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| 1 | Adsorption of heavy metal ions from aqueous solution by carboxylated cellulose nanocrystals显示文摘A novel nanoadsorbent for the removal of heavy metal ions is reported.Cotton was first hydrolyzed to obtain cellulose nanocrystals(CNCs).CNCs were then chemically modified with succinic anhydride to obtain SCNCs.The sodic nanoadsorbent(NaSCNCs) was further prepared by treatment of SCNCs with saturated NaHCO 3 aqueous solution.Batch experiments were carried out with SCNCs and NaSCNCs for the removal of Pb 2+ and Cd 2+.The effects of contact time,pH,initial adsorption concentration,coexisting ions and the regeneration performance were investigated.Kinetic studies showed that the adsorption equilibrium time of Pb 2+ and Cd 2+ was reached within 150 min on SCNCs and 5 min on NaSCNCs.The adsorption capacities of Pb 2+ and Cd 2+ on SCNCs and NaSCNCs increased with increasing pH.The adsorption isotherm was well fitted by the Langmuir model.The maximum adsorption capacities of SCNCs and NaSCNCs for Pb 2+ and Cd 2+ were 367.6 mg/g,259.7 mg/g and 465.1 mg/g,344.8 mg/g,respectively.SCNCs and NaSCNCs showed high selectivity and interference resistance from coexisting ions for the adsorption of Pb 2+.NaSCNCs could be efficiently regenerated with a mild saturated NaCl solution with no loss of capacity after two recycles.The adsorption mechanisms of SCNCs and NaSCNCs were discussed. | Xiaolin Yu Shengrui Tong Maofa Ge Lingyan Wu Junchao Zuo Changyan Cao Weiguo Song | 2013 | Journal of Environmental Sciences2013，25，5： | 29 |
| 2 | Osthole inhibits proliferation of human breast cancer cells by inducing cell cycle arrest and apoptosis显示文摘Recent studies have revealed that osthole,an active constituent isolated from the fruit of Cnidium monnieri(L.) Cusson,a traditional Chinese medicine,possesses anticancer activity.However,its effect on breast cancer cells so far has not been elucidated clearly.In the present study,we evaluated the effects of osthole on the proliferation,cell cycle and apoptosis of human breast cancer cells MDA-MB 435.We demonstrated that osthole is effective in inhibiting the proliferation of MDA-MB 435 cells,The mitochondrion-mediated apoptotic pathway was involved in apoptosis induced by osthole,as indicated by activation of caspase-9 and caspase-3 followed by PARP degradation.The mechanism underlying its effect on the induction of G1 phase arrest was due to the up-regulation of p53 and p21 and down-regulation of Cdk2 and cyclin D1 expression.Were observed taken together,these findings suggest that the anticancer efficacy of osthole is mediated via induction of cell cycle arrest and apoptosis in human breast cancer cells and osthole may be a potential chemotherapeutic agent against human breast cancer. | Lintao Wang Yanyan Peng Kaikai Shi Haixiao Wang Jianlei Lu Yanli Li Changyan Ma | 2015 | The Journal of Biomedical Research2015，29，2： | 12 |
| 3 | Biological mechanism of controlling cotton aphid (Homoptera: aphididae) by the marginal alfalfa zone surrounding cotton field显示文摘At the beginning stage of cotton aphids (Aphis gossypii Glover) invading the cotton field, large numbers of insects have accumulated in the marginal alfalfa (Medicago sativa L.) zone surrounding it. They are 6.94 times (excluded natural enemies) as many as the aphids in cotton field. Most of these insects are Therioaphid maculata (Buckton), and occur in fields 10-15 d earlier than cotton aphids. Consequently, abundant natural enemies have bred in alfalfa zone when cotton aphids increase rapidly in cotton fields in the middle of June