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| 1 | Immune mechanisms of Concanavalin A model of autoimmune hepatitis显示文摘As a chronic inflammatory disease of the liver,the pathogenic mechanisms of autoimmune hepatitis (AIH) have not yet been elucidated,with prognosis and diagnosis remaining unsatisfied.Currently the only viable treatments of AIH are immunosuppressant application and liver transplantation.It is considered that lack of good animal AIH models is the main reason for the shortage of a simple and efficient cure.The Concanavalin A (Con A) model is a typical and well established model for investigating T-cell and macrophage dependent liver injury in mice,which closely mimics the pathogenesis mechanisms and pathological changes of patients,and is regarded as the best experimental model for AIH research so far.In this paper we eluci-dated the pathogenic mechanisms of AIH and the evolution of relative animal models.We go on to further focus on Con A-induced liver injury from the point of immunological mechanisms and the change of cytokine levels.Finally,we manifested the clinical significance of the AIH animal models and the challenges they would meet during their future development. | Hai-Xia Wang Man Liu Shun-Yan Weng Jing-Jing Li Chao Xie Hong-Lin He Wen Guan Yun-Sheng Yuan Jin Gao | 2012 | World Journal of Gastroenterology2012，18，2： | 52 |
| 2 | ^40Ar/^39Ar and Rb-Sr Ages of the Tiegelongnan Porphyry Cu-(Au)Deposit in the Bangong Co-Nujiang Metallogenic Belt of Tibet,China:Implication for Generation of Super-Large Deposit显示文摘The Tiegelongnan deposit is a newly discovered super-large porphyry-epithermal Cu-(Au) deposit in the western part of the Bangong Co-Nujiang metallogenic belt, Tibet(China). Field geology and geochronology indicate that the porphyry mineralization was closely related to the Early Cretaceous intermediate-felsic intrusions(ca. 123–120 Ma). Various epithermal ore and gangue mineral types were discovered in the middle-shallow part of the orebody, indicating the presence of epithermal mineralization at Tiegelongnan. Potassic, propylitic, phyllic and advanced argillic alteration zones were identified. ^(40)Ar/^(39)Ar dating of hydrothermal biotite(potassic zone), sericite(phyllic zone), and alunite(advanced argillic zone) in/around the ore-bearing granodiorite porphyry yielded 121.1±0.6 Ma(1σ), 120.8±0.7 Ma(1σ) and 117.9±1.6 Ma(1σ), respectively. Five hydrothermal mineralization stages were identified, of which the Stage IV pyrite was Rb-Sr dated to be 117.5±1.8 Ma(2σ), representing the end of epithermal mineralization. Field geology and geochronology suggest that both the epithermal and porphyry mineralization belong to the same magmatic-hydrothermal system. The Tiegelongnan super-large Cu-(Au) deposit may have undergone a prolonged magmatichydrothermal evolution, with the major mineralization event occurring at ca.120–117Ma. | LIN Bin CHEN Yuchuan TANG Juxing WANG Qin SONG Yang YANG Chao WANG Wenlei HE Wen ZHANG Lejun | 2017 | Acta Geologica Sinica(English Edition)2017，91，2： | 33 |
| 3 | The prognostic value of preoperative serum levels of CEA,CA19-9 and CA72-4 in patients with colorectal cancer显示文摘INTRODUCTIONCarcinoembryonic antigen ( CEA) , originally described by Gold and Freedman [1] in 1965, is now an acknowledged member of immunoglobulin superfamily[2],with a role as an intracellular adhesion molecule[3].Carbohydrate antigen 19-9(CA19-9), obtained with a monoclonal antibody produced by immunizing a monoclonal antibody produced by immunizing a mouse with a colonic cancer cell line in 1979[4],is a ligand for E-selectin that plays an important role in the addhesion of cancer cells to endothelial cells [5,6]. | Chao Xu Zheng~1 Wen Hua Zhan~1 Ji Zong Zhao~2 Dong Zheng~3 Dong Ping Wang~1 Yu Long He~1 Zhang Qing Zheng~1 ~1Department of General Surgery,~2Laboratory of Surgery,~3Department of Medicine,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,Guangzhou 510080,Guangdong Province,ChinaDr.Chao Xu Zheng now working as a surgeon and lecturer in the Department of General Surgery,First Affiliated Hospital,Sun Yat-Sen University of Medical Sciences,who is a Ph.D.student,having 7 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 25 |
