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| 1 | Efficacy and safety profile of LCR35 complete freeze-dried culture in irritable bowel syndrome:A randomized,double-blind study显示文摘AIM:To assess the effects and safety of Lactobacillus casei rhamnosus LCR35 complete freeze-dried culture(LCR35) in patients suffering from irritable bowel syndrome(IBS).METHODS:A randomized,double-blind pilot study was performed in 50 patients complaining of IBS symptoms complying with RomeⅢcriteria.Patients were allocated to receive either LCR35(n = 25) at a minimum daily dose of 6 × 108 colony forming units or placebo(n = 25) for 4 wk.At inclusion,after treatment and 2 wk later,patients completed the IBS severity scale.Change from baseline in the IBS severity score at the end of treatment was the primary efficacy criterion.Changes were compared between groups in the whole population and in IBS subtypes(IBS with predominance of constipation,IBS with predominance of diarrhoea,mixed IBS,unsubtyped IBS).The presence of lactobacillus casei rhamnosus in stools was investigated at inclusion and at the end of treatment.The gastrointestinal quality of life questionnaire and the hospital anxiety and depression(HAD) scale were also completed.RESULTS:Both groups were balanced for baseline characteristics.In 85% of patients,stool analyses showed that lactobacillus casei rhamnosus able to survive in the digestive tract.In the whole population,improvements in the IBS severity score did not differ significantly between treatments with a 25% decrease after 4-wk treatment,and a 15% decrease from baseline 2 wk later in both groups.In IBS subgroups,statistical analysis could not be performed due to small sample size,but a clinical response in favour of LCR35 was observed in IBS patients with predominance of diarrhoea:no change in the symptom severity score was seen with the placebo after 4 wk treatment,whereas a clinically relevant decrease occurred with LCR35(-37% vs-3%).Furthermore,in spite of an increase in symptom intensity,the IBS severity score was maintained below the baseline value 2 wk later with LCR35(-19% from baseline),whilst a slight 5% increase from baseline was observed with placebo.In the IBS subgroup with predominance of diarrhoea only,a clinically relevant decrease in abdominal pain severity score(-36%)was observed with LCR35,whereas no change occurred with placebo.In mixed IBS patients,the 20% and 30% decreases in the IBS severity score observed after treatment with LCR35 and placebo,respectively,were maintained 2 wk later in both groups.A clinical response slightly in favour of placebo was observed at the end of the treatment period in IBS patients with predominance of constipation(-41% vs-20%) and unsubtyped IBS patients(-47% vs-17%),with the same value maintained 2 wk later.In both groups,no clinically relevant changes were observed either for the gastrointestinal quality of life index or HAD score.Thus,these results suggest that sub-grouping of IBS patients may be important for optimizing treatment responses by the physician.CONCLUSION:This pilot study suggests that LCR35 could have some efficacy in IBS patients complaining of diarrhoea.These preliminary results need to be conf irmed in larger studies. | Michel Dapoigny Thierry Piche Philippe Ducrotte Bernard Lunaud Jean-Michel Cardot Annick Bernalier-Donadille | 2012 | World Journal of Gastroenterology2012，18，17： | 10 |
| 2 | Monitoring of an experimental red blood cell pathology with gravitational field-flow fractionation显示文摘 | A Merino-Dugay Ph J P Cardot M Czok | 1992 | Chromatogr1992，579，： | 1 |
| 3 | Functional linear model显示文摘 | Cardot H Ferraty F Sarda P | 1999 | Statist Probab Lett1999，45，： | 1 |
