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| 1 | Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer显示文摘Colorectal cancer(CRC) is the third most frequent cancer type and the incidence of this disease is increasing gradually per year in individuals younger than 50 years old. The current knowledge is that early-onset CRC(EOCRC) cases are heterogeneous population that includes both hereditary and sporadic forms of the CRC. Although EOCRC cases have some distinguishing clinical and pathological features than elder age CRC, the molecular mechanism underlying the EOCRC is poorly clarified. Given the significance of CRC in the world of medicine, the present review will focus on the recent knowledge in the molecular basis of genetic and epigenetic mechanism of the hereditary forms of EOCRC, which includes Lynch syndrome, Familial CRC type X, Familial adenomatous polyposis, Mut YH-associated polyposis, Juvenile polyposis syndrome, Peutz-Jeghers Syndrome and sporadic forms of EOCRC. Recent findings about molecular genetics and epigenetic basis of EOCRC gave rise to new alternative therapy protocols. Although exact diagnosis of these cases still remains complicated, the present review paves way for better predictions and contributes to more accurate diagnostic and therapeutic strategies into clinical approach. | gulcin tezcan berrin tunca secil ak gulsah cecener unal egeli | 2016 | World Journal of Gastrointestinal Oncology2016，8，1： | 5 |
| 2 | Inhibition of respiration and distri-bution of Cd,Pb,Hg,Ag and Cr species in a nitrifying sludge显示文摘 | Cecen F Semerci N Geyik A G | 2010 | Journal of Hazardous Materials2010，178，1： | 1 |
| 3 | Effect of coarse aggregate type on mechanical properties of concrete with different strengths显示文摘 | Ozturan T Cecen C | 1997 | Cement and Concrete Research1997，27，2： | 1 |
| 4 | Effect of powdered activated carbon addition on sludge dewaterability and substrate removal in landfill leachate treatment显示文摘 | Ferhan Cecen Aysen Erdincler Emel Kilic | 2003 | Advances in Environmental Research2003，7，： | 1 |
| 5 | Kinetic analysis of the inhibitory effect of tfichloroethylene (TCE) on nitrification in cometabolic degradation 显示文摘 | KOCAMEMI B A CECEN F | 2007 | Biodegradation2007，18，： | 1 |
| 6 | Photocatalytic oxidation and subsequent absorption characteristics of humic acids显示文摘 | BEKBOLET M CECEN F OZKOSEMEN G | 1996 | Water science and Technology1996，34，9： | 1 |
| 7 | Identification of nitrifiers and nitrification performance in drinking water biological activated carbon (BAC) filtration 显示文摘 | YAPSAKLI K MERTOGLU B CECEN F | 2010 | Process Biochemistry2010，45，9： | 1 |
| 8 | Nitrification studies on fertilizer wastewaters in aetivated sludge and biofilm reactors显示文摘 | CECEN F ORAK E GOKCIN P | 1995 | Wat Sci Tech1995，32，12： | 1 |
| 9 | Effects of trend and periodicity on thecorrelation dimension and the Lyapunov exponents显示文摘 | Cecen A Erkal C | 2008 | International Journal of Bifurcation and Chaos2008，18，12： | 1 |
| 10 | Expression status of let-7a and miR-335 among breast tumors in patients with and without germ- line BRCA mutations显示文摘 | Erturk E Cecener G Egeli U | 2014 | Mol Cell Biochem2014，395，12： | 1 |
| 11 | Mutation analysis of the FHIT gene in bronchoscopic specimens from patients with suspected lungcancer 显示文摘 | Cecener G Tunca B Egeli U | 2008 | Tumori2008，94，6： | 1 |
| 12 | Impact of landfill leachate on the reatment of domestic wastewater显示文摘 | Cakioglu D | 2003 | Biotechnology Letters2003，23，： | 1 |
| 13 | Nitrogen removal characteristics of nitrification and denitrification filters显示文摘 | Cecen F Gonenc I E | 1994 | Wat Sci Tech1994，29，1011： | 1 |
| 14 | Monitoring of population shifts in an enriched nitrifying system under gradually increased cadmium loading显示文摘 | Bulent Mertoglu Neslihan Semerci Nuray Guler Baris Calli Ferhan Cecen Ahmet Mete Saatci | 2008 | Journal of Hazardous Materials2008，，2： | 1 |
| 15 | Generalized epileptic seizure in an adolescent idiopathic scoliosis (AIS) patient with syringomyelia after deformity correction surgery显示文摘 | Gultekin S?tk? Cecen Deniz Gulabi Ismail Oltulu Tolga Onay | 2013 | International Journal of Surgery Case Reports2013，，8： | 1 |
| 16 | Anatomical and biomechanical evaluation of the tension band technique in patellar fractures显示文摘 | Baran () Manisali M Cecen B | | 0，，04： | 1 |
| 17 | Effect of coarse aggregate type on mechanical properties of concretes with different strengths显示文摘 | TURAN Ozturn CENGIZHAN Cecen | 1997 | Cem Concr Res1997，27，2： | 1 |
| 18 | Flexible Ureterorenoscopy versus SemirigidUreteroscopy for the Treatment of Proximal Ureteral Stones:A Retrospective Comparative Analysis of 124Patients显示文摘 | Karadag MA Demir A Cecen K | 2014 | Urology journal2014，11，5： | 1 |
| 19 | Common Fragile site expression and genetic predisposition to breast cancer显示文摘 | Cecener G Egeli U Tasdelen I | 1998 | Teratog Carcinog Mutagen1998，18，6： | 1 |
| 20 | Identification of nitrifiers and nitrification performance in drinking water bio logical activated carbon (BAC) filtration 显示文摘 | YAPSAKLI K MERTOGLU B CECEN F | 2010 | Process Bio chemistry2010，45，9： | 1 |
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