in Xinhe County, Xinjiang Autonomous Region. The total number of the major natural enemies, including Coccinellids, Chrysopids and Syphid flies in alfalfa zone, is 13.65 times that in cotton field within the same acreage of fields. At this period, it is very effective to force the natural enemies from the alfalfa zone into the nearby cotton field to control the rapid increase of cotton aphid population by cutting the alfalfa stands. | ZHANG Runzhi LIANG Hongbin TIAN Changyan ZHANG Guangxue | 2000 | Chinese Science Bulletin2000，45，4： | 9 |
| 4 | Evaluation of ecological sensitivity in Karamay, Xinjiang, China显示文摘Karamay 城市是一个典型采矿城市,依靠油矿探索和开发。在 60 年建设和开发以后, Karamay 在中国成为了第一个大油矿和国家石油和石油化学的工业的一个重要的底。基于空间分析,和地理信息系统( GIS )格子计算和覆盖技术,虽然考虑油矿开发的效果并且在中国的 Xinjiang Uygur 自治区域瞄准了 Karamay 城市的生态的问题,我们在 Karamay 的全面生态的敏感的空间特征上进行了研究。自然环境进化的生态的问题包括土壤侵蚀,陆地 desertification,土壤 salinization,和生物多样性减小。从在这个区域的人的活动的最重要的骚乱因素是油矿利用。这研究执行单个因素的分析生态的问题敏感和综合生态的敏感。研究的结果如下:(1 ) 土壤侵蚀是相对敏感的,特别在 Karamay 区域, Dushanzi 区域, Urho 区域的北方和 Baijiantan 区域的西方,它主要是垂直落下斜坡的结果。(2 ) 陆地 desertification 的主要类型被高、中等的等级敏感代表,并且高、极其高敏感的区域在 Karamay 和 Baijiantan 区域的交叉是分布式的。这由于在这些区域超过降雨的蒸发,并且土壤主要由沙组成并且是很少由植被盖住。(3 ) 土壤 salinizatiion 敏感等级主要中等、高、极其高。高度敏感的区域主要在 Karamay 区域的 Baijiantan 区域,北方和东方和 Urho 区域的东方的东南被散布。主要原因是超过降雨和极端人的活动的蒸发。(4 ) 生物多样性敏感的主要类型是光和中等等级。高度敏感的区域位于 Karamay 区域的东方和南方, Baiyang 河盆的北方和沼泽地区域的部分。(5 ) 油地发展区域是高度生态地敏感,它位于 Urho 区域, Baijiantan 区域的西方的油矿, Karamay dis trict 的西北的油矿和 Dushanzi 的中央油矿的北油矿区域。(6 ) 综合生态的敏感的主要类型高、中等。高、极其高度敏感的区域位于 Baijiantan 区域的 Karamay 区域,和西南的中央、北的部分。评估结果将为计划的未来和发展提供指导,生态的环境的保护和在 Karamay 的和谐社会、经济、生态的开发的实现城市。 | PAN Feng TIAN Changyan SHAO Feng ZHOU Wei CHEN Fei | 2012 | Journal of Geographical Sciences2012，22，2： | 9 |
| 5 | Arbuscular mycorrhizal associations in the Gurbantunggut Desert显示文摘在位于 Xinjiang 的 Gurbantunggut 沙漠的植物,中国是改编的干旱种类并且在通常滋养穷人的土壤成长。调查在沙漠被进行决定与合适的荒芜的植物联系的 arbuscular mycorrhizal (AM ) 地位从 annuals 和 perennials 的 11 个家庭的 to23 种类。从所有植物的根为决定 mycorrhizal 殖民的地位和程度的内部、外部的 hyphae,泡和 coils/arbuscules 的存在被检验。调查的植物种类,(61%) 14 被发现形成 AMassociations,(22%) 5 是可能的 AM 开拓殖民地于种类,并且 4 是 non-my-corrhizal 植物。形成 AM 的 annuals 和灌木的 Theproportions 分别地是比 perennials 和植物的那些显著地低的。孢子密度在根地区的土壤每 20 g 从 5 ~ 21 变化了。在 3 个类的上午 14 点 fungaltaxa 被孤立并且识别了其 10 属于血管球, 3 到 Acaulospora, and1 到 Archaeospora。血管球是在识别的所有类的主导的类。G。deser-ticola 和 G.etunicatum 是最普通的税一孤立与 77.4% 和 74.8% 的出现频率,并且相对许多 14.4% 和 15.5% 分别地。 | TIAN Changyan SHI Zhaoyong CHEN Zhichao FENG Gu | 2006 | Chinese Science Bulletin2006，51，A01： | 8 |
| 6 | Ability of multicellular salt glands in Tamarix species to secrete Na^+ and K^+ selectively显示文摘The present study aimed to determine the mechanism of cation-selective secretion by multicellular salt glands.Using a hydroponic culture system,the secretion and accumulation of Na+ and K+ in Tamarix ramosissima and T.laxa under different salt stresses (NaCl,KCl and NaCl+KCl) were studied.Additionally,the effects of salt gland inhibitors (orthovanadate,Ba2+,ouabain,tetraethylammonium (TEA) and verapamil) on Na+ and K+ secretion and accumulation were examined.Treatment with NaCl (at 0-200 mmol L 1 levels) significantly increased Na+ secretion,whereas KCl treatment (at 0-200 mmol L 1 levels) significantly increased K+ secretion.The ratio of secretion to accumulation of Na+ was higher than that of K+.The changes in Na+ and K+ secretion differed after adding different ions into the single-salt solutions.Addition of NaCl to the KCl solution (at 100 mmol L 1 level,respectively) led to a significant decrease in K+ secretion rate,whereas addition of KCl to the NaCl solution (at 100 mmol L 1 level,respectively) had little impact on the