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| 1 | Antibacterial,pro-angiogenic and pro-osteointegrative zein-bioactive glass/copper based coatings for implantable stainless steel aimed at bone healing显示文摘Stainless steel implants are suitable candidates for bone replacement due to their cytocompatibility and mechanical resistance,but they suffer from lack of bioactivity and are prone to bacterial infections.Accordingly,to overcome those limitations,in this study we developed by electrophoretic deposition(EPD),an innovative surface coating made of(i)zein,a natural fibroblast-friendly polymer,(ii)bioactive glass,a pro-osteogenic inorganic material and(iii)copper containing bioactive glass,an antibacterial and pro-angiogenic material.FESEM images confirmed that porous,uniform and free of cracks coatings were obtained by EPD;moreover,coatings were resistant to mechanical stress as demonstrated by the tape test,resulting in a 4B classification of adhesion to the substrate.The coatings were cytocompatible as indicated by metabolism evaluation of human fibroblasts,endothelial cells and mature or progenitor osteoblasts cultivated in direct contact with the specimens.They also maintained pro-osteogenic properties towards undifferentiated progenitor cells that expressed osteogenic genes after 15 days of direct cultivation.Copper conferred antibacterial properties as biofilm formation of the joint pathogens Staphylococcus aureus,Staphylococcus epidermidis and Escherichia coli was significantly reduced in comparison with copper-free coatings(p<0.05).Moreover,this anti-infective activity resulted as targeted towards bacteria while the cells viability was preserved when cells and bacteria were cultivated in the same environment by a co-culture assay.Finally,copper ability to recruit blood vessels and to inhibit bacterial infection was confirmed in vivo where the growth of S.aureus biofilm was inhibited and the formation of new(<50μm diameter spread)blood vessels was observed. | Laura Ramos Rivera Andrea Cochis Sarah Biser Elena Canciani Sara Ferraris Lia Rimondini Aldo R.Boccaccini | 2021 | Bioactive Materials2021，6，5： | 2 |
| 2 | Community-acquired pneumonia in chil-dren:what's old?What's new?显示文摘 | Don M Canciani M Korppi M | 2010 | Acta Paediatr2010，99，11： | 1 |
| 3 | Plasma levels of yon Willebrand factor regulate ADAMTS- 13, its major cleaving protease 显示文摘 | Mannucci PM Capoferric Canciani MT | 2004 | Br J Haematol2004，126，： | 1 |
| 4 | Community-acquired pneumonia in children: what's old? What's new? 显示文摘 | Don M Canciani M Korppi M | 2010 | Acta Pediatrica2010，99，： | 1 |
| 5 | Changes in health and disease of the metalloprotease that cleaves von Willebrand factor 显示文摘 | Mannucci PM Canciani MT Forza I | 2001 | Blood2001，98，8： | 1 |
| 6 | Serologic response to Bartonella henselae in patoent with cat scratch disease and in sick and healthy children 显示文摘 | NotT Canciani M Buratti E | 1999 | Acta Paediatr1999，88，3： | 1 |
| 7 | Community-acquired pneumonia in children:what's old? Whatrs new? 显示文摘 | Don M Canciani M Korppi M | 2010 | Acta Paediatr2010，99，11： | 1 |
| 8 | Changes in health and disease of the metalloprotease that cleaves von Willebrand factor显示文摘 | Mannucci PM Canciani MT Forza I | 2001 | {H}Blood2001，，9： | 1 |
| 9 | Changes in health and disease of the metalloprotease that cleaves von Willebrand factor 显示文摘 | Mannucci PM Canciani MT Forza I | 2001 | Blood2001，98，： | 1 |
| 10 | Plasma levels of von Willebrand factor regulate ADAMTS-13,its major cleaving protease显示文摘 | MANNUCCI PM CAPOFERRIC CANCIANI MT | 2004 | Br J Haematol2004，126，2： | 1 |
| 11 | Effects of long time exposure to simulated micro- and hypcrgravity on skeletal architecture显示文摘 | Canciani B Ruggiu A G-iuliani A ct al | 2015 | J Mech Behav Biomed Mater2015，51，： | 1 |
| 12 | Community-acquired pneumonia in children: what's old? what's new? 显示文摘 | Don M Canciani M Corppi M | 2010 | Acta Paediatr2010，99，11： | 1 |
| 13 | Molecullar defects in types von Willebrand disease: updated results from 40 mutienthnic patient 显示文摘 | Cozzi G Canciani | 2003 | Blood Cells Mol Dis2003，30，1： | 1 |
| 14 | Community-acquired pneu- monia in children:what's old? what's new?显示文摘 | Don M Canciani M Korppi M | 2010 | Acta Paedi- atr2010，99，11： | 1 |
| 15 | Moleeular defects in type 3 yon Willebrand disease: updated results from 40 multiethnic patients显示文摘 | Baronciani L Cczzi G Canciani M T | 2003 | Blood Cells Mol Dis2003，30，2： | 1 |
| 16 | Juvenile sudden death and effort induced ventricular tachycardias in a family with right ventricular cardiomyopathy显示文摘 | Nava A Canciani B Daliento L | 1988 | Int J Card iol1988，21，： | 1 |
| 17 | Community-acquired pneumonia inchildren:What's old- What's new-显示文摘 | DON M CANCIANI M KORPPI M | 2010 | Acta Paediatr2010，99，11： | 1 |
| 18 | Community acquired pneumonia in children: what's old? what's new?显示文摘 | Don M Canciani M Korppi M | 2010 | Acta Pediatr2010，99，11： | 1 |
| 19 | Community-acquired pneumonia in children:What' s old? What' s new? 显示文摘 | Don M Canciani M Korppi M | 2010 | Acta Paediatr2010，99，： | 1 |
| 20 | Community-acquired pneumonia in children: what' s old? What' s new 显示文摘 | Don M Canciani M Korppi M | 2010 | Acta paediatrica (Oslo Norway : 1992)2010，99，11： | 1 |
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