| 4 | Antioxidant properties of magnesium lithospermate B contribute to the cardioprotection against myocardial ischemia/reperfusion injury in vivo and in vitro显示文摘OBJECTIVE: To determine the cardioprotective effect of magnesium lithospermate B (MLB) on myocardial ischemia/reperfusion (MI/R) injury and to investigate the antioxidant potential in vivo and in vitro. METHODS: MI/R injury was induced by the occlusion of left anterior descending coronary artery for 30 min followed by reperfusion for 3 h in rats. After reperfusion, hearts were harvested to assess infarct size, histopathological damages, the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and malondialdehyde (MDA). Blood samples were col- lected to determine serum levels of creatine kinase-MB (CK-MB), cardiac troponin (cTnI) and lactate dehydrogenase (LDH). Furthermore, simulatedischemia/reperfusion (SI/R) injury in vitro was established by oxygen and glucose deprivation (OGD) for 2 h followed by 24-hour recovery period in cardiomyocytes. The activity of LDH in the cultured supernatant and the levels of intracellular reactive oxygen species (ROS), SOD and MDA in cardiomyocytes were also measured. Finally, cardiomyocytes apoptosis was determined with flow cytometry. RESULTS: MLB significantly limited infarct size, ameliorated histopathological damages and prevented leakage of CK-MB, cTnI and LDH. Additionally, SOD, CAT, GPx and GSH activities were notably increased by MLB, along with the MDA content decreased as compared with the model group in rats. In vitro study, MLB also decreased LDH activity in the cultured supernatant, increased SOD activity in cardiomyocytes, reduced intracellular ROS and MDA levels, and significantly suppressed cardiomyocytes apoptosis. CONCLUSION: MLB possessed remarkably cardioprotective effects on MI/R injury in vivo and in vitro. The protection of MLB may contribute to its antioxidant properties. | Wei Quan Ying Yin Miaomiao Xi Dan Zhou Yanrong Zhu Yue Guan Chao Guo Yanhua Wang Jialin Duan Aidong Wen | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 21 |
| 5 | Characterization of drug responses of mini patient-derived xenografts in mice for predicting cancer patient clinical therapeutic response显示文摘Background:Patient-derived organoids and xenografts(PDXs)have emerged as powerful models in functional diag-nostics with high predictive power for anticancer drug response.However,limitations such as engraftment failure and time-consuming for establishing and expanding PDX models followed by testing drug efficacy,and inability to subject to systemic drug administration for ex vivo organoid culture hinder realistic and fast decision-making in selecting the right therapeutics in the clinic.The present study aimed to develop an advanced PDX model,namely MiniPDX,for rapidly testing drug efficacy to strengthen its value in personalized cancer treatment.Methods:We developed a rapid in vivo drug sensitivity assay,OncoVee®MiniPDX,for screening clinically relevant regimens for cancer.In this model,patient-derived tumor cells were arrayed within hollow fiber capsules,implanted subcutaneously into mice and cultured for 7 days.The cellular activity morphology and pharmacokinetics were systematically evaluated.MiniPDX performance(sensitivity,specificity,positive and negative predictive values)was examined using PDX as the reference.Drug responses were examined by tumor cell growth inhibition rate and tumor growth inhibition rate in PDX models and MiniPDX assays respectively.The results from MiniPDX were also used to evaluate its predictive power for clinical outcomes.Results:Morphological and histopathological features of tumor cells within the MiniPDX capsules matched those both in PDX models and in original tumors.Drug responses in the PDX tumor graft assays correlated well with those in the corresponding MiniPDX assays using 26 PDX models generated from patients,including 14 gastric cancer,10 lung cancer and 2 pancreatic cancer.The positive predictive value of MiniPDX was 92%,and the negative predictive value was 81%with a sensitivity of 80%and