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| 1 | 高盐饮食通过促进蛋白tau磷酸化损伤大脑认知功能显示文摘来自美国威尔康乃尔医学院的研究人员在一项新的针对小鼠的研究发现,高盐饮食可能会导致化合物一氧化氮的缺乏,从而对认知功能产生负面影响;当一氧化氮水平过低时,大脑中蛋白tau发生磷酸化,从而导致痴呆症。该论文最近在线发表在Nature上。在这项新的研究中,研究人员试图了解食盐摄入与较差认知功能间的关系,发现血管中一氧化氮产生的减少可通过抑制一系列导致蛋白tau病变的酶的活性而影响神经元中tau蛋白的稳定性,而蛋白tau为神经元的支架(细胞骨架)提供结构,一旦蛋白tau脱离细胞骨架则会在大脑中积聚并引起认知问题。因此这些研究人员得出结论:降低食盐摄入量并维持大脑中的健康血管可能“避免”痴呆症。 | FARACO G HOCHRAINER K SEGARRA S G 本刊编辑部 | 2019 | 实用心脑肺血管病杂志2019，27，10： | 8 |
| 2 | Effects of asymmetric dimethylarginine on renal arteries in portal hypertension and cirrhosis显示文摘AIM To evaluate the effects of asymmetric dimethylarginine(ADMA) in renal arteries from portal hypertensive and cirrhotic rats.METHODS Rat renal arteries from Sham(n = 15), pre-hepatic portal hypertension(PPVL; n = 15) and bile duct ligation and excision-induced cirrhosis(BDL; n = 15) were precontracted with norepinephrine, and additional contractions were induced with ADMA(10-6-10-3 mol/L), an endogenous inhibitor of nitric oxide(NO) synthase. Concentration-response curves to acetylcholine(1 × 10-9^(-3) × 10^(-6) mol/L) were determined in precontractedrenal artery segments with norepinephrine in the absence and in the presence of ADMA. Kidneys were collected to determine the protein expression and activity of dimethylarginine dimethylaminohydrolase(DDAH), an enzyme that catabolizes ADMA. RESULTS In renal arteries precontracted with norepinephrine, ADMA caused endothelium-dependent contractions. The pD 2 values to ADMA were similar in the Sham and PPVL groups(4.20 ± 0.08 and 4.11 ± 0.09, P > 0.05, respectively), but were lower than those of the BDL group(4.79 ± 0.16, P < 0.05). Acetylcholine-induced endothelium-dependent relaxation that did not differ, in terms of p D2 and maximal relaxation, among the 3 groups studied. Treatment with ADMA(3 × 10^(-4) mol/L) inhibited acetylcholine-induced relaxation in the 3 groups, but the inhibition was higher(P < 0.05) in the BDL group compared with that for the Sham and PPVL groups. The m RNA and protein expression of DDAH-1 were similar in kidneys from the three groups. Conversely, DDAH-2 expression was increased(P < 0.05) in PPVL and further enhanced(P < 0.05) in the BDL group. However, renal DDAH activity was significantly decreased in the BDL group. CONCLUSION Cirrhosis increased the inhibitory effect of ADMA on basal- and induced-release of NO in renal arteries, and decreased DDAH activity in the kidney. | Gloria Segarra Belén Cortina María Dolores Mauricio Susana Novella Paloma Lluch Javier Navarrete-Navarro Inmaculada Noguera Pascual Medina | 2016 | World Journal of Gastroenterology2016，22，48： | 3 |
| 3 | Asymmetric dimethylarginine as a mediator of vascular dysfunction in cirrhosis显示文摘Cirrhosis is associated with marked abnormalities in the circulatory function that involve a reduction in systemic vascular resistance. An important cause of this vasodilatation is the increased production or activity of nitric oxide(NO) in the splanchnic circulation. During portal hypertension and cirrhosis an increased endothelial NO synthase(e NOS) activity is demonstrated in splanchnic vessels. In contrast, the activity of e NOS in the cirrhotic liver is decreased, which suggests a different regulation of e NOS in the liver and in the splanchnic vessels. Asymmetric dimethylarginine(ADMA) is an endogenous NO inhibitor and higher plasma levels of ADMA are related to increased cardiovascular risk in both the general population and among patients with cirrhosis. It has been demonstrated that the liver is a key player in the metabolism of ADMA. This observation was further supported by investigations in human patients, showing a close correlation between ADMA plasma levels and the degree of hepatic dysfunction. ADMA is degraded to citrulline and dimethylamine