|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4显示文摘最近的尖铁 glycoprotein (S) 鉴别中东呼吸症候群 coronavirus (MERS-CoV ) 指向细胞的受体, dipeptidyl peptidase 4 (DPP4 ) 。顺序比较和当模特儿的分析在病毒的尖铁上揭示了一个通常认为的受体绑定领域(RBD ) ,它调停这个相互作用。我们报导 3.0 Å MERS-CoV RBD 的决定水晶结构跳了到人的 DPP4 的细胞外的领域。我们的结果证明 MERS-CoV RBD 由一个核心和受体绑定子域组成。受体绑定子域与 DPP4 β 交往;推进器然而并非它的内在的 hydrolase 领域。MERS-CoV RBD 和相关 SARS-CoV RBD 分享他们的核心子域的结构的类似的高度,但是在受体绑定子域是尤其是分叉的。Mutagenesis 研究在为到 DPP4 和入口的病毒的绑定是批评的进目标房间的受体绑定子域识别了几关键残余。在在 MERS-CoV RBD 和 DPP4 之间的接口的原子细节提供病毒和受体相互作用的结构的理解,它能对 MERS-CoV 感染指导治疗学和疫苗的开发。 | Nianshuang Wang Xuanling Shi Liwei Jiang Senyan Zhang Dongli Wang Pei Tong Dongxing Guo Lili Fu Ye Cui Xi Liu Kelly C Arledge Ying-Hua Chen Linqi Zhang Xinquan Wang | 2013 | Cell Research2013，23，8： | 26 |
| 2 | In vitro differentiation of rat embryonic stem cells into functional cardiomyocytes显示文摘在老鼠的产生的最近的突破胚胎的干细胞(rESCs ) 打开门到基因指向为人的疾病的学习创造模型的申请。另外,在里面从进三细菌层的衍生物的 rESCs 的 vitro 区别系统将为哺乳动物的开发,房间函数,织物修理,和药发现的调查用作一个强大的工具和资源。然而,这些使用被困难限制了在 vitro 区别。这研究的目的是建立一在里面从 rESCs 并且到的 vitro 区别系统调查 rESCs 是否能够形成区分终端的 cardiomyocytes。用最新确定的 rESCs,我们发现那胚胎植物或动物身体(EB ) 基于在没能为没有浆液的栽培 rESCs 工作的老鼠转换字符(mESC ) 区别使用的方法。我们然后由三个化学禁止者和喂调节媒介的联合开发了一个协议。在这个条件下面, rESCs 变成了 EB,宣传并且区分三胚胎的细菌层。而且,形成 rESC 的 EB 能区分进自发地在 plating 以后打败 cardiomyocytes。分子、结构、功能的性质的分析表明导出 rESC 的 cardiomyocytes 类似于从胎儿的老鼠心和 mESCs 导出的那些。在结论,我们成功地发展了一在里面为功能的 myocytes 通过被产生并且显示老鼠的显型的 rESCs 的 vitro 区别系统胎儿的 cardiomyocytes。这个唯一的细胞的系统将提供一条新途径学习早开发和心脏的功能,并且在测试的药理学和房间治疗用作一个重要工具。 | Nan Cao Jing Liao Zumei Liu Wenmin Zhu Jia Wang Lijun Liu Lili Yu Ping Xu Chun Cui Lei Xiao Huang-Tian Yang | 2011 | Cell Research2011，21，9： | 13 |
| 3 | Novel Water-Based Drilling and Completion Fluid Technology to Improve Wellbore Quality During Drilling and Protect Unconventional Reservoirs显示文摘The efficient exploration and development of unconventional oil and gas are critical for increasing the self-sufficiency of oil and gas supplies in China.However,such operations continue to face serious problems(e.g.,borehole collapse,loss,and high friction),and associated formation damage can severely impact well completion rates,increase costs,and reduce efficiencies.Water-based drilling fluids possess certain advantages over oil-based drilling fluids(OBDFs)and may offer lasting solutions to resolve the aforementioned issues.However,a significant breakthrough with this material has not yet been made,and major technical problems continue to hinder the economic and large-scale development of unconventional oil and gas.Here,the international frontier external method,which only improves drilling fluid inhibition and lubricity,is expanded into an internal-external technique that improves the overall wellbore quality during drilling.Bionic technologies are introduced into the chemical material synthesis process to imitate the activity of life.A novel drilling and completion fluid technique was developed to improve wellbore quality during drilling and safeguard formation integrity.Macroscopic and microscopic analyses indicated that in terms of wellbore stability,lubricity,and formation protection,this approach could outperform methods that use typical OBDFs.The proposed method also achieves a classification upgrade from environmentally protective drilling fluid to an ecologically friendly drilling fluid.The developed technology was verified in more than 1000 unconventional oil and gas wells in China,and the results indicate significant alleviation of the formation damage attributed to borehole collapse,loss,and high friction.It has been recognized as an effective core technology for exploiting unconventional oil and gas resources.This study introduces a novel research direction for formation protection technology and demonstrates that observations and learning from the natural world can provide an inexhaustible source of ideas and inspire the creation of original materials,technologies,and theories for petroleum engineering. | Guancheng Jiang Jinsheng Sun Yinbo He Kaixiao Cui Tengfei Dong Lili Yang Xukun Yang Xingxing Wang | 2022 | Engineering2022，，11： | 11 |
