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| 1 | Neuroprotective effects of Ginkgo biloba extract and GinkgoUde B against oxygen-glucose deprivation/reoxygenation and glucose injury in a new in vitro multicellular network model显示文摘 | Xiaohan Yang Tiezheng Zheng Hao Hong Nan Cai Xiaofeng Zhou Changkai Sun Liying Wu Shuhong Liu Yongqi Zhao Lingling Zhu Ming Fan Xuezhong Zhou Fengxie Jin | 2018 | Frontiers of Medicine2018，12，3： | 12 |
| 2 | An adaptive turbo-shaft engine modeling method based on PS and MRR-LSSVR algorithms显示文摘In order to establish an adaptive turbo-shaft engine model with high accuracy, a new modeling method based on parameter selection (PS) algorithm and multi-input multi-output recursive reduced least square support vector regression (MRR-LSSVR) machine is proposed. Firstly, the PS algorithm is designed to choose the most reasonable inputs of the adaptive module. During this process, a wrapper criterion based on least square support vector regression (LSSVR) machine is adopted, which can not only reduce computational complexity but also enhance generalization performance. Secondly, with the input variables determined by the PS algorithm, a mapping model of engine parameter estimation is trained off-line using MRR-LSSVR, which has a satisfying accuracy within 5&. Finally, based on a numerical simulation platform of an integrated helicopter/ turbo-shaft engine system, an adaptive turbo-shaft engine model is developed and tested in a certain flight envelope. Under the condition of single or multiple engine components being degraded, many simulation experiments are carried out, and the simulation results show the effectiveness and validity of the proposed adaptive modeling method. | Wang Jiankang Zhang Haibo Yan Changkai Duan Shujing Huang Xianghua | 2013 | Chinese Journal of Aeronautics2013，26，1： | 5 |
| 3 | A New Hybrid Control Scheme for an Integrated Helicopter and Engine System显示文摘A new hybrid control scheme is presented with a robust multiple model fusion control(RMMFC) law for a UH-60 helicopter and an active disturbance rejection control(ADRC) controller for its engines.This scheme is a control design method with every subsystem designed separately but fully considering the couplings between them.With three subspaces with respect to forward flight velocity,a RMMFC is proposed to devise a four-loop reference signal tracing control for the helicopter,which escapes the closed-loop system from unstable state due to the extreme complexity of this integrated nonlinear system.The engines are controlled by the proposed ADRC decoupling controller,which fully takes advantage of a good compensation ability for unmodeled dynamics and extra disturbances,so as to compensate torque disturbance in power turbine speed loop.By simulating a forward acceleration flight task,the RMMFC for the helicopter is validated.It is apparent that the integrated helicopter and engine system(IHES) has much better dynamic performance under the new control scheme.Especially in the switching process,the large transient is significantly weakened,and smooth transition among candidate controllers is achieved.Over the entire simulation task,the droop of power turbine speed with the proposed ADRC controller is significantly slighter than with the conventional PID controller,and the response time of the former is much faster than the latter.By simulating a rapid climb and descent flight task,the results also show the feasibility for the application of the proposed multiple model fusion control.Although there is aggressive power demand in this maneuver,the droop of power turbine speed with an ADRC controller is smaller than using a PID controller.The control performance for helicopter and engine is enhanced by adopting this hybrid control scheme,and simulation results in other envelope state give proofs of robustness for this new scheme. | ZHANG Haibo WANG Jiankang CHEN Guoqiang YAN Changkai | 2012 | Chinese Journal of Aeronautics2012，25，4： | 2 |
| 4 | Structured Databases on the Web: Observations and Implications显示文摘 | Chang K C C He Bin Li Changkai | 2004 | SIGMOD Record2004，33，3： | 1 |
