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| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | TOOTH CONTACT ANALYSIS OF CONICAL INVOLUTE GEARS显示文摘圆锥形的复杂齿轮的数学模型基于传动和产生机制的理论被开发。牙齿接触分析(TCA ) 被执行用交叉并且交叉的轴检验圆锥形的复杂齿轮对的协调并且适用的接触。另外,齿轮表面的主要方向和弯曲被调查,交配牙齿表面的接触椭圆也被学习。最后,数字解说性的例子被提供表明计算结果,测试齿轮被成为忍受 fortooth 测试,并且结论被验证理论有适用性。 | HE Jingliang WU Xutang CUI Yahui NIE Gang | 2006 | Chinese Journal of Mechanical Engineering2006，19，1： | 6 |
| 3 | Targeting fatty acid synthase sensitizes human nasopharyngeal carcinoma cells to radiationvia downregulating frizzled class receptor 10显示文摘Objective:Our aim was to test the hypothesis that fatty acid synthase(FASN)expression contributes to radioresistance of nasopharyngeal carcinoma(NPC)cells and that inhibiting FASN enhances radiosensitivity.Methods:Targeting FASN using epigallocatechin gallate(EGCG)or RNA interference in NPC cell lines that overexpress endogenous FASN was performed to determine their effects on cellular response to radiationin vitro using MTT and colony formation assays,andin vivo using xenograft animal models.Western blot,immunohistochemistry,real-time PCR arrays,and real-time RT-PCR were used to determine the relationship between FASN and frizzled class receptor 10(FZD10)expression.FZD10 knockdown and overexpression were used to determine its role in mediating FASN function in cellular response to radiation.Immunohistochemical staining was used to determine FASN and FZD10 expressions in human NPC tissues,followed by analysis of their association with the overall survival of patients.Results:FASN knockdown or inhibition significantly enhanced radiosensitivity of NPC cells,bothin vitro andin vivo.There was a positive association between FASN and FZD10 expression in NPC cell lines grown as monolayers or xenografts,as well as human tissues.FASN knockdown reduced FZD10 expression,and rescue of FZD10 expression abolished FASN knockdown-induced enhancement of radiosensitivity.FASN and FZD10 were both negatively associated with overall survival of NPC patients.Conclusions:FASN contributes to radioresistance,possiblyvia FZD10 in NPC cells.Both FZD10 and FASN expressions were associated with poor outcomes of NPC patients.EGCG may sensitize radioresistance by inhibiting FASN and may possibly be developed as a radiosensitizer for better treatment of NPCs. | Jiongyu Chen Fan Zhang Xiaosha Ren Yahui Wang Wenhe Huang Jianting Zhang Yukun Cui | 2020 | Cancer Biology & Medicine2020，17，3： | 3 |
| 4 | Maillard Products Formed from Chicken Fat Oxidants and Amino Acids Act as a Flavor Enhancer in Comminuted Chicken Products显示文摘 | Lingling Liu Boyan Liu Yahui Cui Yanwen Wu Jie Ouyang | 2013 | Journal of Food Science and Engineering2013，3，3： | 2 |
| 5 | Effect of Plasticizer Poly(Ethylene Glycol)on the Crystallization Properties of Stereocomplex-Type Poly(Lactide Acid)显示文摘The effects of the plasticizer poly(ethylene glycol)(PEG) on crystallization properties of equimolar poly(L-lactide)(PLLA)/poly(D-lactide)(PDLA) blends were investigated. Formation of the stereocomplex-type poly(lactide acid)(sc-PLA) crystallites was confirmed by Wide-angle X-ray diffraction(WAXD) and differential scanning calorimetry(DSC) analyses. Sc-PLA crystallites without any homochiral poly(lactide acid)(hc-PLA) formed, as the result of the incorporation of the plasticizer PEG(more than or equal to 10%(wt)) at a processing temperature(240 ℃). Moreover, when the MW of PEG reached 1 000 g × mol–1, the crystallizability of stereocomplex crystallites was the best. Isothermal crystallization kinetics further revealed that PEG could accelerate the crystallization rate of sc-PLA, with the optimum crystallization kinetic parameters being obtained at 10%(wt) PEG. Several crystallization kinetics equations were applied to describe the effect of PEG on the crystallization behavior of sc-PLA. The influence of PEG on the spherocrystal morphologies of sc-PLA was also investigated using polarized optical microscopy. | CUI Li ZHANG Rundong WANG Yahui ZHANG Chuanjie GUO Yi | 2017 | Wuhan University Journal of Natural Sciences2017，22，5： | 2 |
| 6 | Effects of sand-bentonite backfill materials on the thermal performance of borehole heat exchangers 显示文摘 | Wang Huajun Cui Yahui Qi Chengying | 2013 | Heat Transfer Engineering2013，34，1： | 1 |
| 7 | Notch3 functions as a tumor suppressor by controlling cellular senescence显示文摘 | Hang Cui Yahui Kong Mei Xu | 2013 | Cancer Res2013，73，11： | 1 |
