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| 1 | Application of a biochemical and clinical model to predict individual survival in patients with end-stage liver disease显示文摘AIM:To investigate the capability of a biochemical and clinical model,BioCliM,in predicting the survival of cirrhotic patients.METHODS:We prospectively evaluated the survival of 172 cirrhotic patients.The model was constructed using clinical(ascites,encephalopathy and variceal bleeding) and biochemical(serum creatinine and serum total bilirubin) variables that were selected from a Cox proportional hazards model.It was applied to estimate 12-,52-and 104-wk survival.The model's calibration using the Hosmer-Lemeshow statistic was computed at 104 wk in a validation dataset.Finally,the model's validity was tested among an independent set of 85 patients who were stratified into 2 risk groups(low risk≤8 and high risk>8).RESULTS:In the validation cohort,all measures of fi t,discrimination and calibration were improved when the biochemical and clinical model was used.The proposed model had better predictive values(c-statistic:0.90,0.91,0.91) than the Model for End-stage Liver Disease(MELD) and Child-Pugh(CP) scores for 12-,52-and 104-wk mortality,respectively.In addition,the Hosmer-Lemeshow(H-L) statistic revealed that the biochemical and clinical model(H-L,4.69) is better calibrated than MELD(H-L,17.06) and CP(H-L,14.23).There were no significant differences between the observed and expected survival curves in the stratified risk groups(low risk,P=0.61;high risk,P=0.77).CONCLUSION:Our data suggest that the proposed model is able to accurately predict survival in cirrhotic patients. | Eduardo Vilar Gomez Luis Calzadilla Bertot Bienvenido Gra Oramas Enrique Arus Soler Raimundo Llanio Navarro Javier Diaz Elias Oscar Villa Jiménez Maria del Rosario Abreu Vazquez | 2009 | World Journal of Gastroenterology2009，15，22： | 6 |
| 2 | Antioxidant and immunomodulatory effects of Viusid in patients with chronic hepatitis C显示文摘AIM:To investigate the efficacy of Viusid,a nutritional supplement,as an antioxidant and an immunomodulator in patients with chronic hepatitis C.METHODS:Sixty patients with chronic hepatitis C who were non-responders to standard antiviral treatment were randomly assigned to receive Viusid(3 sachets daily,n=30) or placebo(n=30) for 24 wk.The primary outcome was the change in serum malondialdehyde and 4-hydroxyalkenals(lipid peroxidation products).Secondary outcomes were changes in serum tumor necrosis factor-α(TNF-α),interferon-γ(IFN-γ) and interleukin-10(IL-10).RESULTS:Statistically significant reductions in serum 4-hydroxyalkenals and malondialdehyde levels were observed in both groups in comparison with pretreatment values,but the patients who received Viusid showed a more marked reduction as compared with the control group(P=0.001).TNF-α levels significantly increased from 6.9 to 16.2 pg/mL(P< 0.01) in the patients who received placebo in comparison with almost unchanged levels,from 6.6 to 7.1 pg/mL(P=0.26),in the patients treated with Viusid(P=0.001).In addition,IL-10 levels were markedly increased in the patients treated with Viusid(from 2.6 to 8.3 pg/mL,P=0.04) in contrast to the patients assigned to placebo(from 2.8 to 4.1 pg/mL,P=0.09)(P=0.01).Likewise,the administration of Viusid markedly increased mean IFN-γ levels from 1.92 to 2.89 pg/mL(P< 0.001) in comparison with a reduction in mean levels from 1.80 to 1.68 pg/mL(P=0.70) in the placebo group(P< 0.0001).Viusid administration was well tolerated.CONCLUSION:Our results indicate that treatment with Viusid leads to a notable improvement of oxidative stress and immunological parameters in patients with chronic hepatitis C. | Eduardo Vilar Gomez Yadina Martinez Perez Hector Vega Sanchez Gretel Riveron Forment Enrique Arus Soler Luis Calzadilla Bertot Ali Yasells Garcia Maria del Rosario Abreu Vazquez Licet Gonzalez Fabian | 2010 | World Journal of Gastroenterology2010，16，21： | 2 |