Na+ secretion rate.These results indicated that Na+ secretion in Tamarix was highly selective.In addition,Na+ secretion was significantly inhibited by orthovanadate,ouabain,TEA and verapamil,and K+ secretion was significantly inhibited by ouabain,TEA and verapamil.The different impacts of orthovanadate on Na+ and K+ secretion might be the primary cause for the different Na+ and K+ secretion abilities of multicellular salt glands in Tamarix. | MA HaiYan TIAN ChangYan FENG Gu YUAN JunFeng | 2011 | Science China(Life Sciences)2011，54，3： | 7 |
| 7 | Comparison of paleotemperature reconstructions using microbial tetraether thermometers of the Chinese loess-paleosol sequence for the past 350000 years显示文摘The recently proposed global and local calibrations for the mean annual air temperature(MAT) reconstruction on the basis of 5-and 6-methyl brGDGTs have rarely been applied to the Chinese LPS yet, leaving the applicability of these calibrations unclear. Here, we used the improved chromatography method to analyze 198 loess-paleosol samples from the Weinan section in the southern CLP for the past 350 kyr. The 6-methyl brGDGTs comprise a major proportion of total brGDGTs, pointing to alkaline conditions for most soil samples from the Weinan LPS. The decoupled profile variation of MBT′6ME and MBT′_(5ME) suggests their response to different enviromental factors, possibly soil pH(or soil moisture) and temperature, respectively. This discrimination further corraborates that temperature and monsoonal precipitation were not in phase during the last four deglaciations on the CLP. Temperature estimates for the six calibrations tested show similar trends but remarkably differ in amplitudes. The soil moisture appears to affect the global MBT′/CBT calibration, the global MATmr calibration(a calibration based on the multiple linear regression) and the Chinese local SSM(Stepwise Selection Method) calibration, resulting in a significant underestimation of late Holocene temperature. In contrast, the dry climate has no effect on the global MBT′5ME calibration. Of the six calibrations,only the Chinese local SSM calibration and global MATmr calibration produce temperature variation amplitude over the past 350 ka that is consistent with other independent proxy data. The recently proposed local calibrations based on 5-and 6-methyl brGDGTs for North China yield the amplitude of temperature changes that is much larger than the results determined by other approaches.All the six calibrations have their own weakness in the MAT reconstruction, due partly to the inconsistency between the brGDGT distribution in the Weinan LPS and the modern soils used to establish these calibrations. | TANG ChangYan YANG Huan DANG XinYue XIE ShuCheng | 2017 | Science China Earth Sciences2017，60，6： | 7 |
| 8 | Root growth and spatio-temporal distribution of three common annual halophytes in a saline desert, northern Xinjiang显示文摘Root growth and spatial and temporal distribution in the 0-100 cm soil profiles of three common annual halophytes Salsola subcrassa, Suaeda acuminate and Petrosimonia sibirica distributed in a saline desert in northern Xinjiang, China were studied in 2009 and 2010. The results showed that the root systems of the three halophytes were of the taproot type, vertically distributed in the 90-cm soil profile, and were deepest in late July. Their taproots reached maximum depth rapidly, early in the growth period, but with rare lateral roots. They were then dug out in an orderly way, from bottom to top, exhibiting vertical development first and then horizontal development. The distribution of specific