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| 1 | The Tea Tree Genome Provides Insights into Tea Flavor and Independent Evolution of Caffeine Biosynthesis显示文摘茶是世界有巨大的经济、药用、文化的重要性的最旧、很流行的包含咖啡因的饮料。这里,我们在场第一个高质量的核苷酸序列充满重复(80.9%) ,栽培的茶树山茶 sinensis 的 3.02-Gb 染色体。我们证明茶树的一种非常地大的染色体尺寸从一些 LTR retrotransposon 家庭的慢、稳定、长期的扩大被结果。除了一个最近的整个染色体的复制事件,基因的系特定的扩大把新陈代谢的生合成与 flavonoid 联系了被发现,它提高 catechin 生产,萜烯酶激活,和应力公差,为茶风味和改编的重要特征。我们相对可可子和咖啡表明一个独立人士和茶咖啡因合成小径的快速的进化。在 25 山茶种类之中的比较研究表明那更高的表情大多数 flavonoid- 和咖啡因铺平 -- 然而并非 theanine 相关的基因贡献 catechins 和咖啡因的增加的生产并且因此提高处理茶的适用性和茶质量。这些新奇调查结果为进一步的 metabolomic 和典型生合成小径的功能的 genomic 精炼铺平道路并且将帮助开发将最后满足并且吸引世界范围的更多的茶喝酒者的茶风味的一个更多样化的集合。 | En-Hua Xia Hai-Bin Zhang Jun Sheng Kui Li Qun-Jie Zhang Changhoon Kim Yun Zhang Yuan Liu Ting Zhu Wei Li Hui Huang Yan Tong Hong Nan Cong Shi Chao Shi Jian-Jun Jiang Shu-Yan Mao Jun-Ying Jiao Dan Zhang Yuan Zhao You-Jie Zhao Li-Ping Zhang Yun-Long Liu Ben-Ying Liu Yue Yu Sheng-Fu Shao De-Jiang Ni Evan E. Eichler Li-Zhi Gao | 2017 | Molecular Plant2017，10，6： | 113 |
| 2 | Optimizing radiotherapy with immune checkpoint blockade in hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is the fifth most common cancer, and its incidence is rapidly increasing in North America and Western Europe as well as South-East Asia. Patients with advanced stage HCC have very poor outcomes;therefore, the discovery of new innovative approaches is urgently needed. Cancer immunotherapy has become a game-changer and revolutionized cancer treatment. A comprehensive understanding of tumor-immune interactions led to the development of immune checkpoint inhibitors (ICIs) as new therapeutic tools, which have been used with great success. Targeting immune checkpoint molecules such as programmed cell death-1 (PD-1) and cytotoxic T lymphocyteassociated protein-4 (CTLA-4) reinvigorates anti-tumor immunity by restoring exhausted T cells. Despite their effectiveness in several types of cancer, of the many immune suppressive mechanisms limit the efficacy of ICI monotherapy. Radiation therapy (RT) is an essential local treatment modality for a broad range of malignancies, and it is currently gaining extensive attention as a promising combination partner with ICIs because of its ability to trigger immunogenic cell death. The efficacy of combination approaches using RT and ICIs has been well documented in numerous preclinical and clinical studies on various types of cancers but not HCC. The application of ICIs has now expanded to HCC, and RT is recognized as a promising modality in HCC. This review will highlight the current roles of PD-1 and CTLA-4 therapies and their combination with RT in the treatment of cancers, including HCC. In addition, this review will discuss the future perspectives of the combination of ICIs and RT in HCC treatment. | Changhoon Choi Gyu Sang Yoo Won Kyung Cho Hee Chul Park | 2019 | World Journal of Gastroenterology2019，25，20： | 6 |
| 3 | Companion diagnostics for the targeted therapy of gastric cancer显示文摘Gastric cancer is the fourth most common type ofcancer and represents a major cause of cancer-related deaths worldwide. With recent biomedical advances in our understanding of the molecular characteristics of gastric cancer, many genetic alterations have been identified as potential targets for its treatment. Multiple novel agents are currently under development as the demand for active agents that improve the survival of gastric cancer patients constantly increases. Based on lessons from previous trials of targeted agents, it is now widely accepted that the establishment of an optimal diagnostic test to select molecularly defined patients is of equal importance to the development of active agents against targetable genetic alterations. Herein, we highlight the current status and future perspectives of companion diagnostics in the treatment of gastric cancer. | Changhoon Yoo Young Soo Park | 2015 | World Journal of Gastroenterology2015，21，39： | 3 |
| 4 | An update of adjuvant treatments for localized advanced gastric cancer显示文摘 | Changhoon Yoo Yoon-Koo Kang | 2012 | Clin Invest2012，，11： | 1 |
