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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Refined chronology of prehistoric cultures and its implication for re-evaluating human-environment relations in the Hexi Corridor,northwest China显示文摘The reconstruction of high-resolution chronologies for prehistoric cultures is a prerequisite for understanding the history of human evolution and its relationship with environmental change, and is valuable for exploring the trajectory of transcontinental cultural exchanges in prehistoric time. The Hexi Corridor of northwest China was one of the earliest centers for long-distance culture exchange in the prehistoric world. The timing and sequence of cultural changes in this area remains poorly understood resulting from the lack of radiometric age control. This paper presents a refined radiocarbon(14 C) chronology to resolve the timing of human occupation and cultural evolution in the Hexi Corridor. Radiocarbon dating of crop remains, which have an annual life cycle, has the advantage of eliminating problems such as the carbon stored in ‘old wood’. As a result,14C dates from crop remains are used to test the validity of the14C dates derived from charcoal, bone and plant remains. The resultant database of ages is modelled using the Bayesian approach. The updated chronology presented in this paper shows generally good agreement with the original dates used to constrain cultural evolution in the Hexi Corridor. However, the occupation of the corridor by the Shajing and Shanma Late Bronze Age-Early Iron Age cultures appears to have taken place ~300 years later than previously thought. On the basis of comparing this updated chronology of cultural evolution with palaeoclimatic and historical records, it is proposed that the collapse of the Shajing and Shanma cultures occurred as a result of geopolitical impact rather than climate change. | Yishi YANG Shanjia ZHANG Chris OLDKNOW Menghan QIU Tingting CHEN Haiming LI Yifu CUI Lele REN Guoke CHEN Hui WANG Guanghui DONG | 2019 | Science China Earth Sciences2019，62，10： | 5 |
| 3 | Spatiotemporal evolution of prehistoric Neolithic-Bronze Age settlements and influencing factors in the Guanting Basin, northeast Tibetan Plateau显示文摘For almost two decades, the relationship between prehistoric natural disasters that struck the Guanting Basin in northeast Tibetan Plateau and the destruction of Lajia, an archeological site, has attracted scholarly attention and been widely discussed. Whereas most studies have focused on the impacts of disasters on a single site within the Guanting Basin, few have examined patterns of spatiotemporal evolution of human settlements from the Neolithic to the Bronze Age. Consequently, there is a lack of clarity on the processes and mechanisms underlying the evolution of prehistoric human-land relationships in the Guanting Basin. We therefore examined spatiotemporal variations in settlements in the Guanting Basin during the period, based on the locations, altitudes, and areas of archaeological sites. We found that four sites were located on the third terrace of the Yellow River during the late Yangshao period(5500–5000 cal yr BP) and distributed within a small area. During the period between the Majiayao and Qijia cultures(5300–3600 cal yr BP), the number of sites evidently increased and the scale and distribution of settlements expanded, with settlements generally shifting toward the lower elevation areas of the Guanting Basin.During the Xindian period(3400–2700 cal yr BP), the number and scale of sites showed a downward trend and the distribution of settlements contracted. The Xindian settlement underwent altitude-based spatial differentiation, with some groups moving to areas at higher altitudes and others remained in lower altitude areas. Moreover, we found that the number, scale, and distribution range of Neolithic and Bronze Age sites in the Guanting Basin were closely related to the evolution and distribution patterns of prehistoric cultures in the regions of Gansu and Qinghai, which were further affected by climate change and agricultural development. Furthermore, there is no evidence that the altitudinal distribution pattern of Neolithic and Bronze Age settlements in the Guanting Basin was influenced by paleofloods rather it was primarily influenced by changes in subsistence strategies. | CUI YiFu LIU YuJia MA MinMin | 2018 | Science China Earth Sciences2018，61，2： | 5 |
| 4 | The Integration of Farmers and Nomads: Archaeological Evidence for the Human Subsistence Strategy in Northwestern China during the Han Dynasty显示文摘The integration of farmers and nomads in northwestern China during the Han Dynasty(206 BCE ~ 220 CE) provides a crucial opportunity to reconstruct the material exchanges, formation and development of the Silk Road in antiquity. The subsistence strategy is arguably an effective proxy for the integration of various groups of people(e.g. farmers and nomads). In this paper, we have reported new stable isotope data from the Huangwan tombs dated to the Han dynasty in middle Gansu, which was the key juncture between the Han and Xiongnu empire, in order to fill the gap and further understand the substance strategies employed by the local people. According to the results of plant remains and stable isotopic data, millet farming, the typical agricultural activities for the Han Chinese in the Central Plains, was also the primary lifestyle for the Huangwan people in the mid Gansu. More importantly, this shows fundamentally remarkable difference from the agricultural practices in the Bronze Age Gansu Corridor, which were based on a variety of crops, including wheat, barley and millet. This major shift in the subsistence production at Huangwan can be correlated to a wider historical background in which the Han empire showed increasing political and military presence in the Gansu Corridor, indicating that local indigenous nomads followed the lifestyle of Han Chinese(e.g., millet farming), and/or the Han immigrates maintained millet farming. | LI Xin LU Minxia CUI Yifu LIU Ruiliang MA Minmin | 2020 | Acta Geologica Sinica(English Edition)2020，94，3： | 1 |
