|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The endoplasmic reticulum-associated degradation is necessary for plant salt tolerance显示文摘真核细胞的有机体有允许错误褶层或 unassembled 蛋白质在 endoplasmic 蜂窝胃被保留的质量控制的机制(嗯) 并且随后由嗯联系降级(ERAD ) 降级了。ERAD 小径很好在酵母和哺乳动物被学习;然而,植物 ERAD 的生物功能没被报导。通过分子、细胞的生物途径,我们发现 ERAD 是必要的让植物克服盐应力。在蛋白质在植物房间增加了的盐处理 ubiquitinated 之上,特别展开了快速在 ER 积累了并且随后导致了的蛋白质嗯压力回答。在 ERAD 小径的 HRD1/HRD3 建筑群的 HRD3A 的缺点导致了展开的蛋白质反应(UPR ) 的改变,腌的增加的植物敏感,和在植物房间的 ERAD 底层的保留。而且,我们证明从 ER 的那个 Ca 2+ 版本涉及 UPR 的举起,反应的氧种类(ROS ) 参与 ERAD 相关的植物盐反应小径。 | Lijing Liu Feng Cui Qingliang Li Bojiao Yin Huawei Zhang Baoying Lin Zaorong Wu Ran Xia Sanyuan Tang Qi Xie | 2011 | Cell Research2011，21，6： | 19 |
| 2 | Effects of Service Condition on Rolling Contact Fatigue Failure Mechanism and Lifetime of Thermal Spray Coatings——A Review显示文摘The service condition determines the Rolling Contact Fatigue(RCF) failure mechanism and lifetime under ascertain material structure integrity parameter of thermal spray coating. The available literature on the RCF testing of thermal spray coatings under various condition services is considerable; it is generally difficult to synthesize all of the result to obtain a comprehensive understanding of the parameters which has a great effect on a thermal spray coating's resistance of RCF. The effects of service conditions(lubrication states, contact stresses, revolve speed, and slip ratio) on the changing of thermal spray coatings' contact fatigue lifetime is introduced systematically. The effects of different service condition on RCF failure mechanism of thermal spray coating from the change of material structure integrity are also summarized. Moreover, In order to enhance the RCF performance, the parameter optimal design formula of service condition and material structure integrity is proposed based on the effect of service condition on thermal spray coatings' contact fatigue lifetime and RCF failure mechanism. The shortage of available literature and the forecast focus in future researches are discussed based on available research. The explicit result of RCF lifetime law and parameter optimal design formula in term of lubrication states, contact stresses, revolve speed, and slip ratio, is significant to improve the RCF performance on the engineering application. | CUI Huawei CUI Xiufang WANG Haidou XING Zhiguo JIN Guo | 2015 | Chinese Journal of Mechanical Engineering2015，28，1： | 12 |
| 3 | Co-seismic fault geometry and slip distribution of the 26 December 2004, giant Sumatra–Andaman earthquake constrained by GPS, coral reef, and remote sensing data显示文摘We analyze co-seismic displacement field of the 26 December 2004, giant Sumatra–Andaman earthquake derived from Global Position System observations,geological vertical measurement of coral head, and pivot line observed through remote sensing. Using the co-seismic displacement field and AK135 spherical layered Earth model, we invert co-seismic slip distribution along the seismic fault. We also search the best fault geometry model to fit the observed data. Assuming that the dip angle linearly increases in downward direction, the postfit residual variation of the inversed geometry model with dip angles linearly changing along fault strike are plotted. The geometry model with local minimum misfits is the one with dip angle linearly increasing along strike from 4.3oin top southernmost patch to 4.5oin top northernmost path and dip angle linearly increased. By using the fault shape and geodetic co-seismic data, we estimate the slip distribution on the curved fault. Our result shows that the earthquake ruptured *200-km width down to a depth of about 60 km.0.5–12.5 m of thrust slip is resolved with the largest slip centered around the central section of the rupture zone78N–108N in latitude. The estimated seismic moment is8.2 9 1022 N m, which is larger than estimation from the centroid moment magnitude(4.0 9 1022 N m), and smaller than estimation from normal-mode oscillation data modeling(1.0 9 1023 N m). | Yongge Wan Zheng-kang Shen Min Wang Yuehua Zeng Jichao Huang Xiang Li Huawei Cui Xiwei Gao | 2015 | Earthquake Science2015，28，3： | 1 |