root length, which reflects the characteristics of the feeder root, was gradually increased from top to bottom, whereas root weight displayed an opposite distribution pattern. The root length distribution of the three halophytes was concentrated (62% to 76%) in the middle soil profile (20-60 cm), with less distribution in the surface (0-20 cm) and bottom (60-90 cm) soil profiles. The results indicated that the roots of the three annual halophytes grew rapidly into the deeper soil layer after germination, which ensured the plant survival and uptake of water and nutrition, and thus built up a strong tolerance to an arid, high-salt environment. | Ke ZHANG ChangYan TIAN ChunJian LI | 2012 | Journal of Arid Land2012，4，3： | 7 |
| 9 | Recombinant adenovirus-p53(Gendicine) sensitizes a pancreatic carcinoma cell line to radiation显示文摘Objective:In this study,we examine the effects of recombinant adenovirus-p53(rAd-p53)on the pancreatic carcinoma cell line SW1990.Specifically,we determine if expression of rAd-p53 sensitizes these cells to radiation.Methods:Following transfection of SW1990 cells with rAd-p53,we measured expression of P53,P21 and Bax by immunocytochemistry.Both transfected and control cell lines were irradiated with a range of doses,and the survival fractions(SF)were calculated.Dose survival curves were constructed and modeled for comparison.Results:Transfection of SW1990 cells with rAd-p53 resulted in increased expression of P53,P21 and Bax in a time-dependent manner.At 96 h after transfection,89.92%of cells expressed P53,56.8%expressed P21,and 76.50%expressed Bax.The SF following radiation was lower in the rAd-p53 transfected cells compared to the control cells,suggesting that rAd-p53 sensitizes SW1990 cells to radiation(D0for the experimental and control groups was 2.199 and 2.462,respectively).Conclusions:Use of the adenoviral vector is an effective means of transfecting SW1990 cells with wild-type P53,and this sensitizes the cell line to irradiation.This work suggests that combining rAd-p53with radiation therapy in pancreatic cancer may be therapeutically beneficial. | Jinluan Li Jianji Pan Xianggao Zhu Ying Su Lingling Bao Sufang Qiu Changyan Zou Yong Cai Junxin Wu Ivan W.K.Tham | 2013 | Chinese Journal of Cancer Research2013，25，6： | 6 |
| 10 | Localized salt accumulation: the main reason for cotton root length decrease during advanced growth stages under drip irrigation with mulch film in a saline soil显示文摘High salinity in soil can prevent root growth of most plants. To investigate soil salinity dynamics under drip irrigation with mulch film(DI) and its effects on cotton root length, we conducted field experiments in saline soil based on a monolith method using flooding irrigation with mulch film(FI) as a control at the Korla Experimental Station of the Xinjiang Academy of Agricultural Sciences, China in 2009 and 2010. The results showed that the total root length decreased 120 days after sowing(DAS) under DI, and was mainly centered in the 0–30 cm soil layer and at distances of 30–70 cm from the drip-lines. There was almost complete overlap in the area of root length decline and salt accumulation. In the soil depth of 0–30 cm and at distances of 30–70 cm from the drip-lines at 110 to 160 DAS in 2009 and 171 DAS in 2010, the electrical conductivity(EC) in all soil samples was at least 3 mS/cm and in some cases exceeded 5 mS/cm under DI treatment. However, EC barely exceeded 3 mS/cm and no reduc- tion in root length was observed under FI treatment. Correlation analysis of soil EC and root length density indicated that the root length declined when the soil EC exceeded 2.8 mS/cm. The main reason for the decrease of root length in cotton under DI was localized accumulation of salinity. | WenXuan MAI ChangYan TIAN Li LI | 2014 | Journal of Arid Land2014，6，3： | 6 |