| 5 | NAVER: design and implementation of VR framework for Gyeongju VR Theater 显示文摘 | ChangHoon Park Heedong Ko Taiyun Kim | 2003 | Computer& Graphics2003，，27： | 1 |
| 6 | Serum albumin level is a significant prognostic factor reflecting disease severity in symptomatic multiple myeloma显示文摘 | Jeong Eun Kim Changhoon Yoo Dae Ho Lee Sang-We Kim Jung-Shin Lee Cheolwon Suh | 2010 | Annals of Hematology2010，，4： | 1 |
| 7 | Quality Assessment of Deblocked Images显示文摘 | YIM Changhoon Bovik Alan C | 2011 | IEEE Transactions on Image Processing(S1057-7149)2011，20，1： | 1 |
| 8 | Inhibitory actions of mibefradil on steroidogenesis in mouse Leydig cells: involvement of Ca^2+ entry via the T-type Ca^2+ channel显示文摘细胞内部的营地和 Ca2+ 在 Leydig 房间涉及 steroidogenic 活动的规定,它协调回答到 luteinizing 荷尔蒙(LH ) 和人的 chorionic gonadotropin (hCG ) 。然而, Ca2+ 入口的鉴定在 Leydig 房间 steroidogenesis 含有不是明确的。这研究的目的是识别影响 Leydig 房间 steroidogenesis 的 Ca2+ 隧道的类型。在在刚分裂的 Leydig 的 vitro steroidogenesis,老鼠的房间被 hCG 孵化导致。steroidogenesis 上的 mibefradil (通常认为的 T 类型 Ca2+ 隧道 blocker ) 的效果用反向的抄写(RT ) 被估计为 steroidogenic 的聚合酶链反应分析用放射性免疫测定的尖锐规章的蛋白质(星) mRNA 表示和睾丸激素生产。面对 1.0 mmol L ? 1 细胞外的 Ca2+ ,在 1 ~ 100 IU 的 hCG 显著地提高了两星 mRNA 水平和睾丸激素分泌物(P < 0.05 ) ,并且 hCG 的 stimulatory 效果被 mibefradil 显著地以一种剂量依赖者方式减少(P < 0.05 ) 。而且,当外部 Ca2+ 被省略时,睾丸激素生产的导致 hCG 的增加完全被移开,暗示那个 Ca2+ 条目为导致 hCG 的 steroidogenesis 被需要。而且,补丁夹钳研究揭示了在一个集中范围看见的 mibefradil 敏感的 Ca2+ 水流的存在将近 paralleled 那些禁止的 steroidogenesis。一起,我们的数据提供刺激 hCG 的 steroidogenesis 被在鼠标的 Leydig 房间由 T 类型 Ca2+ 隧道执行的 Ca2+ 入口部分地至少调停的证据。 | Jae-Ho Lee Jong-Uk Kim Changhoon Kim Churl K. Min | 2010 | Asian Journal of Andrology2010，12，6： | 1 |
| 9 | Aqueous dispersion of submicron-sized diamond particles for thermally conductive polyurethane coating显示文摘 | Eunsoo Kang Seongcheol Choi Changhoon Choi Sang Eun Shim | 2012 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2012，，： | 1 |
| 10 | Serum albumin level is a significant prognostic factor reflecting disease severity in symptomatic multiple myeloma显示文摘 | Jeong Eun Kim Changhoon Yoo Dae Ho Lee Sang-We Kim Jung-Shin Lee Cheolwon Suh | 2010 | Annals of Hematology2010，，4： | 1 |
| 11 | Experimental verification of horizontal two-dimensional modified mild- slope equation model显示文摘 | Kyung D S Changhoon Lee Young-Hyun park | 2001 | Coastal Engineering2001，44，： | 1 |
| 12 | Security analysis of pure DDP-based ci- pher proper for multimedia and ubiquitous device显示文摘 | Changhoon Lee | 2010 | Telecom- munication System2010，，44： | 1 |
| 13 | Competitive nonlinear pricing with product differentiation显示文摘 | Taeki Min Sang Yong Kim Changhoon Shin Minhi Hahn | 2002 | International Review of Economics and Finance2002，11，2： | 1 |
| 14 | An efficient method for DCT-domain separable symmetric 2-D linear filtering 显示文摘 | Changhoon Yim | 2004 | IEEE Transactions on Circuits and Systems for Video Technology2004，14，4： | 1 |
| 15 | Related-key differential attacks on Co- bra-H64 and Cobra-H128显示文摘 | Changhoon Lee | 2005 | Lecture Notes in Computer Sci- ence2005，3796，： | 1 |
| 16 | Phase I and pharmacodynamic study of vorinostat combined with capecitabine and cisplatin as first-line chemotherapy in advanced gastric cancer显示文摘 | Changhoon Yoo Min-Hee Ryu Young-Soon Na Baek-Yeol Ryoo Chae-Won Lee Jeheon Maeng Se-Yeon Kim Dong Hoe Koo Inkeun Park Yoon-Koo Kang | 2014 | Investigational New Drugs2014，，2： | 1 |
| 17 | Photocatalytic properties of nano-structured TiO2 plasma sprayed coating显示文摘 | Choia Hanshin Leea Changhee | 2003 | Surface and Coatings Technology2003，173，： | 1 |
| 18 | The effect of attitude and perception on consumer complaint intentions 显示文摘 | Chulmin Kim Sounghie Kim Subin Im Changhoon Shin | | The Journal of Consumer Marketing0，45，： | 1 |
| 19 | Modeling and control of a new robitic deburring system显示文摘 | Kim Changhoon Chung J H | 2007 | Transactions of the ASME2007，129，： | 1 |
| 20 | Characteristics of Jeffrey fluid model for peristaltic flow of chyme in small intestine with magnetic field显示文摘 | Noreen Sher Akbar S. Nadeem Changhoon Lee | 2013 | Results in Physics2013，，： | 1 |
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