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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | A novel methodology for the monitoring of the agricultural production process based on wireless sensor networks显示文摘 | Soledad Escolar Díaz Jesús Carretero Pérez Alejandro Calderón Mateos Maria-Cristina Marinescu Borja Bergua Guerra | 2011 | Computers and Electronics in Agriculture2011，，2： | 2 |
| 3 | Polyunsaturated fatty acids and inflammatory processes: New twists in an old tale显示文摘 | CALDER P C | 2009 | Biochimie2009，91，6： | 1 |
| 4 | The effect of propolis and its components on eicosanoid production during the inflammatory response 显示文摘 | Mirzoeva O K Calder P C | 1996 | Prostaglandins Leukotrienes Essent Fatty Acids1996，55，6： | 1 |
| 5 | DDT induces apoptosis in human mononuclear cells in vitro and is associated with increased apoptosis in exposed children 显示文摘 | Pérez-Maldonado IN D??az-Barriga F de la Fuente H González-Amaro R Calderón J Yá?ez L | 2004 | Environ Res2004，94，1： | 1 |
| 6 | Analysis of the strain transfer in a new FBG sensor for structural health monitoring显示文摘 | Torres B Payá-Zaforteza I Calderón P A | 2011 | Engineering Structures2011，33，2： | 1 |
| 7 | The operative management of displaced intraarticular fractures of the calcaneum : a two- centre study using a defined pmtoeol 显示文摘 | TENNENT T CALDER P SALISBURY R | 2010 | Injury2010，32，6： | 1 |
| 8 | The operative management of displaced intra-articular fractures of the calcaneum : a two-centre study using a defined protocol 显示文摘 | Tennent T D Calder P R Salisbury R D | 2001 | Injury2001，32，6： | 1 |
| 9 | Omega-3(n-3)fatty acids,cardiovascular disease and stability of atherosclerotic plaques显示文摘 | Calder PC Yaqoob P | 2010 | Cell Mol Biol(Noisy-le-grand)2010，56，1： | 1 |
| 10 | Apoptosis-a significant cause of bone cell death in osteonecrosis of the femoral head显示文摘 | CALDER J D BUTTERY L REVELL P A | 2004 | J Bone Joint Surg Br2004，86，8： | 1 |
| 11 | Fuel utilization by cells of the immune system 显示文摘 | Calder P C | 1995 | The Proceedings of Nutrition Society1995，54，1： | 1 |
| 12 | The operative management of disp laced inraarticular fractures of the calcaneum:a two center study using a defined protocol显示文摘 | Tennen T D Calder P R Salisbury R D | 2005 | Injury2005，36，10： | 1 |
| 13 | Cytokine production by human peripheral blood mononuclear cells: differential senstivity to glutamine availability 显示文摘 | Yaqoob P Calder PC | 1998 | Cytokine1998，10，10： | 1 |
| 14 | Olive oil in parenteral nutrition 显示文摘 | SALA-VILA BARBOSA V M CALDER P C et al | 2007 | Curr Opin Clin Nutr Metab Care2007，10，2： | 1 |
| 15 | Understanding omega-3 polyunsaturated fatty acids显示文摘 | Calder PC Yaqoob P | 2009 | Postgrad Med2009，121，6： | 1 |
| 16 | Conversion of a - linolenic acid to longer- chain polyunsaturated fatty acids in human adults 显示文摘 | BURDGE G C CALDER P C | 2005 | Reprod Nutr Dev2005，45，5： | 1 |
| 17 | Glutamine and the immune system显示文摘 | Calder P C Yaqoob P | 1999 | Amino Acids1999，17，： | 1 |
| 18 | BCAA administration increases plasma level of ammonia at exercises in 24h fasted rats显示文摘 | Calder P | 1994 | European Journal of Applied Physiology1994，69，： | 1 |
| 19 | On a problem of Mihlim显示文摘 | CALDER(O)N A P ZYGMUND A | 1995 | Trans Amer Math Soc1995，78，2： | 1 |
| 20 | The proposed role of glutamine in some cells of the immune system and speculative consequences for the whole animal显示文摘 | NEWSHOLME E A CALDER P C | 1997 | Nutrition1997，13，78： | 1 |
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