| 11 | Diversity of arbuscular mycorrhizal fungi associated with desert ephemerals growing under and beyond the canopies of Tamarisk shrubs显示文摘arbuscular mycorrhizal (AM ) 四很普通的短暂植物种的真菌的地位, Chorispora tenella (棺罩) DC, Cerato-cephalus testiculatus (Crantz ) 贝丝, Eremopyrum 面向(L) Jaub et Spash 和在树柳属植物灌木(Tamarix spp ) 统治的一个区域成长的维朗妮卡 campy-lopoda Boiss 被调查。四 ephemerals 和他们的根围土壤的样品从在下面并且在 Tamariskshrubs 的华盖以外被收集。植物 mycorrhizal 地位和土壤 AM 真菌的孢子密度和社区结构被分析并且比较在下面并且在灌木华盖以外。在他们的相应根围土壤的 ephemerals 和孢子密度的 mycorrhizal 殖民率在灌木华盖下面是显著地更低的比在远处。在灌木(12 ) 下面的 AM 真菌的种类的数字也比在华盖(19 ) 以外低。什么时候在四 ephemerals 的根围玷污性质,被检验的、可得到的 N 和 P 和全部的 P,有机物内容,全部的盐内容和电的电导率(EC ) 都在华盖下面是更高的比在远处。相反,玷污显示出的可得到的 K 和酸碱值没有如此的趋势。上午 21 点的一个总数真菌的种类从四 ephemerals 的根围土壤被孤立。五属于 Acaulospora,到 Archaeo-spora, 13 到血管球并且二到 Paraglomus。我们得出结论 Tamarix spp 的华盖。对 ephemerals 的 AM 地位并且在 AM 真菌的社区和一些他们的根围土壤的性质上施加了一些影响。 | SHI Zhaoyong ZHANG Liyun FENG Gu Chr stie Peter TIAN Changyan LI Xiaolin | 2006 | Chinese Science Bulletin2006，51，A01： | 6 |
| 12 | Carbonaceous aerogel and CoNiAl-LDH@CA nanocomposites derived from biomass for high performance pseudo-supercapacitor显示文摘Conversion of waste biomass to valuable carbonaceous material is a sustainable and environmental benign method for energy and reduction of greenhouse gas emission. Herein, a two-step hydrothermal method was developed to fabricate high performance electrode material from pomelo peels. In the first step, the pomelo peels were transformed to carbonaceous aerogel(CA), which constructed of threedimensional, sponge-like brown monolith with hierarchical pores, low-density(0.032 g/cm^3) and excellent mechanical flexibility. Then, the cobalt nickel aluminum layered double hydroxide(CoNiAl-LDH) was in situ loaded on the surface of CA to form exquisite core-shell structure(CoNiAl-LDH@CA) through the second hydrothermal step. When used as an electrode material for supercapacitor, CoNiAl-LDH@CA exhibited high specific capacitances of 1,134 F/g at 1 A/g and 902 F/g at 10 A/g, respectively.Furthermore, they displayed an excellent cycling stability without an obvious capacitance decrease after 4,000 cycles. | Sidi Zhang Jian Liu Peipei Huang Hao Wang Changyan Cao Weiguo Song | 2017 | Science Bulletin2017，62，12： | 5 |
| 13 | Catalytic microwave assisted pyrolysis of aspen显示文摘The effect of catalysts on the microwave pyrolysis of aspen pellets was studied.A range of chlorides,nitrates and metal-oxides were added at 2%of the aspen mass(air dry aspen pellet weight basis).Chlorides in particular were found to favor liquid yield,especially the yield of water phase residue.Average liquid yield with added chlorides was 41%mass of the total biomass input,compared to 35%mass without catalyst.Metal-oxides were found to favor pyrolysis heavy oil,and thus total oil yield,since the yield of light oils seemed to be fairly constant.Nitrates were found to favor pyrolysis gas production.Pure light oils and light oils blended with diesel were found to be a potential diesel fuel substitute. | Johannes Moen Changyan Yang Bo Zhang Hanwu Lei Kevin Hennessy Yiqin Wan Zhiping Le Yuhuan Liu Paul Chen Roger Ruan | 2009 | International Journal of Agricultural and Biological Engineering2009，2，4： | 5 |
| 14 | A MATHEMATICAL PROGRAMMING MODEL FOR THE COEXISTENCE OF COMPETITIONS AND COOPERATIONS PROBLEMS显示文摘我们为比赛和合作问题的共存在这篇论文学习一个数学编程模型。我们介绍一个新答案概念,这个问题的 s 最佳的答案,它总是在紧缩、连续的条件下面存在。一最佳的答案能被解决一个非线性的编程问题获得,这被显示出。一些例子被给解释怎么计算一个 s 最佳的答案。 | MENG Zhiqing HU Qiying DANG Changyan | 2005 | Journal of Systems Science & Complexity2005，18，4： | 5 |
