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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Machine Reasoning about Anomalous Sensor Data显示文摘 | Calder M Morris R A Peri F | 2010 | Ecological In- formatics2010，5，1： | 1 |
| 3 | Computer simulation of point defect properties in dilute Fe-Cu alloy using a many-body interatomic potential显示文摘 | Aekland G J Bacon D J Calder A F | 1997 | Philos Mag A1997，75，3： | 1 |
| 4 | Ap- plication of a U-13C-labeled amino acid tracer in lactating dairy goats for simuhaneous measurements of the flux of amino acids in plasma and the partition of amino acids to the mamma- ry gland 显示文摘 | BEQUETTE B J BACKWELL F R C CALDER A G | 1997 | Journal of Dairy Science1997，80，11： | 1 |
| 5 | Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects 显示文摘 | Wallace F A Miles E A Calder P C | 2003 | Br J Nutr2003，89，5： | 1 |
| 6 | Subclinical infection with the nematode Trichostrongylus colubriformis increases gastrointestinal tract leucine metabolism and reduces availability of leucine for other tissues显示文摘 | Yu F Bruce L A Calder A G | 2000 | J Anim Sci2000，78，2： | 1 |
| 7 | Dietary lipids modify the cytokine response to bacterial lipopolysaccharide in mice显示文摘 | Sadeghi S Wallace F A Calder P C | 1999 | Immunology1999，96，： | 1 |
| 8 | Dynamic behavior of Arabidopsis elF4A-Ⅲ, putative core protein of exon junction complex: fast relocation to nucleolus and splicing speckles under hypoxia显示文摘 | Koroleva O A Calder G Pendle A F | 2009 | Plant Cell2009，21，5： | 1 |
| 9 | Electrical impedance studies on potatoand alfalfa tissue显示文摘 | Hayden R I Moyse C A Calder F W | 1969 | J Exp Bot1969，20，： | 1 |
| 10 | A global and parallel file system for grids显示文摘 | GARCIA-CARBALLEIRA F CARRETERO J CALDERN A | 2007 | Future Generation Computer Systems2007，23，1： | 1 |
| 11 | Impaired recognition and experience of disgust following brain injury显示文摘 | Calder A J Keane J Manes F | 2000 | Nature Neuroscience2000，3，11： | 1 |
| 12 | The design of the expand parallel file system显示文摘 | GARCIA-CARBALLEIRA F CALDER'ON A CARRETERO J | 2003 | International Journal of High Performance Computing Applications2003，17，1： | 1 |
| 13 | Toxic effect of water- soluble fractions of crude, refined, and weathered oils on the growth of marine bacterium显示文摘 | GRIFFIN L F CALDER J A | 1977 | Appl Environ Microbiol1977，33，5： | 1 |
| 14 | Comparison of the effects oflinseed oil and different doses of fish oil on mononuclear cellfunction in healthy human subjects 显示文摘 | Wallace F A Miles E A Calder P C | 2003 | Brit J Nutr2003，89，： | 1 |
| 15 | Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects 显示文摘 | Wallace F A Miles E A Calder P C | 2003 | Br J Nutr2003，89，5： | 1 |
| 16 | A comparative study of the turbulent Rayleigh-Taylor instability using high-resolution three-dimensional numerical simulations: the Alpha-Group collaboration 显示文摘 | Dimonte G Youngs D L Dimits A Weber S Marinak M Wunsch S Garasi C Robinson A Andrews M J Ramaprabhu P Calder A C Fryxell B Biello J Dursi L MacNeice P Olson K Ricker P Rosner R Timmes F Tufo H Young Y N Zingale M | 2004 | Physics of Fluids2004，16，5： | 1 |
| 17 | Subclinical infection with the nematode trichostrongylus colubriformis increases gastrointestinal tract leucine metabolism and reduces availability of leucine for other tissues显示文摘 | Yu F Bruce L A Calder A G | 2000 | Journal of Animal Science2000，78，： | 1 |
| 18 | Phase-con-trolled slow and fast light in current-modulated semicon-ductor optical amplifiers显示文摘 | Antón M A Carreno F CalderónóG | 2009 | Journal of Physics B:Atomic Molecular and Optical Physics2009，42，9： | 1 |
| 19 | Computer simulation of point defect properties in dilute Fe-Cu alloy using a many-body interatomic potential显示文摘 | Akland G J Bacon D J Calder A F | 1997 | Philosophical Magazine A1997，75，： | 1 |
| 20 | Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects 显示文摘 | WALLACE F A MILES E A CALDER P C | 2003 | Br J Nutr2003，89，： | 1 |
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