| 5 | Feasibility of establishing cerebral ischemia models by using aerocyst-blocking bilateral ascending pharyngeal artery of piglets Imaging assessment显示文摘BACKGROUND: The cerebral ischemia and ischemia/reperfusion animal models are used to simulate the human cerebrovascular diseases is one of the popular topics of neurological science recently. To study the pathophysiology, pathogenesis, prophylaxis and treatment of ischemic cerebrovascular diseases and to establish the ideal animal model that is the most similar to the human cerebral ischemia, are the topics that the people generally cared about. OBJECTIVE: To evaluate the effects of aerocyst-blocking bilateral ascending pharyngeal artery on the establishment of cerebral ischemia models by using digital subtraction angiography (DSA), magnetic resonance diffusion-weighted imaging (DWI) and magnetic resonance perfusion-weighted imaging (PWI). DESIGN: Repetitive measure animal experiment. SETTING: Zhongshan Hospital Affiliated to Dalian University. MATERIALS: The experiment was carried out in the Animal Laboratory (Provincial Laboratory), Zhongshan Hospital of Dalian Univeristy from January to May 2006. A total of 14 domestic piglets, of 6 months old, weighing 12-15 kg, of either gender, were selected from Animal Experimental Center, Dalian University. Multistar T.O.P digital subtraction angiography machine was provided by Siemens Company, German. METHODS: Aerocyst-blocking bilateral ascending pharyngeal artery was used to establish cerebral ischemia models. And then, Multistar T.O.P. DSA was used for imaging of cerebral vessels before blocking, during blocking and at 0.5 and 2 hours after ischemia perfusion. GE Signa 1.5 T supraconduction magnetic resonance imaging was used for DWI examination; in addition, PWI was used based on focal sites and areas. Otherwise, magnetic resonance imaging (MRI) was used to detect signal changes of T1WI and T2WI in ischemic areas. MAIN OUTCOME MEASURES: Analytic results of DSA, DWI, PWI and MRI. RESULTS: All 14 experimental piglets were involved in the final analysis. ① DSA: The blood flow of bilateral ascending pharyngeal arteries and its branch were blocked at blocking phase, which restored 0.5 and 2 hours after reperfusion. ② DWI and PWI: There were no observable abnormalities in PWI and DWI at pre-blocking. Abnormal increased signals were found on both DWI and PWI at during and post-blocking. There were reduction in ADC and rCBF and delay in rTTP at all time points except pre-blocking. ③ MRI: There were no abnormal signals observable at any time of pre- and post-blocking in T1WI and T2WI. CONCLUSION: It is feasible to establish this kind of animal experimental models, and it can simulate the ischemic state; meanwhile, the existence and extent can be showed directly by DSA, DWI, and PWI. | Xiangyu Piao Changkai Sun Zhe Jin Jing YU Xiaodan Chang Xin Tang Hongmei Liu Peiyang Zhou | 2007 | Neural Regeneration Research2007，2，9： | 1 |
| 6 | Weakening of functional corticomuscular coupling during muscle fatigue显示文摘 | Yang Qi Fang Yin Sun Changkai | | 0，，： | 1 |
| 7 | Waste water produced from an oilfield and continuous treatment with an oil-degrading bacterium显示文摘 | Li Qingxin Kang Congbao Zhang Changkai | 2005 | Process Biochemistry2005，40，： | 1 |
| 8 | Waste water produced from an oilfield and continuous treatment with an oil-degrading bacterium显示文摘 | Congbao Kang Changkai Zhang | 2005 | Process Biochemistry2005，40，： | 1 |
| 9 | Isolation and characterization of a novel pyrene-degrading Bacillus vallismortis strain JY3A显示文摘 | Jianya Ling Guoying Zhang Haibo Sun Yuanyuan Fan Jianhua Ju Changkai Zhang | 2011 | Science of the Total Environment2011，，10： | 1 |
| 10 | Optimal Computing Budget Allocation for Ordinal Optimization in Solving Stochastic Job Shop Scheduling Problems显示文摘 | Hong-an Yang Yangyang Lv Changkai Xia Shudong Sun Honghao Wang Massimo Scalia | 2014 | Mathematical Problems in Engineering2014，，： | 1 |
| 11 | Quantitative analysis of glutamate compounds in the swine brain following central analgesics nasal spray using proton magnetic resonance spectroscopy and linear combination model显示文摘<正>BACKGROUND:In localized brain proton magnetic resonance spectroscopy(~1H-MRS),metabolite levels are often expressed as ratios,rather than absolute concentrations.Frequently,the denominator is creatine,which is assumed to be stable in normal,as well as many pathological, states.However,in vivo creatine levels do not remain constant.Therefore,absolute metabolite measurements,which provide the precise concentrations of certain chemical compounds,are superior to metabolite ratios for determining pathological and evolutional changes. OBJECTIVE:To investigate the feasibility of quantification analysis of brain metabolite changes caused by central analgesics nasal spray using the ~1H-MRS and linear combination model(LCModel) methods. DESIGN,TIME AND SETTING:This neuroimaging,observational,animal study was performed at the