| 15 | Improving the electrochemical performance of Fe3O4 nanoparticles via a double protection strategy through carbon nanotube decoration and graphene networks显示文摘氧化铁是为锂离子电池的有希望的阳极材料,但是因为它的差的传导性和大体积变化,它通常在锂举起和版本过程期间展出差的电气化学的性质。在这个工作,为改进 Fe 的电气化学的性能的双保护策略 < 潜水艇 class= “ a-plus-plus ” > 3 O < 潜水艇 class= “ a-plus-plus ” > 通过有多围的碳 nanotubes 和减少的 graphene 氧化物网络的装饰的使用的 4 nanoparticles 被开发了。产生 MWCNTs-Fe <潜水艇class=“ a-plus-plus ”> 3 O <潜水艇class=“ a-plus-plus ”> 4 -rGO nanocomposites 与 MWCNTs-Fe 比较展出了优秀骑车的性能和率能力<潜水艇class=“ a-plus-plus ”> 3 O <潜水艇class=“ a-plus-plus ”> 4 , MWCNTs-Fe <潜水艇class=“ a-plus-plus ”> 3 O <潜水艇class=“ a-plus-plus ”>身体上与 rGO 混合的 4 ,和 Fe <潜水艇class=“ a-plus-plus ”> 3 O <潜水艇class= a-plus-plus > 4 -rGO 。680 | Shuliang Yang Changyan Cao Gen Li Yongbin Sun Peipei Huang Fangfang Wei Weiguo Song | 2015 | Nano Research2015，8，4： | 4 |
| 16 | Four residues of propeptide are essential for precursor folding of nattokinase显示文摘Subtilisin propeptide 作为指导先锋合拢的 intramolecular 女伴工作。Nattokinase, subtilisin 家庭的一个成员,当由信号肽, propeptide,和一个 subtilisin 领域组成的一位先锋,和它的合拢的机制尚待被理解,被综合。在这研究,贡献先锋合拢的 nattokinase propeptide 的必要残余是坚定的。删除分析证明在 propeptide 的保存区域为先锋合拢是重要的。单个地点并且多地点 mutagenesis 研究证实了 Tyr10, Gly13, Gly34,和 Gly35 的角色。在期间上演(i) 并且(ii ) 将先锋合拢, Tyr10 和 Gly13 形成 subtilisin 的接口的部分域。当 Gly34 和 Gly35 与将稳定 propeptide 的结构的一个螺旋连接了时。四倍的翼变化, Y10A/G13A/G34A/G35A,为 propeptide 导致了女伴功能的损失。这个工作为先锋经由第二等的结构和运动参数分析合拢显示出 propeptide 的必要残余。 | Yan Jia Xinhua Cao Yu Deng Wei Bao Changyan Tang Hanjing Ding Zhongliang Zheng Guolin Zou | 2014 | Acta Biochimica et Biophysica Sinica2014，46，11： | 4 |
| 17 | Fractionation and characterization of bio-oil from microwave-assisted pyrolysis of corn stover显示文摘Bio-oil from thermochemical conversion of biomass is a complex mixture of polar and non-polar compounds,and cannot be used directly as a combustion engine fuel due to its low heating value,high viscosity,chemical instability,and incomplete volatility.Mixed-solvent extraction was developed to fractionate bio-oils from microwave-assisted pyrolysis of corn stover to produce light oil(a mixture of light and inflammable fuel oil components from bio-oil)with low viscosity and low combustion residue,and high value chemicals.Different fractions from bio-oil were characterized using GC/MS and TG,and a major chemical(hydroxy-butanedioic acid diethyl ester)was separated. | Changyan Yang Bo Zhang Johannes Moen Kevin Hennessy Yuhuan Liu Xiangyang Lin Yiqin Wan Hanwu Lei Paul Chen Roger Ruan | 2010 | International Journal of Agricultural and Biological Engineering2010，3，3： | 4 |
| 18 | Oxygen vacancy enhanced biomimetic superoxide dismutase activity of CeO_(2)-Gd nanozymes显示文摘Cerium oxide-based nanozymes have recently drawn much attention in the field of biomedical and antioxidant applications,because of their unique regenerative or autocatalytic properties.Herein,we studied the biomimetic superoxide dismutase(SOD)nanozymes CeO_(2)-Gd that combines the fluorescence properties of rare earth Gd with the antioxidant properties of CeO_(2)nanoparticles,which was prepared via facile route.The structure and composition of the CeO_(2)-Gd were measured and verified by X-ray powder diffraction(XRD),Raman spectroscopy,transmission electron microscopy(TEM),energydispersive X-ray spectroscopy(EDX),and X-ray electron spectroscopy(XPS).Confocal microscopy was used to image cells.Antioxidant performance and cell viability of these nanozymes were measured in vitro using BGC-803 cell.CeO_(2)-Gd nanozymes with a higher Ce^(3+)/Ce^(4+)ratio show higher superoxide dismutase(SOD)mimetic activity.Their antioxidant activity and fluorescence properties of CeO_(2)-Gd in BGC-803 cancer cells are enhanced by oxygen vacancies generated by doping rare-earth elements Gd.This work may guide the future design of CeO_(2)-Gd-based biomimetic nanozymes for anticancer and antioxidant applications. | Xiangcheng Shi Jingjie Yang Xintong Wen Fuii Tian Changyan Li | 2021 | Journal of Rare Earths2021，39，9： | 4 |
