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| 1 | An HBV-encoded miRNA activates innate immunity to restrict HBV replication显示文摘We previously identified that hepatitis B virus(HBV)encodes a microRNA(HBV-miR-3)that restrains HBV replication by targeting the HBV transcript.However,whether HBV-miR-3 affects host innate immunity to modulate HBV replication remains unclear.Here,we examined the vital functions of HBV-miR-3 in the innate immune response after HBV infection.We found that HBV-miR-3 expression gradually increased in a dose-and time-dependent manner in HBV-infected HepG2-NTCP cells.HBV-miR-3 activated the JAK/STAT signaling pathway by downregulating SOCS5 in hepatocytes,thereby enhancing the IFN-induced anti-HBV effect.In addition,HBVmiR-3 in exosomes facilitated the Ml polarization of macrophages.Furthermore,exosomes containing HBV-miR-3 enhanced the secretion of IL-6 via inhibiting the SOCS5-mediated ubiquitination of EGFR.In short,these results demonstrate that HBV-miR-3 activates the innate immune response to restrain HBV replication by multiple pathways,which may suppress HBV-induced acute liver cell injury and affect the progression of persistent HBV infection. | Xiaoqing Zhao Lu Sun Ting Mu Jianying Yi Chaoqun Ma Hong Xie Min Liu Hua Tang | 2020 | Journal of Molecular Cell Biology2020，12，4： | 17 |
| 2 | Impacts of climate variability and extremes on global net primary production in the first decade of the 21st century显示文摘许多研究估计了全球陆上的网的大小主要生产(NPP ) ,而是它的变化,空间地并且时间地,仍然保持不明确。由使用一个改进基于过程的陆上的生态系统模型( DLEM ,动态陆地生态系统模型),我们提供多重环境因素导致的全球陆上的 NPP 的估计并且在整个 第21 世纪的第一十年在生物群系和全球层次并且沿着纬度检验陆上的 NPP 的反应到气候可变性。模型模拟在 20002009 期间估计 54.6 Pg C 年 1 的平均全球陆上的 NPP,从 2002 ~ 56.4 Pg C 的干燥的年里的 52.8 Pg C 年 1 变化 2008 的湿年里的年 1 。在湿年里,与十的平均数相比的陆上的 NPP 的大增加在 Amazonia,非洲和澳大利亚是流行的。在干燥的年里,然而,我们与十的平均数相比在全球陆上的 NPP 发现了 3.2% 减小,首先由于在热带区域的有限潮湿供应。在全球水平,降水在陆上的 NPP 解释了约 63% 变化,当剩余的在温度和另外的环境因素被归因于变化时。降水是在低纬度的区域在陆上的 NPP 决定内部年度的变化的主要因素。在中间纬度、高纬度的区域,然而,温度可变性大部分控制了陆上的 NPP 的大小。我们的结果暗示温暖并且增加气候极端事件的那投射气候将改变大小和全球陆上的 NPP 的空间与时间的模式。 | PAN Shufen TIAN Hanqin DANGAL Shree R.S. OUYANG Zhiyun LU Chaoqun YANG Jia TAO Bo REN Wei BANGER Kamaljit YANG Qichun ZHANG Bowen | 2015 | Journal of Geographical Sciences2015，25，9： | 15 |
| 3 | Global methane and nitrous oxide emissions from terrestrial ecosystems due to multiple environmental changes显示文摘Greenhouse gas(GHG)-induced climate change is among the most pressing sustainability challenges facing humanity today,posing serious risks for ecosystem health.Methane(CH_(4))and nitrous oxide(N_(2)O)are the two most important GHGs after carbon dioxide(CO_(2)),but their regional and global budgets are not well known.In this study,we applied a process-based coupled biogeochemical model to concurrently estimate the magnitude and spatial and temporal patterns of CH_(4)and N_(2)O fluxes as driven by multiple environmental changes,including climate variability,rising atmospheric CO_(2),increasing nitrogen deposition,tropospheric ozone pollution,land use change,and nitrogen fertilizer use.The estimated CH_(4)and N_(2)O emissions from global land ecosystems during 1981-2010 were 144.39±12.90 Tg C/yr(mean 62 SE;1 Tg=1012 g)and 12.52±0.74 Tg N/yr,respectively.Our simulations indicated a significant(P,0.01)annually increasing trend for CH_(4)(0.43±0.06 Tg C/yr)and N_(2)O(0.14±0.02 Tg N/yr)in the study period.CH_(4)and N_(2)O emissions increased significantly in most climatic zones and continents,especially in the tropical regions and Asia.The most rapid increase in CH_(4)emission was found in natural wetlands and rice fields due to increased rice cultivation area and climate warming.N_(2)O emission increased substantially in all the biome types and the largest increase occurred in upland crops due to increasing air temperature and nitrogen fertilizer use.Clearly,the three major GHGs(CH_(4),N_(2)O,and CO_(2))should be simultaneously considered when evaluating if a policy is effective to mitigate climate change. | Hanqin Tian Guangsheng Chen Chaoqun Lu Xiaofeng Xu Wei Ren Bowen Zhang Kamaljit Banger Bo Tao Shufen Pan Mingliang Liu Chi Zhang Lori Bruhwiler Steven Wofsy | 2015 | Ecosystem Health and Sustainability2015，1，1： | 7 |