Laboratory of the Department of Medical Imaging,Second Affiliated Hospital,Medical College, Shantou University,China from July to December 2007. MATERIALS:Butorphanol tartrate nasal spray,as a mixed agonist-antagonist opioid analgesic,was purchased from Shanghai Hengrui Pharmacy,China.A General Electric Signa 1.5T System (General Electric Medical Systems,Milwaukee,Wl,USA) and LCModel software(Stephen Provencher,Oakville,Ontario,Canada) were used in this study. METHODS:MRS images were acquired in ten healthy swine aged 2 weeks using single-voxel point-resolved spectroscopic sequence.A region of interest(2 cm×2 cm×2 cm) was placed in the image centers of maximum brain parenchyma.Repeated MRS scanning was performed 15-20 minutes after intranasal administration of 1 mg of butorphanol tartrate.Three settings of repetition time/echo time were selected before and after nasal spray administration 3000 ms/30 ms, 1500 ms/30 ms,and 3000 ms/50 ms.Metabolite concentrations were estimated by LCModel software. MAIN OUTCOME MEASURES:~1H-MRS spectra was obtained using various repetition time/echo time settings.Concentrations of glutamate compounds(glutamate+glutamine),N-acetyl aspartate, and choline were detected in swine brain prior to and following nasal spray treatment. RESULTS:The glutamate compounds curve was consistent with original spectra,when a repetition time/echo time of 3 000 ms/30 ms was adopted.Concentrations of glutamate compounds,N-acetyl aspartate,and choline decreased following administration.The most significant reduction was observed in glutamate compound concentrations from(9.28±0.54) mmol/kg to(7.28±0.54) mmol/kg (P<0.05). CONCLUSION:~1H-MRS and LCModel software were effectively utilized to quantitatively analyze and measure brain metabolites.Glutamate compounds might be an important neurotransmitter in central analgesia. | Jianlin Wu Ting Liu Yan Lin Zhiwei Shen Yanwei Miao Renhua Wu Changkai Sun | 2009 | Neural Regeneration Research2009，4，7： | 0 |
| 12 | Practice of Perioperative Rational Use of Antibacterial Drugs Based on Drug Pathway显示文摘[Objectives]To establish a new management model for rational use of perioperative antibacterial drugs in surgical departments.[Methods]Based on evidence-based medicine,the department s drug pathway was formulated,and the new mode of rational drug use control was established by using fine pharmaceutical technology intervention,and the intervention effect was evaluated by the intensity of antibacterial drug use,per capita drug costs and the proportion of drugs.[Results]After adopting drug pathway in departments,the intensity of antibacterial drug use,per capita drug costs and the proportion of drugs decreased significantly,and the effect of rational drug use control was remarkable.[Conclusions]The drug pathway provides a new management and control mode for the rational use of perioperative antibacterial drugs in surgical departments of hospitals.Thus,it is worthy of popularization and application. | Changkai ZHOU Fanbo JING Haijun QU Jing GAO | 2024 | Medicinal Plant2024，15，2： | 0 |
| 13 | Advances in Research of Anti-tumor Effect of Aconiti Radix显示文摘In this paper,the anti-tumor effects of Aconiti Radix were reviewed and summarized,and the clinical feasibility of Aconiti Radix as a potential anti-tumor drug was analyzed,in order to provide a useful reference for the future research and development of new anti-cancer drugs of Aconiti Radix. | Jing GAO Fanbo JING Lifang FENG Wen XU Changkai ZHOU | 2024 | Medicinal Plant2024，15，2： | 0 |
| 14 | Suppression of transmembrane sodium currents on the freshly isolated hippocampal neuron cell with continuous infrared light显示文摘Physiotherapeutic effects of infrared lasers have been proved in clinic.These infrared-based regulations of the bioelectrical activities can roughly be classied into enhancement and suppression of action potential(AP),which are described by sodium(Na)and potassium(K)transmembrane current equations,named as Hodgkin and Huxley(HH)-model.The enhancement effect is able to evoke or strengthen the AP when infrared light is applied.Its corresponding mechanism is commonly ascribed to the changes of the cell membrane capacitance,which is transiently increased in response to the infrared radiation.The distinctive feature of the suppression effect is to inhibit or reduce the AP by the designed protocols of infrared radiation.However,its mechanism presents more complexity than that in enhancement cases.HH-model describes how the Na current determines the initial phase of AP.So,the enhancement and