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| 1 | 手术期间化学疗法与单独手术治疗可切除的胃食管癌疗效比较显示文摘 | Cunningham D Allum WH Stenning SP 菅鑫妍 | 2006 | 中国处方药2006，5，8： | 432 |
| 2 | 围手术期化疗与单纯手术治疗可切除性胃食管癌的比较 | Cunningham D. Allum W.H. Stenning S.P. 程金湘 | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，0，12： | 47 |
| 3 | Etelcalcetide治疗继发性甲状旁腺功能亢进的随机对照3期临床试验显示文摘矿物质代谢紊乱是终末期肾病(ESRD)患者最具挑战性的临床问题之一。从早期阶段开始,慢性肾脏病(CKD)即开始增加成纤维细胞生长因子23(FGF23)的循环浓度, | Block GA Bushinsky DA Cunningham J 王建中 | 2017 | 中华肾病研究电子杂志2017，6，1： | 33 |
| 4 | Targeting the PI3K-AKT-mTOR signaling network in cancer显示文摘The phosphoinositide 3-kinase-AKT-mammalian target of rapamycin (PI3K-AKT-mTOR) pathway is a frequently hyperactivated pathway in cancer and is important for tumor cell growth and survival. The development of targeted therapies against mTOR, a vital substrate along this pathway, led to the approval of allosteric inhibitors, including everolimus and temsirolimus, for the treatment of breast, renal, and pancreatic cancers. However, the suboptimal duration of response in unselected patients remains an unresolved issue. Numerous novel therapies against critical nodes of this pathway are therefore being actively investigated in the clinic in multiple tumour types. In this review, we focus on the progress of these agents in clinical development along with their biological rationale, the need of predictive biomarkers and various combination strategies, which will be useful in counteracting the mechanisms of resistance to this class of drugs. | Khurum H. Khan Timothy A. Yap Li Yan David Cunningham | 2013 | Chinese Journal of Cancer2013，32，5： | 25 |
| 5 | 2009-2013年南京市流感流行病学特征分析显示文摘目的描述2009-2013年期间南京市流感的流行病学规律和特点。方法流感样本来源于流感样病例,利用逆转录聚合酶链反应确定阳性病例以及流感分型。采用Excel 2007整理数据和SPSS 19.0进行统计分析。结果 2009-2013年间,南京地区共有流感样病例17 906例,其中阳性2 990例,流感阳性率为16.7%。流感阳性率随月份、季度和年份而改变,南京阳性率高峰主要出现在秋冬季,也伴有一些夏季的高峰。甲型流感主要在夏季、秋季和冬季流行,乙型流感主要在冬季流行。2009-2013年南京优势毒株为甲型H1N1,H3N2和乙型流感。H3N2通常在秋季和夏季达到流行高峰,甲型H1N1大流行在秋季出现高峰,乙型流感主要在冬季流行。南京地区在秋季和初冬出现流行高峰,但有些年份,在夏季和初秋出现H3N2流行高峰。采用移动流行病学方法建立标准模型,一般流感在南京的流行大约持续11周,流行阈值为25.21%,流感阳性的背景率为5.82%。结论南京流感高峰通常一年发生一次,但在有些年份中,会出现两个流感高峰时期。 | Michael James Cunningham 李伟 资海荣 卫平民 | 2017 | 中华疾病控制杂志2017，21，1： | 24 |
| 6 | 基于InVEST模型的1980–2100年长江中下游地区动植物生境质量时空变化研究显示文摘20世纪80年代以来,人类活动加速了长江流域的土地利用变化,这对当地动植物的生境质量造成了影响,在中国生态文明建设和长江经济带发展战略不断推进的大背景下,对长江中下游地区的生境质量变化开展长时间多时段的研究具有重要的现实意义。本研究以长江中下游地区7省的土地利用覆盖数据(1980–2018年)与未来土地利用模型模拟出未来四种情景(A1B,A2,B1,B2)下的土地利用覆盖数据(2050年,2100年)为基础,借助环境服务与权衡综合评估(In VEST)模型评估了长江中下游地区的生境质量时空变化。结果表明:(1)2000–2015年,研究区的坡度(R=0.502,P <0.01)和海拔(R=0.003,P <0.05)、人口密度(R=0.299,P <0.01)、NDVI(R=0.366,P <0.01)与生境质量显著相关;(2)从1980年到2018年,研究区总面积61.93%的土地生境质量下降,38.07%的土地生境质量上升;在A2情景(人口密度大,环境技术投入少,传统能源成本高)和B2情景(中等人口密度,中等绿色技术,区域政府间缺乏合作)下,研究区的生境质量将下降;(3)长江下游的生境质量恶化程度高于中游,研究区北部的生境质量恶化程度低于南部。整体上,积极的环境保护政策是有效的,但并未根本上遏制生境质量的整体退化趋势。区域发展应加大环境保护力度,控制人口增长,鼓励绿色技术创新,在处理生态问题时,要注重省际合作。本研究可为区域野生动植物保护规划和国际上的类似流域研究提供科学参考。 | 李晴 周勇 Mary Ann CUNNINGHAM 徐涛 | 2021 | Journal of Resources and Ecology2021，12，1： | 17 |