| 4 | Effectiveness and safety of traditional Chinese herbs in children with cough variant asthma: a systematic review and Meta-analysis显示文摘OBJECTIVE:To systematically investigate the clinical effectiveness and safety of traditional Chinese herbs(TCHs)as an alternative to conventional medicine(CM)in children with cough variant asthma(CVA).METHODS:Randomized controlled trial(RCT)studies that were published from their inceptions to March 31,2020,were identified from the electronic databases of China National Knowledge Infrastructure,Wangfang,Pub Med,and Cochrane Central Library.The primary outcome of the review was the total effective rate(TER),and the secondary outcomes were immunoglobulin E(Ig E),peak expiratory flow(PEF),adverse drug reactions,and relapse rates of interventions.RESULTS:For the Meta-analysis,13 studies involving 992 children with CVA were included.In terms of TER and Ig E,the experimental interventions of TCH,when compared with the control interventions of CM,on pediatric CVA were found to be significantly effective(P<0.0001),whereas for spirometry,PEF was not significantly improved in the TCH group(P=0.48).The incident rates of adverse drug reaction and relapse were found to be significantly lower in the TCH group than those in the CM group(P=0.02 and P<0.0001,respectively).CONCLUSION:Compared with CM therapy,the effects of TCH therapy on pediatric CVA were significantly beneficial in terms of TER and Ig E,but not for PEF,and the methodological quality of included studies was poor.Therefore,the results should be interpreted with caution.More randomized controlled trials with rigorous experimental methodologies are required for objectivity in the future. | Kyou-Hwan Han Ki Haeng Cho CUI Shanqin Lily Lin Jaejong Kim | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 6 |
| 5 | Tourist Behaviors in Wetland Park:A Preliminary Study in Xixi National Wetland Park,Hangzhou,China显示文摘Public education as well as tourism and leisure are the two important functions of national wetland park, and tourist behaviors act as the guiding factor in the national wetland park construction and management.As the first national wetland park in China, Xixi National Wetland Park, located in Hangzhou City, Zhejiang Province, will give constructive instructions to the construction and management of other wetland parks and ecotourism resorts.This paper analyzed the tourist behaviors in Xixi National Wetland Park.By the observation, in-depth interview and questionnaire, the results show that tourists in wetland parks are different from those in the other common destinations, and they are also different from those strict eco-tourists.In fact, the tourists in wetland park have unique characteristics, such as the intense perception to the functions of wetland ecosystem and the environment impact behaviors.Those tourists are preferred to natural landscapes in their motivations and expectations.Wetland landscapes are the main image to those tourists in the Xixi National Wetland Park.Tourist expectation, experience and satisfaction are all critical factors for the success of the planning and management in national wetland parks.Based on the results, some measures for the sustainable development of wetland parks, including to optimize wetland theme landscape and tourism products, to improve tourist facilities and services, to enhance quality of visitor experiences, and to implement total quality management based on tourist characteristics, are given to national wetland park ecotourism. | PAN Lili CUI Lijuan WU Ming | 2010 | Chinese Geographical Science2010，20，1： | 5 |
