|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Gastrodin promotes the secretion of brain-derived neurotrophic factor in the injured spinal cord显示文摘Gastrodin, an active component of tall gastrodia tuber, is widely used in the treatment of dizziness, paralysis, epilepsy, stroke and dementia, and exhibits a neuroprotective effect. A rat model of spinal cord injury was established using Allen's method, and gastrodin was administered via the subarachnoid cavity and by intraperitoneal injection for 7 days. Results show that gastrodin promoted the secretion of brain-derived neurotrophic factor in rats with spinal cord injury. After gastrodin treatment, the maximum angle of the inclined plane test, and the Basso, Beattie and Bresnahan scores increased. Moreover, gastrodin improved neural tissue recovery in the injured spinal cord. These results demonstrate that gastrodin promotes the secretion of brain-derived neurotrophic factor, contributes to the recovery of neurological function, and protects neural cells against injury. | Changwei Song Shiqiang Fang Gang Lv Xifan Mei | 2013 | Neural Regeneration Research2013，8，15： | 16 |
| 2 | Na 2 WO 4 /Mn/SiO 2 catalyst for oxidative dehydrogenation of ethane using CO 2 as oxidant显示文摘 | Jianqiang Zhu Song Qin Songtao Ren Xiaoxi Peng Dongmei Tong Changwei Hu | 2009 | Catalysis Today2009，，3： | 1 |
| 3 | Aroma active compounds of Beijing roast duck 显示文摘 | Chen Gengjun Song Huanlu Ma Changwei | 2009 | Flavour and Fragrance Journal2009，24，4： | 1 |
| 4 | Aroma-active compounds of Beijing roast duck显示文摘 | CHEN Gengjun SONG Huanlu MA Changwei | 2009 | Flavour and Fragrance Journal2009，24，4： | 1 |
| 5 | The Co-promotion effect of Mo and Nd on the activity and stability of sulfated zirconia-based solid acids in esterification显示文摘 | Kanghua Jiang Dongmei Tong Jinqiang Tang Ruili Song Changwei Hu | 2010 | Applied Catalysis A General2010，，1： | 1 |
| 6 | Construction of a microsatellite-based genetic linkage map for half-smooth tongue sole Cynoglossus semilaevis显示文摘 | Wentao SONG Guidong MIAO Yongwei ZHAO Yuze NIU Renyi PANG Xiaolin LIAO Changwei SHAO Songlin CHEN | 2013 | Current Zoology2013，59，1： | 1 |
| 7 | Aroma-active compounds of Beijing roast duck 显示文摘 | Chen Gengjun Song Huanlu Ma Changwei | 2009 | Journal of Flavour and Fragrance2009，24，： | 1 |
| 8 | Aroma-active compounds of Beijing roast duck显示文摘 | CHEN Genjun SONG Hualu MA Changwei | 2009 | Flavour and Fragrance Journal2009，24，4： | 1 |
| 9 | Aroma-active compounds of Beijing roast duck显示文摘 | CHEN Genjun SONG Huanlu MA Changwei | 2009 | Flavour and Fragrance Journal2009，24，4： | 1 |
| 10 | Aroma active compounds of Beijing roast duck显示文摘 | CHEN GENGJUN SONG HUANLU MA CHANGWEI | 2009 | Flavour and Fragrance Journal2009，24，4： | 1 |
| 11 | Preparation of EGCG decorated,injectable extracellular vesicles for cartilage repair in rat arthritis显示文摘Arthritis is a kind of chronic inflammatory autoimmune disease,which can destroy joint cartilage and bone,leading to joint pain,joint swelling,and limited mobility.Traditional therapies have many side effects or focus too much on anti-inflammation while neglecting joint repair.In this experiment,we combined Epigallocatechin gallate(EGCG)with extracellular vesicles derived from macrophages to treat rheumatoid arthritis.Sustained-release resulted in a significant decrease in chondrocyte expression of hypoxia-inducible factor 1-alpha,a decrease in apoptosis-related proteins Cytochrome C,Caspase-3,Caspase-9,and Bax.Molecular biological analysis showed that extracellular vesicles-encapsulated EGCG(EVs-EGCG)more significantly upregulated type II collagen expression by about 1.8-fold than EGCG alone,which was more beneficial for arthritis repair.Animal experiments revealed that these EGCG-coated extracellular vesicles significantly reduced swelling,decreased synovial hyperplasia,repaired cartilage,and attenuated arthritis-related pathology scores in arthritic rats.Measurement data showed that EVs-EGCG treatment reduced joint swelling by approximately 39.5%in rheumatoid rats.In vitro studies have shown that this EVs-EGCG can increase the expression of cartilage type II collagen and reduce apoptosis of chondrocytes.Moreover,it was demonstrated in vivo experiments to reduce cartilage destruction in rheumatoid arthritis rats,providing a solution for the treatment of rheumatoid arthritis. | Changwei Song Shibo Xu Linna Chang Xingjun Zhao Xifan Mei Xiuli Ren Zhenhua Chen | 2021 | Regenerative Biomaterials2021，8，6： | 0 |
| 12 | Advances of nanoparticles in transmucosal drug delivery显示文摘Transmucosal drug administration represents a potential strategy for enhancing treatment efficacy and reducing side effects by avoiding the first-pass effect into the systemic circulation and delivering therapeutics directly to the target disease site.However,many challenges still remain in its clinical application,including low drug availability and limited retention time in the mucosa.The burgeoning advancement of nanotechnologies offers great potential to overcome the above limitations,leveraging their distinct advantages of high drug-loading capacity and strong permeability.In this review,the latest developments of nanoparticles(NPs)in transmucosal drug delivery as well as their clinical applications are discussed. | Li Zhang Changwei Yang Yingxiang Song Tao Sheng Junyan Li Jicheng Yu Xiaohong Wu Xiao Ye | 2024 | Nano Research2024，17，4： | 0 |
| 13 | All-in-one phototheranostics based on BTP-4F-DMO nanoparticles for NIR-II fluorescence/photoacoustic dual-mode imaging and combinational therapy显示文摘Various phototheranostics have recently been developed for phototherapy.Through proper molecular design,the photochemical and photophysical properties of these phototheranostics can be promoted.Herein,an acceptor-donor-acceptor(A-D-A)-structured dye,BTP-4F-DMO,was synthesized and prepared into water-soluble nanoparticles(NPs).The obtained BTP-4F-DMO NPs had strong absorption from650 nm to 850 nm and a fluorescence emission peak at~900 nm that tailed to~1100 nm.The NPs showed a superhigh photothermal conversion efficiency of 90.5%±5%and could simultaneously generate·OH and^(1)O_(2)with a^(1)O_(2)generation quantum yield of 4.6%under 808 nm laser irradiation.Due to these advanced properties,BTP-4F-DMO NPs can switch the role of autophagy from pro-survival to prodeath,thereby further promoting cancer cell death.These features make BTP-4F-DMO NPs a promising multifunctional phototheranostic agent for NIR-II fluorescence/photoacoustic dual-mode imaging-guided synergetic photodynamic/photothermal therapy.In general,this work provides a strategy for expanding the biomedical applications of organic A-D-A-structured phototheranostics. | Ke Yang Bowen Yu Wei Liu Zequn Zhang Li Huang Shaojing Zhao Benhua Wang Jianing Yi Jun Yuan Yingping Zou Changwei Lin Xiangzhi Song Minhuan Lan | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员