and 2012显示文摘 | Yu-Xi Wang Yu-Tao Xiang Yun-Ai Su Qian Li Liang Shu Chee H Ng Gabor S Ungvari Helen FK Chiu Yu-Ping Nin Gao-Hua Wang Pei-Shen Bai Tao Li Li-Zhong Sun Jian-Guo Shi Xian-Sheng Chen Qi-Yi Mei Ke-Qing Li Xin Yu Tian-Mei Si | 2015 | Chinese Medical Journal2015，，14： | 2 |
| 6 | 5-HT2A receptor gene promoter polymorphism -1438A/G and bipolar disorder显示文摘 | Chee I S Lee S W Kim J L | 2001 | Psychiatr Genet2001，11，： | 1 |
| 7 | Determination of heavy metalscontent in soils and indoor dusts from nurseries in Dungun,Terengganu显示文摘 | Tahir N M Chee P S Jaafar M | 2007 | The Malaysian Journal of Analytical Sciences2007，11，1： | 1 |
| 8 | Induction ofapoptosis in neurogenie pulmonary edema 显示文摘 | Abu-Bakar S Shafee N Chee HY | 1999 | Med J Malaysia1999，54，3： | 1 |
| 9 | Reducing infusion phlebitis in Singapore hospitals using extended life end-line filters显示文摘 | Chee S Tan W | 2002 | J Intraven Nurs2002，25，2： | 1 |
| 10 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 11 | Recent develop- ments in antiviral agents against enterovirus71 infection 显示文摘 | Chee WT Jeffrey KF I-Ching S | 2014 | J Biomed Seien2014，21，1： | 1 |
| 12 | Identification of enterovirus 71 isolates from an outbreak of hand, foot and mouth disease (HFMD) with fatal cases of encephalomyelitis in Malaysia 显示文摘 | AbuBakar S Chee HY AI-Kobalsi MF | 1999 | Virus Res1999，61，： | 1 |
| 13 | Retrospective review of kirschner wire fixation and casting for displaced lateral condylar fracture of the humerus in children 显示文摘 | Gool S G Chee E K Wong C L | 2008 | Malaysian Orthopaedic Journal2008，2，2： | 1 |
| 14 | Skull stripping using graph cuts 显示文摘 | SADANANTHAN S ZHENG W CHEE M | 2010 | Neuroimage2010，49，1： | 1 |
| 15 | Molecular genetic analysis of para-Bombay phenotypes in Chinese: a novel non-functional FUT1 allele is identified 显示文摘 | Yip S P Chee K Y Chan P Y | 2002 | Vox Sang2002，83，3： | 1 |
| 16 | Prolonged survival after resection and radiotherapy for solitary brain metastases from non-small-cell lung cancer显示文摘 | Chee RJ Bydder S Cameron F | | 0，，02： | 1 |
| 17 | Stock Prediction with BP Networks 显示文摘 | Swamamala s Chee F L | 1991 | Inter Conf On Neural Networks1991，1，4： | 1 |
| 18 | Mo- lecular detection of enteroviruses from an outbreak of hand, foot and mouth disease in Malaysia in 1997显示文摘 | Abubakar S Chee HY Shafee N Chua KB Lam SK | 1999 | Scand J In- fect Dis1999，31，4： | 1 |
| 19 | An enhanced generalized adaptive resonance theory neural network and its application to me-dical pattern classification显示文摘 | Keem S Y Chee P L Junita M S | 2010 | Journal of Intelligent and Fuzzy Systems2010，21，12： | 1 |
| 20 | The role of autophagy in cancer: therapeutic implications 显示文摘 | Yang Z J Chee C E Huang S | 2011 | Molecular Cancer Therapeutics2011，10，9： | 1 |
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