| 8 | Polymer-bubbling for one-step synthesis of three-dimensional cobalt/carbon foams against electromagnetic pollution显示文摘Constructing three-dimensional(3D)foam-like structure in magnetic metal/carbon composites is regarded as a promising pathway to reinforce their electromagnetic(EM)functions.Herein,a nitrateassisted polymer-bubbling strategy is reported for the synthesis of Co/carbon foams,which is simply accomplished by direct pyrolyzing the mixture of polyvinylpyrrolidone(PVP)and cobalt nitrate hexahydrate(Co(NO_(3))_(2)·6 H_(2) O).Co(NO_(3))_(2)·6H_(2)O not only plays as the source of Co nanoparticles,but also accounts for the formation of 3D microstructure through releasing gas.By manipulating the weight ratio of Co(NO_(3))_(2)·6H_(2)O to PVP,the chemical composition,microstructure,and EM properties of these composites can be easily regulated.When the weight ratio reaches 1.5,the resultant composite displays good microwave absorption performance,whose reflection loss intensity and effective absorption bandwidth are superior to those of many common Co/C composites.EM analysis reveals that such architecture is greatly helpful to establish cross-linked conductive networks in the wax matrix,resulting in powerful dielectric loss under low absorber loading.Meanwhile,3D microstructure is also beneficial for multiple reflections that equal to extend the transmission path of incident EM waves.Simple synthesis strategy and desirable properties of these magnetic carbon foams may render them as the low-cost substitute of 3D graphene for the application against EM pollution. | Fengyuan Wang Ping Xu Ning Shi Liru Cui Yahui Wang Dawei Liu Honghong Zhao Xijiang Han Yunchen Du | 2021 | Journal of Materials Science & Technology2021，，34： | 1 |
| 9 | Anti-corrosion and electrically conductive inorganic conversion coatings based on aligned graphene derivatives by electrodeposition显示文摘Ultrathin conversion coatings, made from aligned graphene derivatives and ammonium zirconium carbonate(AZC), were fabricated on stainless steel by electrodeposition. Sulfonated graphene oxide (SGO) provided electronpathways and physical barriers to corrosive molecules. Electrodeposition ensured the alignment of SGO and thefacile fabrication of the coatings. AZC is an environmental-friendly crosslinking agent, water-repellent andcorrosion inhibitor. Upon dehydration reactions, AZC improved the cohesion between SGO layers and anchoredthe conversion coatings on metal substrates. When the mass ratio of SGO to AZC was 2:1, the corrosion currentdensity of the composite coatings reached 0.098 μA cm^(-2), while that of the bared stainless steel was1.04 μA cm ^(-2), given a coating thickness of only 500 nm. The electrical conductivity of SGO/AZC compositecoatings can be tailored from 3.84 × 10^(-5) to 2.28×10^(-3)S‧cm^(-1) by heat treatment and HI reduction, whichsatisfied the electrical conductivity requirement of wide applications in electronic industry, office appliances andpetroleum storage. | Wenxiang Fei Jincan Cui Yahui Sun Junhe Yang Shanglin Gao Jing Li | 2022 | Nano Materials Science2022，4，3： | 1 |
| 10 | Stochastic speed prediction for connected vehicles using improved bayesian networks with back propagation显示文摘Advanced vehicular control technologies rely on accurate speed prediction to make ecological and safe decisions. This paper proposes a novel stochastic speed prediction method for connected vehicles by incorporating a Bayesian network(BN) and a Back Propagation(BP) neural network. A BN model is first designed for predicting the stochastic vehicular speed in a priori. To improve the accuracy of the BN-based speed prediction, a BP-based predicted speed error compensation module is constructed by formulating a mapping between the predicted speed and its corresponding prediction error. In the end, a filtering algorithm is developed to smoothen the compensated stochastic vehicular speed. To validate the workings of the proposed approaches in experiments, two typical scenarios are considered: one predecessor vehicle in a double-vehicle scenario and two predecessor vehicles in a multi-vehicle scenario. Simulation results under the considered scenarios demonstrate that the proposed BN-BP fusion method outperforms the BN-based method with respect to the root mean square error, standardized residuals, and R-squared, and the online prediction time of proposed fusion prediction can satisfy a real-time application requirement. The main highlighted