| 4 | Evolution of the vortex structures and turbulent spots at the late-stage of transitional boundary layers显示文摘The nonlinear evolution process of new vortex structures at the late-stage of the transition, including the 3-D spatial structure of barrel-shaped vortex and 'dark spots' structure observed by experiment research, has been confirmed by our computational results. The formation mechanisms of these structures have been explored. It is revealed that the new vortex structures, the ring-like vortex chain and induced disturbance velocities play a dominant role in the generation of turbulent spots. | CHEN Lin TANG DengBin LU Ping LIU ChaoQun | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，5： | 3 |
| 5 | Diamond semiconductor and elastic strain engineering显示文摘Diamond,as an ultra-wide bandgap semiconductor,has become a promising candidate for next-generation microelec-tronics and optoelectronics due to its numerous advantages over conventional semiconductors,including ultrahigh carrier mo-bility and thermal conductivity,low thermal expansion coefficient,and ultra-high breakdown voltage,etc.Despite these ex-traordinary properties,diamond also faces various challenges before being practically used in the semiconductor industry.This review begins with a brief summary of previous efforts to model and construct diamond-based high-voltage switching diodes,high-power/high-frequency field-effect transistors,MEMS/NEMS,and devices operating at high temperatures.Following that,we will discuss recent developments to address scalable diamond device applications,emphasizing the synthesis of large-area,high-quality CVD diamond films and difficulties in diamond doping.Lastly,we show potential solutions to modulate diamond’s electronic properties by the“elastic strain engineering”strategy,which sheds light on the future development of diamond-based electronics,photonics and quantum systems. | Chaoqun Dang Anliang Lu Heyi Wang Hongti Zhang Yang Lu | 2022 | Journal of Semiconductors2022，43，2： | 2 |
| 6 | Enhancing the power conversion efficiency of PCDTBT:PC_(71)BM polymer solar cells using a mixture of solvents显示文摘Organic polymer solar materials are shown to exhibit better solubility in mixed solvents than in pure ones,which affects the performance of their solar cells.In this article,poly[N-9-hepta-decanyl-2,7-carbazole-alt-5,5-(4.7-di-2-thienyI-2,l,3-benzothiadiazole)(PCDTBT0)and[6,6]-phenyl-C71-butyric acid methyl ester(PC_(71)BM)are used as active layer materials in solar cells.To optimize the performance of these active materials,the ratio of chloroform(CF)to chlorobenzene used as solvents to dissolve PCDTBT,and PC_(71)BM is varied,which is shown to affect power conversion efficiency(PCE).The solar cell that shows the best performance with a PCE as high as 6.82%is produced using a volume ratio of CF to chlorobenzene of1:1. | Shaopeng Yang Ye Zhang Tao Jiang Xuefeng Sun Chaoqun Lu Guang Li Xiaowei Li Guangsheng Fu | 2014 | Chinese Science Bulletin2014，59，3： | 2 |
