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| 1 | Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation显示文摘AIM:To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy.METHODS:Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy.Laparoscopic surgery was planned after 5-8 wk.Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol.Patients with ypT1-2N0 or ypT3-4 or N+were offered 5-fluorouracil-based adjuvant treatment on an individual basis.An external cohort was used as a reference for the findings.RESULTS:One hundred and seventy six patients were treated with induction chemoradiotherapy and 170underwent total mesorectal excision.Cancer staging of ypT0N0 was achieved in 26/170(15.3%)patients.After a median follow-up of 58.3 mo,patients withypT0N0 had five-year disease-free and overall survival rates of 96%(95%CI:77-99)and 100%,respectively.We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation.The inherent good prognosis of these patients will have implications for clinical trial design and care of patients.CONCLUSION:Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team. | Xabier García-Albéniz Rosa Gallego Ralf Dieter Hofheinz Gloria Fernández-Esparrach Juan Ramón Ayuso-Colella Josep Antoni Bombí Carles Conill Miriam Cuatrecasas Salvadora Delgado Angels Ginés Rosa Miquel Mario Pagés Estela Pineda Verónica Pereira Aarón Sosa Oscar Reig Iván Victoria Luis Feliz Antonio María de Lacy Antoni Castells Iris Burkholder Andreas Hochhaus Joan Maurel | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 2 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 3 | Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition显示文摘 | Martín-Villar E Megías D Castel S | 2006 | J Cell Sci2006，119，21： | 1 |
| 4 | Classification of oesophageal motility abnormalities 显示文摘 | Spechler S J Castell DO | 2001 | Gut2001，49，： | 1 |
| 5 | Develo- ping suitable colour in the gonads of cultured green sea urchins ( Strongylocentrotus droebachiensis) 显示文摘 | Robinson S M C Castell J D Kennedy E J | 2002 | Aq- uaculture2002，206，： | 1 |
| 6 | Discrimination of pathogenic clinical isolates and laboratorystrains of Bacillus cereus by NMR-based metabolomicsprofiling 显示文摘 | BUNDY J G WILLEY T L CASTELL R S | 2005 | FEMS Microbiol Lett2005，242，1： | 1 |
| 7 | Subcellular localization of Arabidopsis 3-hydroxy-3-methylglutaryl- coenzyme A reductase显示文摘 | Leivar P Gonzalez V M Castel S | 2005 | Plant Physiology2005，137，1： | 1 |
| 8 | Plasminogen activator inhibitor-1 and tissue-plasmino- gen activator in minority adolescents with type 2 dia- betes and obesity显示文摘 | UMPAICHITRA V HUSSAIN M M CASTELLS S | 2005 | Pediatr Res2005，58，： | 1 |
| 9 | Effects of regulated deficit irrigation on growth and yield of young Japanese plumtrees 显示文摘 | Intriglio D S Castel J R | 2005 | Journal of Horticultural Scienceand Biotechnology2005，80，2： | 1 |
| 10 | Evaluation of microdiets versus live feeds on growth, survival andfatty acid composition of larval haddock (Melano- grammus aeglefinus ) 显示文摘 | BLAIR T CASTELL J NEIL S | 2003 | Aquaculture2003，225，1234： | 1 |
| 11 | Esophageal motility disorders and chest pai n显示文摘 | Castell DO | 1991 | Med Clin North Amer1991，75，： | 1 |
| 12 | Mercury methylation rates of biofilm and plankton microorganisms from a hydroelectric reservoir in French Guiana 显示文摘 | Huguet L Castelle S Schafer J | 2010 | Science of the Total Environment2010，408，6： | 1 |
| 13 | The long-term results of a randomized clinical trial of laparoscopy-assisted versus open surgery for colon cancer显示文摘 | Lacy AM Delgado S Castells A | 2008 | Ann Surg2008，248，1： | 1 |
| 14 | Influence of vacuum impregnation on respiration rate, mechanical and optical properties of cut persimmon显示文摘 | M. Igual M.L. Castelló M.D. Ortolá A. Andrés | 2007 | Journal of Food Engineering2007，，3： | 1 |
| 15 | The long-term results of a randomized clinical trial of laparoscopy-assisted versus open surgery for colon cancer显示文摘 | Lacy AM Delgado S Castells A | 2008 | Ann Surg2008，248，1： | 1 |
| 16 | Tuberculosis infection control-recommendations of the DZK显示文摘 | Ziegler R Just HM Castell S | 2012 | Gesundheitswesen2012，74，6： | 1 |
| 17 | Hemoperitoneum as a First Manifestation of Hepatocellular Carcinoma in Western Patients with Liver Cirrhosis显示文摘 | Lluís Castells Margarita Moreiras Sergi Quiroga Agustí Alvarez-Castells Antonio Segarra Rafael Esteban Jaime Guardia | 2001 | Digestive Diseases and Sciences2001，，3： | 1 |
| 18 | RNA interference in the nucleus: roles for small RNAs in transcription, epige neties and beyond 显示文摘 | CASTEL S E MARTIENSSEN R A | 2013 | Nature Revievas Genetics2013，14，2： | 1 |
| 19 | Bovine piroplasms in Minorca (Balearic Islands,Spain):a comparison of PCR-based and light microscopy detection显示文摘 | Almeria S Castellà J Ferrer D | 2001 | Veterinary Parasitology2001，99，： | 1 |
| 20 | The long-term resuhs of a randomized clinical trial of laparoscopy-assisted versus open surgery for colon cancer显示文摘 | Lacy AM Delgado S Castells A | 2008 | Ann Surg2008，248，1： | 1 |
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