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| 1 | A review of UHMWPE wear-induced osteolysis:the role for early detection of the immune response显示文摘In a world where increasing joint arthroplasties are being performed on increasingly younger patients,osteolysis as the leading cause of failure after total joint arthroplasty(TJA) has gained considerable attention.Ultra-high molecular weight polyethylene wear-induced osteolysis is the process by which prosthetic debris mechanically released from the surface of prosthetic joints induces an immune response that favors bone catabolism, resulting in loosening of prostheses with eventual failure or fracture. The immune response initiated is innate in that it is nonspecific and self-propagating, with monocytic cells and osteoclasts being the main effectors. To date, detecting disease early enough to implement effective intervention without unwanted systemic side effects has been a major barrier. These barriers can be overcome using newer in vivo imaging techniques and modules linked with fluorescence and/or chemotherapies. We discuss the pathogenesis of osteolysis, and provide discussion of the challenges with imaging and therapeutics. We describe a positron emission tomography imaging cinnamoyl-Phe-(D)-Leu-Phe-(D)-Leu-Phe-Lys module,specific to macrophages, which holds promise in early detection of disease and localization of treatment.Further research and increased collaboration among therapeutic and three-dimensional imaging researchers are essential in realizing a solution to clinical osteolysis in TJA. | Adrese M Kandahari Xinlin Yang Kevin A Laroche Abhijit S Dighe Dongfeng Pan Quanjun Cui | 2016 | Bone Research2016，4，2： | 7 |
| 2 | Current evidence on potential of adipose derived stem cells to enhance bone regeneration and future projection显示文摘Injuries to the postnatal skeleton are naturally repaired through successive stepsinvolving specific cell types in a process collectively termed “bone regeneration”.Although complex, bone regeneration occurs through a series of well-orchestratedstages wherein endogenous bone stem cells play a central role. In most situations,bone regeneration is successful;however, there are instances when it fails andcreates non-healing injuries or fracture nonunion requiring surgical or therapeuticinterventions. Transplantation of adult or mesenchymal stem cells (MSCs) definedby the International Society for Cell and Gene Therapy (ISCT) as CD105+-CD90+CD73+CD45-CD34-CD14orCD11b-CD79αorCD19-HLA-DR- is beinginvestigated as an attractive therapy for bone regeneration throughout the world.MSCs isolated from adipose tissue, adipose-derived stem cells (ADSCs), aregaining increasing attention since this is the most abundant source of adult stemcells and the isolation process for ADSCs is straightforward. Currently, there isnot a single Food and Drug Administration (FDA) approved ADSCs product forbone regeneration. Although the safety of ADSCs is established from their usagein numerous clinical trials, the bone-forming potential of ADSCs and MSCs, ingeneral, is highly controversial. Growing evidence suggests that the ISCT definedphenotype may not represent bona fide osteoprogenitors. Transplantation of bothADSCs and the CD105- sub-population of ADSCs has been reported to induce bone regeneration. Most notably, cells expressing other markers such as CD146,AlphaV, CD200, PDPN, CD164, CXCR4, and PDGFRα have been shown torepresent osteogenic sub-population within ADSCs. Amongst other strategies toimprove the bone-forming ability of ADSCs, modulation of VEGF, TGF-β1 andBMP signaling pathways of ADSCs has shown promising results. The U.S. FDAreveals that 73% of Investigational New Drug applications for stem cell-basedproducts rely on CD105 expression as the “positive” marker for adult stem cells.A concerted effort involving the scientific community, clinicians, industries, andregulatory bodies to redefine ADSCs using powerful selection markers andstrategies to modulate signaling pathways of ADSCs will speed up thetherapeutic use of ADSCs for bone regeneration. | Quang Le Vedavathi Madhu Joseph M Hart Charles R Farber Eli R Zunder Abhijit S Dighe Quanjun Cui | 2021 | World Journal of Stem Cells2021，13，9： | 2 |