| 7 | Epirubicin, oxaliplatin, and capecitabine with or without panitumumab for patients with previously untreated advanced oesophagogastric cancer (REAL3): a randomised, open-label phase 3 trial显示文摘 | Tom Waddell Ian Chau David Cunningham David Gonzalez Alicia Frances Clare Okines Andrew Wotherspoon Claire Saffery Gary Middleton Jonathan Wadsley David Ferry Wasat Mansoor Tom Crosby Fareeda Coxon David Smith Justin Waters Timothy Iveson Stephen Falk Sar | 2013 | Lancet Oncology2013，，6： | 10 |
| 8 | 睾酮和代谢综合症显示文摘关于代谢综合症的诊断价值始终存在争议。很多代谢综合症的相关因素亦被认定为心血管疾病的风险因素。尽管代谢综合征的诊断标准包括胰岛素抵抗,但其发生率并不普遍。伴有肥胖和腰围增大的高胰岛素血症及高炎症因子状态可以很好的解释代谢综合症患者的低睾酮和低性激素结合蛋白(SHBG)水平。低SHBG水平可以预测代谢综合症的发病率;低睾酮水平是心血管疾病的风险因素,但不一定是发病因素。国际糖尿病学会推荐的治疗代谢综合症的策略包括心血管风险评估、生活方式及饮食习惯的改善、锻炼、控制体重、以及个体性风险因素的控制等。然而,代谢综合症患者很少可以有效控制自己的体重。近来,有研宄发现睾酮补充可以减轻体重、减少腰围、胰岛素增敏、改善血红蛋白A1c水平,甚至改善代谢综合症的所有发病因素。同时,也有一些观察性研究结果显示睾酮补充会导致心血管事件发生率升高,对此FDA进行了详细追踪,结果显示此类报道有侍商椎。目前,大样本随机对照研究亟待开展,用以验证睾酮补充疗法治疗伴有睾酮水平低下的中老年代谢综合症患者的安全性及有效性。 | Glenn R Cunningham | 2015 | Asian Journal of Andrology2015，17，2： | 9 |
| 9 | 腓骨及其韧带和踝关节稳定性的力学测评显示文摘对下肢各运动时象下腓骨负重功能及踝关节稳定性进行了实验研究。观察了小腿骨间膜和胫腓下韧带对腓骨生理功能的作用,并对临床上采用的腓骨下段固定方法进行了力学测评。实验结果显示,生理情况下腓骨负荷的大小与踝关节的位置和加载方向有关.小腿骨间膜将部分载荷从腓骨下段传递到胫骨上段,胫腓下韧带对于腓骨负重和踝关节稳定性均有重要意义。 | 王前 Kenwright J Whittle M Cunningham J | 1990 | 中国临床解剖学杂志1990，8，3： | 9 |
| 10 | 澳大拉西亚数字长期保存的合作机制显示文摘我的发言内容主要包括以下四个方面:一是澳大利亚和新西兰建立数字长期保存合作机制的背景;二是“澳大拉西亚数字文件管理动议(ADRI)”及其目标和原则;三是数字文件生成、长期保存和利用中面临的挑战及澳大拉西亚统一应对挑战的举措;四是澳大利亚国家档案馆在数字文件长期保存方面取得的最新进展。 | Adrian Cunningham 潇雨(编译) | 2009 | 档案学通讯2009，，6： | 8 |
| 11 | Newmark displacement model for landslides induced by the 2013 Ms 7.0 Lushan earthquake, China显示文摘 | Renmao YUAN Qinghai DENG Dickson CUNNINGHAM Zhujun HAN Dongli ZHANG Bingliang ZHANG | 2016 | Frontiers of Earth Science2016，10，4： | 7 |
| 12 | HIDA scan for functional gallbladder disorder: ensure that you know how the scan was done显示文摘BACKGROUND: Despite the increasing use of fatty meal(FM) as a substitute for cholecystokinin(CCK) in pain reproduction during hepato-imino-diacetic acid(HIDA) scan in functional gallbladder disorder, there are no studies comparing the differences between CCK and FM. The present study was to compare the efficacy of FM in comparison of CCK in FGBD application. METHODS: Patients undergoing HIDA scans from August 2013 to May 2014 were divided into two groups: those undergoing CCK-stimulated HIDA scan versus FM-stimulated HIDA scan. These groups were compared according to demographics and HIDA results.RESULTS: Of 153 patients, 70 received CCK and 83 FM. There was no difference regarding age, gender, gallstones, gallbladder ejection fraction and time to visualization. However, significantly more of the patients receiving CCK than FM experienced pain reproduction(61% vs 30%, P<0.01).CONCLUSIONS: Stimulation of gallbladder contractility with a FM during HIDA is less than half as likely to reproduce biliary symptoms compared to CCK, despite similar ejection fractions and other parameters. It is essential that providers account for this difference when counseling patients regarding cholecystectomy for functional gallbladder disorder. | Naeem Goussous Hadia Maqsood Ethan Spiegler Gopal C Kowdley Steven C Cunningham | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，2： | 5 |