| 6 | Brominated dioxins and furans in a cement kiln co-processing municipal solid waste显示文摘A field study and theoretical calculations were performed to clarify the levels, profiles, and distributions of polybrominated dibenzo-p-dioxins and dibenzofurans(PBDD/Fs) in a cement kiln co-processing solid waste, with a focus on the PBDF formation mechanism.The raw materials contributed greatly to input of PBDD/Fs into the cement kiln. The PBDD/F concentrations in the raw materials were much higher than those in particle samples from different process stages in the cement kiln. The PBDD/F concentrations in the clinkers were1.40% of the concentrations in the raw materials, which indicated that the high destruction efficiencies for PBDD/Fs by cement kiln. PBDD/F distribution patterns in particle samples collected from different process stages indicated the cement kiln backend was a major site for PBDD/F formation. PBDFs with high levels of halogenation, such as heptabrominated furans(Hp BDF), were the dominant contributors to the total PBDD/F concentrations and accounted for 42%–73% of the total PBDD/F concentrations in the particle samples. Our results showed that co-processing of municipal solid waste in a cement kiln may influence the congener profile of PBDD/Fs, especially for the higher halogenated PBDD fraction. In addition, there were significant correlations between the decabromodiphenyl ether and heptabrominated furan concentrations, which is an indicator of transformation from polybrominated diphenyl ethers to PBDD/Fs. Theoretical calculations were performed and demonstrated that elimination of HBr and Br_2 from polybrominated diphenyl ethers were the dominant formation pathways for PBDD/Fs. These pathways differed from that for polychlorinated dibenzo-p-dioxins and dibenzofurans(PCDD/Fs). | Lili Yang Yuyang Zhao Miwei Shi Minghui Zheng Yang Xu Cui Li Yuanping Yang Linjun Qin Guorui Liu | 2019 | Journal of Environmental Sciences2019，31，5： | 5 |
| 7 | Enhancement of T Follicular Helper Cell-Mediated Humoral Immunity Reponses During Development of Experimental Autoimmune Myasthenia Gravis显示文摘Myasthenia gravis(MG) is a prototypical antibody-mediated neurological autoimmune disease with the involvement of humoral immune responses in its pathogenesis. T follicular helper(Tfh) cells have been implicated in many autoimmune diseases. However, whether and how Tfh cells are involved in MG remain unclear.Here, we established and studied a widely-used and approved animal model of human MG, the rat model with acetylcholine receptor alpha(AChRa) subunit(RAChR97–116)-induced experimental autoimmune myasthenia gravis(EAMG). This model presented mild bodyweight loss 10 days after the first immunization(representing the early stage of disease) and more obvious clinical manifestations and body-weight loss 7 days after the second immunization(representing the late stage of disease). AChR-specific pre-Tfh cells and mature Tfh cells were detected in these two stages, respectively. In cocultures of Tfh cells and B cells, the number of IgG2 bsecreting B cells and the level of anti-AChR antibodies in the supernatant were higher in the cultures containing EAMG-derived Tfh cells. In immunohistochemistry and immunofluorescence assays, a substantial number of CD4^+/Bcl-6^+ T cells and a greater number of larger germinal centers were observed in lymph node tissues resected from EAMG rats. Based on these results, wehypothesize that an AChR-specific Tfh cell-mediated humoral immune response contributes to the development of EAMG. | Ying-Zhe Cui Si-Ying Qu Lu-Lu Chang Jia-Rui Zhao Lili Mu Bo Sun Hu-Lun Li Tong-Shuai Zhang Guang-You Wang Qing-Fei Kong | 2019 | Neuroscience Bulletin2019，35，3： | 4 |
