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| 1 | Tumor infiltrating lymphocytes in triple negative breast cancer receiving neoadjuvant chemotherapy显示文摘AIM To determine influence of neoadjuvant-chemotherapy(NAC) over tumor-infiltrating-lymphocytes(TIL) intriple-negative-breast-cancer(TNBC).METHODS TILs were evaluated in 98 TNBC cases who came to Instituto Nacional de Enfermedades Neoplasicas from 2005 to 2010. Immunohistochemistry staining for CD3, CD4, CD8 and FOXP3 was performed in tissue microarrays(TMA) sections. Evaluation of H/E in full-face and immunohistochemistry in TMA sections was performed in pre and post-NAC samples. STATA software was used and P value < 0.05 was considered statistically significant. RESULTS Higher TIL evaluated in full-face sections from pre-NAC tumors was associated to pathologic-complete-response(pCR)(P = 0.0251) and outcome(P = 0.0334). TIL evaluated in TMA sections showed low level of agreement with full-face sections(ICC = 0.017-0.20) and was not associated to pCR or outcome. TIL in post-NAC samples were not associated to response or outcome. PostNAC lesions with pC R had similar TIL levels than those without pCR(P = 0.6331). NAC produced a TIL decrease in full-face sections(P < 0.0001). Percentage of TIL subpopulations was correlated with their absolute counts. Higher counts of CD3, CD4, CD8 and FOXP3 in pre-NAC samples had longer disease-free-survival(DFS). Higher counts of CD3 in pre-NAC samples had longer overallsurvival. Higher ratio of CD8/CD4 counts in pre-NAC was associated with pCR. Higher ratio of CD4/FOXP3 counts in pre-NAC was associated with longer DFS. Higher counts of CD4 in post-NAC samples were associated with pCR.CONCLUSION TIL in pre-NAC full-face sections in TNBC are correlated to longer survival. TIL in full-face differ from TMA sections, absolute count and percentage analysis of TIL subpopulation closely related. | Carlos A Castaneda Elizabeth Mittendorf Sandro Casavilca Yun Wu Miluska Castillo Patricia Arboleda Teresa Nunez Henry Guerra Carlos Barrionuevo Ketty Dolores-Cerna Carolina Belmar-Lopez Julio Abugattas Gabriela Calderon Miguel De La Cruz Manuel Cotrina Jorge Dunstan Henry L Gomez Tatiana Vidaurre | 2016 | World Journal of Clinical Oncology2016，7，5： | 6 |
| 2 | Clinicopathological predictors of long-term benefit in breast cancer treated with neoadjuvant chemotherapy显示文摘AIM To investigate the survival impact of clinicopathological factors, including pathological complete response(p CR) and tumor-infiltrating lymphocytes(s TIL) levels according to subtypes, in breast cancer(BC) patients who received neo-adjuvant chemotherapy(NAC).METHODS We evaluated 435 BC patients who presented and received NAC at the Instituto Nacional de Enfermedades Neoplasicas from 2003 to 2014. s TIL was analyzed as the proportion of tumor stroma occupied by lymphocytes, and was prospectively evaluated on hematoxylin and eosin-stained sections of the preN AC core biopsy. p CR was considered in the absence of infiltrating cancer cells in primary tumor and axillary lymph nodes. Analysis of statistical association between clinical pathological features, s TIL, p CR and survival were carried out using SPSSvs19.RESULTS Median age was 49 years(range 24-84 years) and the most frequent clinical stage was ⅢB(58.3%). Luminal A, Luminal B, HER2-enriched and(triple-negative) TN phenotype was found in 24.6%, 37.9%, 17.7% and 19.8%, respectively. p CR was observed in 11% and median percentage of s TIL was 40%(2%-95%) in the whole population. p CR was associated to Ct1-2(P = 0.045) and to high s TIL(P = 0.029) in the whole population. There was a slight trend towards significance for s TIL(P = 0.054) in Luminal A. s TIL was associated with grade Ⅲ(P < 0.001), no-Luminal A subtype(P < 0.001), RE-negative(P < 0.001), PgR-negative(P < 0.001), HER2-positive(P = 0.002) and p CR(P = 0.029) in the whole population. Longer disease-free survival was associated with grade Ⅰ-Ⅱ(P = 0.006), cN 0(P < 0.001), clinical stage Ⅱ(P = 0.004), ER-positive(P < 0.001), Pg R-positive(P < 0.001), luminal A(P < 0.001) and p CR(P = 0.002). Longer disease-free survival was associated with grade Ⅰ-Ⅱ in Luminal A(P < 0.001), N0-1 in Luminal A(P = 0.045) and TNBC(P = 0.01), clinical stage Ⅱ in Luminal A(P = 0.003) and TNBC(P = 0.038), and pC R in TNBC(P < 0.001). Longer