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| 1 | Evidence for the involvement of NOD2 in regulating colonic epithelial cell growth and survival显示文摘AIM: To investigate the function of NOD2 in colonic epithelial cells (CEC). METHODS: A combination of in vivo and in vitro analyses of epithelial cell turnover in the presence and absence of a functional NOD2 protein and, in response to enteric Salmonella typhimurium infection, were used. shRNA interference was also used to investigate the consequences of knocking down NOD2 gene expression on the growth and survival of colorectal carcinoma cell lines. RESULTS:In the colonic mucosa the highest levels of NOD2 expression were in proliferating crypt epithelial cells. Muramyl dipeptide (MDP), that is recognized by NOD2, promoted CEC growth in vitro . By contrast,the growth of NOD2-deficient CECs was impaired. In vivo CEC proliferation was also reduced and apoptosis increased in Nod2-/- mice, which were also evident following enteric Salmonella infection. Furthermore, neutralization of NOD2 mRNA expression in human colonic carcinoma cells by shRNA interference resulted in decreased survival due to increased levels of apoptosis. CONCLUSION: These findings are consistent with the involvement of NOD2 protein in promoting CEC growth and survival. Defects in proliferation by CECs in cases of CD may contribute to the underlying pathology of disrupted intestinal homeostasis and excessive inflammation. | Sheena M Cruickshank Louise Wakenshaw John Cardone Peter D Howdle Peter J Murray Simon R Carding | 2008 | World Journal of Gastroenterology2008，14，38： | 3 |
| 2 | Perioperative blood conservation显示文摘 | Cardone D Klein A A | 2009 | Eur J Anaesthesiol2009，26，9： | 1 |
| 3 | Shaking table tests on reinforced concrete frames with different isolation systems显示文摘 | Dolce M Cardone D Ponzo F | 2007 | Earthquake Engineering and Structural Dynamics2007，36，5： | 1 |
| 4 | Mechanical behavior of shape memory alloys for seismic applications 2: austenite NiTi wires subjected to tension显示文摘 | Dolce M Cardone D | 2001 | International Journal of Mechanical Sciences2001，43，11： | 1 |
| 5 | Validation of real-time three-dimensional echocardiography for quantifying left ventricular volumes in the presence of a left ventricular aneurysm: in vitro and in vivo studies显示文摘 | Jian Xin Qin Michael Jones Takahiro Shiota Neil L Greenberg Hiroyuki Tsujino Michael S Firstenberg Pankaj C Gupta Arthur D Zetts Yong Xu Jing Ping Sun Lisa A Cardon Jill A Odabashian Scott D Flamm Richard D White Julio A Panza James D Thomas | 2000 | Journal of the American College of Cardiology2000，，3： | 1 |
| 6 | Gene frequenciesof the HPA-15(Gov)platelet alloantigen system in Brazilians显示文摘 | Cardone J D Chiba A K Boturo-Neto E | 2004 | Transfus Med2004，14，6： | 1 |
| 7 | Propofol infusion syndrome显示文摘 | Kam PC Cardone D | 2007 | Anaes- thesia2007，62，7： | 1 |
| 8 | Topical capsaiein for treatment of hemodialysis -related pruritus显示文摘 | BRENEMAN D L CARDONE J S BLUMSACKLTLR F | 1992 | Am Acad Dermatol1992，26，： | 1 |
| 9 | Perioperative blood conservation 显示文摘 | Cardone D Klein AA | 2009 | European Journal of Anaesthesiology2009，26，9： | 1 |
| 10 | Perioperative blood conservation显示文摘 | Cardone D Klein AA | 2009 | Eur J Anaesthesiol2009，26，9： | 1 |
| 11 | Implementation and Testing of Passive Control Devices Based on Shape Memory Alloys 显示文摘 | Dolce M Cardone D Marnetto R | 2000 | Earthquake Engineering and Structural Dynamics2000，29，： | 1 |
| 12 | Implementation and tes- ting of passive control devices based on shape memory al- loys 显示文摘 | Dolce M Cardone D Marnetto R | 2000 | Earthquake Engineering and Structural Dyna- mics2000，29，： | 1 |
| 13 | Implementation and testing of passive control devices based on shape memory alloys 显示文摘 | Dolce M Cardone D Mametto R | 2000 | Earthquake engineering and structuraldynamics2000，29，： | 1 |
| 14 | Misfortunes or Mistakes? Cultural Sensemaking of Entrepreneurial Failure 显示文摘 | CARDON M S STEVENS C E POTTER D R | 2011 | Journal of Business Venturing2011，26，1： | 1 |
| 15 | Clustering of hypertension, diabetes, and obesity in adult male twins: same genes or same environments 显示文摘 | Carmelli D Cardon LR Fabsitz R | 1994 | Am J Hum Genet1994，55，3： | 1 |
| 16 | Implementation and testing of passive control devices based on shape memory alloys显示文摘 | Cardone D Marnetto R | 2000 | Earthquake Engineering and Structural Dynamics2000，29，： | 1 |
| 17 | Topical capsaicin for treatment of hemodialysis-related pruritus 显示文摘 | Breneman D L Cardone J S Blumsack R F | 1992 | J Am Acad Dermatol1992，26，1： | 1 |
| 18 | Mechanical Behavior of Shape Memory Alloys for Seismic Applications-2, Austenite TiNi wires subjected to tension 显示文摘 | Dolce M Cardone D | 2001 | Inter J Mech Sci2001，43，： | 1 |
| 19 | Propofol infusion syndrome显示文摘 | Kam PC Cardone D | 2007 | Anaesthesia2007，62，7： | 1 |
| 20 | Misfortunes or mistakes? Cultural sensemaking of entrepreneurial failure显示文摘 | Cardon M S Stevens C E Potter D R | | 0，，01： | 1 |
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