| 8 | Responses of biotic interactions of dominant and subordinate species to decadal warming and simulated rotational grazing in Tibetan alpine meadow显示文摘Warming increases competition among plant species in alpine communities by ameliorating harsh environmental conditions,such as low temperatures. Grazing, as the main human activity, may mitigate the effect of warming, as previously reported.However, it is critical to refine the effects of warming on biotic interactions among species, for example, by taking the competitive ability of species into consideration. Based on a 10-year warming and grazing experiment in a Tibetan alpine meadow, we evaluated interspecific biotic interactions of dominant and subordinate species, using the approach of interspecific spatial associations. Warming significantly increased competition between subordinate and dominant species as well as among subordinate species, but not among dominant species. Moreover, facilitation of dominant-subordinate species also increased under warming. Simulated rotational grazing had similar effects to warming, with increasing interspecific competition. Our results show that, when studying the effects of warming on biotic interactions among species, it is necessary to characterize different species pairs relative to their competitive ability, and that simulated rotational grazing does not mitigate the effects of warming in the long term. Our results also provide evidence that the spatial pattern of species is a critical mechanism in species coexistence. | Xin'e Li Xiaoxue Zhu Shiping Wang Shujuan Cui Caiyun LUO Zhenhua Zhang Lirong Zhang Lili Jiang Wangwang Lyu | 2018 | Science China(Life Sciences)2018，61，7： | 4 |
| 9 | Evaluating Common Land Model Energy Fluxes Using FLUXNET Data显示文摘Given the crucial role of land surface processes in global and regional climates, there is a pressing need to test and verify the performance of land surface models via comparisons to observations. In this study, the eddy covariance measurements from 20 FLUXNET sites spanning more than 100 site-years were utilized to evaluate the performance of the Common Land Model(Co LM) over different vegetation types in various climate zones. A decomposition method was employed to separate both the observed and simulated energy fluxes, i.e., the sensible heat flux, latent heat flux, net radiation, and ground heat flux, at three timescales ranging from stepwise(30 min) to monthly. A comparison between the simulations and observations indicated that Co LM produced satisfactory simulations of all four energy fluxes, although the different indexes did not exhibit consistent results among the different fluxes. A strong agreement between the simulations and observations was found for the seasonal cycles at the 20 sites, whereas Co LM underestimated the latent heat flux at the sites with distinct dry and wet seasons, which might be associated with its weakness in simulating soil water during the dry season. Co LM cannot explicitly simulate the midday depression of leaf gas exchange, which may explain why Co LM also has a maximum diurnal bias at noon in the summer. Of the eight selected vegetation types analyzed, Co LM performs best for evergreen broadleaf forests and worst for croplands and wetlands. | Xiangxiang ZHANG Yongjiu DAI Hongzhi CUI Robert E.DICKINSON Siguang ZHU Nan WEI Binyan YAN Hua YUAN Wei SHANGGUAN Lili WANG Wenting FU | 2017 | Advances in Atmospheric Sciences2017，34，9： | 4 |
| 10 | The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR显示文摘On January 22,2020,China National Center for Bioinformation(CNCB)released the 2019 Novel Coronavirus Resource(2019nCoVR),an open-access information resource for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).2019nCoVR features a comprehensive integration of sequence and clinical information for all publicly available SARS-CoV-2 isolates,which are manually curated with value-added annotations and quality evaluated by an automated in-house pipeline.Of particular note,2019nCoVR offers systematic analyses to generate a dynamic landscape of SARS-CoV-2 genomic variations at a global