| 13 | Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial显示文摘 | Hansjochen Wilke Kei Muro Eric Van Cutsem Sang-Cheul Oh Gy?rgy Bodoky Yasuhiro Shimada Shuichi Hironaka Naotoshi Sugimoto Oleg Lipatov Tae-You Kim David Cunningham Philippe Rougier Yoshito Komatsu Jaffer Ajani Michael Emig Roberto Carlesi David Ferry Kuma | 2014 | Lancet Oncology2014，，11： | 4 |
| 14 | Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial显示文摘 | JY Douillard D Cunningham AD Roth M Navarro RD James P Karasek P Jandik T Iveson J Carmichael M Alakl G Gruia L Awad P Rougier | 2000 | The Lancet2000，，9209： | 4 |
| 15 | Localized CO_2 laser bonding process for MEMS packaging显示文摘The packaging poses a critical challenge for commercialization of MEMS products. Major problems with the packaging process include degraded reliability caused by the excess stress due to thermal mismatch and altered performance of the MEMS device after packaging caused by thermal exposure. The localized laser bonding technique for ceramic MEMS packaging to address above-mentioned challenges was investigated. A continuous wave CO2 laser was used to locally heat sealing material for ceramic MEMS package lid to substrate bonding. To determine the laser power density and scanning speed, finite element analysis thermal models were constructed to simulate the localized laser bonding process. Further, the effect of external pressure at sealing ring on the bonding formation was studied. Pull testing results show that the scanning speed and external pressure have significant influence on the pull strength at the bonding interface. Cross-sectional microscopy of the bonding interface indicates that the packages bonded with relatively low scanning speed and external pressure conditions have higher bonding quality. This research demonstrates the potential of localized laser bonding process for ceramic MEMS packaging. | SUN Li A. P. MALSHE S. CUNNINGHAM A. MORRIS | 2006 | 中国有色金属学会会刊:英文版2006，16，B02： | 4 |
| 16 | Urogenital schistosomiasis and soiltransmitted helminthiasis(STH)in Cameroon:An epidemiological update at Barombi Mbo and Barombi Kotto crater lakes assessing prospects for intensified control interventions显示文摘Background:The crater lakes of Barombi Mbo and Barombi Kotto are well-known transmission foci of schistosomiasis and soil-transmitted helminthiasis having had several important control initiatives previously.To collect contemporary epidemiological information,a cross-sectional survey was undertaken inclusive of:signs and symptoms of disease,individual treatment histories,local water,sanitation and hygiene(WASH)-related factors and malacological surveillance,with molecular characterisation of specimens.Methods:At each lake,a community cross-sectional survey was undertaken using a combination of stool and urine parasitological sampling,and interview with pro-forma questionnaires.A total of 338 children and adults participated.Material from snail and parasite