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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Development and evaluation of sediment quality guidelines for Florida coastal waters显示文摘 | MACDONALD D D CARR R S CALDER F D | 1996 | Ecotoxicology1996，5，： | 1 |
| 3 | Machine Reasoning about Anomalous Sensor Data显示文摘 | Calder M Morris R A Peri F | 2010 | Ecological In- formatics2010，5，1： | 1 |
| 4 | Epidermoid splenic cysts and partial splenectomy显示文摘 | Seguel Ramírez F Alonso Calderón JL Ollero Caprani JM | | 0，，02： | 1 |
| 5 | DDT induces apoptosis in human mononuclear cells in vitro and is associated with increased apoptosis in exposed children 显示文摘 | Pérez-Maldonado IN D??az-Barriga F de la Fuente H González-Amaro R Calderón J Yá?ez L | 2004 | Environ Res2004，94，1： | 1 |
| 6 | Development and evaluation of sediment quality guidelines for Florida coastal waters显示文摘 | MacDonald D D Carr R S Calder F D | 1996 | Ecotoxicology1996，5，： | 1 |
| 7 | Development and evaluation of sediment quality guidelines for Florida coastal waters显示文摘 | MacDonald D D Carr R S Calder F D | 1996 | Ecotoxicology1996，5，4： | 1 |
| 8 | Practical aspects of arteriovenous fistula formation in the pediatric population 显示文摘 | Manook M Calder F | 2013 | Pediatric Nephrology2013，28，6： | 1 |
| 9 | Devel- opment and evaluation of sediment quality guidelines for Florida coastal waters 显示文摘 | MacDonald D D Carr R S Calder F D | 1996 | Ecotoxicology1996，5，4： | 1 |
| 10 | Impaired recognition and experience of disgust following brain injury显示文摘 | Calder A.J Keane J Manes F Antoun N & Young A.W | | 0，，： | 1 |
| 11 | Development and evaluation of sediment quality guidelines for Florida coastal waters显示文摘 | Macdonald D D Carr R S Calder F D | 1996 | Ecotoxicology1996，5，4： | 1 |
| 12 | Inductive shielding of NMR phase noise显示文摘 | Sigmund E E Mitrovic V F Calder E S | 2002 | J Magn Reson2002，159，2： | 1 |
| 13 | Somicrobial commumity composition and land use history icultivated and grassland ecosystems of coastal California显示文摘 | STEENWERTH K L JACKSON L E CALDER(O)N F J | 2002 | Soil Biology& Biochemistry2002，34，： | 1 |
| 14 | Fatty acids and lymphocyte fimctions显示文摘 | Calder PC Yaqoob P Thies F | 2002 | Br J Nutr2002，87，1： | 1 |
| 15 | Computer simulation of point defect properties in dilute Fe-Cu alloy using a many-body interatomic potential显示文摘 | Aekland G J Bacon D J Calder A F | 1997 | Philos Mag A1997，75，3： | 1 |
| 16 | Ap- plication of a U-13C-labeled amino acid tracer in lactating dairy goats for simuhaneous measurements of the flux of amino acids in plasma and the partition of amino acids to the mamma- ry gland 显示文摘 | BEQUETTE B J BACKWELL F R C CALDER A G | 1997 | Journal of Dairy Science1997，80，11： | 1 |
| 17 | Soil enzyme activities, microbial communities, and carbon and nitrogen availability in organic agroecosystems across an intensively-managed agricultural landscape显示文摘 | Bowles T M Acosta-Martínez V Calderón F | 2014 | Soil Biology and Biochemistry2014，68，1： | 1 |
| 18 | Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects 显示文摘 | Wallace F A Miles E A Calder P C | 2003 | Br J Nutr2003，89，5： | 1 |
| 19 | Development and evaluation of sediment quality guidelines for Florida coastal waters 显示文摘 | MacDonald D D Cart R S Calder F D | 1996 | Ecotoxicology1996，5，： | 1 |
| 20 | Development and evaluation of sediment quality guidelines for Florida coastal waters显示文摘 | MACDONALD D D Carr R S Calder F D acdonald | 1996 | Ecotoxicology1996，5，： | 1 |
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