scale.It provides all identified variants and their detailed statistics for each virus isolate,and congregates the quality score,functional annotation,and population frequency for each variant.Spatiotemporal change for each variant can be visualized and historical viral haplotype network maps for the course of the outbreak are also generated based on all complete and high-quality genomes available.Moreover,2019nCoVR provides a full collection of SARS-CoV-2 relevant literature on the coronavirus disease 2019(COVID-19),including published papers from PubMed as well as preprints from services such as bioRxiv and medRxiv through Europe PMC.Furthermore,by linking with relevant databases in CNCB,2019nCoVR offers data submission services for raw sequence reads and assembled genomes,and data sharing with NCBI.Collectively,SARS-CoV-2 is updated daily to collect the latest information on genome sequences,variants,haplotypes,and literature for a timely reflection,making 2019nCoVR a valuable resource for the global research community.2019nCoVR is accessible at http://gffzzdbc7b6aaae734bddspob5nbfxxkkb6qfc.ffgz.tsg.suse.edu.cn/ncov/. | Shuhui Song Lina Ma Dong Zou Dongmei Tian Cuiping Li Junwei Zhu Meili Chen Anke Wang Yingke Ma Mengwei Li Xufei Teng Ying Cui Guangya Duan Mochen Zhang Tong Jin Chengmin Shi Zhenglin Du Yadong Zhang Chuandong Liu Rujiao Li Jingyao Zeng Lili Hao Shuai Jiang Hua Chen Dali Han Jingfa Xiao Zhang Zhang Wenming Zhao Yongbiao Xue Yiming Bao | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 4 |
| 11 | Antioxidant andα-glucosidase inhibitiory activity of Cercis chinensis flowers显示文摘Antioxidant andα-glucosidase inhibitiory active compounds of Cercis chinensis flowers were investigated with bio-assay guiding method.Ethyl acetate fraction(CLEa)and n-butanol fraction(CLBu)exhibited antioxidant andα-glucosidase inhibitiory activity in vitro,and the corresponding active fractions,EaFr.3,EaFr.5 and BuFr.1,exhibited higher antioxidant andα-glucosidase inhibitiory activity than those of other fractions.Eight compounds,ethyl gallate(1),stearic acid(2),docosanoic acid(3),5α-stigmast-9(11)-en-3β-ol(4),kaempferol-3-O-α-rhamnopyranoside(5),vanillic acid(6),fisetin(7),andβ-sitosterol(8),were isolated and identified from CLEa and CLBu.Ethyl gallate shown the highest antioxidant activity by scavenging DPPH radical and reducing ferric compared.Docosanoic acid and vanillic acid shown strongerα-glucosidase inhibitory activity than that of acarbose. | Juanjuan Zhang Li Zhou Lili Cui Zhenhua Liu Jinfeng Wei Wenyi Kang | 2020 | Food Science and Human Wellness2020，9，4： | 3 |
| 12 | Surface modification of an up-conversion luminescence material by overcoating with SiO_2 and its characterization显示文摘The surface of an up-conversion luminescence material was modified by overcoating with SiO2, which was syn- thesized from a hydrolysis progress of tetraethoxysilane (TEOS) in alkalescent condition. By analyzing the hydrolyzed mechanism of TEOS, it was found that there was not only physical adsorption but also chemical bonding between the up-conversion material and SiO2. At the same time, some adsorption bands at 1100, 475, 950, and 3500 cm?1 were found by FI-IR, which were the characteristic bands of Si?OH and Si?O?Si. By analyzing the surface elements of the coated material by XPS, it was found that its surface only included Si, O, and C elements, and not F and Y. In the picture of XRD, there was no additional peak after surface modification, suggesting that the silica shell was amorphous. The small peak at 2θ = 23° in the X-ray diffraction pattern of the coated material was caused by the amorphous SiO2 shell, and the TEM image also proved that the surface of the material was successfully modified by overcoating with SiO2. The amount of hydroxyls was then increased on the surface of the material, which made it easy to connect with other active groups. | CUI Lili LIU Jiemin FAN Huili XU Xiaowei YANG Min XIAO Junping | 2007 | Rare Metals2007，26，3： | 2 |