suppression of AP can be also ascribed to the regulations of the corresponding Na currents.Here,a continuous infrared light at the wavelength of 980 nm(CIS-980)was employed to stimulate a freshly isolated hippocampal neuron in vitro and a suppression effect on the Na currents of the neuron cell was observed.Both Na and K currents,which are named as whole cell currents,were simultaneously recorded with the cell membrane capacitance current by using a patch clamp combined with infrared irradiation.The results demonstrated that the CIS-980 was able to reversibly increase the capacitance currents,completely suppressed Na currents,but little changed K currents,which forms the steady outward whole cell currents and plays a major role on the AP repolarization.A conrmation experiment was designed and carried out by synchronizing tens of milliseconds of infrared stimulation on the same kinds of hippocampal neuron cells.After the blocked K channel,a reduction of Na current amplitude was still recorded.This proved that infrared suppression of Na current was irrelevant to K channel.A membrane capacitance mediation process was preliminarily proposed to explain the Na channel suppression process. | Fanyi Kong Xinyu Li Ruonan Jiao Kun Liu Xue Han Changkai Sun Changsen Sun | 2023 | Journal of Innovative Optical Health Sciences2023，16，2： | 0 |
| 15 | Discovery of novel exceptionally potent and orally active c-MET PROTACs for the treatment of tumors with MET alterations显示文摘Various c-mesenchymal-to-epithelial transition(c-MET) inhibitors are effective in the treatment of non-small cell lung cancer;however, the inevitable drug resistance remains a challenge, limiting their clinical efficacy. Therefore, novel strategies targeting c-MET are urgently required. Herein, through rational structure optimization, we obtained novel exceptionally potent and orally active c-MET proteolysis targeting chimeras(PROTACs) namely D10 and D15 based on thalidomide and tepotinib. D10 and D15 inhibited cell growth with low nanomolar IC_(50) values and achieved picomolar DC_(50) values and>99% of maximum degradation(D_(max)) in EBC-1 and Hs746T cells. Mechanistically, D10 and D15dramatically induced cell apoptosis, G1 cell cycle arrest and inhibited cell migration and invasion.Notably, intraperitoneal administration of D10 and D15 significantly inhibited tumor growth in the EBC-1 xenograft model and oral administration of D15 induced approximately complete tumor suppression in the Hs746T xenograft model with well-tolerated dose-schedules. Furthermore, D10 and D15 exerted significant anti-tumor effect in cells with c-MET^(Y1230H) and c-MET^(D1228N) mutations, which are resistant to tepotinib in clinic. These findings demonstrated that D10 and D15 could serve as candidates for the treatment of tumors with MET alterations. | Pengyun Li Changkai Jia Zhiya Fan Xiaotong Hu Wenjuan Zhang Ke Liu Shiyang Sun Haoxin Guo Ning Yang Maoxiang Zhu Xiaomei Zhuang Junhai Xiao Zhibing Zheng Song Li | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 0 |
| 16 | Screening of Drought Resistance Identification Indexes for Rice(Oryza sativa L.) Cultivars in Ningxia显示文摘The morphological characters, physiological characters, yield traits and yield per plant of total 49 rice cultivars from Ningxia were investigated under conditions of water stress and non-water stress so as to determine the relationship between each trait and yield per plant under water stress and the relationship between each relative character and drought resistance coefficient under water stress and non-water stress. The correlation, grey correlation, stepwise regression and path analyses showed that the tiller number per plant, plant height, grain density, effective panicle number per plant and grain number per panicle, total 5 traits, were significantly correlated with the drought resistance of rice, and they could be used to identify the drought resistance of rice in Ningxia. In addition, the drought resistance of rice was graded qualitatively according to the subordinate function value of corresponding drought resistance coefficient. The results showed that among the 49 rice cultivars from Ningxia,6 rice cultivars were highly drought resistant, and 9 rice cultivars were moderately drought resistant, suggesting that the evaluation method was feasible and effective. | Changkai LAI Wenyin ZHANG Qi HE Jianchang SUN Xingsheng WANG Yanbo YIN | 2016 | Agricultural Science & Technology2016，17，3： | 0 |