species were characterised by DNA methods.Results:Egg-patent prevalence of urogenital schistosomiasis was 8.7%at Barombi Mbo(all light-intensity infections)and 40.1%at Barombi Kotto(21.2%heavy-intensity infections).Intestinal schistosomiasis was absent.At Barombi Kotto,significantly more women reported signs and symptoms associated with female genital schistosomiasis.While there had been extensive recent improvement in WASH-related infrastructure at Barombi Mbo,water contact risk scores were higher among schistosomiasis-infected participants(P<0.001)and at Barombi Kotto in general(P<0.001).Across both lakes,mean prevalence of STH was very low(6.3%)evidencing an impressive decrease of 79.0%over the last decade;neither Strongyloides stercoralis nor Ascaris lumbricoides were found.A total of 29 freshwater sampling sites were inspected for snails,13 in Barombi Mbo and 16 in Barombi Kotto;water chemistry differed significantly(P<0.0001)between lakes for both mean pH(7.9 v.9.6)and mean conductivity(64.3μS v.202.1μS)respectively.Only two Bulinus camerunensis found on the central island of Barombi Kotto were observed to shed schistosome cercariae,but schistosome DNA was later detected in Bulinus sampled from both lakes as well as in Indoplanorbis exustus,an invasive species from Asia.Conclusions:STH is currently at very low levels while urogenital schistosomiasis is of greatest concern at Barombi Kotto.This assessment highlights a unique opportunity for further study of the epidemiological dynamics at these crater lakes,to evaluate future intensified interventions both in terms of gaining and sustaining control at Barombi Kotto or in moving towards local interruption of transmission of both diseases at Barombi Mbo. | Suzy J.Campbell J.Russell Stothard Faye O’Halloran Deborah Sankey Timothy Durant Dieudonne Eloundou Ombede Gwladys Djomkam Chuinteu Bonnie LWebster Lucas Cunningham EJames LaCourse Louis-Albert Tchuem-Tchuente | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 17 | Four models of the creative industries显示文摘 | Jason Potts Stuart Cunningham | 2008 | International Journal of Cultural Policy2008，，3： | 4 |
| 18 | 指南儿童毛细支气管炎:NICE指南概要显示文摘本文是英国医学杂志发布的基于现有最佳证据得出的系列新指南概要之一。它们重点对临床实践提供重要建议,尤其是尚无定论或存有争议的领域。 | Valentina Ricci research fellow Vanessa Delgado Nunes senior research fellow and guideline lead M Stephen Murphy clinical director for children's guidelines Steve Cunningham consultant and honorary reader in paediatric respiratory medicine 许菲 梁志欣 | 2015 | 英国医学杂志中文版2015，0，12： | 4 |
| 19 | Cetuximab monotherapy and cetuximab plus irinotecan in irinotecanrefractory metastatic colorectal cancer显示文摘 | Cunningham D Humblet Y Siena S | | New England Journal of Medicine0，，： | 3 |
| 20 | 成人直肠脱垂、直肠内套叠、直肠前膨出及阴道肠疝的评估与处理显示文摘直肠脱垂是指直肠全层肠壁突出于肛缘。直肠内脱垂或称直肠内套叠的定义为直肠全层肠壁脱垂但并没有突出于肛门外。直肠脱垂和内套叠常常与直肠前膨出(直肠阴道隔向前方疝人阴道)和阴道肠疝(直肠阴道腹膜形成深疝)同时存在。总地来说,这些问题常统称作“盆底功能障碍”。本综述的重点是后盆腔,即直肠,上述疾病均绕其发生。 | Oliver M Jones Christopher Cunningham Ian Lindsey 苏万春(译) 陈雷(校) | 2011 | 英国医学杂志中文版2011，14，3： | 3 |
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