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| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | Caerulin-induced pancreatitis in rats: Histological and genetic expression changes from acute phase to recuperation显示文摘瞄准:为了学习组织学、联系胰腺炎的蛋白质 mRNA 累积,在老鼠从导致 caerulin 的胰腺炎的尖锐阶段胰改变到恢复。方法:尖锐胰腺炎被 caerulein 在男 Wistar 老鼠导致并且列在后面在上面为 90 d 由组织学并且胰的 mRNA 分析。胰在 0 点被把, 9, 24 h 并且 3, 5, 15, 30, 60, 90 d 正式就职以后。浮肿(E) , polymorphonuclear neutrophil (PMN ) 渗入,细胞质的空泡形成(V) ,酶原小粒弄空(ZD ) 和腺泡组织的破坏(广告) 是评估的用显微镜。联系胰腺炎的蛋白质(奶头) 和 L13A mRNAs 的累积被即时 PCR 确定。结果:主要组织学的变化出现在为 PMN 渗入和细胞质的 V 正式就职以后的 9 h 在为 E 和 ZD 的 24 h 和 3 d 分别地。所有参数在 5 d 以后被恢复,除了推迟了超过 30 d 的 ZD。主要广告在 15 d 以后被观察,值在 30 d 以后回到了正常。同样到组织学的变化, PAP mRNA 的累积在 24 h 与最高的累积在 9 h 被增加,差别消失在 5 d 以后。结论:从尖锐阶段发生到胰的胰腺炎,新生和重新区别的恢复并且奶头表示是只胰腺炎的尖锐回答。 | Javier Magaa-Gómez Guillermo López-Cervantes Ana María Calderón de la Barca | 2006 | World Journal of Gastroenterology2006，12，25： | 2 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Apoptosis--a significant cause of bone cell death in osteonecrceis of the femoral head显示文摘 | Buttery L Revdl PA | 2004 | J Bone Joint Surg Br2004，86，： | 1 |
| 5 | Structural basis for membrane fusion enveloped viruses显示文摘 | WEISSNHORN W DESSEN A CALDER L J | 1999 | Mol Membr Biol1999，16，： | 1 |
| 6 | Multifactorial index of cardiac risk in non-cardiac surgical procedures显示文摘 | Goldman L Calder D L Nussbaum S R | 1977 | N Eng J Med1977，297，16： | 1 |
| 7 | DDT induces apoptosis in human mononuclear cells in vitro and is associated with increased apoptosis in exposed children 显示文摘 | Pérez-Maldonado IN D??az-Barriga F de la Fuente H González-Amaro R Calderón J Yá?ez L | 2004 | Environ Res2004，94，1： | 1 |
| 8 | The hospital transfusion committee: a step towards improved quality assurance显示文摘 | Calder L Woodfield G | 1991 | N Z Med J1991，104，921： | 1 |
| 9 | Apoptosis-a significant cause of bone cell death in osteonecrosis of the femoral head显示文摘 | CALDER J D BUTTERY L REVELL P A | 2004 | J Bone Joint Surg Br2004，86，8： | 1 |
| 10 | Osteonecrosis of osteoapoptosis显示文摘 | Calder J DF Buttery L Perasse M | 2001 | Bone Joint Surg Br2001，83，： | 1 |
| 11 | The hospital transfusion committee:a step towards improved quality assurance显示文摘 | Calder L Woodfield G | 1991 | N Z Med J1991，104，921： | 1 |
| 12 | Apoptosis ofperipheral blood mononuclear cells in children exposed to arsenic andfluoride显示文摘 | Rocha-amador DO Calderón J Carrizalea L | 2011 | Environ Toxicol Pharmacol2011，32，3： | 1 |
| 13 | Apoptosis--a significant cause of bone cel death in osteonecrosis of the femoral head显示文摘 | Calder JD Buttery L Revel PA | | 0，，08： | 1 |
| 14 | Thymus cells in myasthenia gravis selectively enhance production of anti-acetylcholine-receptor antibody by autologous blood lymphocytes显示文摘 | Newsom-Davis J Wilcox N Calder L | 1981 | N Engl J Med1981，305，： | 1 |
| 15 | Somicrobial commumity composition and land use history icultivated and grassland ecosystems of coastal California显示文摘 | STEENWERTH K L JACKSON L E CALDER(O)N F J | 2002 | Soil Biology& Biochemistry2002，34，： | 1 |
| 16 | Hydrological impact of Eucalyptus plantation in India 显示文摘 | CALDER I R HALL R L PRASANNA K T | 1993 | Journal of Hydrology1993，150，： | 1 |
| 17 | Polyunsaturated fatty acid concentrations in young men and women consuming their habitual diets显示文摘 | BAKEWELL L BURDGE G C CALDER P C | 2006 | Br J Nutr2006，96，1： | 1 |
| 18 | Water Resources Planning and Modelling Tools for the Assessment of Land Use Change in the Luvuvhu Catchment,South Mrica显示文摘 | Jewitt G P W Garratt J A Calder I R Fuller L | 2004 | Physics and Chemistry of the Earth2004，29，： | 1 |
| 19 | Survey of conditions to produce metal-boron amorphous and nanocrystalline alloys by chemical reduction显示文摘 | Yedra A Fernández Barquin L Garcia Calderó R | 2001 | Journal of Non-Crystaline Solids2001，287，： | 1 |
| 20 | Polyunsat- urated fatty acid concentrations in young men and women consuming their habitual diets 显示文摘 | BAKEWELL L BURDGE G C CALDER P C | 2006 | Br J Nutr2006，96，： | 1 |
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