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| 1 | Effect of Ni on the microstructure, mechanical properties and corrosion behavior of MgGd_1Ni_(x) alloys for fracturing ball applications显示文摘The effects of Ni addition on the mechanical properties, corrosion behaviors, and corrosion mechanism of Mg Gd_1 Ni_(x) alloys have been investigated by compressive tests, weight loss, hydrogen evolution, and scanning electron microscopy. The results show that the constitution of the second phase is large dependence on Ni/Gd molar ratios, which can transform from LPSO(long-period stacking ordered)+Mg_5 Gd,LPSO to eutectic phase. In addition, with increasing Ni/Gd molar ratios, the content of second phase increases gradually, while the LPSO phase shows a parabola relationship. Furthermore, the formation of Nicontaining LPSO phase not only can improve the strength but also accelerate the degradation of Mg alloys owing to the galvanic corrosion. The optimal properties with ultimate compressive strength, degradation rate are 340 MPa, 2066 mm/y for Mg Gd1 Ni0.75, respectively, which can meet the engineering application standard of fracturing ball and can be used as candidate materials for fracturing ball. | Kai Ma Shijie Liu Chaoneng Dai Xiuying Liu Jie Ren Yuanlang Pan Yinhong Peng Chen Su Jingfeng Wang Fusheng Pan | 2021 | Journal of Materials Science & Technology2021，，32： | 4 |
| 2 | Detecting genetic hypermutability of gastrointestinal tumor by using a forensic STR kit显示文摘Growing evidence suggests that somatic hypermutational status and programmed cell death-1 overexpression are potential predictive biomarkers indicating treatment benefits from immunotherapy using immune checkpoint inhibitors.However,biomarker-matched trials are still limited,and many of the genomic alterations remain difficult to target.To isolate the potential somatic hypermutational tumor from microsatellite instability low/microsatellite stability(MSI-L/MSS)cases,we employed two commercial kits to determine MSI and forensic short tandem repeat(STR)alternations in 250 gastrointestinal(GI)tumors.Three types of forensic STR alternations,namely,allelic loss,Aadd,and Anew,were identified.62.4%(156/250)of the patients with GI exhibited STR alternation,including 100%(15/15)and 60%(141/235)of the microsatellite high instability and MSI-L/MSS cases,respectively.30%(75/250)of the patients exhibited STR instability with more than 26.32%(26.32%–84.21%)STR alternation.The cutoff with 26.32%of the STR alternations covered all 15 MSI cases and suggested that it might be a potential threshold.Given the similar mechanism of the mutations of MSI and forensic STR,the widely used forensic identifier STR kit might provide potential usage for identifying hypermutational status in GI cancers. | Anqi Chen Suhua Zhang Jixi Li Chaoneng Ji Jinzhong Chen Chengtao Li | 2020 | Frontiers of Medicine2020，14，1： | 2 |
| 3 | Shut-in time optimization after fracturing in shale oil reservoirs显示文摘A multi-process(fracturing,shut-in and production)multi-phase flow model was derived considering the osmotic pressure,membrane effect,elastic energy and capillary force,to determine the optimal shut-in time after multi-cluster staged hydraulic fracturing in shale reservoirs for the maximum production.The accuracy of the model was verified by using production data and commercial software.Based on this model and method,a physical model was made based on the inversion of fracture parameters from fracturing pressure data,to simulate the dynamic changes of pore pressure and oil saturation during fracturing,soaking and production,examine effects of 7 factors on the optimal shut-in time,and find out the main factors affecting the optimal shut-in time through orthogonal experiments.With the increase of shut-in time,the increment of cumulative production increases rapidly first and then tended to a stable value,and the shut-in time corresponding to the inflection point of the change was the optimal shut-in time.The optimal shut-in time has a nonlinear negative correlation with matrix permeability,porosity,capillary pressure multiple and fracture length,a nonlinear positive correlation with the membrane efficiency and total volume of injected fluid,and a nearly linear positive correlation with displacement.The seven factors in descending order of influence degree on optimal shut-in time are total volume of injected fluid,capillary force multiple,matrix permeability,porosity,membrane efficiency,salinity of fracturing fluid,fracturing fluid displacement. | WANG Qiang ZHAO Jinzhou HU Yongquan REN Lan ZHAO Chaoneng | 2022 | Petroleum Exploration and Development2022，49，3： | 1 |
| 4 | Isola- tion and charaeterization of a human putative receptor protein kinase cDNA STYK1 显示文摘 | Ye Xing Ji Chaoneng Huang Qingshan | 2003 | Molecular Biology Reports2003，30，2： | 1 |