| 19 | Differential mRNA expression profiling of oral squamous cell carcinoma by high-throughput RNA sequencing显示文摘Differentially expressed genes are thought to regulate the development and progression of oral squamous cell carcinomas(OSCC).The purpose of this study was to screen differentially expressed mRNAs in OSCC and matched paraneoplastic normal tissues,and to explore the intrinsic mechanism of OSCC development and progression.We obtained the differentially expressed mRNA expression profiles in 10 pairs of fresh-frozen OSCC tissue specimens and matched paraneoplastic normal tissue specimens by high-throughput RNA sequencing.By using Gene Ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analyses,the functional significance of the differentially expressed genes were analyzed.We identified 1,120 significantly up-regulated mRNAs and 178 significantly down-regulated mRNAs in OSCC,compared to normal tissue.The differentially expressed mRNAs were involved in 20 biological processes and 68 signal pathways.Compared to adjacent normal tissue,the expression of MAGEA11 was up-regulated;TCHH was down-regulated.These findings were verified by real-time PCR.These differentially expressed mRNAs may function as oncogenes or tumor suppressors in the development and progression of OSCC.This study provides novel insights into OSCC.However,further work is needed to determine if these differentially expressed mRNAs have potential roles as diagnostic biomarkers and candidate therapeutic targets for OSCC. | Liangyu Ge Siyu Liu Long Xie Lei Sang Changyan Ma Hongwei Li | 2015 | The Journal of Biomedical Research2015，29，5： | 4 |
| 20 | Synthesis and biological evaluation of 8-substituted and deglucuronidated scutellarin and baicalin analogues as antioxidant responsive element activators显示文摘Flavonoids are important bioactive dietary compounds, which are proved to be antioxidant responsive element (ARE) activators to defend against electrophilic toxicants and oxidative stress. The activators induce ARE gene transcription through Nrf2 factor, a major transcriptional stimulator of cytoprotective genes, relieved from a Keap1 complex. In this report, based on the structures of two flavonoids, scutellarin and baicalin, which are extracted from two common Chinese plants Dengzhanhua (Erigeron breviscapus (vant) Hand-Mazz) and Huangqin (Scutellaria baicalensis Georigi), respectively, we synthesized several 8-substituted and deglucuronidated analogues and identified the ARE activation effects of these flavonoids. We found that the Baicalin, deglucurnonidated Baicalin and diaza cyclopenta derivative were more active. Their dose-dependent upregulation activities of ARE and NQO1 and induction effects of Nrf2 were testified. The results presented that these three analogues had good upregulation effects on ARE, and they could be potentially utilized in relieving oxidative stress, upon further neuroprotective tests. | YANG Ping KONG XiangZhen CHENG ChangMei LI ChangYan YANG XiaoMing ZHAO Xing'E | 2011 | Science China Chemistry2011，54，10： | 3 |
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