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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Breastfeeding and school achievement in Brazilian adolescents显示文摘 | Cesar G Fernando C Bernardo L | 2005 | Acta Paediatr2005，94，： | 1 |
| 3 | Reli- able teleportation in trappedions显示文摘 | Solano E Cesar C L de Matos Filho R L | 2001 | European Physi- cal Journal D2001，13，1： | 1 |
| 4 | Involvement ofα7n ACh R subtype in rat oxaliplatin-induced neuropathy:effects of selective activation显示文摘 | Di Cesare Mannelli L Pacini A Matera C | 2014 | Neuropharmacology2014，79，： | 1 |
| 5 | Analgesic and antineuropathic drugs acting through central cholinergic mechanisms显示文摘 | Bartolini A Di Cesare Mannelli L Ghelardini C | 2011 | Recent Pat CNS Drug Discov2011，6，2： | 1 |
| 6 | Bacteriologic flora of aspiration-induced pulmonary infections显示文摘 | Cesar L Gonzalez C Calia FM | | 0，，： | 1 |
| 7 | Polylysine induces changes in membrane electrical properties of K562 cells 显示文摘 | Santini M Cesare C Pietro L | 1997 | Journal of Biomedical Materials Research1997，35，2： | 1 |
| 8 | L-valve behavior with solids of different size and density显示文摘 | Umberto A Cesare B L Antonio C | 1998 | Powder Technology1998，98，3： | 1 |
| 9 | Tellurite glass optical fiber doped with PbTe quantum dots显示文摘 | Jacob G J Barbosa L C Cesar C L | 2005 | Proceedings of SPIE-The International Society for Optical Engineering Ⅱ2005，5734，： | 1 |
| 10 | Bacteriologic Flora of Aspiration-Induced Pulmonary Infections显示文摘 | Cesar L Gonzalez C Calia FM | 1975 | Arch In- tern Med1975，135，5： | 1 |
| 11 | Polylysine induces changes in membrane electrical properties of K562 cells显示文摘 | Santini M Cesare C Pietro L | 1997 | Journal of Biomedical Materials Research1997，35，2： | 1 |
| 12 | Raman spectroscopy study of edible oils and determination of the oxidative stability at frying temperatures 显示文摘 | Maria A C Femando L Cesar J | 2014 | European Journal of Lipid Science and Technology2014，1164，： | 1 |
| 13 | Material waste in building industry:main causes and prevention显示文摘 | Formoso C T Soibelman L Cesare C D | 2002 | Journal of Construction Engineering and Management2002，128，4： | 1 |
| 14 | Preclinical profile of antitumor activity of a novel hydrophilic camptothecin,ST1968显示文摘 | Pisano C De Cesare M Beretta G L | 2008 | Mol Cancer Ther2008，7，7： | 1 |
| 15 | Output synchronization of chaotic systems under nonvanishing perturbations显示文摘 | DIDIER L CESAR C | 2008 | Chaos Solitons and Fractals2008，37，： | 1 |
| 16 | Local anaesthetic activity of 13 - caryophyllene 显示文摘 | Ghelardini C Galeotti N Di Cesare Mannelli L | 2001 | Farmaco2001，56，： | 1 |
| 17 | Local anaesthetic activity of β-caryophyllene 显示文摘 | GHELARDINI C GALEOUTFI N DI CESARE MANNELLI L | 2001 | Farmaco2001，56，567： | 1 |
| 18 | Involvement of a7 nAChR subtype in rat oxaliplatin-induced neuropathy:Effects of selective activation显示文摘 | Di Cesare Mannelli L Pacini A Matera C | 2014 | Neuropharmacology2014，79，： | 1 |
| 19 | Local anaesthetic activity of β-caryophyllene显示文摘 | Ghelardinia C Galeottia N L Di Cesare Mannellia | 2001 | II Farmaco2001，56，： | 1 |
| 20 | The neuropat hy-prot ective agent aeetyl-L-carnitine activates protein kinase C-gamma and MAPKs in a rat model of neuro-pathic pain显示文摘 | Di Cesare Mannelli L Ghelardini C Toscano A | 2010 | Neuroscience2010，165，4： | 1 |
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