a specificity of 93%.Through expanding to clinical tumor samples,Min-iPDX assay showed potential of wide clinical application.Conclusions:Fast in vivo MiniPDX assay based on capsule implantation was developed-to assess drug responses of both PDX tumor grafts and clinical cancer specimens.The high correlation between drug responses of paired MiniPDX and PDX tumor graft assay,as well as translational data suggest that MiniPDX assay is an advanced tool for personalized cancer treatment. | Feifei Zhang Wenjie Wang Yuan Long Hui Liu Jijun Cheng Lin Guo Rongyu Li Chao Meng Shan Yu Qingchuan Zhao Shun Lu Lili Wang Haitao Wang Danyi Wen | 2018 | Cancer Communications2018，38，1： | 20 |
| 6 | Gene expression of hepatocyte growth factor and its receptor in HCC and nontumorous liver tissues显示文摘METHODSGeneexpressionofHGFandHGFrin26casesofHCCtissueandtheiradjacentnontumorouslivertissueswasdeterminedwithdigoxigeninla... | LUO Yun Quan, WU Meng Chao and CONG Wen Ming | 1999 | World Journal of Gastroenterology1999，5，2： | 17 |
| 7 | Safety of different acupuncture manipulations for posterior circulation ischemia with vertigo显示文摘Acupuncture at Fengchi(GB20) in the posterior neck improves vertigo.However,subarachnoid hemorrhage and spinal epidural hematoma have been reported to occur after acupuncture in the posterior neck.Therefore,in the present study,we assessed the safety of acupuncture at Fengchi.Laboratory tests and adverse event reports were used to evaluate the safety of different acupuncture manipulations for the treatment of posterior circulation ischemia with vertigo.A total of 136 patients were randomly assigned to four groups.Verum acupuncture was conducted with different needle insertion directions(contralateral paropia or prominentia laryngea) and different needle twisting frequencies(60 or 120 times/minute) at Fengchi and matching acupoints(for example,Zhongwan [CV12],Qihai [CV6],Zusanli [ST36],and Fenglong [ST40]).The patients received 14 treatments over 3–4 weeks.Routine blood analysis,hepatic and renal function tests,urine and feces tests and electrocardiography were performed before the first treatment session and after the final session.Adverse events were recorded after every session.Of the 136 patients,120 completed the study.There were no significant differences between pretreatment and posttreatment test results in any of the groups.Only five patients suffered from minor adverse events(needling pain,slight hematoma and transient chest tightness).No serious adverse events were found.Our results indicate that a 14-session course of needling at Fengchi is relatively safe for treating posterior circulation ischemia with vertigo. | Yan Wen Chao Zhang Xiao-feng Zhao Shi-zhe Deng Si He Ling-hui Huang Guang Tian Zhi-hong Meng | 2016 | Neural Regeneration Research2016，11，8： | 16 |
| 8 | Therapeutic effects of different durations of acupuncture on rats with middle cerebral artery occlusion显示文摘Acupuncture is regarded as an effective therapy for cerebral ischemia. Different acupuncture manipulations and durations may result in different therapeutic effects. In the present study, the Neig uan(PC6) acupoint of rats with occluded middle cerebral arteries was needled at a fixed frequency(3 Hz) with different durations, i.e., 5, 60 and 180 seconds under a twisting-rotating acupuncture method. Results showed that different durations of acupuncture had different therapeutic effects, with 60 seconds yielding a better therapeutic effect than the other two groups. This duration of treatment demonstrated rapid cerebral blood flow, encouraging recovery of neurological function, and small cerebral infarct volume. Experimental findings indicated that under 3 Hz frequency, the treatment of needling Neiguan for 60 seconds is effective for ischemic stroke. | Chao Zhang Yan Wen Xiao-nong Fan Guang Tian Xue-yi Zhou Shi-zhe Deng Zhi-hong Meng | 2015 | Neural Regeneration Research2015，10，1： | 15 |