| 4 | Programmable deaminase-free base editors for G-to-Y conversion by engineered glycosylase显示文摘Current DNA base editors contain nuclease and DNA deaminase that enables deamination of cytosine(C)or adenine(A),but no method for guanine(G)or thymine(T)editing is available at present.Here we developed a deaminase-free glycosylase-based guanine base editor(gGBE)with G editing ability,by fusing Cas9 nickase with engineered N-methylpurine DNA glycosylase protein(MPG).By several rounds of MPG mutagenesis via unbiased and rational screening using an intron-split EGFP reporter,we demonstrated that gGBE with engineered MPG could increase G editing efficiency by more than 1500 fold.Furthermore,this gGBE exhibited high base editing efficiency(up to 81.2%)and high G-to-T or G-to-C(i.e.G-to-Y)conversion ratio(up to 0.95)in both cultured human cells and mouse embryos.Thus,we have provided a proof-of-concept of a new base editing approach by endowing the engineered DNA glycosylase the capability to selectively excise a new type of substrate. | Huawei Tong Nana Liu Yinghui Wei Yingsi Zhou Yun Li Danni Wu Ming Jin Shuna Cui Hengbin Li Guoling Li Jingxing Zhou Yuan Yuan Hainan Zhang Linyu Shi Xuan Yao Hui Yang | 2023 | National Science Review2023，10，8： | 1 |
| 5 | Preventing autosomal-dominant hearing loss in Bth mice with CRISPR/CasRx-based RNA editing显示文摘CRISPR/RfxCas13d(CasRx)editing system can specifically and precisely cleave single-strand RNAs,which is a promising treatment for various disorders by downregulation of related gene expression.Here,we tested this RNA-editing approach on Beethoven(Bth)mice,an animal model for human DFNA36 due to a point mutation in Tmc1.We first screened 30 sgRNAs in cell cultures and found that CasRx with sgRNA3 reduced the Tmc1^(Bth)transcript by 90.8%,and the Tmc1 wild type transcript(Tmc1^(+))by 44.3%.We then injected a newly developed AAV vector(AAV-PHP.eB)based CasRx into the inner ears of neonatal Bth mice,and we found that Tmc1^(Bth)was reduced by 70.2%in 2 weeks with few off-target effects in the whole transcriptome.Consistently,we found improved hair cell survival,rescued hair bundle degeneration,and reduced mechanoelectrical transduction current.Importantly,the hearing performance,measured in both ABR and DPOAE thresholds,was improved significantly in all ages over 8 weeks.We,therefore,have validated the CRISPR/CasRx-based RNA editing strategy in treating autosomal-dominant hearing loss,paving way for its further application in many other hereditary diseases in hearing and beyond. | Ziwen Zheng Guo Li Chong Cui Fang Wang Xiaohan Wang Zhijiao Xu Huiping Guo Yuxin Chen Honghai Tang Daqi Wang Mingqian Huang Zheng-Yi Chen Xingxu Huang Huawei Li Geng-Lin Li Xiaoxiang Hu Yilai Shu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 1 |
| 6 | 'Seed Science and Engineering'Exploration on the Construction of Curriculum Ideological and Political System显示文摘The specialty of'seed science and Engineering'has trained a large number of scarce seed talents for China.This paper summarizes the experience,existing problems and future improvement direction of the ideological and political system construction of the curriculum of'seed science and Engineering'in our university,in order to improve the ideological and political system construction of colleges and universities. | Huawei Cui Bin Yang Yixiong Zheng | 2021 | Review of Educational Theory2021，4，4： | 0 |
