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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Multifactorial index of cardiac risk in non-cardiac surgical procedures显示文摘 | Goldman L Calder D L Nussbaum S R | 1977 | N Eng J Med1977，297，16： | 1 |
| 3 | DDT induces apoptosis in human mononuclear cells in vitro and is associated with increased apoptosis in exposed children 显示文摘 | Pérez-Maldonado IN D??az-Barriga F de la Fuente H González-Amaro R Calderón J Yá?ez L | 2004 | Environ Res2004，94，1： | 1 |
| 4 | Hydrological impact of Eucalyptus plantation in India 显示文摘 | CALDER I R HALL R L PRASANNA K T | 1993 | Journal of Hydrology1993，150，： | 1 |
| 5 | Water Resources Planning and Modelling Tools for the Assessment of Land Use Change in the Luvuvhu Catchment,South Mrica显示文摘 | Jewitt G P W Garratt J A Calder I R Fuller L | 2004 | Physics and Chemistry of the Earth2004，29，： | 1 |
| 6 | Survey of conditions to produce metal-boron amorphous and nanocrystalline alloys by chemical reduction显示文摘 | Yedra A Fernández Barquin L Garcia Calderó R | 2001 | Journal of Non-Crystaline Solids2001，287，： | 1 |
| 7 | Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial显示文摘 | Jeremy Chataway Nadine Schuerer Ali Alsanousi Dennis Chan David MacManus Kelvin Hunter Val Anderson Charles R M Bangham Shona Clegg Casper Nielsen Nick C Fox David Wilkie Jennifer M Nicholas Virginia L Calder John Greenwood Chris Frost Richard Nicholas | 2014 | The Lancet2014，，： | 1 |
| 8 | Incidence of adverse biological effects within ranges of chemical concentrations in marine and estuary sediments 显示文摘 | Long E R MacDonald D D Smith S L Calder F D | 1995 | Environ Manage1995，19，： | 1 |
| 9 | On the Effect of Random Errors in Gridded Bathymetric Compilations 显示文摘 | Calder B R L A Mayer | 2002 | Journal of Geophysical Reseach2002，107，12： | 1 |
| 10 | Automatic Processing of High- Rate, High- Density Multibeam Echosounder data 显示文摘 | Calder B R L A Mayer | 2003 | Geochem Geophys Geosyst2003，4，6： | 1 |
| 11 | Drop size modification by forest canopies : Measurements using a disdrometer显示文摘 | Hall R L Calder I R | 1993 | Journal of Geophysical Research1993，98，18： | 1 |
| 12 | Megacities air pollution problems:Mexico City Metropolitan Area critical issues on the central nervous system pediatric impact显示文摘 | CALDERN-GARCIDUE N~AS L KULESZA R J DOTY R L | 2015 | Environ Res2015，137，： | 1 |
| 13 | Electrical resistance in alfalfa roots asaffected by temperature and light显示文摘 | Calder F W Macleod L B Hayden R I | 1966 | Can J Plant Sci1966，46，： | 1 |
| 14 | Monitoring Babesia bovis infections in cattle by using PCR-based tests显示文摘 | Calder J A M Reddy G R Chieves L | 1996 | Journal of Clinical Microbiology1996，34，11： | 1 |
| 15 | A comparative study of the turbulent Rayleigh-Taylor instability using high-resolution three-dimensional numerical simulations: the Alpha-Group collaboration 显示文摘 | Dimonte G Youngs D L Dimits A Weber S Marinak M Wunsch S Garasi C Robinson A Andrews M J Ramaprabhu P Calder A C Fryxell B Biello J Dursi L MacNeice P Olson K Ricker P Rosner R Timmes F Tufo H Young Y N Zingale M | 2004 | Physics of Fluids2004，16，5： | 1 |
| 16 | On the effect of random errors in gridded bathymetric compilations显示文摘 | JAKOBSSON M CALDER B R MAYER L A | 2002 | Journal of Geophysical Research2002，107，12： | 1 |
| 17 | Clinical, angiocardiographic and pathologic findings in 100 patients显示文摘 | CALDER L VAN PRAAGH R VAN PRAAGI-I S Truncus arteriosus communis | 1976 | Am Heart J1976，92，1： | 1 |
| 18 | Automatic Processing of High-Rate,High-Density Multibeam Echosounder data显示文摘 | CALDER B R MAYER L A | 2002 | Geochem Geophys Geosyst2002，4，6： | 1 |
| 19 | Automatic Processing of High-Rate,High-Density Multibeam Echosounder data显示文摘 | CALDER B R MAYER L A | 2002 | Geochem Geophys Geosyst2002，4，6： | 1 |
| 20 | The role of dopamine and GABA in the frontal cortex of mice in modulating a motor-stimulant effect of amphetamine and cocaine显示文摘 | Karler R Calder L D Thai D K | 1998 | Pharmacol Biochem Behav1998，60，1： | 1 |
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