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| 1 | A randomized controlled trial of imipramine in patients with irritable bowel syndrome显示文摘AIM: To study the efficacy of low-dose imipramine in relieving symptoms associated with the irritable bowel syndrome (IBS). METHODS: A randomized, double-blind trial of 25 mg imipramine vs matched placebo for 12 wk was performed. Doubling the dose was allowed once at week 2 in case of an unsatisfactory early response. Primary efficacy variables were subjective global symptom relief and quality of life (QoL) using SF-36 at week 12. RESULTS: One hundred and seven patients were enrolled by advertisement or referral by general practitioners and 56 (31 imipramine: 25 placebo) completed the 16-wk study. Baseline characteristics were comparable. A high overall dropout rate was noted in the imipramine and placebo arms (47.5% vs 47.9%, P > 0.05), a mean of 25.0 and 37.4 d from enrollment, respectively (P < 0.05). At the end of 12 wk, there was a significant difference in global symptom relief with imipramine over placebo (per-protocol: 80.6% vs48.0%, P = 0.01) and a trend on intent-to-treat (ITT) analysis (42.4% vs 25.0%, P = 0.06). This improvement was evident early and persisted to week 16 (P = 0.024 and 0.053 by per-protocol and ITT analyses, respectively). Mean cumulative and componentspecific SF-36 scores improved in the imipramine group only (per-protocol, P < 0.01). Drug-related adverse events leading to patient dropout were more common in the imipramine group (25.4% vs 12.5%, P > 0.05). CONCLUSION: Imipramine may be effective in the treatment of IBS patients and is associated with improved QoL. Careful patient selection, initiation of a low dose with gradual escalation and monitoring for side effects may result in an improved therapeutic response. | Heitham Abdul-Baki Ihab I El Hajj Lara ElZahabi Cecilio Azar Elie Aoun Assaad Skoury Hani Chaar Ala I Sharara | 2009 | World Journal of Gastroenterology2009，15，29： | 11 |
| 2 | Soft tissue closure of grafted extraction sockets in the posterior maxilla:the rotated pedicle palatal connective tissue flap technique 显示文摘 | El Chaar ES | 2010 | Implant Dent2010，19，5： | 1 |
| 3 | Orthogonal defect classification - A concept for in-process measurements 显示文摘 | CHILLAREGE R BHANDARI I CHAAR J | 1992 | IEEE Transactions on Software Engineering1992，18，11： | 1 |
| 4 | Defect Classification-A Concept for Inprocess Measurements 显示文摘 | Chillarege R Bhandari I Chaar J | 1992 | IEEE Transactions on Software Engineering1992，18，11： | 1 |
| 5 | p73 gene expression in colorectal adenocarcinoma: a prognostic or etiopathogenetic factor?显示文摘 | Ben Mahmoud LK Toumi AA Chaar I | 2009 | Tunis Med2009，87，： | 1 |
| 6 | In-process Evaluation for Software Inspection and Test显示文摘 | Jarir K Chaar Michael J Halliday Inderpal S Bhandari | 1993 | IEEE Transa-ctions on Software Engineering1993，19，11： | 1 |
| 7 | Orthogonal Defect Classification: A Concept for In--Process Measurements 显示文摘 | CHILLAREGE R BHANDARI I S CHAAR J K | 1992 | IEEE Transac- tions on Software Engineering1992，18，11： | 1 |
| 8 | Impact of hepatitis B virus surface protein mutations on the diagnosis of occult hepatitis B virus infection显示文摘 | El Chaar M Cando(ni) D Crowther RA | | 0，，： | 1 |
| 9 | Effects of polycythemia on systemic endothehal function in chronic hypoxic lung dis- ease 显示文摘 | Boyer L Chaar V Pelle G eta/ | 2011 | JApplPhysiol2011，110，5： | 1 |
| 10 | Expanding the role of en- dovenous laser therapy:results in large diameter saphenous, small saphe- nous, and anterior accessory veins 显示文摘 | Chaar CI Hirsch SA Cwenar MT | 2011 | Ann Vasc Surg2011，25，5： | 1 |
| 11 | Laparoscopic sleeve gastrectomy versus laparoscopic Roux-en-Y gastric bypass:a single center experience with 2 years follow-up显示文摘 | El Chaar M Hammoud N Ezeji G | 2015 | Obes Surg2015，25，2： | 1 |
| 12 | Renal damage progresses despite improvement of renal function after relief of unilateral ureteral obstruction in adult rats显示文摘 | Ito K Chen J El Chaar M | 2004 | Am J Physiol Renal Physiol2004，287，6： | 1 |
| 13 | HBV reactivation after fludarabine chemotherapy identified on investigation of suspected transfusion-transmitted Hepatitis B virus显示文摘 | J.P. Power M. El Chaar J. Temple M. Thomas D. Spillane D. Candotti J.P. Allain | 2010 | Journal of Hepatology2010，，： | 1 |
| 14 | Simulation of vehicle-track interaction with flexible wheelsets,moving track models and field tests显示文摘 | CHAAR N BERG M | 2006 | Vehicle System Dynamics2006，44，： | 1 |
| 15 | Biological significance of promoter hypermethylation of pl4/ARF gene: Relationships to p53 mutational status in Tunisian population with colorectal carcinoma 显示文摘 | Chaar I Amara S Elamine OE | 2013 | Tumor Biol2013，11，5： | 1 |
| 16 | Ten year clinical outcome of three-unit posterior FDPs made from a glass-infiltrated zirconia reinforced alumina ceramic (In-Ceram Zirconia)显示文摘 | Chaar MS Passia N Kern M | 2015 | J Dent2015，43，5： | 1 |
| 17 | Biological significance of promoter hypermethylation of pl4/ARF gene: relationships to p53 mutational status in Tunisian population with eolorectal carcinoma显示文摘 | Chaar I Amara S Elamine OE | 2014 | Tumour Biol2014，35，2： | 1 |
| 18 | Environmental effects on a grid connected 900 W photovoltaic thin-film amorphous silicon system 显示文摘 | Hanai T A Hashim R B Chaar L E Lamont L A | 2011 | Renewable Energy2011，36，： | 1 |
| 19 | Effect of combination therapy with Enalapril and the :TGF-beta antagonist 1 D 11 in unilateral ureteral obstruction 显示文摘 | El Chaar M Chen J Seshan S V | 2007 | Am J Physiol Renal Physiol2007，292，4： | 1 |
| 20 | Impact of M-DM2 polymorphism : in- creased risk of developing colorectal cancer and a poor prognosis in the Tunisian population 显示文摘 | Chaar I Arfaoui TA Aminel HO | 2012 | Eur J Gastroenterol Hepatol2012，24，3： | 1 |
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