overall survival was associated with grade Ⅰ-Ⅱ(P < 0.001), ER-positive(P < 0.001), PgR-positive(P < 0.001), Luminal A(P < 0.001), cN 0(P = 0.002) and p CR(P = 0.002) in the whole population. Overall survival was associated with clinical stage Ⅱ(P = 0.017) in Luminal A, older age(P = 0.042) in Luminal B, and pC R in TNBC(P = 0.005).CONCLUSION Predictive and prognostic values of clinicopathological features, like p CR and s TIL, differ depending on the evaluated molecular subtype. | Marco Galvez Carlos A Castaneda Joselyn Sanchez Miluska Castillo Lia Pamela Rebaza Gabriela Calderon Miguel De La Cruz Jose Manuel Cotrina Julio Abugattas Jorge Dunstan Henry Guerra Omar Mejia Henry L Gomez | 2018 | World Journal of Clinical Oncology2018，9，2： | 4 |
| 3 | Highly oxygenated flavonoids from Ageratum corymbosum 显示文摘 | Quijano L Calderon JS Gomez G | 1980 | Phytochemistry1980，19，11： | 1 |
| 4 | The requirement for sulfur amino acid by laying hens as influenced by the protein concentration显示文摘 | Calderon V M L S Jensen | 1990 | Poultry Sci1990，69，： | 1 |
| 5 | Role of magnetic resonance cholangiopancreatography in patients with suspected choledocholithiasis显示文摘 | Calvo MM Bujanda L Calderon A | 2002 | Mayo Clin Proc2002，77，5： | 1 |
| 6 | Changes in oxygenation indexes with the use of nitric oxide in the postoperative period of congenital heart disease surgery in patients with severe pulmonary hypertension显示文摘 | Ramirez L Calderon CJ Zarco ME | 2001 | Arch Cardiol Mex2001，71，： | 1 |
| 7 | Rodent models of Alzheimer's disease rat Abeta infusion approaches to am- yloid deposits 显示文摘 | Frautschy SA Yang F Calderon L | 1996 | Neurobiol Aging1996，17，2： | 1 |
| 8 | Cardiac ATP-sensitive potassium channels: a potential target for an anti-ischaemic pharmacological strategy 显示文摘 | Testai L Rapposelli S Calderone V | 2007 | Cardiovasc Hematol Agents Med Chem2007，5，1： | 1 |
| 9 | Rodent models of Alzheimer's disease:rat A beta infusion approaches to amyloid deposits显示文摘 | Frautschy SA Yang F Calderon L | 1996 | Neurobiol Aging1996，17，2： | 1 |
| 10 | Sex determination in flowering plants显示文摘 | DELLAPORTA S L CALDERON U A | 1993 | Plant Cell1993，5，10： | 1 |
| 11 | PHR1 ,a pH-regulated gene of Candida albicans encoding a glu-can-remodelling enzyme, is required for adhesion and invasion显示文摘 | Calderon J Zavrel M Ragni E Fonzi W A Rupp S’Popolo L | 2010 | Microbiology2010，156，8： | 1 |
| 12 | The PprA-PprB two-component system activates CupE, the first non-archetypalPseudomonas aeruginosa chaperone-usher pathway system assembling fimbriae显示文摘 | Giraud C Bernard C S Calderon V Yang L Filloux A Molin S Fichant G Bordi C de Bentzmann S | 2011 | Environmental Microbiology2011，13，3： | 1 |
| 13 | Fructan metabolism: Reversal of cold acclimation显示文摘 | Tognetti J A Calderon P L Pontis H G | 1989 | Journal of Plant Physiology1989，14，： | 1 |
| 14 | Chronic inter- mittent hypoxia increases sympathetic control of blood pressure: role of neuronal activity in the hypothalamic paraventricular nucle- us显示文摘 | Sharpe A L Calderon A S Andrade M A | 2013 | Am J Physiol Heart Circ Physiol2013，305，12： | 1 |
| 15 | Intergeneric hybrids of Saccharomyces cerevisiae and Zygosaccharomyees fermentati Obtained by Protoplast Fusion显示文摘 | Alfonso Pina Isabel L Calderon Tahfa Benftez | 1986 | Applied and Environmental Microbiology1986，51，： | 1 |
| 16 | Rodent models of Alzheimer's disease:rat A beta infusion approaches to amyloid deposits显示文摘 | Frautschy S A Yang F Calderon L | 1996 | Neurobiol Aging1996，17，2： | 1 |
| 17 | Inactivation of Zygosaccharomyces bailii in fruit juices by heat , high hydrostatic pressure and pulsed electric fields显示文摘 | Raso J Calderon M L Gongora M | 1998 | J Food Sci1998，63，： | 1 |
| 18 | Rodent models of Alzhei- mer's disease:rat A beta infusion approaches to amyloid deposits显示文摘 | Fraut schy SA Yang F Calderon L | 1996 | Neurobiol Aging1996，17，2： | 1 |
| 19 | T-cell cytokine profiles are altered in childhood asthma exacerbation显示文摘 | Calderon C Rivera L Hutchinson P | | 0，，02： | 1 |
| 20 | Diversity of Saccharomyces and Non-Saccharomyces yeasts in three red grape varieties cultured in the Serranla de Ronda (Spain) vine-growing region显示文摘 | CLAVIJO A CALDERON I L PANEQUE P | 2010 | International Journal of Food Microbiology2010，143，3： | 1 |
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