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| 1 | 在有类型 2 糖尿病的病人的 nephropathy 的管理。 | Critchley JA Zhao HL Tomlinson B Leung W Thomas GN Chan JC Cockram CS | 2002 | Chinese Medical Journal2002，，1： | 12 |
| 2 | Potential role of metabolomics in diagnosis and surveillance of gastric cancer显示文摘Gastric cancer is one of the deadliest cancers worldwide, and is especially prevalent in Asian countries. With such high morbidity and mortality, early diagnosis is essential to achieving curative intent treatment and long term survival. Metabolomics is a new field of study that analyzes metabolites from biofluids and tissue samples. While metabolomics is still in its infancy, there are numerous potential applications in oncology, specifically early diagnosis. Only a few studies in the literature have examined metabolomics' role in gastric cancer. Various fatty acid, carbohydrate, nucleic acid, and amino acid metabolites have been identified that distinguish gastric cancer from normal tissue and benign gastric disease. However, findings from these few studies are at times conflicting. Most studies demonstrate some relationship of cancer cells to the Warburg Effect, in that glycolysis predominates with conversion of pyruvate to lactate. This is one of the most consistent findings across the literature. There is less consistency in metabolomic signature with respect to nucleic acids, lipids and amino acids. In spite of this, metabolomics holds some promise for cancer surveillance but further studies are necessary to achieve consistency and validation before it can be widely employed as a clinical tool. | Angela W Chan Richdeep S Gill Daniel Schiller Michael B Sawyer | 2014 | World Journal of Gastroenterology2014，20，36： | 9 |
| 3 | Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-Analysis显示文摘 | Ulrike Peters Shuo Jiao Fredrick R. Schumacher Carolyn M. Hutter Aaron K. Aragaki John A. Baron Sonja I. Berndt Stéphane Bézieau Hermann Brenner Katja Butterbach Bette J. Caan Peter T. Campbell Christopher S. Carlson Graham Casey Andrew T. Chan Jenny Chan | 2012 | Gastroenterology2012，，： | 4 |
| 4 | Mitochondrial neuronal uncoupling proteins:a target for potential disease-modification in Parkinson’s disease Philip显示文摘This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson’s disease(PD).Mitochondria provide cellular energy in the form of ATP via oxidative phosphorylation,but as an integral part of this process,superoxides and other reactive oxygen species are also produced.Excessive free radical production contributes to oxidative stress.Cells have evolved to handle such stress via various endogenous anti-oxidant proteins.One such family of proteins is the mitochondrial uncoupling proteins(UCPs),which are anion carriers located in the mitochondrial inner membrane.There are five known homologues(UCP1 to 5),of which UCP4 and 5 are predominantly expressed in neural cells.In a series of previous publications,we have shown how these neuronal UCPs respond to 1-methyl-4-phenylpyridinium(MPP+;toxic metabolite of MPTP)and dopamine-induced toxicity to alleviate neuronal cell death by preserving ATP levels and mitochondrial membrane potential,and reducing oxidative stress.We also showed how their expression can be influenced by nuclear factor kappa-B(NF-B)signaling pathway specifically in UCP4.Furthermore,we previously reported an interesting link between PD and metabolic processes through the protective effects of leptin(hormone produced by adipocytes)acting via UCP2 against MPP+-induced toxicity.There is increasing evidence that these endogenous neuronal UCPs can play a vital role to protect neurons against various pathogenic stresses including those associated with PD.Their expression,which can be induced,may well be a potential therapeutic target for various drugs to alleviate the harmful effects of pathogenic processes in PD and hence modify the progression of this disease. | WL Ho Jessica WM Ho Hui-Fang Liu Danny HF So Zero HM Tse Koon-Ho Chan David B Ramsden Shu-Leong Ho | 2012 | Translational Neurodegeneration2012，1，1： | 3 |
| 5 | Optimal birth control of population dynamics 显示文摘 | Chan W L Guo B Z | 1990 | J Math Anal Appl1990，146，2： | 2 |
| 6 | Clay strength under earthquake loading conditions显示文摘 | Seed H B Chan C K | 1966 | Journal of the soil mechanics and foundations division1966，2，： | 2 |
| 7 | Circulating nitric oxide is suppressed in obstructive sleep apnea and is reversed by nasal continuous positive airway pressure显示文摘 | Ip M S Lam B Chan L Y | 2000 | Am J Respir Crit Care Med2000，162，6： | 2 |
| 8 | Mechanisms underlying nonsteroidal anti inflammatory drug-mediated apoptosis显示文摘 | Chan TA Morin PJ Vogelstein B | | 0，，： | 2 |
| 9 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 10 | Size distributions of maternal and fetal DNA in maternal plasma显示文摘 | Chan K C ZhangJ Hui A B Wong N Lau T K Leung T N | 2004 | Clin Chem2004，50，： | 1 |
| 11 | Surface characterization in ultra-precision machining of Al/SiC metal matrix composites using data dependent systems analysis显示文摘 | CHEUNG C F CHAN K C LEE W B | 2003 | Journal of Materials Processing Technology2003，140，： | 1 |
| 12 | Upwelling-driven nearshore hypoxia signals ecosystem and oceanographic changes in the northeast Pacific显示文摘 | GRANTHAM B A CHAN F NIELSEN K J | 2004 | Nature2004，429，6993： | 1 |
| 13 | Poisoning effect of nitrogen compounds on the performance of CoMoS/ Al2O3 catalyst in the hydrodesulfurization of dibeuzothiophene,4-methyldibenzothiophene,and 4,6-dimethyldibenzothiophene显示文摘 | CHAN K JUNG J L JUN S B | 2001 | Applied Catalysis B:Environmental2001，35，1： | 1 |
| 14 | How strong ENSO events affect tropical storm activity over the western North Pacific显示文摘 | WANG B CHAN J C L | 2002 | J Climate2002，15，： | 1 |
| 15 | Laser Bending of Leadframe Materials显示文摘 | Yau C L Chan K C Lee W B | 1998 | Journal of Materials Pro- cessing Technology1998，82，： | 1 |
| 16 | Fluid capacity distributions of random porous media 显示文摘 | Chan D Y C Hughes B D Paterson L | 1988 | Transport in Porous Media1988，，3： | 1 |
| 17 | Circulating nitric oxide is suppressed in obstructive sleep apnea and is reversed by nasal continuous positive airway pressure显示文摘 | Ip MS Lam B Chan LY | 2000 | Am J Respir Crit Care Med2000，162，6： | 1 |
| 18 | Effect of interdiffusion on the subbands in an Alx Ga1-xAs single quantum-well structure显示文摘 | Li E H Weiss B L Chan K S | 1992 | Phys Rev B1992，46，15： | 1 |
| 19 | Relationship between novel isoforms, functionally important domains, and subcellular distribution of CD164/endolyn 显示文摘 | Chan JY Lee-Pmdhoe JE Jorgensen B | 2001 | J Biol Chem2001，276，： | 1 |
| 20 | The conversion of procyanidins and prodelphinidins to cuaniding and delphinidin显示文摘 | Porter L J Hrstich L N Chan B G | 1986 | Phytochemistry1986，25，： | 1 |
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