| 7 | Tea stain-inspired solar energy harvesting polyphenolic nanocoatings with tunable absorption spectra显示文摘Discovery and development of new sustainable photothermal materials with tunable light absorption spectra play a key role in solar energy harvesting and conversion.One possible solution to this quest is to check nature as a source of matters or inspiration.Inspired by the formation of tea stains,a unique class of dark stain materials generated by the interfacial reaction between tea polyphenols and metal substance,we reported the facile preparation and screening of a series of photothermal nanocoating layers via the metal ion(i.e.C u(ll)>Fe(lll),Ni(ll),Zn(ll))promoted in situ polymerization of typical phenolic moieties of tea polyphenols(i.e.,catechol and pyrogallol).It was found that those resulting metal-polyphenolic nanocoatings showed various promising features,such as high blackness and strong adhesion,excellent and tunable light absorption properties,good hydrophilicity and long-term stability.We further fabricated the photothermal composite devices by/n s/'fty formation of meta卜polyphenolic nanocoatings on pristine silks for solar desalination,which demonstrated promising durable evaporation behaviors with excellent evaporation rates and steam generation efficiencies.We believe that this work could provide more opportunities towards new types of bio-inspired and sustainable photothermal nanomaterials for solar energy harvesting applications such as water desalination. | Lu Yang Yuan Zou Wei Xia Haotian Li Xinyu He Yi Zhou Xianhu Liu Chaoqun Zhang Yiwen Li | 2021 | Nano Research2021，14，4： | 2 |
| 8 | Microvortex generators in high-speed flow显示文摘 | Frank K. Lu Qin Li Chaoqun Liu | 2012 | Progress in Aerospace Sciences2012，，： | 1 |
| 9 | Physics of turbulence generation and sustenance in a boundary layer显示文摘 | Chaoqun Liu Yonghua Yan Ping Lu | 2014 | Computers and Fluids2014，，： | 1 |
| 10 | DNS study on mechanism of small length scale generation in late boundary layer transition显示文摘 | Ping Lu Chaoqun Liu | 2011 | Physica D: Nonlinear Phenomena2011，，1： | 1 |
| 11 | Effects of multiple environment stresses on evapotranspiration and runoff over eastern China 显示文摘 | Mingliang Liu Hanqin Tian Chaoqun Lu | 2012 | Journal of Hydrology2012，，： | 1 |
| 12 | DNS study on mechanism of small length scale generation in late boundary layer transition显示文摘 | Lu Ping Liu Chaoqun | 2012 | Physiea D2012，，241： | 1 |
| 13 | Numerical investi -gation on mechanism of multiple vortex rings formation in late boundary-layer transition 显示文摘 | Lu Ping Liu Chaoqun | 2013 | Computers & Fluids2013，，71： | 1 |
| 14 | Enhanced tensile ductility of tungsten microwires via high-density dislocations and reduced grain boundaries显示文摘Despite being strong with many outstanding physical properties,tungsten is inherently brittle at room temperature,restricting its structural and functional applications at small scales.Here,a facile strategy has been adopted,to introduce high-density dislocations while reducing grain boundaries,through electron backscatter diffraction(EBSD)-guided microfabrication of cold-drawn bulk tungsten wires.The designed tungsten microwire attains an ultralarge uniform tensile elongation of~10.6%,while retains a high yield strength of~2.4 GPa.in situ TEM tensile testing reveals that the large uniform elongation of tungsten microwires originates from the motion of pre-existing high-density dislocations,while the subsequent ductile fracture is attributed to crack-tip plasticity and the inhibition of grain boundary cracking.This work demonstrates the application potential of tungsten microcomponents with superior ductility and workability for micro/nanoscale mechanical,electronic,and energy systems. | Chaoqun Dang Weitong Lin Fanling Meng Hongti Zhang Sufeng Fan Xiaocui Li Ke Cao Haokun Yang Wenzhao Zhou Zhengjie Fan Ji-jung Kai Yang Lu | 2021 | Journal of Materials Science & Technology2021，，36： | 0 |