| 9 | Estrogenic activities of two synthetic pyrethroids and their metabolites显示文摘Synthetic pyrethroids(SPs) are among the most common pesticides in current use,and so far,several SPs have been assessed for their potential estrogenicities by various methods.Previous studies have shown that the estrogenicities partly come from their metabolites.Although considerable information is available with respect to the metabolism and environmental degradation of SPs,little is known about the estrogenicities of the metabolites.In this study,permethrin(PM) and β-cypermethrin(CP),as well as their metabolites(3-phenoxybenzoic alcohol(PBCOH),3-phenoxybenzaldehyde(PBCHO) and 3-phenoxybenzoic acid(PBCOOH) were evaluated for their estrogenic activities in the MCF-7 human breast carcinoma cell line.In the MCF-7 cell proliferation assay,PM and CP exhibited significant estrogenic activities at 10-7 mol/L,comparable to 17β-estradiol(E2 ) of 10-9 mol/L,with the relative proliferative effect ratios of 55.4% and 56.3%,respectively.The real-time quantitative polymerase chain reaction(qRT-PCR) results confirmed the estrogenicities of PM and CP with significant alteration of pS2 and ERα mRNA levels observed at 10-6 mol/L.For the three major metabolites,PBCOH and PBCOOH exhibited estrogenic activities in all assays,while no significant estrogenic responses was observed for PBCHO compared to the vehicle control.In particular,PBCOH had even slightly stronger estrogenic activity than its parent compounds,indicating that metabolism may be one of the reasons for the estrogenicities of the SPs.Given the widespread use of SPs,the toxicological effects of parent compounds and their metabolites should be taken into consideration in the risk assessment of SPs. | Meiqing Jin Ling Li Chao Xu Yuezhong Wen Meirong Zhao | 2010 | Journal of Environmental Sciences2010，22，2： | 13 |
| 10 | Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Treatment of severe Coronavirus Disease 2019(COVID-19)is challenging.We performed a phase 2 trial to assess the efficacy andsafety of human umbilical cord-mesenchymal stem cells(UC-MScs)to treat severe coViD-19 patients with lung damage,based onour phase 1 data.In this randomized,double-blind,and placebo-controlled trial,we recruited 101 severe coVID-19 patients withlung damage.They were randomly assigned at a 2:1 ratio to receive either UC-MSCs(4×10^(7)cells per infusion)or placebo on day 0,3,and 6.The primary endpoint was an altered proportion of whole lung lesion volumes from baseline to day 28.Other imagingoutcomes,6-minute walk test(6-MWT),maximum vital capacity,diffusing capacity,and adverse events were recorded and analyzed.In all,100 COVID-19 patients were finally received either UC-MSCs in=65)or placebo(n=35).UC-MSCs administrationexerted numerical improvement in whole lung lesion volume from baseline to day 28 compared with the placebo(the mediandifference was-13.31%,95%Cl-29.14%,2.13%,P=0.08).UC-MSCs significanty reduced the proportions of solid componentlesion volume compared with the placebo(median difference:-15.45%;95%CI-30.82%,-0.39%;P=0.043).The 6-MWT showedan increased distance in patients treated with UC-MSCs(difference:27.00 m;95%CI 0.00,57.00;P=0.057).The incidence of adverseevents was similar in the two groups.These results suggest that UC-MSCs treatment is a safe and potentially effective therapeuticapproach for COVID-19 patients with lung damage.A phase 3 trial is required to evaluate effects on reducing mortality andpreventing long-term pulmonary disability. | Lei Shi Hai Huang Xuechun Lu Xiaoyan Yan Xiaojing Jiang Ruonan Xu Siyu Wang Chao Zhang Xin Yuan Zhe Xu Lei Huang Jun-Liang Fu Yuanyuan Li Yu Zhang Wei-Qi Yao Tianyi Liu Jinwen Song Liangliang Sun Fan Yang Xin Zhang Bo Zhang Ming Shi Fanping Meng Yanning Song Yongpei Yu Jiqiu Wen Qi Li Qing Mao Markus Maeurer Alimuddin Zumla Chen Yao Wei-Fen Xie Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 13 |
| 11 | BRAFV600E mutation is not a positive predictor for distant metastasis in sporadic papillary thyroid carcinoma显示文摘 | JING Fan-jing LIANG Jun LIANG Zhi-yong MENG Chao LONG Wen LI Xiao-yi LIN Yan-song | 2013 | Chinese Medical Journal2013，，16： | 11 |