by dimethylarginine dimethylaminohydrolases(DDAHs). DDAHs are expressed as type 1 and 2 isoforms and are widely distributed in various organs and tissues, including the liver. In this review, we discuss experimental and clinical data that document the effects of dimethylarginines on vascular function in cirrhosis. Our increasing understanding of the routes of synthesis and metabolism of methylarginines is beginning to provide insights into novel mechanisms of liver disease and allowing us to identify potential therapeutic opportunities. | Paloma Lluch Gloria Segarra Pascual Medina | 2015 | World Journal of Gastroenterology2015，21，32： | 2 |
| 4 | Systematic review of outcomes for endoscopic sinus surgery and subsequent aspirin desensitization in aspirin-exacerbated respiratory disease显示文摘Objective:To review and evaluate outcomes of patients with aspirin-exacerbated respiratory disease(AERD)following endoscopic sinus surgery and subsequent aspirin desensitization.Methods:Electronic searches of OVID MEDLINE(1948 to September 10,2019),EMBASE(1980 to September 10,2019),and PubMed were performed on September 10,2019.A systematic review of the literature was performed using the 2009 PRISMA guidelines.Studies with both preoperative and postoperative data for patients with AERD who underwent sinus surgery and aspirin desensitization were considered appropriate for inclusion.Publications were written in English and included patients aged 18 years or older.Results:Six studies met inclusion criteria for this systematic review.The primary outcome measure was change in symptom profile measured by patient-reported quality of life scores.The results demonstrate statistically significant improvement in symptoms following endoscopic sinus surgery,with sustained improvement following aspirin desensitization.Revision surgery rates were significantly lower in patients maintained on aspirin therapy.Conclusion:This review suggests that surgery followed by aspirin desensitization results in improvement in both subjective and objective outcome measures.The adjunctive use of aspirin desensitization allows for long-term stability in symptom scores.Recurrence of polyps and worsening symptoms requiring revision surgery occurs when aspirin maintenance therapy is inter-rupted. | Lindsey Ryan Daniel Segarra Mark Tabor Arjun Parasher | 2020 | World Journal of Otorhinolaryngology-Head and Neck Surgery2020，6，4： | 2 |
| 5 | Behavioral inhibition and activation dimensions:relationship to MMPI-2 indices of personality disorder显示文摘 | Paster MC Ross SR Segarra P | | 0，，： | 1 |
| 6 | Successful treatment of membranous glomerulonephritis with rituximab in calcineurin inhibitor-dependent patients显示文摘 | SEGARRA A PRAGA M RAMOS N | 2009 | Clin J Am Soc Nephrol2009，4，6： | 1 |
| 7 | Successful treatment of membranous glomerulonephritis with rituximab in calcineurin inhibitor-dependent patients显示文摘 | Segarra A Praga M Ramos N | 2009 | Clin J Am Soc Nephrol2009，4，6： | 1 |
| 8 | The prokinetic cinitapride has no clinically relevant pharmacokinetic interaction and effect on QT during coadministration with ketoconazole显示文摘 | Robert M Salva M Segarra R | 2007 | Drug Metabolism and Disposition:the Biological Fate of Chemicals2007，35，7： | 1 |
| 9 | Baseline of butyltin pollution in coastal sediments within the Basque Country (northern Spain), in 2007-2008显示文摘 | Rodriguez J G~ Solaun O Larreta J Segarra M J B Franco J Alonso J I G Sariego C Valencia V Borja A | 2010 | Marine Pollution Bulletin2010，60，1： | 1 |
| 10 | Physiological effects of the induction of resistance by compost or Tr/choderma aspereum strain I34 against Botryt/ dnerea in tmato显示文摘 | Femmdez E Segarra G Trillas M I | 2014 | Biological Control2014，78，6： | 1 |