contributions of this article are threefold:(1) We put forward an improved BN method, which is combined with a BP neural network, to construct a stochastic vehicular speed prediction method under connected driving;(2) different from existing methods, a unique interconnected framework that consists of a stochastic vehicular speed prediction module, a compensation module, and a speed smoothing module is proposed;(3) extensive simulation studies based on a set of evaluation metrics are illustrated to reveal the advantages and merits of the proposed approaches. | WANG LiHua CUI YaHui ZHANG FengQi COSKUN Serdar LIU KaiLong LI GuangLei | 2022 | Science China(Technological Sciences)2022，65，7： | 1 |
| 11 | Highly efficient solution-processed organic photovoltaics enabled by improving packing behavior of organic semiconductors显示文摘Solution processability is a unique property of organic semiconductors. The compact and regular π-π stacking between molecules is paramount in the performance of organic optoelectronic devices. However, it is still a challenge to improve their stacking quality without sacrificing the solution-processability from the aspect of materials design. Here, delicately engineered additives are presented to promote the formation of ordered aggregation of conjugated molecules by regulating their nucleation and growth dynamics. Intriguingly, the long-chain BTP-eC9-4F molecules can realize ordered aggregation comparable to short-chain ones without sacrificing processability. The domain size of BTP-eC9-4F aggregation is enlarged from 24.2 to 32.2 nm in blend films.Thereby exciton diffusion and charge transport become faster, contributing to the suppression of recombination losses. As a result, a power conversion efficiency of 19.2% is achieved in D18:BTP-eC9-4F based organic photovoltaics. Our findings demonstrate a facile strategy to improve the packing quality of solution-processed organic semiconductors for high-efficiency photovoltaics and beyond photovoltaics. | Xinyue Cui Hongxiang Li Hao Lu Yuqiang Liu Guangliu Ran Rui Liu Huarui Zhang Xueqing Ma Dawei Li Yi Lin Jifa Yu Wenkai Zhang Lei Cai Yahui Liu Pei Cheng Andong Zhang Zaifei Ma Guanghao Lu Zhishan Bo | 2024 | Science China Chemistry2024，67，3： | 0 |
| 12 | A post-GWAS replication study confirming the association of C14H8orf33 gene with milk production traits in dairy cattle显示文摘Genome-wide association studies with an Illumina Bovine50K chip have detected 105 SNPs associated with one or multiple milk production traits in the Chinese Holstein population.Of these,38 significant SNPs detected with high confidence by both L1-TDT and MMRA methods were selected to further mine potential key genes affecting milk yield and milk composition.By blasting the flanking sequences of these 38 SNPs with the bovine genome sequence combined with comparative genomics analysis,26 genes were found to contain or be near to such SNPs.Among them,the C14H8orf33 gene is merely 87 bp away from the significant SNP,Hapmap30383-BTC-005848.Hence,we report herein genotype-phenotype associations to further validate the genetic effects of the C14H8orf33 gene.By pooled DNA sequencing of 14 unrelated Holstein sires,a total of 18 with seven novel SNPs were identified.Among them,nine SNPs were in the 5′regulatory region,one in exon 6 and the other in the 3′UTR and 3′regulatory region.A total of nine of these identified SNPs were successfully genotyped and analyzed by mass spectrometry for association with five milk production traits in an independent resource population.The results showed that these SNPs were statistically significant for more than two traits[P<(0.0001–0.0267)].In addition,mRNA expression analyses revealed that C14H8orf33 was ubiquitous in eight different tissues,with a relatively higher expression level in the mammary gland than in other tissues.These findings,therefore,provide strong evidence for association of C14H8orf33 variants with milk yield and milk composition traits and may be applied in Chinese Holstein breeding programs. | Shaohua YANG Chao QI Yan XIE Xiaogang CUI Yahui GAO Jianping JIANG Li JIANG Shengli ZHANG Qin ZHANG Dongxiao SUN | 2014 | Frontiers of Agricultural Science and Engineering2014，1，4： | 0 |