| 12 | Reversal of multidrug resistance in gastric cancer cells by CDX2 downregulation显示文摘AIM: To explore the role of CDX2 in the multi-drug resistance (MDR) process of gastric cancer in vitro and in vivo . METHODS: A cisplatin-resistant gastric cancer cell line with stable downregulation of CDX2 was established. mRNA and protein expression levels of CDX2, survivin, cyclin D1, and c-Myc were detected by western blotting and semi-quantitative reverse-transcriptase polymerase chain reaction (RT-PCR). The influence of downregulation of CDX2 on MDR was assessed by measuring IC50 of SGC7901/DDP cells to cisplatin, doxorubicin, and 5-fluorouracil, rate of doxorubicin efflux, apoptosis, and cell cycle progression detected by flow cytometry. In addition, we determined the in vivo effects of CDX2 small interfering RNA (siRNA) on tumor size, and apoptotic cells in tumor tissues were detected by deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling and hematoxylin and eosin staining. RESULTS: CDX2 siRNA led to downregulation of endogenous CDX2 mRNA (0.31 ± 0.05 vs 1.10 ± 0.51, 0.31 ± 0.05 vs 1.05 ± 0.21, P = 0.003) and protein (0.12 ± 0.08 vs 0.51 ± 0.07, 0.12 ± 0.08 vs 0.55 ± 0.16, P = 2.57 × 10 -4) expression. It significantly promoted the sensitivity of SGC7901/DDP cells to cisplatin (0.12 ± 0.05 vs 0.33 ± 0.08, 0.12 ± 0.05 vs 0.39 ± 0.15, P = 0.001), doxorubicin (0.52 ± 0.13 vs 4.11 ± 1.25, 0.52 ± 0.13 vs 4.05 ± 1.44, P = 2.81 × 10-4), and 5-fluorouracil (0.82 ± 0.13 vs 2.81 ± 0.51, 0.82 ± 0.13 vs 3.28 ± 1.03, P = 1.71 × 10-4). Flow cytometry confirmed that the percentage of apoptotic cells increased after CDX2 downregulation (32.15% ± 2.15% vs 17.63% ± 3.16%, 32.15% ± 2.15% vs 19.3% ± 2.25%, P = 1.73 × 10-6). This notion was further supported by the observation that downregulation of CDX2 blocked entry into the S-phase of the cell cycle (31.53% ± 3.78% vs 65.05% ± 7.25%, 31.53% ± 3.78% vs 62.27% ± 5.02%, P = 7.55 × 10-7). Furthermore, downregulation of CDX2 significantly increased intracellular accumulation of doxorubicin (0.21 ± 0.06 vs 0.41 ± 0.11, 0.21 ± 0.06 vs 0.40 ± 0.08, P = 0.003). In molecular studies, semiquantitative RT-PCR and western blotting revealed that CDX2 downregulation could inhibit expression of c-Myc, survivin and cyclin D1. CONCLUSION: CDX2 may be involved in regulating multiple signaling pathways in reversing MDR, suggesting that CDX2 may represent a novel target for gastric cancer therapy. | Lin-Hai Yan Xiao-Tong Wang Jie Yang Chao Lian Fan-Biao Kong Wei-Yuan Wei Wen Luo Qiang Xiao Yu-Bo Xie | 2013 | World Journal of Gastroenterology2013，19，26： | 10 |
| 13 | Establishment of transgenic mouse harboring hepatitis B virus (adr subtype) genomes显示文摘INTRODUCTIONHepatitis B virus (HBV) belongs to the group ofhepatovirus, a major pathogen of human acute andchronic hepatitis B[1 4], which has a very closeassociation with human hepatocellular carcinoma(HCC)[5-8], For example, a statistical data from ahospital in Shanghai showed that 80% of HCCpatients were positive for HBsAg ( personalcommunication). | Yi Ping Hu1 Wei Jiang Hu1 Wen Chao Zheng2 Jian Xiu Li1 De Shun Dai1 Xin Min Wang1 Shu Zhong Zhang1 Hong Yu Yu3 Wei Sun4 Guang Rong Hao4 1Department of Cell Biology, Second Military Medical University, Shanghai 200433, China2University of Wisconsin, Madison, WI 53705, USA3Department of Pathology, Second Military Medical University, Shanghai 200433, China4Center of laboratory Animals, Second Military Medical University, Shanghai 200433, China | 2001 | World Journal of Gastroenterology2001，7，1： | 9 |
| 14 | Geochemical characteristics and diagenetic systems of dolomite reservoirs of the Changxing Formation in the eastern Sichuan Basin, China显示文摘In order to discuss the relationship between dolomite reservoirs and diagenetic systems of the Changxing Formation, we studied carbon, oxygen and strontium stable isotopes, iron, manganese and strontium trace elements and the Mg/Ca (mol%) ratio, dolomite order degree, and determined that burial dolomitization is the key to controlling the distribution of high quality dolomite reservoir in the Changxing Formation in the eastern Sichuan Basin. The dolomite of the Changxing Formation is divided into four diagenetic systems: (1) penecontemporaneous stage syngenetic brine diagenetic system, (2) early diagenetic stage strata seal brine diagenetic