| 3 | Climate change and agriculture: Impacts and adaptation options in South Africa显示文摘 | Alvaro Calzadilla Tingju Zhu Katrin Rehdanz Richard S.J. Tol Claudia Ringler | 2014 | Water Resources and Economics2014，，： | 1 |
| 4 | Transcriptional regulation of 9- cis -epoxycarotenoid dioxygenase (NCED) gene by putrescine accumulation positively modulates ABA synthesis and drought tolerance in Lotus tenuis plants显示文摘 | Fabiana D. Espasandin Santiago J. Maiale Pablo Calzadilla Oscar A. Ruiz Pedro A. Sansberro | 2014 | Plant Physiology and Biochemistry2014，，： | 1 |
| 5 | The natural history of compensated HCV-related cirrhosis: A prospective long-term study显示文摘 | Eduardo Vilar Gomez Yoan Sanchez Rodriguez Luis Calzadilla Bertot Ana Torres Gonzalez Yadina Martinez Perez Enrique Arus Soler Ali Yasells Garcia Luis Perez Blanco | 2012 | Journal of Hepatology2012，，： | 1 |
| 6 | Evidence and analysis of parallel growth mechanisms in Cu2O films prepared by Cu anodization 显示文摘 | Briones F C Padros A P Calzadilla O | 2010 | Electrochimica Acta2010，55，： | 1 |
| 7 | Cardiovascular risk assessment using high - sensitivity C -reactive protein in patients with erectile dysfunction显示文摘 | Ferrandis - Cortes C Martinez - Jabaloyas JM Diez - Calzadilla NA | 2013 | Urol Int2013，91，2： | 1 |
| 8 | The natural history of compensated HCV-related cirrhosis: A prospective long-term study显示文摘 | Eduardo Vilar Gomez Yoan Sanchez Rodriguez Luis Calzadilla Bertot Ana Torres Gonzalez Yadina Martinez Perez Enrique Arus Soler Ali Yasells Garcia Luis Perez Blanco | 2012 | Journal of Hepatology2012，，： | 1 |
| 9 | Evidence and analysis of parallel growth mechanisms in Cu2 O films prepared by Cu anodization显示文摘 | BRIONES F C PADROS A P CALZADILLA O | 2010 | Electrochimica Acta2010，55，14： | 1 |
| 10 | The natural history of compensated HCV-related cirrhosis: A prospective long-term study显示文摘 | Eduardo Vilar Gomez Yoan Sanchez Rodriguez Luis Calzadilla Bertot Ana Torres Gonzalez Yadina Martinez Perez Enrique Arus Soler Ali Yasells Garcia Luis Perez Blanco | | Journal of Hepatology0，，： | 1 |
| 11 | Water scarcity and the impact of improved irrigation management: a computable general equilibrium analysis 显示文摘 | CALZADILLA A REHDANZ K TOL R S | 2011 | Agricultural Economics2011，42，3： | 1 |
| 12 | Effect of surface structure on photo sensitivity in chemically deposited PbS thin films显示文摘 | Larramendi E M Calzadilla O Gonzalez-Arias A | 2001 | Thin Solid Films2001，389，1： | 1 |
| 13 | Cardiovascular effects and hemodynamic mechanism of action of the novel,nonpeptidic renin inhibitor A-74273 in dogs显示文摘 | WESSALE J L CALZADILLA S V BOYD S A | 1993 | J Cardiovasc Pharmacol1993，22，4： | 1 |
| 14 | Transcriptional regulation of 9 -cis-epoxycarotenoid dioxygenase (NCED) gene by putreseine accumulation positively modulates ABA synthesis and drought tolerance in Lotus tenuis plants 显示文摘 | Espasandin F D Maiale S J Calzadilla P Ruiz O A Sansherro P A | 2014 | Plant Physiology and Biochemistry2014，70，1： | 1 |
| 15 | 出色的混合显示文摘我们试图挪用并延伸那些我们在街上找到的东西,如闲置的空间、草场和那些无法运输的东西,我们会邀请观众参与到这些事物中。美术馆是世界的日常经验。——Allora and | 王青云 Allora Calzadilla | 2011 | 建筑知识2011，31，4： | 0 |
| 16 | Pricing and Valuation of Intangible Assets显示文摘 | Jesus Timoteo Alvarez Sonia A. Ferruz Gonzailez Jesus Calzadilla Daguerre | 2012 | Journal of Modern Accounting and Auditing2012，8，12： | 0 |
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