| 7 | High-silica faujasite zeolite-tailored metal encapsulation for the low-temperature production of pentanoic biofuels显示文摘Zeolite-encapsulated metal nanoclusters are at the heart of bifunctional catalysts,which hold great potential for petrochemical conversion and the emerging sustainable biorefineries.Nevertheless,efficient encapsulation of metal nanoclusters into a high-silica zeolite Y in particular with good structural integrity still remains a significant challenge.Herein,we have constructed Ru nanoclusters(~1 nm)encapsulated inside a high-silica zeolite Y(SY)with a SiO_(2)/Al_(2)O_(3) ratio(SAR)of 10 via a cooperative strategy for direct zeolite synthesis and a consecutive impregnation for metal encapsulation.Compared with the benchmark Ru/H-USY and other analogues,the as-prepared Ru/H-SY markedly boosts the yields of pentanoic biofuels and stability in the direct hydrodeoxygenation of biomass-derived levulinate even at a mild temperature of 180℃,which are attributed to the notable stabilization of transition states by the enhanced acid accessibility and properly sized constraints of zeolite cavities owing to the good structural integrity. | Wenhao Cui Yuanshuai Liu Pengfei Guo Zhijie Wu Liqun Kang Huawei Geng Shengqi Chu Linying Wang Dong Fan Zhenghao Jia Haifeng Qi Wenhao Luo Peng Tian Zhongmin Liu | 2024 | Journal of Energy Chemistry2024，88，1： | 0 |
| 8 | Single-frequency upconverted laser generation by phase summation显示文摘The phase summation effect in sum-frequency mixing process is utilized to avoid a nonlinearity obstacle in the power scaling of single-frequency visible or ultraviolet lasers.Two single-frequency fundamental lasers are spectrally broadened by phase modulation to suppress stimulated Brillouin scattering in fiber amplifier and achieve higher power.After sum-frequency mixing in a nonlinear optical crystal,the upconverted laser returns to single frequency due to phase summation,when the phase modulations on two fundamental lasers have a similar amplitude but opposite sign.The method was experimentally proved in a Raman fiber amplifier-based laser system,which generated a power-scalable sideband-free single-frequency 590 nm laser.The proposal manifests the importance of phase operation in wave-mixing processes for precision laser technology. | Xin Zeng Shuzhen Cui Huawei Jiang Bowen Ruan Xin Cheng Jiaqi Zhou Zhiquan Lin Xuezong Yang Weibiao Chen Yan Feng | 2023 | High Power Laser Science and Engineering2023，11，2： | 0 |
| 9 | High-power 1560 nm single-frequency erbium fiber amplifier core-pumped at 1480 nm-ERRATUM显示文摘The publisher apologises that due to a publishing error this article was published into volume 10(2022)rather than volume 11.Unfortunately,we are unable to correct this error and so this article has now been updated to confirm the publishing volume as volume 10(2022).Any accepted and publication dates associated with the article are still correct. | Xin Cheng Zhiquan Lin Xuezong Yang Shuizhen Cui Xin Zeng Huawei Jiang Yan Feng | 2023 | High Power Laser Science and Engineering2023，11，2： | 0 |
| 10 | Controllable deformation based self-adaptive drag reduction for complex surface显示文摘Reduction of energy consumption and improvement of cruising speed are greatly necessary for underwater vehicles.Previously,regular riblets have been machined and the drag reduction has been verified;however,the riblet parameters are not adjusted like the denticles of sharkskin,which adapt quickly to the complex changing fluid flow.To achieve an improved drag reduction effect on the complicated shape surface,a simple,low-cost,and timesaving stretching approach was proposed to adjust the riblet parameters on the underwater vehicle surface by controllable deformation.Nature latex rubber membrane with regular micro-riblets was prepared as a stretching flexible film,and the spacing and height of the micro-riblets were adjusted by adaptive control of the stretching ratio.The circulating water channel experiment verified the effectiveness and feasibility of the selfadaptive drag reduction by the controllable deformation method.The results demonstrated that the drag reduction rate of the controllable deformation bionic fish skin was 4.26%compared with a smooth surface at 0.25 m/s with an angle of attack of 0°,which is better than any other angle.The controllable deformation bionic fish skin provides a feasible method for the drag reduction of complex surface adaptive underwater vehicles. | Dengke Chen Xianxian Cui Huawei Chen | 2023 | Biosurface and Biotribology2023，9，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员