| 13 | Flexible,durable,and anti-fouling nanocellulose-based membrane functionalized by block copolymer with ultra-high flux and efficiency for oil-in-water emulsions separation显示文摘The clearwater obtained from stabilized oily wastewater has become a worldwide challenge.Nowdays,the area of oil/water emulsion separation materials have accomplished great progress,but still faces the enormous problems of low flux,poor stability,and pollution resistance.Nanocelluloses(cellulose nanocrystals(CNC))with the advantages of hydrophilicity,ecofriendliness,and regeneration are ideal materials for the construction of separation membranes.In this paper,a flexible,antifouling,and durable nanocellulose-based membrane functionalized by block copolymer(poly(N-isopropylacrylamide)-b-poly(N,Ndimethylaminoethyl methacrylate))is prepared via chemical modification and self-assembly,showing high separation efficiency(above 99.6%)for stabilized oil-in-water emulsions,excellent anti-fouling and cycling stability,high-temperature resistance,and acid and alkali resistance.More importantly,the composite membrane has ultra-high flux in separating oil-in-water emulsions(29,003 L·m^(−2)·h^(−1)·bar^(−1))and oil/water mixture(51,444 L·m^(−2)·h^(−1)·bar^(−1)),which ensures high separation efficiency.With its durability,easy scale-up,and green regeneration,we envision this biomass-derived membrane will be an alternative to the existing commercial filter membrane in environmental remediation. | Jianfei Wu Yuxuan Su Ziwei Cui Yang Yu Jiafu Qu Jundie Hu Yahui Cai Jianzhang Li Dan Tian Qichun Zhang | 2023 | Nano Research2023，16，4： | 0 |
| 14 | GSZ Formula Enhances Sleep Quality:Exploring Its Active Ingredients and Mechanism Using a Network Medicine Approach显示文摘Background:Sleep is essential for maintaining human health,and insomnia is a widespread problem.Traditional Chinese medicine(TCM)has been used for centuries to treat sleep disorders,with fewer reported side effects compared to conventional treatments.Objective:This study seeks to investigate the sleep-promoting effects of the GSZ formula,which comprisesγ-aminobutyric acid(GABA),Schisandrae Chinensis Fructus(Wuweizi in Chinese),and Ziziphi Spinosae Semen(Suanzaoren in Chinese).In addition,this study aims to explore the active ingredients and potential mechanisms underlying the sleep-enhancing effects of the formula.Methods:The impact of GSZ on sleep was evaluated using two models,the complete sleep model and the sub-threshold sleep model.Mice were randomly divided into five groups and orally administered GSZ solution(0.33 g/kg/day or 0.99 g/kg/day),positive drug diazepam(2.50 mg/kg)or a control solution for 30 days.Hypno-sis model was established in mice using pentobarbital sodium.Sleep duration and incidence were measured by recording when the righting reflex of mice disappeared for more than 1 min.GABA and dopamine(DA)levels in mouse brain tissue were measured using ELISA kits.The ingredients of the GSZ formula were identified using mass spectrometry,and the targets of these ingredients and disease-related genes were retrieved from public databases.A network medicine approach was used to calculate the shortest path between ingredient targets and disease-related proteins.The expression levels of potential proteins,such as Akt,p-Akt,GSK-3β,and p-GSK-3β,were analyzed using Western blotting based on the predicted results.Results:GSZ significantly prolonged sleep duration and enhanced the sleep rate in mice(P<0.05).Furthermore,it elevated GABA levels and reduced DA levels in the mouse brain(P<0.05).Network medicine analysis suggested that GABA,stearic acid,genistin,and coumestrol may be the most crucial active ingredients for sleep improve-ment.Western blotting analysis demonstrated that GSZ modulated the protein expression levels of p-Akt/Akt and p-GSK-3β/GSK-3β(P<0.05).Conclusion:Our study demonstrated that the GSZ formula could improve sleep,with key ingredients likely being GABA,stearic acid,genistin,and coumestrol.The mechanism might involve the regulation of the Akt/GSK-3βpathway,as revealed by the network medicine analysis and experimental validation.Our current new findings shed light on the potential mechanisms underlying the sleep-enhancing effects of the GSZ formula,which could provide experimental evidence to develop innovative treatments for insomnia. | Airong Ren Mingxuan Ma Yongyin Liang Yarong Wang Zhengkun Li Yahui Liu Qing Fan Guozhen Cui | 2024 | Clinical Complementary Medicine and Pharmacology2024，4，1： | 0 |
