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| 1 | Hepatocyte transplantation program:Lessons learned andfuture strategies显示文摘This review aims to share the lessons we learned over time during the setting of the hepatocyte transplantation(HT) program at the Hepatic Cell Therapy Unit at Hospital La Fe in Valencia. New sources of liver tissue for hepatocyte isolation have been explored. The hepatocyte isolation and cryopreservation procedures have been optimized and quality criteria for assessment of functionality of hepatocyte preparations and suitability for HT have been established. The results indicate that:(1) Only highly viable and functional hepatocytes allow to recover those functions lacking in the native liver;(2) Organs with steatosis(≥ 40%) and from elderly donors are declined since low hepatocyte yields, viability and cell survival after cryopreservation, are obtained;(3) Neonatal hepatocytes are cryopreserved without significant loss of viability or function representing high-quality cells to improve human HT;(4) Cryopreservation has the advantage of providing hepatocytes constantly available and of allowing the quality evaluation and suitability for transplantation; and(5) Our results from 5 adults with acute liver failure and 4 from children with inborn metabolic diseases, indicate that HT could be a veryuseful and safe cell therapy, as long as viable and metabolically functional human hepatocytes are used. | Eugenia Pareja Ibars Miriam Cortes Laia Tolosa Maria JoséGómez-Lechón Slivia López JoséVicente Castell JoséMir | 2016 | World Journal of Gastroenterology2016，22，2： | 3 |
| 2 | Fatigue crack growth in pavements显示文摘 | CASTELL M A INGRAFFEA A R IRWIN L H | 2000 | Journal of Transportation Engineering ASCE2000，126，4： | 1 |
| 3 | Detection of colonic cells in peripheral blood of colorectal cancer patients by means of reverse transcription and polymerase chain reaction显示文摘 | Castells A Boix L Bessa X | 1998 | Br J Cancer1998，78，： | 1 |
| 4 | Esophageal chest pain:Current controversies in pathogenesis,diagnosis and therapy显示文摘 | Bradley L Castell D | 1989 | Ann Intern Med1989，110，1： | 1 |
| 5 | Influence of dietary lipid sources on fecundity, egg hatchability and fatty acid composition of Chinese prawn ( Penaeus chinensis ) broodstock 显示文摘 | Xu X L Ji W J Castell J D | 1994 | Aquaculture1994，119，： | 1 |
| 6 | Discrimination of pathogenic clinical isolates and laboratorystrains of Bacillus cereus by NMR-based metabolomicsprofiling 显示文摘 | BUNDY J G WILLEY T L CASTELL R S | 2005 | FEMS Microbiol Lett2005，242，1： | 1 |
| 7 | Influence of dietary lipid sources on fecunditv,egg hatchability and fatty acid composition of Chinese prawn(Penaeus chinensis) broodstock显示文摘 | XU X L JI W J CASTELL J D | 1994 | Aquac1994，，119： | 1 |
| 8 | Materials used as PCM in thermal energy storage in buildings: A review 显示文摘 | Cabeza L F Castell A Barreneche C | 2011 | Renewable Sustainable Energy Rev2011，15，3： | 1 |
| 9 | Colonoscopy versus fecal immuneoch-emical testing in colorectal cancer screening 显示文摘 | Quinlero E Castells A Bujanda L | 2012 | N Engl J Med2012，366，： | 1 |
| 10 | Hepatitis B vaccination in liver transplant candidates显示文摘 | Castells L Esteban R | 2001 | Eur J Gastroenterol Hepatol2001，13，4： | 1 |
| 11 | The role of tryptophan in fatigue in different condition of stress显示文摘 | Castell L M Yamamoto T Phoenix J | 1999 | Adv Exp Med Biol1999，467，： | 1 |
| 12 | Resection for hepatocellular carcinoma is a good option in Child-Turcotte-Pugh Class A patients with cirrhosis who are eligible for liver transplantation 显示文摘 | Margarit C Escartin A Castells L | 2005 | Liver Transpl2005，11，10： | 1 |
| 13 | Pharma- cokintics of thiamphenico] in dogs 显示文摘 | Castell I L Franquelo C Cristofol C | 1998 | Am J Vet Res1998，59，11： | 1 |
| 14 | Canglutamine modify the apparent immunodepression oberserved after prolonged,exhaustive exercise? 显示文摘 | Castell L M | 2002 | Nutrition2002，18，5： | 1 |
| 15 | Culture of human hepatocytes from small surgical liver biopsies. Biochemical characterization and comparison with in vivo显示文摘 | M. José Gómez-Lechón Pilar López Teresa Donato Angel Montoya Amparo Larrauri Patricia Giménez Ramón Trullenque Ricardo Fabra José V. Castell | 1990 | In Vitro Cellular & Developmental Biology1990，，1： | 1 |
| 16 | Detection of colonic cells in peripheral blood of colorectal cancer patients by means of reverse transcriptase and polymerase chain reaction 显示文摘 | Castells A Boix L Bessa X | 1998 | Br J Cancer1998，78，10： | 1 |
| 17 | The potential identification of the geographic origin of lobster eggs from various wild stocks based on fatty acid composition 显示文摘 | CASTELL J D BOSTON L D MILLER R J | 1995 | Canadian Journal of Fisheries and Aquatic Sciences1995，52，6： | 1 |
| 18 | Glutamine supplementation in vivo, in exercise and in immunodepression显示文摘 | Castell L | 2003 | Sports Med2003，33，5： | 1 |
| 19 | The information have-less: inequality, mobility, translocal networks in Chinese cit- ies显示文摘 | Cartier C Castells M Qiu J L | 2005 | Studies in Comparative International Development2005，40，1： | 1 |
| 20 | The relation between glutamine and the immunodepression observed in exercise 显示文摘 | Castell L M | 2001 | Amino Acids2001，20，1： | 1 |
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