| 11 | DLL4 activation of Notch signaling reduces tumor vascularity and inhibits tumor growth 显示文摘 | Segarra M Williams CK Sierra Mde L | 2008 | Blood2008，112，5： | 1 |
| 12 | Increased levels of atherosclerosis markers in salt-sensitive hypertension显示文摘 | Larrousse M Bragulat E Segarra M | 2006 | Am J Hypertens2006，19，1： | 1 |
| 13 | Assessing glomerular filtration rate in hospitalized patients: a comparison between CKD-EPI and four cystatin C-based equations 显示文摘 | Segarra A de la Torre J Ramos N | 2011 | Clin J Am Soc Nephrol2011，6，10： | 1 |
| 14 | Confirmatory factor analysis of VISA-P scale and measurement invariance across sexes in athletes with patellar tendinopathy显示文摘Background:The Victorian Institute of Sport Assessment–Patella(VISA-P) scale is the most condition-specific patient-reported outcome measure used to assess symptom severity in athletes with patellar tendinopathy.Previous exploratory factor analyses have been conducted to evaluate the scale's dimensionality,with inconsistent results,and the factor structure of the scale remains unclear.The aims of the present study were to determine the factorial structure of the VISA-P scale using confirmatory factor analysis(CFA) and test measurement invariance across sexes.Methods:The study included a convenience sample of 249 Spanish athletes with patellar tendinopathy.CFA was performed to assess factorial validity.Hypothesized 1-and 2-factor models were tested.Measurement invariance across sexes was evaluated via multi-group CFA with several fit indices using EQS 6.1 software.Results:The internal consistency coefficient was 0.74.Several CFA models were examined and the 1-factor model in which errors for Items 7 and8 were correlated showed acceptable fit in terms of comparative fit index(CFI) and goodness-of-fit index(GFI) statistics(CFI = 0.93;GFI = 0.94;standardized root mean square residual = 0.06;root mean square error of approximation = 0.10;90% confidence interval:0.08–0.13).This model was invariant across sexes.Conclusion:The 1-factor model of the Spanish version of the VISA-P scale(VISA-P-Sp) in which errors for Items 7 and 8 were correlated demonstrated relative fit in CFA.Scores obtained via VISA-P-Sp can be compared between men and women without sexes bias.Further studies should examine the VISA-P scale and other single-score patient-reported outcome measures concurrently. | Sergio Hernandez-Sanchez Ferran Abat María D.Hidalgo Antonio I.Cuesta-Vargas Victor Segarra Jose M.Sanchez-Ibanez Antonia Gomez-Conesa | 2017 | Journal of Sport and Health Science2017，6，3： | 1 |
| 15 | Use of serial analysis of gene expression (SAGE) technology reveals new granulocyte markers显示文摘 | Bertrand G Coste J Segarra C | 2004 | J Immunol Methods2004，292，12： | 1 |
| 16 | Characterization of the bottom ash in municipal solid waste incinerator显示文摘 | Segarra M Fernández M A etal | 1999 | Journal of Hazardous Materials1999，64，3： | 1 |
| 17 | Impact of electron acceptor availability on the anaerobic oxidation of methane in coastal freshwater and brackish wetland sediments显示文摘 | Segarra Katherine E A Comerford C Slaughter J | 2013 | Geochimica et Cosmochimica Acta2013，115，： | 1 |
| 18 | Selective leac- hing of arsenic and antimony contained in theanode slimes from copper refining 显示文摘 | FERNADEZ M A SEGARRA M ESPIELL F | 1996 | Hydrometallurgy1996，41，2： | 1 |
| 19 | Pharmacokinetics and tissue distribution after intravenous administration of a single dose of amphotericin B cochleates, a new lipid-based delivery system显示文摘 | Segarra I Movshin D A Zarif L | 2002 | J Pharm Sci2002，91，： | 1 |
| 20 | Irrigation technology adop- tion and its implication for water conservation in the Texas High Plains: a real options approach 显示文摘 | Seo S Segarra E Mitchell PD | 2008 | Agricultural Economics2008，38，1： | 1 |
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