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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Machine Reasoning about Anomalous Sensor Data显示文摘 | Calder M Morris R A Peri F | 2010 | Ecological In- formatics2010，5，1： | 1 |
| 3 | Amino acid exchange by the mammary gland of lactating goats when histidine limits milk production 显示文摘 | BEQUETI'E B J HANIGAN M D CALDER A G | 2000 | J Dairy Sci2000，83，4： | 1 |
| 4 | Feature interaction:a critical review and considered forecast显示文摘 | Kolberg M Magill E H | 2003 | Computer Networks2003，41，1： | 1 |
| 5 | Osteonecrosis of osteoapoptosis显示文摘 | Calder J DF Buttery L Perasse M | 2001 | Bone Joint Surg Br2001，83，： | 1 |
| 6 | Olive oil in parenteral nutrition 显示文摘 | SALA-VILA BARBOSA V M CALDER P C et al | 2007 | Curr Opin Clin Nutr Metab Care2007，10，2： | 1 |
| 7 | Does glutamine contribute to immunosuppression after major bums 显示文摘 | Parry-billings M Evans J Calder PC | 1990 | Lancet1990，336，： | 1 |
| 8 | Gemeprost-induced cervical ripening:histological and biophysical effects 显示文摘 | Geer LA Millar M Calder A | 1992 | Eur J Obstet Gynecol Reprod Biol1992，47，： | 1 |
| 9 | Practical aspects of arteriovenous fistula formation in the pediatric population 显示文摘 | Manook M Calder F | 2013 | Pediatric Nephrology2013，28，6： | 1 |
| 10 | Chemical and biological weathering of oil from the Amoco Cadiz spillage,within the littoral zone显示文摘 | BOEHM P D CALDER J A | 1981 | Estuar Coast Shelf Sci1981，12，： | 1 |
| 11 | Lateral photodetectors on ARROW structures for optical interconnections显示文摘 | Moreno M Calderer J | 1997 | Optics Communications1997，140，： | 1 |
| 12 | Maternal plasma phosphatidylcholine fatty acids and atopy and wheeze in the offspring at age of 6 years显示文摘 | PIKE K C CALDER P C INSKIP H M | 2012 | Clin Dev Immunol2012，2012，47： | 1 |
| 13 | The fate of absorbed and exogenous ammonia as influenced by forage or forage- concentrate diets in growing sheep显示文摘 | Lobley G E Weijs P J M Connell A Calder A G Brown D S Milne E | 1996 | British Journal of Nutrition1996，76，： | 1 |
| 14 | Microstructure evolution in magnetorheological suspensions governed by Mason number显示文摘 | Melle S Calderón O G Rubio M A | 2003 | Phys Rev2003，68，04： | 1 |
| 15 | n-3 Polyunsaturated fatty acids and colon cancer prevention显示文摘 | Roynette C E Calder P C Dnpertnis Y M | 2004 | Clin Nutr2004，24，： | 1 |
| 16 | The use of tranexamic acid to reduce blood loss during total knee arthroplasty 显示文摘 | Hynes M Calder P Scott G | 2003 | Knee2003，10，4： | 1 |
| 17 | Oxidation of natural hydroxybenzoic acids by grapevine peroxidases:kinetic characteristics and substrate specificity显示文摘 | Zapata J M Calderón A A Mu-oz R | 1992 | Am J Enol Vitic1992，43，1： | 1 |
| 18 | Amino acid exchange by the mammary gland of lactating goats when histidine limits milk production 显示文摘 | BEQUETTE B J HANIGAN M D CALDER A G | 2000 | Journal of Dairy Science2000，83，4： | 1 |
| 19 | the self-perception of intrinsic and extrinsic motivation显示文摘 | Calder B J Staw B M | 1975 | Personality Social Psy- chology1975，31，4： | 1 |
| 20 | LaNiO3 nanopowder prepared by an 'amorphous citrate' route显示文摘 | Ngo Thi Hong Le Jos'e M Calder'on - Moreno M'onica Popa | 2006 | Journal of the European Ceramic Society2006，，26： | 1 |
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