| 13 | In situ FTIR investigation on phase transformations in BN nanoparticles显示文摘Fourier transformation infrared spectrum (FTIR) was employed to investigate phase transformation of nanoparticle BN, containing eBN, rBN, wBN and cBN, in which eBN and rBN are the main components. We found that part of eBN was converted into rBN at 200―350℃. At and above 400℃, eBN transformed into wBN, and some of wBN were converted into cBN simultaneously. This conclusion is supported by the results from high- resolution transmission electron microscopic (HRTEM) and Raman spectroscopic measurements. In this work, the converting processes be- tween different BN phases were continuously monitored by in situ FTIR spectroscopy. The results will be helpful for synthesis of cBN at moderate conditions. | YU Lili GAO Bin CHEN Zhi SUN Chuantao CUI Deliang WANG Chengjian WANG Qilong JIANG Minhua | 2005 | Chinese Science Bulletin2005，50，24： | 2 |
| 14 | Caffeic acid phenethyl ester (CAPE), an active component of propolis, inhibits Helicobacter pylori peptide deformylase activity显示文摘 | Kunqiang Cui Weiqiang Lu Lili Zhu Xu Shen Jin Huang | 2013 | Biochemical and Biophysical Research Communications2013，，2： | 2 |
| 15 | Microstructure and mechanical properties of cast Ti-47Al-2Cr-2Nb alloy melted in various crucibles显示文摘The main factors limiting the mass production of TiAl-based components are the high reactivity of TiAl-based alloys with the crucible or mould at high temperature.In this work,various crucibles (e.g.CaO,Y2O3 ceramic crucibles and water-cooled copper crucible) were used to fabricate the Ti-47Al-2Cr-2Nb alloy in a vacuum induction furnace.The effects of crucible materials and melting parameters on the microstructure and mechanical properties of the alloy were analyzed by means of microstructure observation,chemical analysis,tensile test and fracture surface observation.The possibilities of melting TiAl alloys in crucibles made of CaO and Y2O3 refractory materials were also discussed. | Wang Ligang Zheng Lijing Cui Renjie Yang Lili Zhang Hu | 2012 | China Foundry2012，9，1： | 2 |
| 16 | Reduction-induced interface reconstruction to fabricate MoNi_(4) - based hollow nanorods for hydrazine oxidation assisted energysaving hydrogen production in seawater显示文摘Seawater electrolysis could address the water scarcity issue and realize the grid-scale production of carbon-neutral hydrogen,while facing the challenge of high energy consumption and chloride corrosion.Thermodynamically more favorable hydrazine oxidation reaction(HzOR)assisted water electrolysis is efficiency for energy-saving and chlorine-free hydrogen production.Herein,the MoNi alloys supported on MoO_(2) nanorods with enlarged hollow diameter on Ni foam(MoNi@NF)are synthesized,which is constructed by limiting the outward diffusion of Ni via annealing and thermal reduction of NiMoO_(4) nanorods.When coupling HzOR and hydrogen evolution reaction(HER)by employing MoNi@NF as both anode and cathode in two-electrode seawater system,a low cell voltage of 0.54 V is required to achieve 1,000 mA·cm^(−2) and with long-term durability for 100 h to keep above 100 mA·cm^(−2) and nearly 100%Faradaic efficiency.It can save 2.94 W·h to generate per liter H_(2) relative to alkaline seawater electrolysis with 37%lower energy equivalent input. | Lili Guo Qingping Yu Xuejun Zhai Jingqi Chi Tong Cui Yu Zhang Jianping Lai Lei Wang | 2022 | Nano Research2022，15，10： | 2 |
