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| 1 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 2 | Antibacterial activity of marine-derived fungi显示文摘 | Carsten C Oscar C Jens C F | 1999 | Mycopathologia1999，143，： | 1 |
| 3 | FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex显示文摘 | Marta Muzio Arul M Chinnaiyan Frank C Kischkel Karen O’Rourke Andrej Shevchenko Jian Ni Carsten Scaffidi James D Bretz Mei Zhang Reiner Gentz Matthias Mann Peter H Krammer Marcus E Peter Vishva M Dixit | 1996 | Cell1996，，： | 1 |
| 4 | Unstable diaphyseal fractures of both bones of the forearm in children:plate fixation versus intramedullary nailing显示文摘 | Fernandez FF Egenolf M Carsten C | | 0，，10： | 1 |
| 5 | Anaerobic ammonium oxidation in a tropical freshwater system ( Lake Tanganyika) 显示文摘 | Carsten J Schubert C J Durisch-Kaiser E | 2006 | Environmental Microbiology2006，8，10： | 1 |
| 6 | Multiobjective Output-Feedback Control Via LMI Optimization显示文摘 | Carsten S Pascal G Mahmoud C | 1997 | IEEE Trans on Automatic Control1997，42，7： | 1 |
| 7 | Listening to Mozart may not enhance performance on the revised Minnesota paper form board test 显示文摘 | CARSTENS C B HUSKINS E HOUNSHELL G W | 1995 | Psy- chol Rep1995，77，1： | 1 |
| 8 | The relevance of the sagittal pro- file in cervical artificial discs显示文摘 | Carstens C Carstens M Copf F | 2011 | Orthopade2011，40，8： | 1 |
| 9 | Enzymatic hydrolysis of Ovomucin and effect on foaming properties显示文摘 | HAMMERSHOJ M NEBELA C CARSTENS J | 2008 | Food Research International2008，41，5： | 1 |
| 10 | Codon bias-adjusted BL21 derivatives for protein expression显示文摘 | Carstens C P Waeshe A | 1999 | Strategies1999，12，： | 1 |
| 11 | Factors affecting the catalytic activity of Pd/ZrO2 for the combustion of methane显示文摘 | Carstens J N Su S C Bell A T | 1998 | Jour-hal of Catalysis1998，176，1： | 1 |
| 12 | Role of cyclic nucleotide signaling in oocyte maturation显示文摘 | Mahrco C Carsten B Andersen | 2002 | Mol Endocfinol2002，187，： | 1 |
| 13 | Rapid quantifi- cation of bile acids and their conjugates in serum by liquid chro- matography - tandem mass spectrometry 显示文摘 | Scherer M Carsten Gnewuch C Schmitz G | 2009 | Journal of Chroma- tography B2009，877，30： | 1 |
| 14 | Targeting the HIF pathway in inflammation and immunity显示文摘 | Carsten C Scholz Cormac T Taylor | 2013 | Current Opinion in Pharmacology2013，，： | 1 |
| 15 | Om geokjemisk undersokelser av maimer 显示文摘 | Carstens C W | 1941 | Norsk Geol Tids1941，21，： | 1 |
| 16 | Tissue culture propagation of broccoli,Brassica oleracea (Italica group),for use in F1 hybrid seed production显示文摘 | ANDERSON W C CARSTENS J B | 1997 | J Amer Soc Hort Sci1997，102，： | 1 |
| 17 | Tissue culture propagation of broccoli, Brassica olercea( Italica group), for use in Fl hybrid seed production 显示文摘 | Anderson W C Carstens J B | 1977 | J Amer Soc Hort Sci1977，102，： | 1 |
| 18 | X chromosome inactivation and Xist evolution in a rodent lacking LINE-1 activity显示文摘 | Cantrel! M A Carstens B C Wichman H A | 2009 | PLoS One2009，4，： | 1 |
| 19 | Chromium( Ⅵ ) reductase activity is associated with the cytoplasmic membrane of anaerobically grown Shewanella putrefaciens MR- 1 显示文摘 | Myers C R Carstens B P Antholine W E | 2000 | Journal of Applied Microbiology2000，88，1： | 1 |
| 20 | Unstable diaphyseal fractures of both bones of the forearm in children : platefixation ver- sus intramedullary nailing 显示文摘 | Fernandez FF Egenolf M Carsten C | 2005 | Injury2005，36，10： | 1 |
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