| 15 | Enhanced Water Resistance Performance of Castor Oil—Based Waterborne Polyurethane Modified by Methoxysilane Coupling Agents via Thiol-Ene Photo Click Reaction显示文摘Nowadays,waterborne polyurethanes(WPUs)prepared from renewable resources has attracted more and more attention.However,due to its structure,the prepared films easily swells in water and greatly affects the application range of WPUs.Therefore,solving the problem of water resistance is a way to improve the application range of WPUs.In this study,a series of WPU dispersions were prepared using castor oil as the bio-based polyol.Besides,the thiol-ene photo click reaction was carried out on the WPU films for silane modification.The effect of the silane modification on the chemical structures of the WPU dispersions and the properties of the WPU films was investigated and discussed.The results revealed that the WPU dispersions had a smaller particle size and potential,showing excellent stability.In addition,the modified WPU films showed highly water resistance which 72 h water absorption could be reduced to 1.94%and the contact angle was up to 99.34?.Moreover,the modified WPU films also exhibited excellent solvent resistance(in acid and salt solution)and thermal stability.This study can provide a new way to improve the water-resistance,hydrophobicity,and thermal stability of bio-based waterborne polyurethane for potential application in painting,adhesives and inks. | Zhipeng He Junqi Xue Yanzi Ke Ying Luo Qiming Lu Yuehua Xu Chaoqun Zhang | 2022 | Journal of Renewable Materials2022，10，3： | 0 |
| 16 | Application of Fuzzy Comprehensive Evaluation to Air-conditioning Competitive Power Analysis显示文摘As the conceptual design of air-conditioning is done using the theory of Quality Function Deployment (QFD),cus- tomer requirements should be understood and the product competitive power be analyzed as exactly as possible for new product de- signing.Lots of information in the process of this research is fuzzy and uncertain,but traditional QFD can not deal with it well. Fuzzy theory can solve the problem.So a fuzzy model for analyzing product competitive power is formulated in this paper to im- prove traditional QFD,after that it is applied to analyze air-conditioning competitive power.When air-conditioning competitive power is analyzed using this model,firstly the importance weight of the customer requirements o fair-conditioning is determined us- ing the Analytic Hierarchy Process (AHP) weighting process,then air-conditloning competitive power is evaluated using fuzzy comprehensive evaluation.It is proved that the model is feasible and has good applicability. | LU Congda LIU Gaojin JIANG Shaofei LV Chaoqun (The MOE Key Laboratory of Mechanical Manufacture and Automation,Zhejiang University of Technology,Hangzhou 310032,China | 2006 | 武汉理工大学学报2006，28，S2： | 0 |
| 17 | High elasticity of CsPbBr_(3) perovskite nanowires for flexible electronics显示文摘Due to the enhanced ambient structural stability and excellent optoelectronic properties, all-inorganic metal halide perovskite nanowires have become one of the most attractive candidates for flexible electronics, photovoltaics and optoelectronics. Their elastic property and mechanical robustness become the key factors for device applications under realistic service conditions with various mechanical loadings. Here, we demonstrate that high tensile elastic strain (∼ 4% to ∼ 5.1%) can be achieved in vapor-liquid-solid-grown single-crystalline CsPbBr_(3) nanowires through in situ scanning electron microscope (SEM) buckling experiments. Such high flexural elasticity can be attributed to the structural defect-scarce, smooth surface, single-crystallinity and nanomechanical size effect of CsPbBr_(3) nanowires. The mechanical reliability of CsPbBr_(3) nanowire-based flexible photodetectors was examined by cyclic bending tests, with no noticeable performance deterioration observed after 5,000 cycles. The above results suggest great application potential for using all-inorganic perovskite nanowires in flexible electronics and energy harvesting systems. | Xiaocui Li You Meng Rong Fan Sufeng Fan Chaoqun Dang Xiaobin Feng Johnny C.Ho Yang Lu | 2021 | Nano Research2021，14，11： | 0 |
