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174篇 您的检索式：作者名="Chan HS"

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	题名	作者	年代	出处	被引量
1	Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC.	Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson	2005	World Journal of Gastroenterology2005，11，42：	4
2	Increme- ntal benefit and cost-effectiveness of high-dose statin therapy in high- risk patients with eoronary artery disease 显示文摘	Chan PS Nallamothu BK Gurm HS Hayward RA Vijan S	2007	Circulation2007，115，18：	1
3	Thalidomide for severe refractory ankylosing spondylitis:a 6-month open-label trial显示文摘	Wei JC Chan TW Lin HS	2003	J Rheumatol2003，30，12：	1
4	Energy metabolism in children with newly diagnosed acute lymphoblastic leukemia显示文摘	Stallings VA Vaisman N Chan HS	1989	Pediatr Res1989，26，：	1
5	Correlations between umbilical and maternal serum adiponectin levels and neonatal birthweights显示文摘	Chan TF Yuan SS Chen HS	2004	Acta Obstet Gynecol Scan2004，83，2：	1
6	Extragonadal endo-dermal sinus tumors in children: a review of 24 cases显示文摘	0 ’ Sullivan P Daneman A Chan HS	1983	PediatrRadiol1983，13，5：	1
7	A rare case of' giant' right-sided retroperitoneal bronchogenic cyst显示文摘	Goh BK Chan HS Wong WK	2004	Dig Dis Sci2004，49，：	1
8	Aberrant serum adiponectin levels in women with uterine leiomyomas显示文摘	Chen HS Chan TF Chung YF	2004	Gynecol Obstet Invest2004，58，3：	1
9	Correlations between umbilical and maternal serum adiponectin levels and neonatal birthweights显示文摘	Chan TF Yuan SS Chen HS	2004	Acts Obstet Gynecol Scand2004，83，2：	1
10	Pernicious anemia in Chinese:a study of 181 patients in a Hong Kong hospital显示文摘	Wun Chan JC Yu Liu HS Sang Kho BC		0，，：	1
11	Anticentromere antibodies(ACA) : Clinical distribution and disease specificity 显示文摘	Chan HL Lee YS Hong HS	1994	Clin Exp Dermatol1994，1994，4：	1
12	Bronchoscopic aspiration and bronchoalveolar lavage in the diagnosis of sputum smeamegative pul-monary tubereulosis显示文摘	Chan HS Sun AJ Hoheisel GB	1990	Lung1990，168，：	1
13	Granulosa-lutein cell growth differentiation factor-9 (GDF-9) messenger RNA and protein expression in vitro fertilization (IVF) cycles:relation to characteristics of ovulation induction and IVF显示文摘	Huang HY Wang HS Chan SH	2009	Fertil Steril2009，91，4：	1
14	Population pharmacokinetics of carbamazepine in Singapore epileptic patients显示文摘	Chan E Lee HS	2001	Br J Clin Pharmacol2001，51，6：	1
15	Obstructive sleep apnea presenting with nocturnal angina, heart failure ,and near miss sudden death 显示文摘	Chan HS Chiu HF Tse LK	1991	Chest1991，99，4：	1
16	Increased serum retinol-binding protein 4 concentrations in women with gestational diabetes mellitus显示文摘	Chan TF Chen HS Chen YC	2007	Reprod Sci2007，14，：	1
17	Subinhibitory concentrations of protein synthesis-inhibiting antibiotics promote increased expression of the agr virulence regulator and production of phenol- soluble modulin cytolysins in community-associated methicillin- resistant Staphylococcus aureus 显示文摘	Joo HS Chan JL Cheung GY	2010	Antimicrob Agents Chemother2010，54，11：	1
18	The role of nm23-H1 in the progression of transitional cell bladder cancer显示文摘	Chow NH Liu HS Chan SH	2000	Clin Cancer Res2000，6，9：	1
19	Opportunistic breast cancerscreening in Hong Kong: A revisit of the Kwong Wah Hospital expe-rience显示文摘	Lui CY? Lam HS Chan LK	2007	Hong Kong Med2007，13，2：	1
20	Thalidomide for severe refractory anklosing spondylitis : a 6-month open-label trial显示文摘	Wei JC Chan TW Lin HS	2003	J Rheumatol2003，30，12：	1

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