| 15 | On the Pragmatic Thought of Gabelentz from the Address Words of Chinesische Grammatik显示文摘Chinesische Grammatik is a book about Chinese grammar compiled by Hans Georg von der Gabelentz,in the 19th century.It is also a textbook for teaching Chinese as a second language.Among them,“weft”is a comprehensive system,which contains his pragmatic thought beyond the times.The study of appellations not only shows Hans Georg von der Gabelentz’s pragmatic thought,but also reflects his idea that the cultivation of learners’language ability should be the overall goal in Chinese teaching and the role of culture in cross-cultural communication.And the advanced educational concept of learning to use. | Yahui Cui | 2020 | Review of Educational Theory2020，3，4： | 0 |
| 16 | RPS15 interacted with IGF2BP1 to promote esophageal squamous cell carcinoma development via recognizing m^(6)A modification显示文摘Increased rates of ribosome biogenesis have been recognized as hallmarks of many cancers and are associated with poor prognosis.Using a CRISPR synergistic activation mediator(SAM)system library targeting 89 ribosomal proteins(RPs)to screen for the most oncogenic functional RPs in human esophageal squamous cell carcinoma(ESCC),we found that high expression of RPS15 correlates with malignant phenotype and poor prognosis of ESCC. | Yahui Zhao Yang Li Rui Zhu Riyue Feng Heyang Cui Xiao Yu Furong Huang Ruixiang Zhang Xiankai Chen Lei Li Yinghui Chen Yuhao Liu Jinhua Wang Guanhua Du Zhihua Liu | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 0 |
| 17 | Author Correction:Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prog nosis in esophageal squamous cell carcinoma显示文摘Correction to:Cell Research http://gffzzd3cc09b8251d45dfs5o0uk69kwq666wko.ffgz.tsg.suse.edu.cn/10.1038/s41422-020-0333-6,published online 12 May 2020 In the initial published version of this article,there was an error in the Supplementary information,Table S1.Row 463 and row 80 have the same sample id BDESCC-01-838.After checking the original id of these two samples,we found that they were actually two different samples.This error was caused by Excel random numbering when we assigned the external id to each sample.Thus,we re-assigned a new id BDESCC-01-839 to the row 4P3 sample to fix this issue. | Yongping Cui Hongyan Chen Ruibin Xie Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qi min Zhan Yanhong Li Zhihua Liu | 2022 | Cell Research2022，32，4： | 0 |
| 18 | Dissolution and recrystallization of perovskite induced by N-methyl-2-pyrrolidone in a closed steam annealing method显示文摘High quality perovskite films with large columnar grains are greatly desired for efficient perovskite solar cells. Here, low volatility N-methyl-2-pyrrolidone(NMP) was added in MAI/IPA solution in a two-step spin-coating method, which promoted the conversion of lead iodide to perovskite. The perovskite films were annealed by a closed-steam annealing method to prolong the recrystallization process of perovskite films assisted by the residual NMP. It leaded to high quality CH_3NH_3PbI_3 perovskite films with large columnar grains due to its enhancement of the Oswald ripening. The large grain perovskite film leaded to efficient carrier transformation and injection, and low recombination. The photovoltaic performance of the perovskite solar cells was improved significantly. | Lili Zhi Yanqing Li Xiaobing Cao Yahui Li Xian Cui Lijie Ci Jinquan Wei | 2019 | Journal of Energy Chemistry2019，28，3： | 0 |
| 19 | Characterization and functional analysis of pollen-specific PwSWEET1 in Picea wilsonii显示文摘SWEET transporters play a pivotal role in sugar transport in plants.However,their functions in pollen tube growth,especially in coniferous species remain unknown.Here,we used RT-qPCR to reveal that a SWEET1 gene was specifically expressed in pollen and pollen tubes of Picea wilsonii.A pollen germination assay showed that PwSWEET1 was induced by H3BO3 but not by Ca^2+.In a sugar specificity experiment,sucrose(Suc)and glucose(Glc)were effective sugars for pollen germination and pollen tube growth.PwSWEET1 expression was induced most by Suc and Glc.Heterologous expression of PwSWEET1 in yeast showed that PwSWEET1 can restore the glucose absorption in yeast strain EBY.VW4000,which has a hexose absorption defect,and the absorption of glucose is pH-independent.This evidence supports the involvment of PwSWEET1 in boron-dependent glucose transport in pollen germination and pollen tube growth of Picea wilsonii. | Yanni Zhou Xiaoyue Cui Anni Hu Yahui Miao Lingyun Zhang | 2020 | Journal of Forestry Research2020，31，5： | 0 |
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