| 18 | Analysis of volatile organic compounds in exhaled breath after radiotherapy显示文摘Radiotherapy uses high-energy X-rays or other particles to destroy cancer cells and medical practitioners have used this approach extensively for cancer treatment(Hachadorian et al.,2020).However,it is accompanied by risks because it seriously harms normal cells while killing cancer cells.The side effects can lower cancer patients’quality of life and are very unpredictable due to individual differences(Bentzen,2006). | Dianlong GE Xue ZOU Yajing CHU Jijuan ZHOU Wei XU Yue LIU Qiangling ZHANG Yan LU Lei XIA Aiyue LI Chaoqun HUANG Pei WANG Chengyin SHEN Yannan CHU | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，2： | 0 |
| 19 | Geometry Flow-Based Deep Riemannian Metric Learning显示文摘Deep metric learning(DML)has achieved great results on visual understanding tasks by seamlessly integrating conventional metric learning with deep neural networks.Existing deep metric learning methods focus on designing pair-based distance loss to decrease intra-class distance while increasing interclass distance.However,these methods fail to preserve the geometric structure of data in the embedding space,which leads to the spatial structure shift across mini-batches and may slow down the convergence of embedding learning.To alleviate these issues,by assuming that the input data is embedded in a lower-dimensional sub-manifold,we propose a novel deep Riemannian metric learning(DRML)framework that exploits the non-Euclidean geometric structural information.Considering that the curvature information of data measures how much the Riemannian(nonEuclidean)metric deviates from the Euclidean metric,we leverage geometry flow,which is called a geometric evolution equation,to characterize the relation between the Riemannian metric and its curvature.Our DRML not only regularizes the local neighborhoods connection of the embeddings at the hidden layer but also adapts the embeddings to preserve the geometric structure of the data.On several benchmark datasets,the proposed DRML outperforms all existing methods and these results demonstrate its effectiveness. | Yangyang Li Chaoqun Fei Chuanqing Wang Hongming Shan Ruqian Lu | 2023 | IEEE/CAA Journal of Automatica Sinica2023，10，9： | 0 |
| 20 | Effects of dietary macronutrients and body composition on glucose homeostasis in mice显示文摘As a major health issue,obesity is linked with elevated risk of type 2 diabetes.However,whether disrupted glucose homeostasis is due to altered body composition alone,or whether dietary macronutrients play an additional role,independent of their impact on body composition,remains unclear.We investigated the associations between macronutrients,body composition,blood hormones and glucose homeostasis.We fed C57BL/6N mice 29 different diets with variable macronutrients for 12 weeks.After 10 weeks,intraperitoneal glucose tolerance tests were performed.Generalized linear models were generated to evaluate the impacts of macronutrients,body composition and blood hormones on glucose homeostasis.The area under the glucose curve(AUC)was strongly associated with body fat mass,but not dietary macronutrients.AUC was significantly associated with fasting insulin levels.Six genes from transcriptomic analysis of epididymal white adipose tissue and subcutaneous white adipose tissue were significantly associated with AUC.These genes may encode secreted proteins that play important previously unanticipated roles in glucose homeostasis. | Sumei Hu Jacques Togo Lu Wang Yingga Wu Dengbao Yang Yanchao Xu Li Li Baoguo Li Min Li Jianbo Li Guanlin Wang Xueying Zhang Chaoqun Niu Mohsen Mazidi Alex Douglas John R.Speakman | 2021 | National Science Review2021，8，1： | 0 |
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