| 5 | Spatiotemporal variation of agricultural patterns in different geomorphologic and climatic environments in the eastern Loess Plateau,north-central China during the late Neolithic and Bronze Ages显示文摘Human settlement and agricultural development are closely linked to local geomorphological and climatic environments.However,the variation in agricultural systems in different environmental and prehistoric contexts remains unknown.We report new archaeobotanical and radiocarbon dates from 34 Neolithic and Bronze Age sites in the Hutuo River Valley(HTRV)in north-central China and compare them with updated archaeobotanical studies in the Sushui River Valley(SSRV)and Henan Province(HNP),to explore the similarities and differences of agricultural patterns under different geomorphologic and climatic environments in north-central China.Our results reveal that humans consistently cultivated foxtail and broomcorn millet in the HTRV from the Miaodigou(6000–5700 cal.a BP)to the Shang-Zhou(3600–2256 cal.a BP)period,despite the introduction of wheat and barley into the area around 4000 a BP.Climate conditions and hilly landforms in the HTRV,SSRV and some parts of the HNP led people to develop foxtail and broomcorn millet dry land farming practices between 7000 and 3000 a BP.Alternatively,in other areas of the HNP,the climate conditions and alluvial plains enabled people to develop a mixed agriculture of millets,soybeans,and rice from 7000 to 4000 a BP,with the addition of wheat between 4000 and 3000 a BP.Farmers’different agricultural technologies and interactions with foreign cultures may have also influenced the formation of different agricultural patterns in the three regions between 7000 and 3000 a BP.Population growth during 7000–3000 a BP can explain the overall propensity of the higher-yield foxtail millet rather than broomcorn millet as the main cultivated crop.In the HTRV,however,higher proportions of broomcorn millet(as compared to the SSRV and HNP),may reflect the greater drought and heat tolerance of broomcorn millet,representing an adaptive agricultural strategy in the river valley. | Haiming LI Yifu CUI Nathaniel JAMES Melissa RITCHEY Fengwen LIU Junna ZHANG Minmin MA Guanghui DONG | 2022 | Science China Earth Sciences2022，65，5： | 0 |
| 6 | In situ confined vertical growth of Co_(2.5)Ni_(0.5)Si_(2)O_(5)(OH)_(4)nanoarrays on rGO for an efficient oxygen evolution reaction显示文摘Rational design of oxygen evolution reaction(OER)catalysts at low cost would greatly benefit the economy.Taking advantage of earth-abundant elements Si,Co and Ni,we produce a unique-structure where cobalt-nickel silicate hydroxide[Co_(2.5)Ni_(0.5)Si_(2)O_(5)(OH)_(4)]is vertically grown on a reduced graphene oxide(rGO)support(CNS@rGO).This is developed as a low-cost and prospective OER catalyst.Compared to cobalt or nickel silicate hydroxide@rGO(CS@rGO and NS@rGO,respectively)nanoarrays,the bimetal CNS@rGO nanoarray exhibits impressive OER performance with an overpotential of 307 mV@10 mA cm^(-2).This value is higher than that of CS@rGO and NS@rGO.The CNS@rGO nanoarray has an overpotential of 446 mV@100 mA cm^(-2),about 1.4 times that of the commercial RuO_(2)electrocatalyst.The achieved OER activity is superior to the state-of-the-art metal oxides/hydroxides and their derivatives.The vertically grown nanostructure and optimized metal-support electronic interactions play an indispensable role for OER performance improvement,including a fast electron transfer pathway,short proton/electron diffusion distance,more active metal centers,as well as optimized dualatomic electron density.Taking advantage of interlay chemical regulation and the in-situ growth method,the advanced-structural CNS@rGO nanoarrays provide a new horizon to the rational and flexible design of efficient and promising OER electrocatalysts. | Yang Mu Xiaoyu Pei Yunfeng Zhao Xueying Dong Zongkui Kou Miao Cui Changgong Meng Yifu Zhang | 2023 | Nano Materials Science2023，5，4： | 0 |
| 7 | Flexible quasi-solid-state zinc-ion hybrid supercapacitor based on carbon cloths displays ultrahigh areal capacitance显示文摘Over the past few years,the flexible quasi-solid-state zinc-ion hybrid supercapacitors(FQSS ZHSCs)have been found to be ideal for wearable electronics applications due to their high areal capacitance and energy density.The assembly of desirable ZHSCs devices that have promising practical applications is of high importance,whereas it is still challenging to assemble ZHSCs devices.In this study,a ZHSC that exhibited ultrahigh areal capacitance and high stability was developed by using an active carbon cloth(ACC)cathode,which could improve ionic adsorption.The as-obtained ACC cathode had an energy storage mechanism due to the electrical double-layer capacitive behavior of Zn^(2+),which was accompanied by the dissolution/deposition of Zn_(4)SO_(4)(OH)6·5H2O.The ACC//Zn@ACC ZHSC device exhibited an areal capacitance of 2437 mF cm^(−2)(81 F cm^(−3),203 F g^(-1) under the mass of ACC with∼12 mg cm^(−2))at 1 mA cm^(−2),an areal energy density of 1.354 mWh cm^(−2) at 1 mW cm^(−2),as well as high stability(with an insignificant capacitance decline after 20000 cycles),which was demonstrated to outperform the existing ZHSCs.Furthermore,the assembled flexible device still had competitive capacitance,energy density and service life when integrated into a FQSS ZHSC.When applied in practice,the device could achieve high mechanical flexibility,wearable stability and output.This study can inspire the development of the FQSS ZHSC device to satisfy the demands for wearable energy storage devices with high performance. | Yifu Zhang Peng Wang Xueying Dong Hanmei Jiang Miao Cui | 2023 | Fundamental Research2023，3，2： | 0 |
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