system, (3) middle-late diagenetic stage mixed hot brine diagenetic system and (4) tectonic uplift stage mixed hydrothermal fluid diagenetic system. New understanding of the controlling factors and distribution of dolomite reservoir development is discussed. Reef shoal facies belts controlled regional reservoir distribution and the scale of development. Burial dolomitization of a strata seal brine diagenetic system is the foundation of reservoir development, mainly developing pore reservoir. Burial dolomitization of mixed hot brine diagenetic system expanded the reservoir distribution and improved the reservoir quality, mainly developing pore-vug reservoir. Fracturing and dissolution of a mixed hydrothermal fluid diagenetic system is the key to improving the reservoir quality, mainly developing pore-vug-crack complex reservoirs. | Zhang Bing Zheng Rongcai Wang Xuben Zheng Chao Wen Huaguo Luo Yuan Chi Yuelong | 2012 | Petroleum Science2012，9，2： | 9 |
| 15 | Deep Learning Based Attack Detection for Cyber-Physical System Cybersecurity:A Survey显示文摘With the booming of cyber attacks and cyber criminals against cyber-physical systems(CPSs),detecting these attacks remains challenging.It might be the worst of times,but it might be the best of times because of opportunities brought by machine learning(ML),in particular deep learning(DL).In general,DL delivers superior performance to ML because of its layered setting and its effective algorithm for extract useful information from training data.DL models are adopted quickly to cyber attacks against CPS systems.In this survey,a holistic view of recently proposed DL solutions is provided to cyber attack detection in the CPS context.A six-step DL driven methodology is provided to summarize and analyze the surveyed literature for applying DL methods to detect cyber attacks against CPS systems.The methodology includes CPS scenario analysis,cyber attack identification,ML problem formulation,DL model customization,data acquisition for training,and performance evaluation.The reviewed works indicate great potential to detect cyber attacks against CPS through DL modules.Moreover,excellent performance is achieved partly because of several highquality datasets that are readily available for public use.Furthermore,challenges,opportunities,and research trends are pointed out for future research. | Jun Zhang Lei Pan Qing-Long Han Chao Chen Sheng Wen Yang Xiang | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，3： | 9 |
| 16 | Expression and significance of fat mass and obesity associated gene and forkhead transcription factor O1 in non-alcoholic fatty liver disease显示文摘 | Zhang Jielei Li Shan Li Jingyi Han Chao Wang Zhifang Li Chong Wang Xiaoman Liu Zhenzhen Wen Jianguo Zheng Lili | 2014 | Chinese Medical Journal2014，，21： | 9 |
| 17 | The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala显示文摘The short allele of the serotonin-transporter gene is associated with higher risk for anxiety and depression in Caucasians, but this association is still unclear in Asians. Here, we addressed this issue using behavioral and multi-modal MRI approaches in a large group of healthy Han Chinese participants (n = 233). In contrast to findings in Caucasians, we found that long-allele (L) carriers had higher anxiety scores. In another group (n = 64) experiencing significant levels of depression or anxiety, the L-allele frequency was also significantly higher. In healthy participants, L-carriers had reduced functional and anatomical connectivity between the amygdala and prefrontal cortex (PFC), which was correlated with anxiety or depression scores. Our findings demonstrated that in Chinese Han participants, in contrast to Caucasians, the L-allele confers vulnerability to anxiety or depression and weakens top-down emotional control between the PFC and amygdala. Therefore, ethnic background should be taken into account in gene-related studies and their potential clinical applications. | Haixia Long Bing Liu Bing Hou Chao Wang Jin Li Wen Qin Dawei Wang Yuan Zhou Keith M. Kendrick Chunshui Yu Tianzi Jiang | 2013 | Neuroscience Bulletin2013，29，1： | 9 |
