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| 1 | CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients显示文摘AIM To characterize peripheral blood natural killer(NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus(HIV)/hepatitis C virus(HCV) coinfected patients.METHODS Peripheral mononuclear cells from 24 HIV/HCV(HBVnegative) coinfected and 5 HIV/HCV/HBV seronegative individuals were evaluated. HIV/HCV coinfected patients were divided in to groups: G1, patients with METAVIR F0-F2 and G2, patients with METAVIR F3-F4. NK surface cell staining was performed with: AntiCD3(APC/Cy7), anti-CD56(PE/Cy5), anti-CD57(APC), anti-CD25(PE), anti-CD69(FITC), anti-NKp30(PE), antiNKp46(PE/Cy7), anti-NKG2D(APC), anti-DNAM(FITC); anti-CD62L(PE/Cy7), anti-CCR7(PE), anti-TRAIL(PE), anti-Fas L(PE), anti CD94(FITC). Flow cytometry data acquisition was performed on BD FACSCanto, analyzed using Flow Jo software. Frequency of fluorescence was analyzed for all single markers. Clinical records were reviewed, and epidemiological and clinical data were obtained.RESULTS Samples from 11 patients were included in G1 and from 13 in G2. All patients were on ARV, with undetectable HIV viral load. Liver fibrosis was evaluated by transient elastography in 90% of the patients and with biopsy in 10% of the patients. Mean HCV viral load was(6.18 ± 0.7 log10). Even though, no major significant differences were observed between G1 and G2 regarding NK surface markers, it was found that patients with higher liver fibrosis presented statistically lower percentage of NK cells than individual with low to mild fibrosis and healthy controls(G2: 5.4% ± 2.3%, G1: 12.6% ± 8.2%, P = 0.002 and healthy controls 12.2% ± 2.7%, P = 0.008). It was also found that individuals with higher liver fibrosis presented lower CD4 LT count than those from G1(G2: 521 ± 312 cells/μL, G1: 770 ± 205 cells/μL; P = 0.035).CONCLUSION Higher levels of liver fibrosis were associated with lower percentage of NK cells and LTCD4+ count; and they may serve as noninvasive biomarkers of liver damage. | Natalia Laufer Diego Ojeda María Laura Polo Ana Martinez Héctor Pérez Gabriela Turk Pedro Cahn Norberto Walter Zwirner Jorge Quarleri | 2017 | World Journal of Hepatology2017，9，25： | 2 |
| 2 | In vitro susceptibility studies of cryprococcus neoformans isolated from patients with no clinical response to arnpbotericin B therapy显示文摘 | Rodero L Cordoba S Cahn P | 2000 | J Antimicrob Chemother2000，45，2： | 1 |
| 3 | Low dose T-cell lymphocyte infusion combined with marrow T-cell depletion as praphylaxis of acute graft-versus-host diseasefor HLA identical sibling bone marrow transplantation显示文摘 | Cahn JY Deconinck E Tiberghien P | 1999 | Hematol Cell Ther1999，41，2： | 1 |
| 4 | Resistance profile of the new nucleoside reverse transcriptase inhibitor apricitabine显示文摘 | Cahn P Wainberg MA | 2010 | J Antimicrob Che- mother2010，65，2： | 1 |
| 5 | In vitro susceptibility studies of cryptococcus neoformans isolated from patients with no clinical response to amphoteriein B therapy 显示文摘 | Rodero L Cordoba S Cahn P | 2000 | Journal of Antimicrobial Chemotherapy2000，45，： | 1 |
| 6 | Antiviral activity of aprici- tabine in treatment-experienced HIV-1-infected patients with M184V who are failing combination therapy显示文摘 | Cahn P Ahclas J Martins M | 2011 | HIV Med2011，12，6： | 1 |