| 17 | Increase Renaturation Yield of Reteplase Using the Recombinant Human Protein Disulfide Isomerase显示文摘Reteplase, the recombinant type of novel tissue plasminogen activator (t-PA) variant, is a promising thrombolytics in clinics. Expressed in the form of an inclusion body, reteplase consists of about 40 % of the total intracellular proteins of Escherichia coli. The recombinant human protein disulfide isomerase (rhPDI) is used to increase the chance for the correct matching of the 18 hydrosulfide groups of the reteplase molecule in the renaturation process and it increase is the reteplase renaturation yield from 1%~2% to 15%~20% with a the purity aboue 99% and the specific activity of 5(105 IU/mg is reached. This novel method can reduce significantly the cost of production. | 赵友春 Wang Ge Kong Yang WANG Yanbing Zhang Changkai Chen Chao Liang Bufeng | 2004 | High Technology Letters2004，10，1： | 0 |
| 18 | Identification, characterization, and expression profiles of the GASA genes in cotton显示文摘Background:GASA(Giberellic Acid Stimulated in Arabidopsis)gene family plays a crucial role in the phytohormone signaling pathway,growth and development,and stress responses in plants.Many GASA homologs have been identified in various plants.Nevertheless,little is known about these proteins in cotton.Results:In the current study,we identified 19,17,25,33,and 38 GASA genes via genome-wide analyses of Gossypium herbaceum,G.arboreum,G.raimondii,G.barbadense,and G.hirsutum,respectively,and performed comprehensive bioinformatics and expression analyses.According to our results,132 GASA proteins shared similar protein structures and were classified into four groups based on the phylogenetic tree.A synteny analysis suggested that segmental duplication was a key driver in the expansion of the GASA gene family.Meanwhile,the cis-element and protein interaction analyses indicated that GhGASA proteins play a significant role in the hormone responses.Transcriptomic and qRT-PCR(Quantitative real time-polymerase chain reaction)analyses revealed diverse expression profiles of the GhGASA genes in different organs under abiotic stresses,indicating that some GhGASA genes possibly participate in fiber development and abiotic-stress responses.Conclusions:The GASA genes in cotton were systematically identified and analyzed for the first time in this paper,and it suggested that the GASA genes are important to the development and growth of cotton.These results will support future exploration of the functions of GASA genes in cotton. | QIAO Kaikai MA Changkai LV Jiaoyan ZHANG Chaojun MA Qifeng FAN Shuli | 2021 | Journal of Cotton Research2021，4，1： | 0 |
| 19 | Optimization of the Ethanol Extraction Method of Monoester Alkaloids from Radix Aconiti Preparata Based on HPLC-MS and Orthogonal Test显示文摘[Objectives] This study was conducted to optimize the ethanol extraction technology of monoester alkaloids from Radix Aconiti Preparata. [Methods]On the basis of defined extraction times,ethanol concentration,ethanol times and extraction time were investigated by HPLC-MS combined with orthogonal test to optimize extraction process using the content of monoester alkaloids( the sum of benzoyl neoaconitine,benzoyl hypoaconitine and benzoyl aconitine) as an index.[Results]The optimum ethanol extraction technology was as follows: 75% ethanol,ethanol amount 25 times of the medicinal material,and each extraction for 1. 5 h.[Conclusions] The optimal extraction technology is simple,feasible,stable and reliable. It can provide reference for the industrial production and quality control of monoester alkaloids from Radix Aconiti Preparata. | Changkai ZHOU Rui ZHANG Xiuling SHANG Lihua ZHOU Zukang ZHANG Jing GAO Hongxia YU Hongyan JI Xiaomin XING Qie GUO Donghua LIU Fangang MENG Jingchun YAO Na ZHANG Yongjun LIU Fanbo JING | 2020 | Agricultural Biotechnology2020，9，3： | 0 |
| 20 | Research Progress of Noninvasive Diagnostic Methods for Nonalcoholic Steatohepatitis显示文摘Distinguishing between nonalcoholic steatohepatitis(NASH) and advanced liver fibrosis is the key for clinical diagnosis of non-alcoholic fatty liver disease(NAFLD). Liver biopsy, which is widely used for diagnosis of liver diseases at present, has many drawbacks, such as being invasive, expensive and unstable. This article compares and summarizes the commonly used non-invasive diagnostic methods, including their diagnostic parameters, advantages and disadvantages, in order to provide a useful reference for the diagnosis of NASH. | Yishi JIA Changkai ZHOU Ci SONG | 2023 | Agricultural Biotechnology2023，12，3： | 0 |
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