| 3 | Cause-related marketing How generation Y responds 显示文摘 | Cui Yanli Trent Elizabeth S Sullivan Pauline M Matiru Grace N | 2003 | International Journal of Retail & Distribution Management2003，31，67： | 1 |
| 4 | Effect of a feeding stimulant on feeding adaptation of gibel carp Carassius auratus gibelio (Bloch),fed diets with replacement of fish meal by meat and bone meal显示文摘 | Xue M Xie S Q Cui Y B | 2004 | Aquaculture Research2004，35，： | 1 |
| 5 | Highly polarized photoluminescence and photodetection from single indium phosphide nanowires 显示文摘 | Wang J F Gudiksen M S Duan X F Cui Y Lieberet H M | 2001 | Science2001，293，5534： | 1 |
| 6 | Towards Efficient Design and Implementation of a Hadoop-based Distributed Video Transcoding System in Cloud Computing Environment显示文摘 | KIM M CUI Y HAN S | 2013 | International Journal of Multimedia and Ubiquitous Engi- neering2013，8，2： | 1 |
| 7 | Elevated expression of CAPON and neuronal nitric oxide synthase in the sciatic nerve of rats following constriction injury显示文摘 | Cui Z M Lü Q S Yan M J | 2011 | Veterinary J2011，187，： | 1 |
| 8 | The cytotoxic activity of ursolic acid derivatives 显示文摘 | Ma C M Cai S Q Cui J R | 2005 | Eur J Med Chem2005，40，： | 1 |
| 9 | Some properties and morphology ofpoly ( 2-vinyl pyridine ) -g-pnlyoxyethylene 显示文摘 | Xie H Q Cui M H Guo J S | 1997 | Eur Polym J1997，33，9： | 1 |
| 10 | Fabricalion and interfacial modification of woodrecycled plastic composite materlals显示文摘 | Cui Y H Lee S Noruziaan B Cheung M Tao J | 2008 | Composites: Part A2008，，39： | 1 |
| 11 | Effect of a feeding stim- ulant on feeding adaptation of gibel carp Carassius au- ratus gibelio ( Bloch), fed diets with replacement of fish meal by meat and bone meal显示文摘 | XUE M XIE S Q CUI Y B | 2004 | Aquaculture Re- search2004，35，5： | 1 |
| 12 | An Arabidopsis R2R3-MYB transcription factor, AtMYB20, negatively regulates type 2C ser- ine/threonine protein phosphatases to enhance salt tolerance显示文摘 | Cui M H Kyoung S Y Hyoung S J | 2013 | Febs Letters2013，587，12： | 1 |
| 13 | Pyrometallurgical separa-tion of boron from iron in ludwigite ore显示文摘 | Liu S L Cui C M Zhang X P | | 0，，10： | 1 |
| 14 | Structure and properties of multi-walled carbon nanotubes/ polyethylene nanocomposites synthesized by in situ polymerization with supported Cp2ZrC12 catalyst 显示文摘 | LI S Y CHEN H CUI D M | 2010 | Polymer Composites2010，31，3： | 1 |
| 15 | Inhibitory effect of icariin on Ti-induced inflammatory osteoclastogenesis 显示文摘 | Cui J Zhu M Zhu S | 2014 | J Surg Res2014，192，2： | 1 |
| 16 | Light management for photovoltaics using high-index nanostructures显示文摘 | Brongersma M L Cui Y Fan S | 2014 | Nature Materials2014，13，： | 1 |
| 17 | Producing more grain with lower environmental costs 显示文摘 | Chen X P Cui Z L Fan M S | 2014 | Nature2014，514，7523： | 1 |
| 18 | Design and simulation of a self-excited all-air-core and fabrication of a separate excited all-iron-core passive compulsator显示文摘 | Cui S M Wu S P Cheng S K | 2009 | IEEE Transactions on Magnetics2009，45，1： | 1 |
| 19 | 显示文摘 | Cui S Liu Y Fan M H | 2011 | Mater Lett2011，65，4： | 1 |
| 20 | Influence of ultra- sonic vibration on the mesoporosity and surface fractal di- mensions of resultant silica xerogels显示文摘 | Huang W L Liang K M Cui S H | 2001 | Mater Res Bull2001，36，34： | 1 |
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