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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | DDT induces apoptosis in human mononuclear cells in vitro and is associated with increased apoptosis in exposed children 显示文摘 | Pérez-Maldonado IN D??az-Barriga F de la Fuente H González-Amaro R Calderón J Yá?ez L | 2004 | Environ Res2004，94，1： | 1 |
| 3 | The operative management of displaced intraarticular fractures of the calcaneum : a two- centre study using a defined pmtoeol 显示文摘 | TENNENT T CALDER P SALISBURY R | 2010 | Injury2010，32，6： | 1 |
| 4 | The operative management of displaced intra-articular fractures of the calcaneum : a two-centre study using a defined protocol 显示文摘 | Tennent T D Calder P R Salisbury R D | 2001 | Injury2001，32，6： | 1 |
| 5 | The operative management of disp laced inraarticular fractures of the calcaneum:a two center study using a defined protocol显示文摘 | Tennen T D Calder P R Salisbury R D | 2005 | Injury2005，36，10： | 1 |
| 6 | Chemical and biological weathering of oil from the Amoco Cadiz spillage,within the littoral zone显示文摘 | BOEHM P D CALDER J A | 1981 | Estuar Coast Shelf Sci1981，12，： | 1 |
| 7 | In vitro transdermal delivery of the major catechins and caffeine from extract of Camellia sinensis显示文摘 | Batchelder R J Calder R J Thomas C P | 2004 | International Journal of Pharmaceutics2004，4551，： | 1 |
| 8 | In situ identification of the silicide phase in super-oL titanium alloys 显示文摘 | KOTVAL P S CALDER R W | 1972 | Metallurgical and Materials Transaction (B)1972，3，5： | 1 |
| 9 | Eucalyptus water use greater than rainfall input-a possible explanation from southern India显示文摘 | Calder I R Rosier P T W Prasanna K T | 1997 | Hydrology and Earth System Sciences1997，1，2： | 1 |
| 10 | Water Resources Planning and Modelling Tools for the Assessment of Land Use Change in the Luvuvhu Catchment,South Mrica显示文摘 | Jewitt G P W Garratt J A Calder I R Fuller L | 2004 | Physics and Chemistry of the Earth2004，29，： | 1 |
| 11 | The operative management of displaced intra - articular fractures of the calcaneum: a two - centre study using a defined protocol 显示文摘 | Tennent T Calder P Salisbury R | 2001 | Injury2001，32，6： | 1 |
| 12 | The operative management of dispiaced intra-articrlar fractures of the caleane- um:a two-centere study using a defined protocol 显示文摘 | T D Tennent P R Calder R D Salisbury | 2001 | Injury2001，32，： | 1 |
| 13 | Peat formation in a Westphalian B piedmont setting, Cumberland basin, Nova Scotia: implications for the maceral-based interpretation of rheotrophic and raised paleomires显示文摘 | CALDER J H GIBLING M R MUKHOPADHYAY P K | 1991 | Geology Bull1991，162，： | 1 |
| 14 | Water resources planning and modeling tools for the assessment of land use change in the Luvuvhu Catchment, South Africa 显示文摘 | JEWITT G P W GARRATY J A CALDER I R | 2004 | Physics and Chemistry of the Earth2004，29，1518： | 1 |
| 15 | Polyunsaturated fatty acids,inflammation and immunity显示文摘 | Calder P C R F Grimble | 2002 | Eur J Clin Nutr2002，56，3： | 1 |
| 16 | The operative Management of displaced inraarticular fractures of the calca- neum:a two center study using a defined protocol显示文摘 | TennenT D Calder P R Salisbury RD | 2005 | Inju- ry2005，36，： | 1 |
| 17 | The operative man- agement of displaced intra-artieular fractures of the calcaneum: a two-centre study using a defined protocol显示文摘 | Tennent T D Calder P R SaliSbury R D | 2001 | Injury2001，32，5： | 1 |
| 18 | A randomised clinical trial to assess the effect of total enteral and total parenteral nutritional support on metabolic, inflammatory and oxidative markers in patients with predicted severe acute pancreatitis显示文摘 | Gupta R Patel K Calder P C | 2003 | Pancreatology2003，3，： | 1 |
| 19 | The operative man- agement of displaced intra-articular fractures of the calca- neum: a two centre study using a defined protocol显示文摘 | Tennent T Calder P Salisbury R | 2001 | Inju- ry2001，32，6： | 1 |
| 20 | A randomised clinical trial to assess the effect of total enteral and total parenteral nutritional support on metabolic, inflammatory and oxidative markers in patients with predicted severe acute pancreatitis( APACHE II > or=6) 显示文摘 | GUPTA R PATEL K CALDER P C | 2003 | Pancreatology2003，3，5： | 1 |
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