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| 1 | Role of MMP-2 and MMP-9 and their natural inhibitors in liver fibrosis, chronic pancreatitis and non-specific inflammatory bowel diseases显示文摘BACKGROUND: There is a growing evidence that matrix metalloproteinase (MMP)-2 and MMP-9 (gelatinases) play an important role in the pathogenesis of numerous disorders especially with inflammatory etiology and extracellular matrix (ECM) remodeling. Despite the fact that gelatinases involve in liver cirrhosis is provided in the literature, their role in the pathogenesis of chronic pancreatitis and non-specific inflammatory bowel diseases is still under investigation.DATA SOURCES: We carried out a PubM ed search of English language articles relevant to the involvement of gelatinases in the pathogenesis of liver fibrosis, pancreatitis, and non-specific inflammatory bowel diseases.RESULTS: The decreased activity of gelatinases, especially MMP-2, is related to the development of liver fibrosis, probably due to the decrease of capability for ECM remodeling. Similar situation can be found in chronic pancreatitis; however reports on this matter are rare. The presence of non-specific inflammatory bowel diseases results in MMP-9 activity elevation.CONCLUSION: The fluctuation of gelatinases activity during liver fibrosis, chronic pancreatitis and non-specific inflammatorybowel diseases is observed, but the exact role of these enzymes demands further studies. | Jacek Kurzepa Agnieszka M?dro Gra?yna Czechowska Joanna Kurzepa Krzysztof Celiński Weronika Kazmierak Maria S?omka | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，6： | 15 |
| 2 | Tribo-surface characteristics of Al-B4C and Al-SiC composites worn under different contact pressures显示文摘 | SHOROWORDI K M HASEEB A S M A CELIS J P | 2006 | Wear2006，261，： | 1 |
| 3 | Heavy metal adsorption by functionalized days 显示文摘 | Celis R Hermosin M Comejo J | 2000 | Environmental Science & Technology2000，，34： | 1 |
| 4 | Plasma adrenomedullin con- centrations in patients with renovascular or malignant hypertension 显示文摘 | CallUmi C Cianei R Celi M | 2004 | Minerva Cardioangiol2004，52，： | 1 |
| 5 | Fretting wear of multilayered (Ti,Al)N/TiN coatings in air of different relative humidity显示文摘 | Huq M Z Celis J P | 1999 | Wear1999，，： | 1 |
| 6 | Plasma adrenomedullin concentrations in patiests with renovascular or malignant hypertension显示文摘 | Caliumi C Cianci R Celi M | 2004 | Minerva Cardioangiol2004，52，4： | 1 |
| 7 | Sorption of two polar herbicides in solids and soil clay suspensions显示文摘 | COX L HERMOSIN M C CELIS R | 1997 | Water Research1997，31，6： | 1 |
| 8 | Heavy metal adsorption by functionalized clays显示文摘 | CELIS R HERMOSIN M C CORNEJO J | 2000 | Environment Science Technology2000，34，21： | 1 |
| 9 | Does the addition of a specialized postpartum clinic improve the care of women with preeclampsia?显示文摘 | Bibbo C Celi A Thomas A M | 2014 | Obstet Gynecol2014，123，1： | 1 |
| 10 | Acute thyroid hormone withdrawal in athyreotic patients results in a state of insulin resistance显示文摘 | Brenta G Celi FS Pisarev M | | 0，，： | 1 |
| 11 | Heavy metal adsorption by functionalized clays 显示文摘 | Celis R Hermosin M C Comejo J | 2000 | Environmental Science & Technology2000，34，21： | 1 |
| 12 | Oscillating sliding wear of mono- and multilayer ceramic coatings in air 显示文摘 | Huq M Z Celis J P Meneve J | 1999 | Surface and Coatings Technology1999，113，： | 1 |
| 13 | Processing,structure and tribological behaviour of TiC-reinforced plasma sprayed coatings 显示文摘 | Economous S De Bonte M Celis J E | 1998 | Wear1998，220，： | 1 |
| 14 | Inorganic and Organic Clays as Carriers for Controlled Release of the Herbicide Hexazinone显示文摘 | CELIS R HERMOSIN M C CARRIZOSA M J | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 15 | Interaction of organic phosphorus With clays extracted from oxisols 显示文摘 | Iexaphosphate with aluminum and Interface Science 2006 Giaveno C Celi L Cessa R M A | 2008 | Soll Science2008，173，10： | 1 |
| 16 | Helicobacter pylori eradication with a capsule containing bismuth subcitrate potassium, metronidazole, and tetracycline given with omeprazole versus clarithromycin-based triple therapy: a randomised, open-label, non-inferiority, phase 3 trial显示文摘 | Peter Malfertheiner Franco Bazzoli Jean-Charles Delchier Krysztof Celi?ski Monique Giguère Marc Rivière Francis Mégraud | 2011 | The Lancet2011，，9769： | 1 |
| 17 | Tribological behaviour at room temperature and at 550 ℃ of TiC-based plasma sprayed coatings in fretting gross slip conditions显示文摘 | Economou S Bonte M De Celis J P | 2000 | Wear2000，244，： | 1 |
| 18 | Inorganic and organic clays as carriers for controlled release of the herbicide hexazinone 显示文摘 | Celis R Hermosin M C Carrizosa M J | 2002 | Agricultural Food Chemical2002，50，8： | 1 |
| 19 | Histomorphometric analysis of subchondral bone of the femoral head in osteoarthritis and osteoporosis显示文摘 | Marinovi(c) M Bazdulj E Celi(c) T | | 0，，： | 1 |
| 20 | Determination of low concentrations of organic phosphorus in soil solution 显示文摘 | Martin M Celi L Barberis E | 1999 | Communications in Soil Science and Plant Analysis1999，30，1314： | 1 |
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