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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Enzymatic hydrolysis of lime-pretreated corn stover and investigation of the HCH-1 model: inhibition pattern, degree of inhibition,validity of simplified HCH-1 model 显示文摘 | Jonathan P Zhu L Cesar B G | 2007 | Bioresource Technology2007，98，16： | 1 |
| 3 | Triterpenes and other constituents of Nassauvia axillaris显示文摘 | CLAUDIA KOTOWICZ CESAR A N CATALAN CLAIRE L GRIFFIN | 2005 | Biochemical Systematics and Ecology2005，33，： | 1 |
| 4 | Long-term clinical outcome based on aspirin and clopidogrel responsiveness status after elective percutaneous coronary intervention 显示文摘 | Campo G Fileti L de Cesare N | 2010 | J Am College Cardiol2010，56，18： | 1 |
| 5 | Estimating and modeling space-time correlation structures显示文摘 | De Cesare L Myers D E Posa D | 2001 | Statistics &Probability Letters2001，51，1： | 1 |
| 6 | Breastfeeding and school achievement in Brazilian adolescents显示文摘 | Cesar G Fernando C Bernardo L | 2005 | Acta Paediatr2005，94，： | 1 |
| 7 | TLR9 agonists oppositely modulate DN repair genes in tumor versus immune cells and enhance chemotherapy effects显示文摘 | Sommariva M De Cecco L De Cesare M | 2011 | Cancer Res2011，71，20： | 1 |
| 8 | Characteristics of bladder leiomyoma in our setting显示文摘 | Blasco Cesares FJ Sacristan Sanfelipe J Ibarez Servio L | 1995 | Arch Esp Urol1995，48，10： | 1 |
| 9 | The recreational value of coral reefs : A meta-analysis显示文摘 | Brander L M Beukering P V Cesar H SJ | 2007 | Ecological Economics2007，63，1： | 1 |
| 10 | High power density superconducting motor for all-electric aircraft propulsion 显示文摘 | Philippe J M Cesar A L | 2005 | IEEE Transaction on Applied Superconductivity2005，15，2： | 1 |
| 11 | Probabilistic approach for determining Salmonella spp. and L. monocytogenes concentration in pork meat from presence/absence microbiological data显示文摘 | Antonio Valero Marta Hernandez Alessandra De Cesare Gerardo Manfreda Rosa Maria García-Gimeno Patricia González-García David Rodríguez Lázaro | 2014 | International Journal of Food Microbiology2014，，： | 1 |
| 12 | Antidepres- sant-like effect of artemin in mice: A mechanism for acetyl-L: - carnitine activity on depression 显示文摘 | Di Cesare Mannelli L Vivoli E Salvicchi A | 2011 | Psychopharmacology2011，218，2： | 1 |
| 13 | Promotion Profitability for a Retailer: The Role of Promotion, Brand, Category, and Store Charac- teristics显示文摘 | AILAWADI K L HARLAM B A CESAR J | 2006 | Journal of Marketing Research2006，43，4： | 1 |
| 14 | Gi/o Proteins: Expression for Direct Activation Enquiry显示文摘 | DI CESARE MANNELLI L PACINI A TOSCANO A | 2006 | Protein Expr Pufif2006，47，1： | 1 |
| 15 | A literature review on business process modelling:new frontiers of reusability显示文摘 | ALDIN L DE CESARE S | | 0，，03： | 1 |
| 16 | Oxaliplatininduced oxidative stress in nervous system-derived cellular models:could it correlate with in vivo neuropathy?显示文摘 | Di Cesare Mannelli L Zanardelli M Failli P | 2013 | Free Radical Biology and Medicine2013，61，： | 1 |
| 17 | Biosurfactant and biodegradation enhanced partitioning of polycyclic aromatic hydrocarbons from nonaqueous-phase liquids显示文摘 | MARTA G J CESAR G L JOSE L N A | 2003 | Environment Science Technology2003，37，13： | 1 |
| 18 | Enzyme stabili- zation by glutaraldehyde crosslinking of adsorbed proteins on aminated supports显示文摘 | Fernando L G Lorena B Cesar M | 2005 | Journal of Biotechnology2005，119，： | 1 |
| 19 | Reli- able teleportation in trappedions显示文摘 | Solano E Cesar C L de Matos Filho R L | 2001 | European Physi- cal Journal D2001，13，1： | 1 |
| 20 | Involvement ofα7n ACh R subtype in rat oxaliplatin-induced neuropathy:effects of selective activation显示文摘 | Di Cesare Mannelli L Pacini A Matera C | 2014 | Neuropharmacology2014，79，： | 1 |
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