| 17 | Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase显示文摘Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) has become one major threat to human population health.The RNA-dependent RNA polymerase(RdRp) presents an ideal target of antivirals,whereas nucleoside analogs inhibitor is hindered by the proofreading activity of coronavirus.Herein,we report that corilagin(RAI-S-37) as a non-nucleoside inhibitor of SARS-CoV-2 RdRp,binds directly to RdRp,effectively inhibits the polymerase activity in both cell-free and cell-based assays,fully resists the proofreading activity and potently inhibits SARS-CoV-2 infection with a low 50% effective concentration(EC50) value of 0.13 μmol/L.Computation modeling predicts that RAI-S-37 lands at the palm domain of RdRp and prevents conformational changes required for nucleotide incorporation by RdRp.In addition,combination of RAI-S-37 with remdesivir exhibits additive activity against antiSARS-CoV-2 RdRp.Together with the current data available on the safety and pharmacokinetics of corilagin as a medicinal herbal agent,these results demonstrate the potential of being developed into one of the much-needed SARS-CoV-2 therapeutics. | Quanjie Li Dongrong Yi Xiaobo Lei Jianyuan Zhao Yongxin Zhang Xiangling Cui Xia Xiao Tao Jiao Xiaojing Dong Xuesen Zhao Hui Zeng Chen Liang Lili Ren Fei Guo Xiaoyu Li Jianwei Wang Shan Cen | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 2 |
| 18 | Surface modification of up-conversion luminescence material Na[Y_(0.57)Yb_(0.39)Er_(0.04)]F_4 with hydrosulfide group显示文摘A new method was reported for surface modification of an up-conversion luminescence material with hydrosulfide group. The factors that may influence the surface modification,such as reaction time,amount of catalyzer and modifier,and reaction solvent,were investigated. The optimal conditions were that the reaction time,the quantity of the basic catalyzer,the quantity of modifier and the volume of reaction solvent were 40 min,1.0,1.0,and 40 mL,respectively. The results indicated that hydrosulfide group content modified on the surface of up-conversion luminescence material reached to 0.1430 mmol/g,and this modified up-conversion lumi-nescence material could be widely used in the study of structure of protein and the property of microenvironment. | Lili Cui Huili Fan Junping Xiao Xiaowei Xu Dong Su | 2008 | Journal of University of Science and Technology Beijing2008，15，5： | 2 |
| 19 | Agricultural expansion in Yunnan Province and its environmental consequences显示文摘 | LI Renqiang DONG Ming PENG Hua ZHANG Lili CUI Qingguo HE Weiming | 2006 | Chinese Science Bulletin2006，51，B11： | 2 |
| 20 | Chemical composition and glucose uptake effect on 3T3-L1 adipocytes of Ligustrum lucidum Ait. flowers显示文摘Ligustri lucidi Fructus is a traditional Chinese medicine and possesses various bioactivities,including hypoglycemic effect.Ligustrum lucidum Ait flowers are poorly investigated.Thus,we hypothesized that L.lucidum flowers also could have hypoglycemic effect.Chemical composition and glucose uptake effect of L.lucidum flowers on 3T3-L1 adipocytes were investigated.In this study,the components of L.lucidum flowers were investigated by various chromatographic and spectroscopic methods and the effects of L.lucidum flowers on the induction of glucose uptake were investigated by 3T3-L1 adipocytes.Seven compounds were isolated and identified from L.lucidum flowers,including ursolic acid(1),kaempferol-7-O-α-Lrhamnoside(2,KR),β-sitosterol(3),β-daucosterol(4),kaempferitrin(5,KF),10-hydroxy oleuropein(6,HO),and kaempferol-3-O-β-D-glucopyranoside-7-α-L-rhamnopyranoside(7,KGR).The results of glucose uptake showed that total extract(TE),KR,KF and HO from L.lucidum flowers significantly enhanced glucose uptake.This study demonstrated that compounds 2,5-7 were isolated for the first time from this plant and compounds 2 and 7 were isolated for the first time in genus Ligustrum,L.lucidum flowers,KR,KF and HO may possess potential hypoglycemic effect. | Lili Cui Jinmei Wang Mengke Wang Baoguang Wang Zhenhua Liu Jinfeng Wei Wenyi Kang | 2020 | Food Science and Human Wellness2020，9，2： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员