| 4 | Multivariate denoising methods combining wavelets and principal component analysis for mass spectrometry data显示文摘 | Mostacci E Truntzer C Cardot H | 2010 | Proteomics2010，10，14： | 1 |
| 5 | The influence of food on the disposition of the antiepileptic oxcarbazepine and its major metabolites in healthy volunteers显示文摘 | Degen PH Flesch G Cardot JM | 1994 | Biopharm Drug Dispos1994，15，： | 1 |
| 6 | A level A in vitro/in vivo correlation in fasted and fed states using different methods: Applied to solid immediate release oral dosage form显示文摘 | Sabah Souliman Stéphanie Blanquet Eric Beyssac Jean-Michel Cardot | 2005 | European Journal of Pharmaceutical Sciences2005，，1： | 1 |
| 7 | Testing hypotheses in the functional data via penalized likelihood显示文摘 | Cardot H Ferraty F Mas A Sarda P | 2003 | Journal of Multivariate Analysis2003，92，： | 1 |
| 8 | Neurogenic tumors of the thorax显示文摘 | Ribet M E Cardot G R | 1994 | Ann Thorac Surg1994，58，： | 1 |
| 9 | Influence of thermal drive on central sleep apnea in the preterm neonate显示文摘 | Toumeux P Cardot V Museux N | 2008 | Sleep2008，31，4： | 1 |
| 10 | Requirement of Cellular Prion Protein for Intestinal Barrier Function and Mislocalization in Patients With Inflammatory Bowel Disease显示文摘 | Constance S.V. Petit Frédérick Barreau Laura Besnier Pierre Gandille Béatrice Riveau Danielle Chateau Maryline Roy Dominique Berrebi Magali Svrcek Philippe Cardot Monique Rousset Caroline Clair Sophie Thenet | 2012 | Gastroenterology2012，，： | 1 |
| 11 | Paraganglioma after maternal transmission of a succinate dehydrogenase gene mutation显示文摘 | Pigny P Vincent A Cardot Bauters G | 2008 | J Clin Endocrinol Metab2008，93，5： | 1 |
| 12 | Possible association of erythema muldforme with acamprosate显示文摘 | Fortier-Beaulieu M Noblet C Cardot F | 1992 | Lancet1992，339，8799： | 1 |
| 13 | The influence of food on the disposition of the antiepileptic rufinamide in healthy volunteers 显示文摘 | CARDOT J M LECAILLON J B CZENDLIK C | 1998 | Biopharm Drug Dispos1998，19，4： | 1 |
| 14 | Use of rotary fluidized-bed technology for development of sustained-release plant extractspellets: potential application for feed additive deli very 显示文摘 | Meunier JP Cardot JM Gauthier P | 2006 | J Anim Sci2006，84，7： | 1 |
| 15 | Specific activation of platelets from patients allergic to Dermatophagoides pteronyssinus by synthetic peptides derived from the allergen Der pI显示文摘 | Cardot E Pestel J Callebaut I | 1992 | Int Arch Allergy Immunol1992，98，2： | 1 |
| 16 | 一种新的中空纤维液流场流分离装置及其对葡聚糖保留行为的研究显示文摘中空纤维液流场流分离法对高分子和小粒子分离效果好,但目前因所使用的中空纤维均为各实验室自制且分子量阻断值不够小,使该技术的推广应用受到限制.设计了一种新的中空纤维液流场流分离装置,该装置的优越性在于其中空纤维分子量阻断值小,可以用于分离较小分子量的分子;并且中空纤维为商业购买,使得该技术的推广成为可能;该装置易于安装,操作简便.应用它获得了高分子物质葡聚糖的保留,并探讨了液流交汇时间、外场强度、流速和进样量对葡聚糖保留行为的影响.研究结果表明,给予足够的液流交汇时间,足够强的外场,葡聚糖能得到很好的保留.超量进样时,被测葡聚糖的保留时间不变,峰的对称性良好,结果重现性好. | 秦泉 BATTU Serge CARDOT Philippe | 2010 | 四川师范大学学报(自然科学版)2010，33，5： | 1 |
| 17 | Cooperation of color px- el classification schemes and color watershed 显示文摘 | LEZORAY O CARDOT H | 2002 | IEEE Transactions on Image Processing2002，11，7： | 1 |
| 18 | Cooperation of color pixel classification schemes and color watershed:A study for microscopic images显示文摘 | Lezoray O Cardot H | 2002 | IEEE Transactions on Image Processing2002，11，7： | 1 |
| 19 | Simulation ofturbulence with the k-εmodel显示文摘 | Cardot B Coron F Mohammadi B | 1991 | Computer Methodsin Applied Mechanics and Engineering1991，87，23： | 1 |
| 20 | Three-stage continuous culture system with a self-generated anaerobia to study the regionalized metabolism of the human gut microbiota显示文摘 | David Feria-Gervasio William Tottey Nadia Gaci Monique Alric Jean-Michel Cardot Pierre Peyret Jean-Fran?ois Martin Estelle Pujos Jean-Louis Sébédio Jean-Fran?ois Brugère | 2014 | Journal of Microbiological Methods2014，，： | 1 |
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