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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Interactions of posaconazole and flucytosine against Cryptococcus neoformans 显示文摘 | Barchiesi F Schimizzi AM Najvar LK Bocanegra R Caselli F Cesare SD | 2001 | Antimicrob Agents Chemother2001，45，5： | 1 |
| 3 | Failure analysis of crude oil pipeline 显示文摘 | Cesar R F Azevdo | 2007 | Engineering Failure Analysis2007，，14： | 1 |
| 4 | Structural change of bitumen in the recycling process by using rhe- ology and NMR显示文摘 | LUIGI F LUIGI G CESARE O R | 2012 | Ind Eng Chem Res2012，51，16： | 1 |
| 5 | Cardiopulmonary responses to exercise in patients of different age group with conges tive heart failure显示文摘 | Cesar Mde C Montesano F T Diniz R V | 2006 | Arq Bras Cardiol2006，86，1： | 1 |
| 6 | Adaptive Genetic Algo- rithms for Dynamic Channel Assignment in Mobile Cellular Communication Systerns显示文摘 | Lima M A C Araujo A F R Cesar A C | 2007 | IEEE Transactions on Vehicular Technolgoy2007，56，5： | 1 |
| 7 | Brambilla, Volatile compounds and soluble substances in freeze-concentrated feijoa juices显示文摘 | Di Cesare L F Nani R | 2000 | Industriedelle Bevande2000，29，166： | 1 |
| 8 | Volatile compounds and soluble substances in freeze- concentrated feijoa juices显示文摘 | Di Cesare L F Nani R Brambilla | 2000 | Industrie delle Bevande2000，29，166： | 1 |
| 9 | A rapid HPLCESI-MS/MS method for determination of dihydrouracil/uracil ratio in plasma:evaluation of toxicity to 5-flurouracil in patients with gastrointestinal cancer显示文摘 | Cesar I C Cunha-Junior G F Duarte Byrro R M | 2012 | Ther Drug Monit2012，34，1： | 1 |
| 10 | Failure analysis of a crude oil pipeline显示文摘 | Cesar R F Azevedo | 2007 | Engineering Failure Analysis2007，，14： | 1 |
| 11 | Changes in the chemical composition of basil caused by different drying procedures显示文摘 | Di CESARE L F FORNI E VISCARDI D NANI R C | 2003 | Journal of Agricultural and Food Chemistery2003，51，12： | 1 |
| 12 | Adaptive Genetic Algorithmsfor Dynamic Channel Assignment in Mobile Cellular CommunicationSystems显示文摘 | Lima M A C Araujo A F R CeSar A C | 2007 | Vehicular Technology IEEE Transactions on2007，56，5： | 1 |
| 13 | Aroma retention during the drying of peach juice in a vacuum belt dryer显示文摘 | Cesare L F di Nani R | 1995 | Fruit Processing1995，5，4： | 1 |
| 14 | RNA interference as new biotechnological tool for the control of virus disease in plants显示文摘 | Tenllado F Cesar L JoseRamon D R | 2004 | Virus Res2004，，： | 1 |
| 15 | Production of xylanolytic enzymes by Pencillium janczewskii 显示文摘 | Cesar R F T Beatriz T Marta C T D | 2010 | Bioresource Tech- nology2010，101，： | 1 |
| 16 | Adaptive genetic algorithms for dynamic channel assignment in mobile cellular communication systems vehicular technology显示文摘 | Lima M A C Araujoa F R Cesar A C | | 0，，05： | 1 |
| 17 | Immobilization of ibuprofen and copper-ibuprofen drugs on layered double hydroxides显示文摘 | Claudia R G Cesar A S Ana M F | 2005 | J Pha Sci2005，94，5： | 1 |
| 18 | Adaptive Genetic Algorithms for Dynamic Channel Assignment in Mobile Cellular Communication Systems Vehicular Technology显示文摘 | LIMA M A C ARAUJOA F R CESAR A C | 2007 | IEEE Transactions2007，56，05： | 1 |
| 19 | Changes in anthocyanin concentration in lychee (litchi chinensis sonn) pericarp during maturation 显示文摘 | Javier R L Cesar O F Pedro W E | 1999 | Food Chemistry1999，65，： | 1 |
| 20 | Changes in anthocyanin concentration in lychee ( litchi chinensis sonn ) pericarp during maturation 显示文摘 | Javier R L Cesar O F Pedro W E | 1999 | Food Chem1999，65，： | 1 |
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