| 18 | Long-term hepatic consequences of chemotherapy-related HBV reactivation in lymphoma patients显示文摘AIM: To investigate the long-term consequences of chemotherapy-related HBV reactivation in patients with lymphoma.METHODS: This study was based on the database of published prospective study evaluating HBV reactivation in HBV lymphoma patients during chemotherapy.Deteriorated liver reserve (DLR) was defined as development of either one of the following conditions during follow-up: (1) newly onset parenchyma liver disease, splenomegaly or ascites without evidence of lymphoma involvement; (2) decrease of the ratio (albumin/globulin ratio) to less than 0.8 or increase of the ratio of INR of prothrombin time to larger than 1.2 without evidence of malnutrition or infection. Liver cirrhosis was diagnosed by imaging studies.RESULTS: A total of 49 patients were included. The median follow-up was 6.2 years (range, 3.9-8.1 years).There were 31 patients with and 18 patients without HBV reactivation. Although there was no difference of overall survival (OS) and chemotherapy response rate between the two groups, DLR developed more frequently in patients with HBV reactivation (48.4% vs 16.7%; P= 0.0342). Among the HBV reactivators, HBV genotype C was associated with a higher risk of developing DLR (P = 0.0768) and liver cirrhosis (P = 0.003). Four of five patients with sustained high titer of HBV DNA and two of three patients with multiple HBV reactivation developed DLR. Further, patients with a sustained high titer of HBV DNA had the shortest OS among the HBV reactivators (P= 0.0000). No patients in the non-HBV reactivation group developed hepatic failure or liver cirrhosis.CONCLUSION: Chemotherapy-related HBV reactivation is associated with the long-term effect of deterioration of hepatic function. | Chi-Chung Wen Chao A.Hsiung Ih-Jen Su Ann-Lii Cheng Ming-Chih Chang Chao-Jung Tsao Woei-Yao Kao Wu-Ching Uen Chiun Hsu Chih-Hung Hsu Yen-Shen Lu Hwei-Fan Tien Tsu-Yi Chao Li-Tzong Chen Jacqueline Whang-Peng Pei-Jer Chen | 2005 | World Journal of Gastroenterology2005，11，34： | 8 |
| 19 | Prognosis of hepatic cirrhosis patients with esophageal or gastric variceal hemorrhage: multivariate analysis显示文摘Objective: To study the effect of bacterial infection,use of antibiotics, active bleeding at endoscopy, andthe severity of liver disease as prognostic factors inhepatic cirrhotic patients during the first 5 days afterthe episode of esophageal or gastric variceal hemor-rhage.Methods: Seventy-six hepatic cirrhosis patients withesophageal or gastric variceal bleeding were enrolled.Bleeding was managed in a standardized protocol u-sing octreotide and vasopressin in sclerotherapy orband ligation for active bleeding at endoscopy. Thescreening protocol for bacterial infection consisted ofchest radiograph; blood, urine and ascitic fluid cul-tures; the severity of liver disease shown by Child-Pugh score.Results: Active bleeding was observed at endoscopyin 40 patients (53%). Failure to control bleedingWithin 5 days occurred in 36 patients (45%). Empir-ical antibiotic treatment was used in 53 patients(67%), whereas bacterial infections were documen-ted in 43 patients (57%). Multivariate analysisshowed that proven bacterial infection (P<0.01) orantibiotic use (P<0.05) as well as active bleeding atendoscopy (P<0.01) and Child-Pugh score (P<0.01) were independent prognostic factors of failureto control bleeding.Conclusion: Bacterial infection is associated with fai-lure to control esophageal or gastric variceal bleedingin hepatic cirrhotic patients. | Chao Zhao Shao-Bo Chen Jian-Pin Zhou Wen Xiao Han-Gong Fan Xue-Wei Wu Gan-Xin Feng Wei-Xiong He the Department of Gatroenterology, Zhongshan Municipal Bo’ai Hospital, Zhongshan 528403, China | 2002 | Hepatobiliary & Pancreatic Diseases International2002，1，3： | 7 |
| 20 | Sequential and Concomitant Therapy With Four Drugs Is Equally Effective for Eradication of H pylori Infection显示文摘 | Deng–Chyang Wu Ping–I. Hsu Jeng–Yih Wu Antone R. Opekun Chao–Hung Kuo I.–Chen Wu Sophie S.W. Wang Angela Chen Wen–Chun Hung David Y. Graham | 2010 | Clinical Gastroenterology and Hepatology2010，，1： | 7 |
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