| 5 | Isolation and identification of a novel cDNA that encodes human yrdC protein显示文摘 | Jinzhong Chen Chaoneng Ji Shaohua Gu Enpeng Zhao Jianliang Dai Lu Huang Ji Qian Kang Ying Yi Xie Yumin Mao | 2003 | Journal of Human Genetics2003，，4： | 1 |
| 6 | The crystal structure of human GDP-L-fucose synthase显示文摘人的 GDP-l-fucose synthase,也作为 FX 蛋白质知道,综合从它的底层 GDP-4-keto-6-deoxy-d-mannose 的 GDP-l-fucose。反应在羰基的 NADPH 依赖的减小在 C-4 跟随的 C-3 和 C-5 包含 epimerization。在这份报纸,人的 FX 蛋白质的第一水晶结构在 2.37 点被决定吗?分辨率。水晶结构的不对称的单位包含形成二 homodimers 的四个分子。每个分子由二域,一个 Rossmann 褶层 NADPH 有约束力的主题和 carboxyl 终端域组成。与 Escherichia coli GDP-l-fucose synthase 相比,这二酶的全面结构有四主要差别。在 E 的在相应于二 -helices 和二张表的人的 FX 蛋白质的结构有四个环。coli 酶。而且,有有从 E 把人的 FX 蛋白质与那作比较的 NAPDH 的七不同氨基酸残余绑定。coli。人的 FX 的结构揭示关键催化残余并且能为为发炎的治疗的药的设计有用,自体免疫的疾病,并且可能肯定癌症的类型。 | Huan Zhou Lihua Sun Jian Li Chunyan Xu Feng yu Yahui Liu Chaoneng Ji Jianhua He | 2013 | Acta Biochimica et Biophysica Sinica2013，45，9： | 1 |
| 7 | The dual role of ubiquitin-like protein Urm1 as a protein modifier and sulfur carrier显示文摘The ubiquitin-related modifier Urm1 can be covalently conjugated to lysine residues of other proteins,such as yeast Ahp1 and human MOCS3,through a mechanism involving the E1-like protein Uba4(MOCS3 in humans).Similar to ubiquitination,urmylation requires a thioester intermediate and forms isopeptide bonds between Urm1 and its substrates.In addition,the urmylation process can be significantly enhanced by oxidative stress.Recent findings have demonstrated that Urm1 also acts as a sulfur carrier in the thiolation of eukaryotic tRNA via a mechanism that requires the formation of a thiocarboxylated Urm1.This role is very similar to that of prokaryotic sulfur carriers such as MoaD and ThiS.Evidence strongly supports the hypothesis that Urm1 is the molecular fossil in the evolutionary link between prokaryotic sulfur carriers and eukaryotic ubiquitin-like proteins.In the present review,we discuss the dual role of Urm1 in protein and tRNA modification. | Fengbin Wang Meiruo Liu Rui Qiu Chaoneng Ji | 2011 | Protein & Cell2011，2，8： | 0 |
| 8 | Particle-bound polycyclic aromatic hydrocarbons in typical urban of Yunnan-Guizhou Plateau:Characterization,sources and risk assessment显示文摘Monthly particle-phase ambient samples collected at six sampling locations in Yuxi,a high-altitude city on the edge of Southeast Asia,were measured for particle-associated PAHs.As trace substances,polycyclic aromatic hydrocarbons(PAHs)are susceptible to the influences of meteorological conditions,emissions,and gas-particulate partitioning and it is challenging job to precise quantify the source and define the transmission path.The daily concentrations of total PM_(2.5)-bound PAHs ranged from 0.65 to 80.76 ng/m^(3),with an annual mean of 11.94 ng/m^(3).Here,we found that the concentration of PM_(2.5)-bound PAHs in winter was significantly higher than that in summer,which was mainly due to source and meteorology influence.The increase of fossil combustion and biomass burning in cold season became the main contributors of PAHs,while precipitation and low temperature exacerbated this difference.According to the concentration variation trend of PM_(2.5)-bound PAHs and their relationship with meteorological conditions,a new grouping of PAHs is applied,which suggested that PAHs have different environmental fates and migration paths.A combination of source analysis and trajectory model supported local sources from combustion of fossil fuel and vehicle exhaust contributed to the major portion on PAHs in particle,but on the Indochina Peninsula the large number of pollutants emitted by biomass burning during the fire season would affect the composition of PAHs through long-range transporting.Risk assessment in spatial and temporal variability suggested that citizens living in industrial areas were higher health risk caused by exposure the PM_(2.5)-bound PAHs than that in other regions,and the risk in winter was three times than in summer. | Yaoqian Zhong Bingxin Xia Jianwu Shi Ping Ning Chaoneng Zhang Xinyu Han Jiming Hao | 2022 | Frontiers of Environmental Science & Engineering2022，16，9： | 0 |
| 9 | Crystal structure of thermostable catechol 2,3-dioxygenase determined by multiwavelength anomalous dispersion method显示文摘The selenomethionyl derivative of the thermo-stable catechol 2,3-dioxygenase (SeMet-TC23O) is expressed, purified and crystallized. By using multiwave length anoma-lous dispersion (MAD) phasing techniques, the crystal structure of TC23O at 0.3 nm resolutions is determined. TC23O is a homotetramer. Each monomer is composed of N-terminal and C-terminal domains (residues 1-153 and 153-319, respectively). The two domains are proximately symmetric by a non-crystallographic axis. Each domain contains two characteristic motifs which are found in almost all of extradial dioxygenases. | JIANG Tao JI Chaoneng SHENG Xiaoyu CHEN Mingqin XIE Yi GONG Weimin MAO Yumin | 2002 | Chinese Science Bulletin2002，47，4： | 0 |
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