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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Spark plasma sintering of Ti x Ta 1? x C 0.5 N 0.5 -based cermets: Effects of processing conditions on chemistry, microstructure and mechanical properties显示文摘 | José M. Córdoba Ernesto Chicardi Rosalía Poyato Francisco J. Gotor Valentina Medri Stefano Guicciardi Cesare Melandri | 2013 | Chemical Engineering Journal2013，，： | 1 |
| 3 | p95-APPl links membranetransport to Rac-mediated reorganization of actin显示文摘 | Di Cesare A Paris S Albertinazzi C | 2000 | Nat Cell Biol2000，2，8： | 1 |
| 4 | Understanding individual human mobility patterns显示文摘 | Marta C Gonzalez Cesar A Hidalgo Albert-Laszlo Barabisi | 2008 | Nature 4532008，，5： | 1 |
| 5 | Acute retroviral syndrome and high baseline viral load are predictors of rapid HIV progression among un- treated Argentinean seroconverters 显示文摘 | Soclas ME Sued O Laufer N Lfzaro ME Mingrone H Pryluka D Remondegui C Figueroa MI Cesar C Gun A Turk G Bouzas MB Kavasery R Krolewiecki A P6rez H Salom6u H Cahn P Grupo Argentino de Seroconversi6r Study Group | 2011 | J Int AIDS Soc2011，14，1： | 1 |
| 6 | Involvement ofα7n ACh R subtype in rat oxaliplatin-induced neuropathy:effects of selective activation显示文摘 | Di Cesare Mannelli L Pacini A Matera C | 2014 | Neuropharmacology2014，79，： | 1 |
| 7 | Analgesic and antineuropathic drugs acting through central cholinergic mechanisms显示文摘 | Bartolini A Di Cesare Mannelli L Ghelardini C | 2011 | Recent Pat CNS Drug Discov2011，6，2： | 1 |
| 8 | Adaptive Genetic Algo- rithms for Dynamic Channel Assignment in Mobile Cellular Communication Systerns显示文摘 | Lima M A C Araujo A F R Cesar A C | 2007 | IEEE Transactions on Vehicular Technolgoy2007，56，5： | 1 |
| 9 | Stability and selectivity of bimetallic Cu-Co/SiOz catalysts for cyclo- hexanol dehydrogenation 显示文摘 | Cesar D V Perez C A Salim V M M | 1999 | Appl Catal A: Gen1999，176，： | 1 |
| 10 | Impact of deltamethrin on arthropods in maize under conventional and no-tillage cultivation显示文摘 | RAUL NARCISO C GUEDSE ANTONIO A SILVA | 2004 | Crop Protection2004，，23： | 1 |
| 11 | L-valve behavior with solids of different size and density显示文摘 | Umberto A Cesare B L Antonio C | 1998 | Powder Technology1998，98，3： | 1 |
| 12 | Genetic and environmen- tal factors in gastric carcinogenesis显示文摘 | Cesar A C Silva A E Tajara E H | 2002 | Arq Gastroenterol2002，39，4： | 1 |
| 13 | Quantitative XPS analysis of silica - supported Cu - Co oxides 显示文摘 | Cesar D V Perez C A Schmal M | 2000 | Applied Surface Science2000，157，3： | 1 |
| 14 | A Hybrid Methodology for Synthesis of Petri Net Models for Manufacturing Systems 显示文摘 | F D Cesare A Desrochers | 1992 | IEEE Trans Robot Automation1992，8，3： | 1 |
| 15 | Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow显示文摘 | Cesare C Irene A G Robert | 2001 | Blood2001，98，8： | 1 |
| 16 | The timecourse of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise 显示文摘 | Adlard P A Perreau V M Engesser - Cesar C | 2004 | Neurosci2004，363，1： | 1 |
| 17 | Reconstruction of the failed femoral component and proximal femoral bone loss in revision hip surgery 显示文摘 | Maurer S G Baitner A C Di Cesare P E | 2000 | J Am Acad Orthop Surg2000，8，6： | 1 |
| 18 | Raman spectroscopy study of edible oils and determination of the oxidative stability at frying temperatures 显示文摘 | Maria A C Femando L Cesar J | 2014 | European Journal of Lipid Science and Technology2014，1164，： | 1 |
| 19 | Stability and selectivity of bimetallic Cu-Co/SiO2 catalysts for cyclohexanol dehydrogenation显示文摘 | Cesar D V Per6z C A Salim V M M | 1999 | Applied Catalysis A: General1999，176，2： | 1 |
| 20 | Involvement of a7 nAChR subtype in rat oxaliplatin-induced neuropathy:Effects of selective activation显示文摘 | Di Cesare Mannelli L Pacini A Matera C | 2014 | Neuropharmacology2014，79，： | 1 |
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