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| 1 | Effectiveness of gastric cancer screening programs in South Korea:Organized vs opportunistic models显示文摘AIM:To investigate the outcome and effectiveness of two screening programs,National Cancer Screening Program(NCSP)and opportunistic screening(OS),for the detection of gastric cancer. METHODS:A total of 45 654 subjects underwent upper endoscopy as part of the NCSP or OS at the Chung-Ang University Healthcare System in Korea between January 2007 and December 2010.The study population was comprised of subjects over the age of 40 years.More specifically,subjects who took part in the NCSP were Medicaid recipients and beneficiaries of the National Health Insurance Corporation.Still photo-graphs from the endoscopies diagnosed as gastric cancer were reviewed by two experienced endoscopists. RESULTS:The mean age of the screened subjects was 55 years for men and 54 years for women.A total of 126 cases(0.28%)of gastric cancer were detected from both screening programs;100 cases(0.3%)from NCSP and in 26 cases(0.2%)from OS.The proportion of early gastric cancer(EGC)detected in NCSP was higher than that in OS(74.0%vs 53.8%,P=0.046). Among the 34 416 screenees in NCSP,6585(19.1%) underwent upper endoscopy every other year as scheduled.Among the 11 238 screenees in OS,3050(27.1%) underwent upper endoscopy at least once every two years during the study period.The detection rate of gastric cancer was found to be significantly higher during irregular follow-up than during regular follow-up in both screening programs(0.3%vs 0.2%,P=0.036).A higher incidence of EGC than advanced gastric cancer was observed during regular follow-up compared with irregular follow-up. CONCLUSION:Compliance to the screening program is more important than the type of screening system used. | Beom Jin Kim Chae Heo Byoung Kwon Kim Jae Yeol Kim Jae Gyu Kim | 2013 | World Journal of Gastroenterology2013，19，5： | 3 |
| 2 | Molecular variations in the promoter and coding regions of human Tim-1 gene and their association in Koreans with asthma显示文摘 | Chae S C Song J H Heo J C | 2003 | Hum Immunol2003，64，12： | 1 |
| 3 | Molecular variations in the promoter and coding regions of human Tim-1 gene and their association in Koreans with asthma显示文摘 | Chae S C Song J H Heo J C | 2003 | Hum Immunol2003，64，12： | 1 |
| 4 | Molecular variations in the promoter and coding regions of human Tim - 1 gene and their association in the Korean with asthma 显示文摘 | Chae SC Song JH Heo JC | 2003 | Hum Immunol2003，64，12： | 1 |
| 5 | Effects of dietary energy and lysine intake during late gestation and lactation on blood metabolites,hormones,milk composition and reproductive performance in multiparous sows显示文摘 | Yang YX Heo S Jin Z Yun JH Shinde P Choi JY Yang BK Chae BJ | | 0，，： | 1 |
| 6 | Independent and incremental prognostic value of exercise single-photon emission computed tomographic (SPECT) thallium imaging in coronary artery disease显示文摘 | Iskandrian AS Chae SC Heo J | 1993 | J Am Coll Cardiol1993，22，3： | 1 |
| 7 | Collapsin response mediator protein - 2 regulates neurite formation by modulating tubulin GTPase activity显示文摘 | Chae YC Lee S Heo K | 2009 | Cell Signall2009，21，12： | 1 |
| 8 | Effects of lysine intake during late gestation and lactation on blood metabolites,hormones,milk composition and reproductive performance in primiparous and multiparous sows显示文摘 | Yang YX Heo S Jin Z Yun JH Choi JY Yoon SY Park MS Yang BK Chae BJ | | 0，，： | 1 |
| 9 | Molecular variations in the promoter and coding regions of human Tim-lgene and their association in Koreans with asthma显示文摘 | Chae SC Song JH Heo JC | 2003 | Hum Immunol2003，64，12： | 1 |
| 10 | Molecular variations in the promoter and coding regions of human timl gene and their association in Koreans with asthma显示文摘 | Chae SC Song JH Heo JC | 2003 | Hum Immu- nol2003，64，12： | 1 |
| 11 | Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity显示文摘 | Chae YC Lee S Heo K | 2009 | Cell Signal2009，21，： | 1 |
| 12 | Segmentation of tooth in CT images for the 3D reconstruction of teeth显示文摘 | Heo H Chae | 2004 | Proceedings of SHE The International Society for Optical Engineering2004，5298，1： | 1 |
| 13 | Molecular variations in the promoter and coding regions of human tim1 gene and their association in Koreans with asthma显示文摘 | SONG J H HEO J C | 2003 | Hum Immunol2003，64，12： | 1 |
| 14 | Clinicopathological fea- tures and differences of p53 and Ki-67 expression in ade- nosquamous and squamous cell carcinomas of the stomach 显示文摘 | Kim YSI Heo WS Chae K H | 2006 | Korean J Gastroenterol2006，47，： | 1 |
| 15 | Collapsin response mediator pro-tein-2 regulates neurite formation by modulating tubulin GTPase ac- tivity显示文摘 | Chae YC Lee S Heo K | 2009 | Cell Signal2009，21，： | 1 |
| 16 | Preclinical Long-term Magnetic Resonance Imaging Study of Silymarin Liver-protective Effects显示文摘Background and Aims:Efficacy evaluations with preclini-cal magnetic resonance imaging(MRI)are uncommon,but MRI in the preclinical phase of drug development provides information that is useful for longitudinal monitoring.The study aim was to monitor the protective effectiveness of silymarin with multiparameter MRI and biomarkers in a thioacetamide(TAA)-induced model of liver injury in rats.Correlation analysis was conducted to assess compare the monitoring of liver function by MRI and biomarkers.Meth-ods:TAA was injected three times a week for 8 weeks to generate a disease model(TAA group).In the TAA and sily-marin-treated(TAA-SY)groups,silymarin was administered three times weekly from week 4.MR images were acquired at 0,2,4,6,and 8 weeks in the control,TAA,and TAA-SY groups.Results:The area under the curve to maximum time(AUCtmax)and T_(2)*values of the TAA group decreased over the study period,but the serological markers of liver abnormality increased significantly more than those in the control group.In the TAA-SY group,MRI and serological biomarkers indicated attenuation of liver function as in the TAA group.However,pattern changes were observed from week 6 to comparable levels in the control group with si-lymarin treatment.Negative correlations between either AUCtmax or T_(2)*values and the serological biomarkers were observed.Conclusions:Silymarin had hepatoprotective effects on TAA-induced liver injury and demonstrated the usefulness of multiparametric MRI to evaluate efficacy in preclinical studies of liver drug development. | Yeon Ji Chae Hwon Heo Chul-Woong Woo Sang-Tae Kim Jae-Im Kwon Monica Young Choi Yu Sub Sung Kyung Won Kim Jeong Kon Kim Yoonseok Choi Dong-Cheol Woo | 2022 | Journal of Clinical and Translational Hepatology2022，10，6： | 0 |
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