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| 1 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 2 | Fatigue crack growth in pavements显示文摘 | CASTELL M A INGRAFFEA A R IRWIN L H | 2000 | Journal of Transportation Engineering ASCE2000，126，4： | 1 |
| 3 | Value of postoperative surveillance after radical surgeryfor colorectal cancer: results of a cohort study显示文摘 | Castells A Bessa X Daniels M | 1998 | Dis Colon Reclum1998，41，6： | 1 |
| 4 | Maximisation of heat transfer in a coil in tank PCM cold storage system显示文摘 | Castell A Belusko M Bruno F | 2011 | Applied Energy2011，88，11： | 1 |
| 5 | Performance,carcass and pork characteristics of castrates and gills self-fed diets differing in protein content and lysine:energy ratio显示文摘 | CASTELL A G CIIPLET R L POSTE-FLYNN L M | 1994 | Can J Anim Sci1994，74，3： | 1 |
| 6 | Perceiving Numbers Causes Spatial Shifts of Attention 显示文摘 | Fischer M H Castel A D Dodd M D etal | 2003 | Nature Neuroscience2003，6，6： | 1 |
| 7 | In s itu gas analysis of Li4Ti5O12 based electroldes at elevated temperatures显示文摘 | He M L Castel E Laumann A | 2015 | J Electrochem Soc2015，6，162： | 1 |
| 8 | Maximisa-tion of heat transfer in a coil in tank PCM cold storage system显示文摘 | Castell A Belusko M Bruno F Cabeza L | 2011 | Applied Energy2011，，88： | 1 |
| 9 | Developmental regulation of GLUT-1 (erythroid/Hep G2) and GLUT-4 (muscle/fat)glucose transporter expression in rat heart,skeletal muscle,and brown adipose tissue显示文摘 | Santalucía T Camps M Castelló A | | 0，，： | 1 |
| 10 | Value of postoperative surveillance after radical surgery for colorectal cancer: results of a cohort study显示文摘 | Castells A Bessa X Daniels M | 1998 | Dis Colon Rectum1998，41，6： | 1 |
| 11 | Experimental study on the performance of insulation materials in mediterranean construction 显示文摘 | Cabeza L F Castell A Medrano M | 2010 | Energy and Building2010，42，5： | 1 |
| 12 | Fatigue Crack Growth in Pavements显示文摘 | Castell M A Ingraffea A R Irwin L H | 2000 | Journal of Transportation Engineering2000，126，4： | 1 |
| 13 | Diagnosis and management of drug hypersensitivity reactions 显示文摘 | Romano A Torres MJ Castells M | 2011 | J Aller- gy Clin Immunol2011，127，3： | 1 |
| 14 | Ex- perimental study of using PCM in brick con- structive solutions for passive cooling 显示文摘 | Castell A Martorell I Medrano M | 2010 | En- ergy and Buildings2010，42，： | 1 |
| 15 | LIN28B promotes coloncancer progression and metastasis显示文摘 | King CE Cuatrecasas M Castells A | 2011 | Cancer Res2011，71，12： | 1 |
| 16 | Fatigue crack growth in pavements 显示文摘 | Castell M Ingraffea A Irwin L | 2000 | Journal of Transportation Engineering American Society of Civil Engineering2000，26，4： | 1 |
| 17 | Inhibition of return with rapid serial shifts of attention:Implications for memory and visual search显示文摘 | DODD M CASTEL A D PRATT J | 2003 | Perception and Psychophysics2003，65，7： | 1 |
| 18 | Determination of toluenesulfonic acid isomers by gas chromatography显示文摘 | Castels R C Arancibia E L | 1988 | Chromatographia1988，25，7： | 1 |
| 19 | Transarterial embolization versus symptomatic treatment in patients with advanced hepatocel- lular carcinoma: results of a randomized, controlled trial in a single institution显示文摘 | Bruix J Llovet J M Castells A | 1998 | Hepatology1998，27，： | 1 |
| 20 | Fatigue crack Growth in pavements显示文摘 | M A Castell A R Ingraffea L H Irwin | 2000 | Journal of Transpor-tation Engineering/July/August2000，，： | 1 |
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