| 7 | Antiretroviral treatment of adult HIV infection: 2010 recommendations of the International AIDS Society-USA panel 显示文摘 | Thompson MA Aberg JA Cahn P | 2010 | JAMA2010，304，3： | 1 |
| 8 | A broad spectrum human lung fibroblast derived mitogen is a variant of hepatocyte growth factor显示文摘 | RUBIN J S CAHN A M L BATTARO D P | 1991 | Proc Natl Acad Sci U S A1991，88，2： | 1 |
| 9 | Efficacy and safety of rilpivi- rine (TMC278) versus efavirenz at 48 weeks in treatment-naive HIV-l-infected patients: pooled results from the phase 3 double- blind randomized ECHO and THRIVE Trials显示文摘 | Cohen CJ Molina JM Cahn P et d | 2012 | J Acquir Immune Defic Syndr2012，60，1： | 1 |
| 10 | Acute retroviral syndrome and high baseline viral load are predictors of rapid HIV progression among un- treated Argentinean seroconverters 显示文摘 | Soclas ME Sued O Laufer N Lfzaro ME Mingrone H Pryluka D Remondegui C Figueroa MI Cesar C Gun A Turk G Bouzas MB Kavasery R Krolewiecki A P6rez H Salom6u H Cahn P Grupo Argentino de Seroconversi6r Study Group | 2011 | J Int AIDS Soc2011，14，1： | 1 |
| 11 | 2010 Recommendations of the International AIDS Society- USA Panel 显示文摘 | Thompson MA Aberg JA Cahn P | 2010 | JAMA2010，304，3： | 1 |
| 12 | Efficacy and safety of rilpi-virine(TMC278)versus efavirenz at 48 weeks in treatment-naive HIV-1-infected patients:pooled results from the Phase3 doubleblind randomized ECHO and THRIVE trials显示文摘 | Cohen CJ Molina JM Cahn P | 2012 | JAcquir Immune Defic Syndr2012，60，1： | 1 |
| 13 | Randomized, controlled study of the effects of a short course of prednisone on the incidence of rash associated with nevirapine in patients infected with HIV-1显示文摘 | Montaner JS Cahn P Zala C | 2003 | J Acquir Immune Defic Syndr2003，33，1： | 1 |
| 14 | Abacavir compared to protease inhibitors as part of HAART regimens for treatment of HIV infection: patient satisfaction and implications for adherence显示文摘 | Jordan J Cahn P Goebel F | 2005 | AIDS Patient Care STDS2005，19，1： | 1 |
| 15 | Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-1: 24-week results from a randomised, double-blind, placebocontrolled trial 显示文摘 | Madruga JV P Cahn Grinsztejn B | 2007 | Lancet2007，370，9581： | 1 |
| 16 | Antiretroviral treatment of adult HIV infection: 2010 recommendations of the International AIDS Society-USA panel 显示文摘 | Thompson MA Aberg JA Cahn P etal | 2010 | JAMA2010，304，3： | 1 |
| 17 | Efficacy and safety of tipranavir co-administered with ritonavir in HIV-l-infected children and adolescents: 5 years of experience显示文摘 | SALAZAR JC CAHN P NEGRA MD | 2014 | Pediatr Infect Dis J2014，33，4： | 1 |
| 18 | Dolutegravir versus raltegravir in antiretroviral- experienced, integrase- inhibitor- naive adults with HIV: week 48 results from the randomised, double - blind, non - inferiority SAILING study 显示文摘 | CAHN P POZNIAK AL MINGRONE H eta! | 2013 | Lancet2013，382，9893： | 1 |
| 19 | A phase 1, randomi- zed, placebo-controlled, dose-escalation study of an anti-IL-13 monoclonal antibody in healthy subjects and mild asthmatics 显示文摘 | Hodsman P Ashman C Cahn A et d | 2012 | BrJ Clin Pharmacol2012，75，1： | 1 |
| 20 | The order-disorder transformation in Ni3Al and Ni3Al-Fe alloys (I):Determination of the transition temperatures and their relation to ductility显示文摘 | CAHN R W SIEMERS P A GEIGER J E BARDHAN P | 1987 | Acta Metall1987，35，11： | 1 |
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